How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

3,473 results for

Laser Skin Procedure

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

121. Opportunities for laser-assisted drug delivery in the treatment of cutaneous disorders. (Abstract)

Opportunities for laser-assisted drug delivery in the treatment of cutaneous disorders. Fractional laser-assisted drug delivery (LADD) is increasingly finding its way into clinical practice as a new means to enhance topical drug uptake and improve treatment of cutaneous disorders. To date, LADD has been used for a wide range of conditions, including photodamaged skin, neoplastic lesions, scars, cutaneous infections, and vitiligo as well as for topical anesthetic and aesthetic procedures (...) . Substantiated by randomized controlled clinical trials, strong evidence is available for LADD's usefulness for photodynamic therapy (PDT), for which improved efficacy using laser-assisted photosensitizer treatment is established for actinic keratosis compared with conventional PDT. Over time, the modality has undergone increasing refinement and offers the potential advantages of reduced treatment durations, shortened incubation times, and the replacement of cumbersome, patient-dependent treatment regimens

2017 Seminars in Cutaneous Medicine and Surgery

122. Efficacy of a Topical Anesthetic Containing Lidocaine and Prilocaine in Treatment With CO2 Fractional Laser

treatment is routinely used by plastic surgery and dermatology for treatment with aesthetic purposes of skin imperfections. It's a procedure until certain painful point, which as a rule is performed without prior use of topical anesthetic. The test product is believed to produce a clinically significant reduction of pain when compared to placebo, during the application of CO2 laser on the forehead for the aesthetic treatment of the face. Condition or disease Intervention/treatment Phase Lidocaine (...) in the forehead. In addition to efficacy, safety and tolerability of the product have been studied. The product under investigation is a topical formulation containing lidocaine 25 mg/g and prilocaine 25mg/g which in previous studies performed in the same institution with healthy subjects in adulthood showed faster onset than other formulations. In these previous studies, the product was well tolerated, and there were no signs of a skin reaction or adverse events of a systemic nature. The CO2 fractional laser

2017 Clinical Trials

123. Randomized CO2 vs Sham Laser Treatment of Provoked Vestibulodynia

is common. Fractional carbon-dioxide (CO2) laser is a technology widely used in dermatology for the treatment of various skin conditions. It has also been found to be an effective and safe treatment modality for symptoms of the genitourinary syndrome of menopause. A recent pilot study explored the use of fractional CO2 laser for the treatment of vestibulodynia in 37 subjects, 67.6% of which reported that their symptoms were "improved" or "very improved" after 3 fractional CO2 laser sessions. In addition (...) Treatment Fractional CO2 laser will be applied to the entire vestibule, anteriorly to the fourchette, and laterally to the labia majora. This takes approximately 5 minutes to complete. A treatment cycle will consist of three laser sessions separated by 6 weeks +/- 1 week. The procedures will take place in the outpatient clinic. EMLA cream will be applied to the introitus for 20 minutes and wiped clean and dried prior to each laser session. Subjects will be advised to avoid intercourse for at least 3

2017 Clinical Trials

124. Treatment of Atrofic Striae With Percutaneous Collagen Induction Therapy Versus Fractional Nonablative Laser

1340nm laser Device: Microneedling Not Applicable Detailed Description: Twenty patients will be treated at the dermatologic clinic of the Hospital de Clínicas de Porto Alegre (HCPA). Each patient will be treated with laser and microneedle at the same time, being applied a therapeutic procedure in each part of the abdomen (divided lengthwise and in equal parts). Each part of the abdomen will be randomized for the treatment of laser or microneedling with the help of the Excel 2013 program (...) . The investigator responsible for procedures and patients are the only ones with unblinded assessment in relation to the side of each treatment. There will be 5 sessions with monthly intervals of the proposed treatments. The ND-yap 1340-nm laser will be used, and in the other segment of the abdomen, the dermaroller 2.5 mm was applied. Photographic records of patients will be performed at pre-treatment and 1 month after the third and fifth sessions. The questionnaires will be applied to assess the quality

