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Late Pregnancy Loss

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1. Early or Late Pregnancy Loss and Development of Clinical Cardiovascular Disease Risk Factors: a Prospective Cohort Study. (PubMed)

Early or Late Pregnancy Loss and Development of Clinical Cardiovascular Disease Risk Factors: a Prospective Cohort Study. To assess the association between the outcome of a woman's first pregnancy and risk of clinical cardiovascular disease risk factors.Prospective cohort study.Nurses' Health Study II.Multivariable-adjusted Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between first pregnancy outcome (...) with a singleton live birth.Several types of pregnancy loss were associated with an increased rate of hypertension, type 2 diabetes, and hypercholesterolemia, which may provide novel insight into the pathways through which pregnancy outcomes and CVD are linked.Pregnancy loss is associated with later maternal risk of hypertension, type 2 diabetes, and hypercholesterolemia.© 2018 Royal College of Obstetricians and Gynaecologists.

2018 BJOG

2. Guidelines on autopsy practice: Fetal autopsy (2nd trimester fetal loss and termination of pregnancy for congenital anomaly)

losses (and if post-mortem examination had been carried out), malformation and growth restriction and other complications. · History of current pregnancy, including: estimated delivery date antenatal infection screen, including HIV abnormal findings from ultrasound or other antenatal investigations (copies of reports are helpful) hypertension/bleeding/pyrexia/membrane rupture events leading up to delivery for late miscarriages, live born or stillborn. [Level of evidence: GPP] 7 The autopsy procedure (...) Guidelines on autopsy practice: Fetal autopsy (2nd trimester fetal loss and termination of pregnancy for congenital anomaly) CEff 150617 1 FINAL Guidelines on autopsy practice: Fetal autopsy (2 nd trimester fetal loss and termination of pregnancy for congenital anomaly) June 2017 Series authors: Dr Michael Osborn, Imperial College Healthcare NHS Trust Professor Jim Lowe, Nottingham University Hospitals NHS Trust Specialist authors: Dr Phillip Cox, Birmingham Women s Hospital NHS Foundation

2017 Royal College of Pathologists

3. Early pregnancy loss

Early pregnancy loss Maternity and Neonatal C linical G uideline Queensland Health Early pregnancy loss Queensland Clinical Guideline: Early pregnancy loss Document title: Early pregnancy loss Publication date: May 2017 Document number: MN17.29-V5-R22 Document supplement: The document supplement is integral to and should be read in conjunction with this guideline Amendments: Full version history is supplied in the document supplement Amendment date: May 2018 Replaces document: MN17.29-V4-R22 (...) , Brisbane Qld 4001, email ip_officer@health.qld.gov.au, phone (07) 3234 1479. Refer to online version, destroy printed copies after use Page 2 of 39 Queensland Clinical Guideline: Early pregnancy loss Flow Chart: Assessment of suspected early pregnancy loss Haemodynamically stable? Assessment • History • Confirm pregnancy • Physical Exam • Serial ß-hCG • USS (TVS preferred) • FBC and blood group • MSU as indicated • STI screen as indicated Ectopic pregnancy Refer to flowchart: Ectopic pregnancy Confirm

2017 Queensland Health

4. Late Pregnancy Loss

Late Pregnancy Loss Late Pregnancy Loss Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Late Pregnancy Loss Late Pregnancy Loss Aka (...) : Late Pregnancy Loss , Second Trimester Pregnancy Loss , Stillborn , Intrauterine Fetal Demise , IUFD , Stillbirth From Related Chapters II. Epidemiology: Incidence Overall of Intrauterine Fetal Demise in U.S.: 6.2 of every 1000 pregnancies Pregnancy loss at 13 to 19 weeks gestation: 1-5% Pregnancy loss after 20 weeks gestation: 0.3% III. Definitions Fetal loss before 20 weeks Early Stillbirth Fetal loss between 20-27 weeks (or fetal weight 350 grams or less) Late Stillbirth Fetal loss between 28-36

