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Lemierre Syndrome

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2. Lemierre's syndrome: A persistent unusual neck pain and swelling Full Text available with Trip Pro

Lemierre's syndrome: A persistent unusual neck pain and swelling Lemierre's syndrome is a systemic complication commonly caused by oropharyngeal infection by Fusobacterium species, which manifests itself as an internal jugular vein thrombosis formation. It is a rare occurrence nowadays with the availability of broad spectrum antibiotics for treatment. Most cases in the literature presented with a life-threatening condition. We are reporting a case of Lemierre's syndrome that presented

2018 Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia

3. Lemierre's Syndrome – A rare cause of disseminated sepsis requiring multi-organ support Full Text available with Trip Pro

Lemierre's Syndrome – A rare cause of disseminated sepsis requiring multi-organ support Lemierre's syndrome is a rare complication of acute pharyngitis characterised by septicaemia with infective thrombophlebitis of the internal jugular vein, most commonly due to Fusobacterium necrophorum. It characteristically affects healthy young adults causing persistent pyrexia and systemic sepsis presenting several days after an initial pharyngitis. Septic emboli seed via the bloodstream to distant (...) sites including the lung, joints, skin, liver, spleen and brain. Prolonged antimicrobial therapy is required and admission to intensive care common. This once rare condition is increasing in incidence but awareness amongst clinicians is low. We present a classic case in a young man who developed multi-organ failure requiring intensive care support and describe the epidemiology, pathophysiology, microbiology, clinical features and management of the disease.

2017 Journal of the Intensive Care Society

4. Lemierre's syndrome presented with acute pancreatitis Full Text available with Trip Pro

Lemierre's syndrome presented with acute pancreatitis Lemierre's syndrome is a rare clinical condition that is characterized by infected internal jugular vein thrombosis with metastatic septicemia. The most common causative agent is Fusobacterium necrophorum. A previously healthy 37-year-old woman presented to our emergency department with nausea, vomiting, and diarrhea. She was admitted to the general practice unit with a diagnosis of acute pancreatitis then was subsequently transferred (...) to the intensive care unit due to shock. Physical examination revealed tenderness on right side of the neck. Blood cultures were remarkable for F. necrophorum. Clinical symptoms led to subsequent ultrasound and computed tomography scan of the neck, confirming internal jugular vein thrombosis.The patient was treated with antibiotics for 6 weeks. Anticoagulation therapy was initiated.We report a case of Lemierre's syndrome that presented as acute pancreatitis. The high index of suspicion of this disease

2017 Acute medicine & surgery

5. Atypical Presentation of Lemierre's Syndrome Causing Septic Shock and Acute Respiratory Distress Syndrome Full Text available with Trip Pro

Atypical Presentation of Lemierre's Syndrome Causing Septic Shock and Acute Respiratory Distress Syndrome Lemierre's disease is a rare but life-threatening condition characterized by an oropharyngeal infection complicating with thrombophlebitis of the internal jugular vein and disseminated abscesses. We are presenting a case of a young female who initially presented with fevers, chills, sore throat, and swollen neck later developed progressively worsening shortness of breath along with sudden (...) onset pleuritic chest pain. She then developed progressively worsening acute hypoxic respiratory failure requiring intubation and mechanical ventilation. Interval chest X-ray showed worsening bilateral effusions. She also developed septic shock requiring pressors. Blood culture showed Fusobacterium, and antibiotics were changed accordingly following which there was a clinical improvement. The diagnosis of Lemierre's syndrome was then established based on her presenting age and bilateral pulmonary

2018 Case reports in infectious diseases

6. Methicillin-Resistant Staphylococcus aureus Septic Internal Jugular Thrombophlebitis: Updates in the Etiology and Treatment of Lemierre's Syndrome. (Abstract)

Methicillin-Resistant Staphylococcus aureus Septic Internal Jugular Thrombophlebitis: Updates in the Etiology and Treatment of Lemierre's Syndrome. Lemierre's syndrome is classically precipitated by oropharyngeal infections that progress to suppurative internal jugular vein thrombophlebitis via direct extension. Metastatic pneumonia from septic emboli is nearly universal and bacterial seeding frequently results in disseminated septic foci. Fusobacterium necrophorum is the most commonly reported (...) etiologic agent, though methicillin-resistant Staphylococcus aureus (MRSA) is an emerging pathogen and a myriad of oropharyngeal flora must be covered until blood cultures return. Prompt identification is paramount to minimizing morbidity. Empiric treatment with antibiotics exhibiting predominantly anaerobic activity has been standard, but now may be insufficient, given an evolving microbial landscape. Anticoagulation continues to be debated.We describe an uncommon presentation of Lemierre's syndrome