2017 Clinical Trials

125. Static and dynamic modes of 810 nm diode laser hair removal compared: A clinical and histological study Full Text available with Trip Pro

the static and dynamic laser depilation modes, nor in the severity of the pain experienced during the procedure. Histologically, degenerative changes in the hair follicles were noted immediately after laser treatment. At one month, cystic formation was seen in the hair follicles showing a strong tendency towards apoptotic cell death.With the diode laser system and at the parameters used in the present study, high depilation efficacy was seen with no significant difference between the static and dynamic (...) Static and dynamic modes of 810 nm diode laser hair removal compared: A clinical and histological study Laser hair removal has recently become a major indication. Diode lasers have become commercially available offering two modes of application: a stamping or static mode, and a dynamic mode whereby the handpiece is continuously moved across the target tissue. The present study was designed to compare the efficacy of these two approaches clinically and histologically.Twenty-five subjects

2017 Laser therapy

126. Stimulation Effect of Low Level Laser Therapy on Sciatic Nerve Regeneration in Rat Full Text available with Trip Pro

right side sciatic nerve was investigated. Twelve adult male Wistar rats underwent surgery in aseptic conditions under general anesthesia to induce a lesion to their right side sciatic nerve according to standard protocol. Before suturing the location, only the experimental group was treated by laser. The damaged nerve was directly irradiated with (2 J, 100 mW, 40 seconds). The irradiation procedure was terminated in 21 days with little improvement (4 J, 200 mW, 40 seconds) across the skin surface (...) Stimulation Effect of Low Level Laser Therapy on Sciatic Nerve Regeneration in Rat Introduction: Recent studies showed that low-level laser therapy (LLLT) accelerates the regeneration process of injured peripheral nerve tissue. The objective of this study was investigate the effect of LLLT (780 nm) on regeneration of injured right sciatic nerve of male Wistar rat. Methods: In this research work, the effect of LLLT (780 nm) on the regeneration process and reconstruction of injured peripheral

2017 Journal of lasers in medical sciences

127. Lasers and intense pulsed light (IPL) association with cancerous lesions Full Text available with Trip Pro

Lasers and intense pulsed light (IPL) association with cancerous lesions The development and use of light and lasers for medical and cosmetic procedures has increased exponentially over the past decade. This review article focuses on the incidence of reported cases of skin cancer post laser or IPL treatment. The existing evidence base of over 25 years of laser and IPL use to date has not raised any concerns regarding its long-term safety with only a few anecdotal cases of melanoma post (...) treatment over two decades of use; therefore, there is no evidence to suggest that there is a credible cancer risk. Although laser and IPL technology has not been known to cause skin cancer, this does not mean that laser and IPL therapies are without long-term risks. Light therapies and lasers to treat existing lesions and CO2 laser resurfacing can be a preventative measure against BCC and SCC tumour formation by removing photo-damaged keratinocytes and encouraged re-epithelisation from stem cells

2017 Lasers in medical science

128. Aplasia cutis congenita as a result of interstitial laser therapy for fetal reduction in monochorionic twins: Conservative approach and outcome Full Text available with Trip Pro

Aplasia cutis congenita as a result of interstitial laser therapy for fetal reduction in monochorionic twins: Conservative approach and outcome Monochorionic (MC) twin pregnancies are known to carry a high risk of twin-to-twin transfusion syndrome (TTTS) that could lead to miscarriage and perinatal death. Demise of one fetus is frequently associated with co-fetal death. Fetal reduction by interstitial laser therapy is an effective procedure to prevent this outcome, but it may be associated (...) with significant risks for both mother and fetus. Aplasia Cutis Congenita (ACC) may occur in up to 8% cases of fetal reduction by laser therapy. We report ACC in a preterm infant, a survivor of interstitial laser therapy for fetal reduction in MC pregnancy. Despite of massive skin lesions we were able to manage this case conservatively. Follow-up at 5 years of age revealed minimal scarring and no motor function limitations.Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