2018 FP Notebook

5. Influencing factors of pregnancy loss and survival probability of clinical pregnancies conceived through assisted reproductive technology (PubMed)

pregnancy and demographics and clinical characteristics of clinical pregnancies were estimated using the Kaplan-Meier method and the Log-rank test.The overall PL rate in current ART population was 12.5%. Among the 685 pregnancy loss cycles, a total of 460 ended as early miscarriage, 191 as late miscarriage. We found couples in ART pregnancies demonstrated a significantly increased risk of PL as maternal age (HR = 1.31, Ptrend < 0.001) grows. Pregnancies received controlled ovarian hyperstimulation (COH (...) Influencing factors of pregnancy loss and survival probability of clinical pregnancies conceived through assisted reproductive technology Pregnancies following assisted reproductive technology (ART) may have elevated potential risk of pregnancy loss (PL) when compared to natural conception. However, rare studies comprehensively analyzed the IVF/ICSI cycle-dependent factors for loss of clinical pregnancy. Therefore, we aimed to determine the ART subgroup-specific risks of PL throughout pregnancy

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2018 Reproductive biology and endocrinology : RB&E

6. Low risk of venous thromboembolism following early pregnancy loss in pregnancies conceived by IVF. (PubMed)

, 7567 IVF pregnancies with early pregnancy loss, and 663 IVF pregnancies terminated by late abortion (≥gestational weeks 10). We followed women for 12 weeks after termination of pregnancy and calculated the absolute risk of VTE during follow-up with 95% CI. As a relative risk estimate, we calculated the risk ratio for VTE following IVF pregnancies with early loss compared to the VTE risk following complete IVF pregnancies.During the 12 weeks of follow-up, only one case of VTE occurred in the group (...) of early pregnancy loss, none in the late abortion group, and 13 VTE cases occurred in complete IVF pregnancies. The VTE risk per 10 000 pregnancies was 1.3 [0.03-7.4] for IVF pregnancies with early loss and 7.8 [4.1-13.3] for complete pregnancies; the corresponding risk ratio was 0.17 [0.02-1.3]. Thus, we found a low absolute VTE risk in the 12 weeks following early pregnancy loss in IVF pregnancies. The relative VTE risk was low in comparison to the VTE risk in early gestation reported for complete

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2018 Human Reproduction

7. Beyond thrombosis: Anti-β2GPI domain 1 antibodies identify late pregnancy morbidity in anti-phospholipid syndrome. (PubMed)

for anti-phospholipid antibodies displayed higher anti-D1 titres and lower anti-D4/5 titres compared to women with one or two positive tests (p < 0.0001 and p = 0.005, respectively). Reactivity against D1 was identified as a predictor for PM (OR 2.4, 95% confidence interval [CI] 1.2-5.0, p = 0.017); in particular, anti-D1 antibodies were predictive of late PM, conveying an odds ratio of 7.3 (95% CI 2.1-25.5, p = 0.022). Positivity for anti-D1 antibodies was not associated with early pregnancy loss (...) Beyond thrombosis: Anti-β2GPI domain 1 antibodies identify late pregnancy morbidity in anti-phospholipid syndrome. Antibodies against β2 glycoprotein I (anti-β2GPI) have been identified as the main pathogenic autoantibody subset in anti-phospholipid syndrome (APS); the most relevant epitope is a cryptic and conformation-dependent structure on β2GPI domain (D) 1. Anti-β2GPI domain profiling has been investigated in thrombotic APS, leading to the identification of antibodies targeting D1

2018 Journal of Autoimmunity

8. Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy (PubMed)

Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy The participation of cyclooxygenase (COX) in embryo implantation and parturition has been studied extensively. However, the distinct role of the two COX isoforms in these processes still remains unclear. Using three characterized mouse lines where the Ptgs1 and Ptgs2 genes substitute for one another, this study focused on the reproductive significance of their distinct roles and potential (...) biological substitution. In both non-gravid and gravid uteri, the knock-in COX-2 is expressed constitutively, whereas the knock-in COX-1 is slightly induced in early implantation. The delayed onset of parturition previously found in COX-1 null mice was corrected by COX-2 exchange in COX-2>COX-1 mice, with normal term pregnancy, gestation length and litter size. In contrast, loss of native COX-2 in COX-1>COX-2 mice resulted in severely impaired reproductive functions. Knock-in COX-1 failed to substitute

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2018 Scientific reports

9. Effects of Late Dinner Against Early Dinner on Weight Loss Healthy Obese Women

Effects of Late Dinner Against Early Dinner on Weight Loss Healthy Obese Women Effects of Late Dinner Against Early Dinner on Weight Loss Healthy Obese Women - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Effects of Late Dinner Against Early Dinner on Weight Loss Healthy Obese Women The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03129841 Recruitment Status : Completed First Posted : April 26, 2017 Last Update Posted : March 29, 2018 Sponsor: Novindiet Clinic Collaborators: University of Nottingham

2017 Clinical Trials

10. ACTRAMAT-D: Impact of Post-Traumatic Stress Disorder After Pregnancy Loss After 12 Weeks of Gestation

and analytical study. Masking: None (Open Label) Primary Purpose: Diagnostic Official Title: Impact of Post-Traumatic Stress Disorder After Pregnancy Loss After 12 Weeks of Gestation (Termination of Pregnancy , Stillbirth, Late Miscarriage) Estimated Study Start Date : February 15, 2018 Estimated Primary Completion Date : May 15, 2019 Estimated Study Completion Date : August 15, 2019 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention (...) ACTRAMAT-D: Impact of Post-Traumatic Stress Disorder After Pregnancy Loss After 12 Weeks of Gestation ACTRAMAT-D: Impact of Post-Traumatic Stress Disorder After Pregnancy Loss After 12 Weeks of Gestation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2018 Clinical Trials

11. Can Ureaplasma diversum be transmitted from donor to recipient through the embryo? Two case reports outlining U. diversum losses in bovine embryo pregnancies (PubMed)

Can Ureaplasma diversum be transmitted from donor to recipient through the embryo? Two case reports outlining U. diversum losses in bovine embryo pregnancies Two bovine embryo recovery results are outlined from different herds. Both cases involve significant late gestational loss from embryos relating back to a single donor. Ureaplasma diversum was confirmed in 3 of 4 cases submitted for postmortem examination. Natural infection originating from the donor and transmitted to the recipient has

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2018 The Canadian Veterinary Journal

12. Extent and pattern of pregnancy losses and progesterone levels during gestation in Swedish Red and Swedish Holstein dairy cows (PubMed)

) dairy cows, as well as, the relationship to oestrus intensity (OI) and progesterone (P4) concentration. In total, 2130 AIs and 16,176 milk P4 samples from 359 SR and 212 SH dairy cows were included in the study. Pregnancy losses were estimated using data from P4 values combined with AI information and calving data.Total pregnancy loss from AI to the day of calving was 65%. Early embryonic loss, late embryonic loss and foetal loss were estimated to be 29, 14 and 13%, respectively. There is strong (...) Extent and pattern of pregnancy losses and progesterone levels during gestation in Swedish Red and Swedish Holstein dairy cows Pregnancy loss is a major source of infertility in dairy cows. Despite a fertilization rate after insemination (AI) of approximately 90%, calving rates are 30%-50%, indicating the occurrence of extensive embryonic and foetal losses. The aim of this study was to establish the extent and pattern of embryonic and foetal loss in Swedish Red (SR) and Swedish Holstein (SH

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2018 Acta veterinaria Scandinavica

13. Laparoscopic Adnexectomy for Ovarian Torsion during Late Pregnancy: Case Report of a Non-Conservative Treatment and Literature Analysis (PubMed)