2019 Journal of Emergency Medicine

7. Mastoiditis with concomitant Lemierre's syndrome: A case report. (Abstract)

Mastoiditis with concomitant Lemierre's syndrome: A case report. Otalgia with mastoiditis is an infrequently encountered complication of acute otitis media (Pfaff and Moore, 2018). Even more rare is the development of infected jugular venous thrombosis, Lemierre's disease. We present a case of a six year-old girl with otalgia for over two months who presented to our Emergency Department (ED) with clinical mastoiditis, confirmed on CT scan, as well as an incidental diagnosis of complete (...) thrombosis of the internal jugular (IJ) vein, Lemierre's syndrome. The true prevalence of Lemierre's from mastoiditis is difficult to discern. This clinical case highlights the importance of the consideration of these pathologies by the emergency physician.Copyright © 2019 Elsevier Inc. All rights reserved.

2019 American Journal of Emergency Medicine

8. Senile Lemierre syndrome complicated with descending necrotizing mediastinitis: A case report. Full Text available with Trip Pro

Senile Lemierre syndrome complicated with descending necrotizing mediastinitis: A case report. Senile patients with LS complicated with DNM are rarely seen in clinical practice, and extensive cervical incision and drainage plus administration of effective antibiotics are the basis for treatment. Currently, the treatment controversy mainly has focused on whether mediastinal incision and drainage is necessary for patients with type I DNM, and whether anticoagulation therapy is required

2018 Medicine

9. Cone beam computed tomography-guided transpterygoidal aspiration of a carotid space abscess in Lemierre's syndrome Full Text available with Trip Pro

Cone beam computed tomography-guided transpterygoidal aspiration of a carotid space abscess in Lemierre's syndrome Lemierre's syndrome results from anaerobic bacterial thrombophlebitis of the cervical venous vasculature, occasionally complicated by deep neck space abscesses, sepsis, septic emboli, vascular occlusions, or mycotic aneurysms. Fastidious organisms, such as Fusobacterium necrophorum, may be slow to respond to intravenous antibiotic therapy, prompting a need for more aggressive (...) source control. Concomitant vascular occlusions and mycotic aneurysms present difficult decisions regarding anticoagulation, and the anatomy involved implies important technical considerations for intervention. A case of Lemierre's syndrome complicated by a carotid space abscess and mycotic internal carotid artery pseudoaneurysm progressed despite intravenous antibiosis. Transpterygoidal aspiration using cone beam computed tomography guidance provided both technical and clinical success.

2018 Radiology Case Reports

10. A Rare Case of Lemierre-Like Syndrome: A Case Report and Literature Review Full Text available with Trip Pro

A Rare Case of Lemierre-Like Syndrome: A Case Report and Literature Review Lemierre's syndrome (LS) is a serious rare complication of oropharyngeal infections. It is characterized by thrombosis of internal jugular vein that rapidly progresses into sepsis and is typically caused by anaerobes. Most of the reported cases have been linked to Fusobacterium necrophorum; however, there are a handful of reported cases due to aerobes. It is primarily the disease of healthy young adults and can present (...) in school-aged children. The early recognition and treatment of this complication results in resolution of the illness; nevertheless, there have been some concerns about chronic venous insufficiency as a long-term complication. We report a case of a 6-year-old boy, who presented with fever and headache with a history of sore throat. His blood culture was positive for group A Streptococcus (GAS) and was subsequently found to have internal jugular vein, sigmoid, and transverse sinus vein thrombosis.