2017 International journal of surgery case reports

129. A Topical Anti-inflammatory Healing Regimen Utilizing Conjugated Linolenic Acid for Use Post-ablative Laser Resurfacing of the Face: A Randomized, Controlled Trial Full Text available with Trip Pro

regeneration. By modulating the early inflammatory milieu and directly affecting skin structure and function, conjugated linolenic acid might therefore shorten downtime following fractionated ablative laser resurfacing of the face. Objective: To evaluate the efficacy and subject satisfaction of a topical regimen containing conjugated linolenic acid derived from pomegranate seed extract in accelerating wound healing and improving skin quality following fractionated ablative laser resurfacing of the face (...) . Materials and Methods: Thirty-four subjects were enrolled and received fractionated CO2 laser resurfacing. Subjects were randomized to use the test healing regimen (n=24) or 1% dimethicone ointment (n=10) post-procedure. The primary endpoint was the degree of erythema, edema, crusting, and exudation evaluated by a blinded clinician at post-treatment Days 1,3,7,10, 14, and 30. Secondary endpoints included a blinded evaluator assessment of the degree of wrinkling and elastosis using the Fitzpatrick

2017 The Journal of clinical and aesthetic dermatology Controlled trial quality: predicted high

130. A Case of Facial Partial Unilateral Lentiginosis Treated with Low-Fluence 1,064 nm Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser Full Text available with Trip Pro

A Case of Facial Partial Unilateral Lentiginosis Treated with Low-Fluence 1,064 nm Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser Partial unilateral lentiginosis (PUL) is an unusual pigmentary disorder characterized by numerous lentigines grouped within an area of normal skin. Although treatment is not necessary, many patients with facial PUL seek medical help for cosmetic reasons. There is no established standard treatment for PUL. Conventional lasers may cause postinflammatory (...) proposed. If appropriate measures are taken to monitor patient response during and after the procedure, low-fluence 1,064-nm QS Nd:YAG laser may achieve good cosmetic results in the treatment of PUL with a very safe and effective profile.

2017 Case reports in dermatology

131. Prostaglandin E1 Increases Microcirculation in Random Pattern Flaps on Rats Measured with Laser Doppler Perfusion Imaging Full Text available with Trip Pro

Prostaglandin E1 Increases Microcirculation in Random Pattern Flaps on Rats Measured with Laser Doppler Perfusion Imaging Reconstructive procedures with pedicled and free flaps are associated with a risk of ischemia. Prostaglandin E1 (PGE1) is a hormone-like substance with known antiischemic and tissue-protective effects. The aim of this study was to evaluate the effect of PGE1 on the microcirculation in random pattern skin flaps on rats.Twenty-four rats were divided into 2 groups (...) : an intervention group given PGE1 for 6 hours and a control group given saline. The flap (2 × 10 cm) was created on the back of the rats, and the microcirculation was monitored with laser Doppler perfusion imaging in 5 different zones (1, proximal; 5, distal) before surgery and after 60, 180, and 360 minutes postoperatively.Before surgery, there was no difference in the perfusion in any zones between the intervention group and the control group. The mean perfusion values in zone 1 in the intervention group