Laparoscopic Adnexectomy for Ovarian Torsion during Late Pregnancy: Case Report of a Non-Conservative Treatment and Literature Analysis Diagnosis of adnexial torsion is difficult during pregancy (1). The time of decision and laparoscopy is that of the risk of necrosis of the adnexa and, therefore, of the ovarian prognosis. The loss of an ovary can compromise the following fertility. Even if concerns related to laparoscopy in pregnant patients include a limited surgical field, with a risk (...) of uterine injury and negative fetal effects of CO2 insufflation. Evidence base suggests that minimally invasive surgery can be safe and better than laparotomy for management of adnexal masses during late pregnancy with good postoperative and obstetric outcomes. If for most authors laparoscopy appears to become the best approach for ovarian torsion during pregnancy (2), nonetheless, the ideal surgical laparoscopic approach of adnexa in late pregnancy remains controversial. Since there is no technical

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2017 Frontiers in surgery

14. Ectopic pregnancy and miscarriage: diagnosis and initial management

early pregnancy loss is diagnosed, and the support women are given, to limit the psychological impact of their loss. Who is it for? Healthcare professionals Commissioners Women with complications in early pregnancy (up to 13 completed weeks of pregnancy), their families and carers Ectopic pregnancy and miscarriage: diagnosis and initial management (NG126) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 4 (...) women with early pregnancy complications with dignity and respect. Be aware that women will react to complications or the loss of a pregnancy in different ways. Provide all women with information and support in a sensitive manner, taking into account their individual circumstances and emotional response. For more guidance about providing information, see the NICE guideline on patient experience in adult NHS services. [2012] [2012] 1.1.2 Healthcare professionals providing care for women with early

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

15. Recurrent pregnancy loss: what is the impact of consecutive versus non-consecutive losses? (PubMed)

and a second trimester pregnancy loss before or after the last birth, respectively. The outcome variable was unexplained loss in the index pregnancy.In patients with secondary RPL, both a late and each early loss before the last birth did not significantly influence the risk of a new pregnancy loss in the index pregnancy: incidence rate ratio (IRR) 1.31 (95% CI 0.62-2.77) and IRR 0.88 (95% CI 0.70-1.11), respectively. In contrast, the impact on risk of pregnancy loss conferred by a late and by each early (...) Recurrent pregnancy loss: what is the impact of consecutive versus non-consecutive losses? Is there a different prognostic impact for consecutive and non-consecutive early pregnancy losses in women with secondary recurrent pregnancy loss (RPL)?Only consecutive early pregnancy losses after the last birth have a statistically significant negative prognostic impact in women with secondary RPL.The risk of a new pregnancy loss increases with the number of previous pregnancy losses in patients

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2016 Human Reproduction

16. Timing of pregnancy, postpartum risk of virologic failure and loss to follow-up among HIV-positive women. (PubMed)

consecutive viral load measurements of >1000 copies/ml) and loss to follow-up (>3 months late for a visit) during 24 months postpartum were assessed using Cox proportional hazards modelling.The rate of postpartum virologic failure was higher following an incident pregnancy on ART [adjusted hazard ratio 1.8, 95% confidence interval (CI): 1.1-2.7] than among women who initiated ART during pregnancy. This difference was sustained among women with CD4 cell count less than 350 cells/μl at delivery (adjusted (...) Timing of pregnancy, postpartum risk of virologic failure and loss to follow-up among HIV-positive women. We assessed the association between the timing of pregnancy with the risk of postpartum virologic failure and loss from HIV care in South Africa.This is a retrospective cohort study of 6306 HIV-positive women aged 15-49 at antiretroviral therapy (ART) initiation, initiated on ART between January 2004 and December 2013 in Johannesburg, South Africa.The incidence of virologic failure (two