2018 Case reports in pediatrics

11. Purpura fulminans with Lemierre's syndrome caused by Gemella bergeri and Eikenella corrodens: a case report. Full Text available with Trip Pro

Purpura fulminans with Lemierre's syndrome caused by Gemella bergeri and Eikenella corrodens: a case report. Gemella bergeri is one of the nine species of the genus Gemella and is relatively difficult to identify. We herein describe the first case of septic shock due to a Gemella bergeri coinfection with Eikenella corrodens.A 44-year-old Asian man with a medical history of IgG4-related ophthalmic disease who was prescribed corticosteroids (prednisolone) presented to our hospital with dyspnea (...) thrombosis. Following this, the patient was diagnosed with Lemierre's syndrome. Furthermore, he went into shock again on day 6 of hospitalization. Additional soft tissue infections were suspected; therefore, bilateral below the knee amputations were performed for source control. Cultures of the exudates from skin lesions and histopathological samples did not identify any pathogens, and histopathological findings showed arterial thrombosis; therefore it was concluded that the second time shock

2018 BMC Infectious Diseases

12. Lemierre Syndrome as a Complication of Laryngeal Carcinoma Full Text available with Trip Pro

Lemierre Syndrome as a Complication of Laryngeal Carcinoma Lemierre syndrome is a rare condition characterized by a septic thrombophlebitis of the internal jugular vein with septicemia and metastatic foci of infection. It typically occurs as the result of an infection in the head and neck, most commonly pharyngitis. For reasons that are unclear, the incidence of Lemierre syndrome has been increasing over the past 15 years. Diagnosis of Lemierre syndrome is often delayed, and identification (...) of internal jugular vein thrombosis is often the first indicator of its presence. We report a case of Lemierre syndrome associated with a laryngeal carcinoma.

2018 Clinical Practice and Cases in Emergency Medicine

13. A Case of Lemierre's Syndrome in Intensive Care Unit Full Text available with Trip Pro

A Case of Lemierre's Syndrome in Intensive Care Unit We report a 21-year-old young male with Lemierre's syndrome presented as tonsillitis and Fusobacterium septicemia with respiratory failure and required intensive care. Lemierre's syndrome is the septic embolic complication of recent pharyngeal illness. Fusobacterium spp. accounts for the majority of cases. High index of suspicion is needed and prolonged antibiotic is advised. It is seldom seen in intensive care but should never be forgotten.

2018 Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

14. The co-existence of Lemierre's syndrome and Bezold's abscesses due to Streptococcus constellatus: A case report. Full Text available with Trip Pro

The co-existence of Lemierre's syndrome and Bezold's abscesses due to Streptococcus constellatus: A case report. The ancient infectious diseases, Lemierre's Syndrome and Bezold's Abscesses are rare.A 70-year-old Japanese woman with a 15-year history of Parkinson's disease was referred to our hospital due to fever, occipital headache and bilateral shoulder pain that had continued for three months. She had been prescribed prednisolone due to a diagnosis of polymyalgia rheumatica.A blood culture (...) revealed bacteremia of Streptococcus constellatus. In addition, computed tomography revealed Bezold's abscesses and Lemierre's syndrome.We administered ceftriaxone for 31 days, followed by oral amoxicillin.The patient recovered and the abscesses improved.This case underscores the importance of blood culture tests and cross-referencing with radiological imagings in the diagnoses of these rare critical infectious diseases that mimic polymyalgia rheumatica.

2018 Medicine

15. Lemierre Syndrome in Adolescent with Active Ulcerative Colitis Full Text available with Trip Pro

Lemierre Syndrome in Adolescent with Active Ulcerative Colitis Inflammatory bowel disease (IBD) is a well-recognized risk factor for thrombotic events in adults but data on children are scarce. In the great majority of adult patients, thrombotic events are usually deep vein thrombosis and pulmonary embolism. Other sites such as jugular veins are extremely rare. We present a case of Lemierre syndrome in an adolescent girl with active ulcerative colitis and discuss possible risk factors (...) . This is the first reported case of severe Lemierre syndrome with thrombus extension to cranial veins in a patient with ulcerative colitis. Early recognition of Lemierre syndrome in patients who present with rapidly worsening symptoms of neck pain, fever and signs of pharyngitis is imperative because it increases a chance of favorable prognosis. It is important for pediatricians treating IBD patients not to underestimate possible thrombotic events in children with IBD. Recognition of additional risk factors