2017 Plastic and Reconstructive Surgery Global Open

132. Administration of Low-level Laser on Muscles of Mastication Following the Induction of Initial Fatigue

: Active laser Three points on the masseter muscle (upper, middle and lower portions) and one point on the anterior temporal on each side of the face will be irradiated with a wavelength of 780 nm, radiant exposure of 134 J/cm2, power of 50 mW and irradiance of 1.675 W/cm2 for 80 seconds per point, resulting in an energy of 4 J per point and total energy of 32 J per volunteer.20,21 Point application will be performed with a conventional tip in contact with the skin (beam spot: 0.04 cm2). Radiation (...) : Active laser Three points on the masseter muscle (upper, middle and lower portions) and one point on the anterior temporal on each side of the face will be irradiated with a wavelength of 780 nm, radiant exposure of 134 J/cm2, power of 50 mW and irradiance of 1.675 W/cm2 for 80 seconds per point, resulting in an energy of 4 J per point and total energy of 32 J per volunteer.20,21 Point application will be performed with a conventional tip in contact with the skin (beam spot: 0.04 cm2). Sham

2017 Clinical Trials

133. Non-invasive Glucose Measurement Using Laser Technology

Non-invasive Glucose Measurement Using Laser Technology Non-invasive Glucose Measurement Using Laser Technology - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Non-invasive Glucose Measurement Using Laser (...) by (Responsible Party): Uzma Z Khan, University of Missouri-Columbia Study Details Study Description Go to Brief Summary: This study is to evaluate the capability of Raman spectroscopy as a non-invasive method for monitoring concentrations of glucose by illuminating a small spot on the skin, collecting and analyzing the return light. The glucose measurements obtained by Raman Spectroscopy are correlated with those obtained using YSI glucose analyzer and ACCUCHECK instruments. Condition or disease Intervention

2017 Clinical Trials

134. Fractional Laser Assisted Delivery of Anesthetics IIIb

) Penetration of local anesthetics could be enhanced by pretreatment of the skin with ablative fractional lasers (AFXL) which locally disrupts the stratum corneum by creating an array of microscopic ablation channels. (Sklar, Burnett et al. 2014) In a previous pilot study, conducted at our institute, we demonstrated that effective anesthesia could be achieved within ten minutes after application of a topical anesthetic on skin pretreated with AFXL at painless settings. (Meesters, Bakker et al. 2015) However (...) will be given at unanesthetized skin. Subjects will be asked to indicate pain on a visual analogue scale (VAS) from 0-10 (0: no pain; 10: worst imaginable pain) directly after each pain stimulus Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 15 participants Allocation: Randomized Intervention Model: Factorial Assignment Masking: Single (Participant) Primary Purpose: Treatment Official Title: Parameters in Fractional Laser Assisted

2017 Clinical Trials

135. Laser Interstitial Thermotherapy (LITT) Combined With Checkpoint Inhibitor for Recurrent GBM (RGBM)

is an investigational (experimental) drug that works by helping participants' immune system work correctly to detect and fight cancer cells. Pembrolizumab is experimental because it is not approved by the Food and Drug Administration (FDA), for this use, though it is approved to treat other cancers. Condition or disease Intervention/treatment Phase Glioblastoma, Adult Drug: Pembrolizumab at 7 days prior Drug: Pembrolizumab at 14 days post Drug: Pembrolizumab at 35 days post Procedure: Laser Interstitial (...) : Pembrolizumab injections 7 days before surgery Patients will have intravenous pembrolizumab 7 days before surgery with Laser Interstitial Thermotherapy Drug: Pembrolizumab at 7 days prior Pembrolizumab injections 7 days before surgery Other Name: Pembrolizumab Procedure: Laser Interstitial Thermotherapy surgical procedure to heat hard to reach tumors with a laser beam Other Name: LITT Experimental: Pembrolizumab injections 14 days after surgery Patients will have intravenous pembrolizumab 14 days after

2017 Clinical Trials

136. Fraxel Laser for Alopecia

of this procedure. Condition or disease Intervention/treatment Phase Alopecia Device: Fractional erbium-glass 1550 nm laser Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 20 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Pilot Study on 1550 nm Fractional Erbium-glass Laser for Alopecia Treatment Estimated Study Start Date : April 1, 2019 (...) Fraxel Laser for Alopecia Fraxel Laser for Alopecia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Fraxel Laser for Alopecia The safety and scientific validity of this study is the responsibility