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2017 AIDS

17. Low levels of exosomal-miRNAs in maternal blood are associated with early pregnancy loss in cloned cattle (PubMed)

mammalian development. Thus, the aim of this study was to identify exosomal-miRNAs in maternal blood at 21 days of gestation that could be used for diagnosis and prognosis during early clone pregnancies in cattle. Out of 40 bovine-specific miRNAs, 27 (67.5%) were with low abundance in the C-EPL (Clone - Early pregnancy loss) group compared with the C-LTP (Clone - Late pregnancy) and AI-LTP (Artificial Insemination - Late pregnancy) groups, which had similar miRNAs levels. Bioinformatics analysis (...) Low levels of exosomal-miRNAs in maternal blood are associated with early pregnancy loss in cloned cattle Nuclear reprogramming mediated by somatic cell nuclear transfer (SCNT) has many applications in medicine. However, animal clones show increased rates of abortion and reduced neonatal viability. Herein, we used exosomal-miRNA profiles as a non-invasive biomarker to identify pathological pregnancies. MiRNAs play important roles in cellular proliferation and differentiation during early

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2017 Scientific reports

18. Prediction of Recurrent Pregnancy Loss by a New Thrombophilia Based Genetic Risk Score

the antiphospholipid syndrome as opposed to the hereditary forms) or the type of pregnancy loss (either isolated or recurrent, or early or late). It has therefore been accepted that thrombophilia is detected in a significant number of idiopathic pregnancy losses, reaching 66% of the cases in some series. Since the 1990's, a number of studies have associated recurrent pregnancy loss with FVL mutations (most frequently) and G20210 PT. In a systematic review, it was confirmed that women with thrombophilia have (...) a higher risk of developing thromboembolism and complications in pregnancy. Another recent meta-analysis of prospective cohort studies concluded that women who were carriers of FVL had a higher risk of late pregnancy loss, at 52%, as opposed to non-carriers (OR=1.52), though the differences in absolute risk were discreet (4.2% and 3.2%, respectively). However, the analysis of these 2 single nucleotide polymorphisms (SNPs) showed low discriminative capacity and diagnostic sensitivity. This study

2017 Clinical Trials

19. AntiPhospholipid Syndrome Low-molecular-weight Heparin Pregnancy Loss Evaluation: The Pilot Study

: The purpose of this pilot trial is to determine the feasibility of conducting a multicenter randomized full trial evaluating antepartum prophylaxis with ASA versus LMWH/ASA in women with confirmed APS and a history of late or recurrent early pregnancy loss. Given the large sample size needed to adequately power a large multicenter trial that assesses the efficacy of ASA alone versus LMWH/ASA, the investigators first need to determine if it is possible to meet minimum recruitment rates needed for a full (...) -risk' or 'non-high risk' laboratory criteria and the timing of pregnancy loss (late loss or no late loss). Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Pilot Study Assessing the Feasibility of a Randomized Controlled Trial Evaluating Aspirin Versus Low-molecular-weight Heparin (LMWH) and Aspirin in Women With Antiphospholipid Syndrome and Pregnancy Loss Actual Study Start Date : November 6, 2017 Estimated Primary Completion Date : November 6, 2020 Estimated Study

2017 Clinical Trials

20. Early Pregnancy Loss

Early Pregnancy Loss Early Pregnancy Loss Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Early Pregnancy Loss Early Pregnancy Loss (...) Aka: Early Pregnancy Loss , Spontaneous Abortion , Miscarriage , Inevitable Abortion , Missed Abortion , Septic Abortion , Incomplete Abortion , Complete Abortion , Blighted Ovum , Embryonic Resorption , Subchorionic Hemorrhage , Threatened Abortion , Decidua , Decidual Cyst From Related Chapters II. Epidemiology of : 25-30% Miscarriage occurs in 50% of bleeding cases Even if viable, higher complication risk post-bleed Half of conceptions miscarry in first 12 weeks III. Definitions Spontaneous

2019 FP Notebook

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