2018 Pediatric gastroenterology, hepatology & nutrition

16. Lemierre syndrome: a diagnostic dilemma in paediatric patients Full Text available with Trip Pro

Lemierre syndrome: a diagnostic dilemma in paediatric patients Lemierre's syndrome is a rare disease of the head and neck, characterized by an initial infection, usually within the oropharynx, which can develop into a septic thrombophlebitis. It can involve the jugular vein, facial veins and respiratory tract. A 7-year-old child attended our institution with a 1-week history of fever and cough. Initial imaging demonstrated a large left sided empyema with multiple cavitating lung lesions (...) and persisting pneumothoraces secondary to the development of a bronchopleural fistula. There was no clinical improvement, despite an initial course of antibiotics. A contrast enhanced computed tomography (CT) of the head and neck revealed left mastoiditis, multiple cerebral abscesses and thrombus within the left internal jugular vein. Antibiotic therapy was modified. The empyema was surgically drained and bronchopleural fistula repaired. This case illustrates an atypical presentation of Lemierre's syndrome

2017 Journal of surgical case reports

17. Lemierre's Syndrome Presenting as Multifocal Pyomyositis in a Young Child. (Abstract)

Lemierre's Syndrome Presenting as Multifocal Pyomyositis in a Young Child. Lemierre's syndrome is more common in young adults and the majority of patients present with pharyngitis. Multifocal pyomyositis is very rare in this setting and in young children. We present here a case of multifocal pyomyositis caused by Fusobacterium spp. in a young child. Fusobacterium should be considered in the differential diagnosis of multifocal pyomyositis of unclear etiology.

2017 Pediatric Infectious Dsease Journal

18. Lemierre's Syndrome Associated with Mechanical Ventilation and Profound Deafness Full Text available with Trip Pro

Lemierre's Syndrome Associated with Mechanical Ventilation and Profound Deafness Lemierre's syndrome is a rare disorder that is characterized by anaerobic organisms inducing a thrombophlebitis of the internal jugular vein (IJV) following a course of oropharyngeal infection. It often occurs in young and healthy patients. Clinicians continuously misinterpret early symptoms until infection disseminates systematically and life-threatening sepsis transpires. We report the case of a 58-year-old (...) female developing Lemierre's syndrome accompanied by invasive ventilation support and a profound deafness requiring the implementation of a cochlear implant. This is one of two reported cases of Lemierre's syndrome associated with mechanical ventilation support and the only case associated with a cochlear implant.

2017 Case reports in infectious diseases

19. Human Infection with Fusobacterium necrophorum without Jugular Venous Thrombosis: A Varied Presentation of Lemierre's Syndrome Full Text available with Trip Pro

Human Infection with Fusobacterium necrophorum without Jugular Venous Thrombosis: A Varied Presentation of Lemierre's Syndrome Lemierre's syndrome is also known as postangina septicemia, which is commonly caused by Fusobacterium necrophorum also known as Necrobacillus and also by other microorganisms like Staphylococcus, Streptococcus, Peptostreptococcus, and Bacteroides. Though the disease starts as an upper respiratory tract infection, it may spread and cause thrombophlebitis of the internal (...) jugular vein. It may present itself through cranial nerve palsy or sepsis involving distant organs like the lungs or bones. It is also known as forgotten disease because of its rarity. Fusobacterium necrophorum usually causes infection in animals and rarely affects humans. We hereby present a case of Necrobacillus infection which did not cause any thrombophlebitis but resulted in severe pneumonia and acute kidney injury, leading to respiratory failure and requiring mechanical ventilation.

2017 Case reports in infectious diseases

20. Lemierre's syndrome: forgotten, but not absent Full Text available with Trip Pro

Lemierre's syndrome: forgotten, but not absent Lemierre's syndrome is rare, with no known reported cases in the Caribbean thus far. We highlight a case of a young woman who presented with diabetic ketoacidosis precipitated by oral pharyngeal sepsis, whose condition rapidly deteriorated within 24 hours requiring ventilation and administration of antibiotics. Her sepsis was accompanied by internal jugular vein thrombosis in keeping with a diagnosis of Lemierre's syndrome, which was treated (...) aggressively with antibiotics, intensive care and mechanical ventilatory support in the intensive care unit. She made a full recovery. Though this is the first reported case in the Caribbean of this 'forgotten disease', it must not be forgotten because prognosis and outcome are markedly improved with prompt and aggressive treatment.© BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

2017 BMJ case reports

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