2017 Clinical Trials

137. Exploring Laser-Induced Breakdown Spectroscopy as a Potential Tool in Mohs Micrography: A Mini Review Full Text available with Trip Pro

Exploring Laser-Induced Breakdown Spectroscopy as a Potential Tool in Mohs Micrography: A Mini Review Mohs micrographic surgery is the technique of surgically removing skin tumors by gradually excising thin layers and visualizing under a microscope till a tumor-free zone is obtained. During the surgical procedure, visible tumors are surgically removed. During the second stage, if tumor margins are clear with the positive specimen at depth, only depth cavitations need to be done without altering (...) the tumor diameter. Defining the depth during this procedure is a major challenge due to the nonexistence of proper guidelines. Using the laser-induced breakdown spectroscopy (LIBS) technique, depth profiling can be performed precisely, preventing excessive tissue removal and reducing time consumption during the microscopic examination.

2017 Cureus

138. Pilot Study of the Ablative Fractional CO2 Laser in Hypertrophic Scars in Adult Burn Patients

Date : February 2015 Actual Primary Completion Date : May 2016 Actual Study Completion Date : December 2016 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Laser treated HSc scar Co2 laser treatment Procedure: Laser treatment CORE fractional CO2 laser treatment No Intervention: Control scar Standard care Outcome Measures Go to Primary Outcome Measures : Skin Characteristics changes (...) . Condition or disease Intervention/treatment Phase Burns Procedure: Laser treatment Not Applicable Detailed Description: Prior to treatment initiation, two independent scars sites will be selected and an anatomically- on each individual. At the selected treatment site the scar will be treated with the CORE fractional CO2 laser Participants will receive 3 treatment sessions scheduled 4 weeks apart. The scar sites will be evaluated at baseline, immediately before the 3rd treatment and 12 weeks after

2017 Clinical Trials

139. enLighten Laser With MLA Handpiece for Treatment of Moderate and Severe Acne Scars

handpiece attachment for the improvement of skin quality as assessed by the investigator and/or blinded evaluators 12-weeks-post final study treatment. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 42 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Other Official Title: Open-label, Prospective, Multicenter Study to Evaluate the Cutera enLighten™ Laser and a Micro-Lens Array (...) for Study: 18 Years to 65 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Subject must be able to read, understand and sign the Informed Consent Form. Female or Male, 18 to 65 years of age (inclusive). Fitzpatrick Skin Type I - VI (Appendix 6). Subject desires treatment for acne scars and wishes to undergo laser treatments for improvement. Subject has bilateral moderate to severe signs of facial acne scarring. Must be willing to have

2017 Clinical Trials

140. Evaluation of Cutera Excel Vâ„¢ Laser With Green Genesis and Micro-Lens Array (MLA)Attachment

attachment as assessed by frequency and severity (0=none, 1=mild, 2=moderate or 3=severe) of device adverse events as reported up to the 12 week follow-up visit. Measurement #3 of skin quality [ Time Frame: 2 to 4 weeks after third treatment and12 weeks post-final treatment ] Efficacy of the Cutera excel V laser with Green Genesis to diffuse facial redness and/or improve dyschromia (pigment) as compared to the Standard-of-Care (SOC) procedure using Excel V, as assessed by the study investigator at 2-4 (...) weeks after the 3rd laser treatment visit and at the 12 week follow-up visit, using Skin Quality Rating Scale (1-10): for Radiance, Smoothness, Pigmentation, Erythema and Pore size. Measurement #4 of wrinkles [ Time Frame: 2 to 4 weeks after third treatment and12 weeks post-final treatment ] Efficacy of the Cutera excel V laser with the Micro-Lens Array to treat fine lines and skin texture, as compared to the Standard-of-Care (SOC) procedure using Excel V, as assessed by the study investigator at 2

2017 Clinical Trials

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>