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Laser Skin Procedure

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3341. Evaluation of the Effects of Urotensin-II and Soluble Epoxide Hydrolase Inhibitors on Skin Microvessel Tone in Patients With Heart Failure, and in Healthy Volunteers

. The technique to be used is iontophoresis. This is a non invasive technique in which a small amount of the compound is placed on the skin of the forearm. The drug is delivered across the skin by passing a small electric current over the area. The change in blood flow is then measured and analysed. We will also administer U-II agonist, noradrenaline, and distilled water (all via iontophoresis). Noradrenaline will be used a positive constrictor control. Change in blood flow will be assessed by Laser Doppler (...) Evaluation of the Effects of Urotensin-II and Soluble Epoxide Hydrolase Inhibitors on Skin Microvessel Tone in Patients With Heart Failure, and in Healthy Volunteers Evaluation of the Effects of Urotensin-II and Soluble Epoxide Hydrolase Inhibitors on Skin Microvessel Tone in Patients With Heart Failure, and in Healthy Volunteers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x

2008 Clinical Trials

3342. Cidofovir in Treating HIV-Infected Patients With High-Grade Squamous Intraepithelial Lesions of the Skin Near the Anus

against viruses and may stop these lesions from becoming cancer. PURPOSE: This phase II trial is studying the side effects and how well topical cidofovir works in treating HIV-infected patients with high-grade squamous intraepithelial lesions of the skin near the anus. Condition or disease Intervention/treatment Phase Anal Cancer Precancerous Condition Drug: cidofovir Genetic: DNA methylation analysis Genetic: gene expression analysis Genetic: polymerase chain reaction Procedure: biopsy Procedure (...) Cidofovir in Treating HIV-Infected Patients With High-Grade Squamous Intraepithelial Lesions of the Skin Near the Anus Cidofovir in Treating HIV-Infected Patients With High-Grade Squamous Intraepithelial Lesions of the Skin Near the Anus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2007 Clinical Trials

3343. Photodynamic Therapy Using Aminolevulinic Acid in Treating Patients With Skin Cancer

, 2008 Last Update Posted : January 10, 2014 Sponsor: Laser and Skin Surgery Center of New York Information provided by: National Cancer Institute (NCI) Study Details Study Description Go to Brief Summary: RATIONALE: Photodynamic therapy uses a drug that becomes active when it is exposed to a certain kind of light. When the drug is active, tumor cells are killed. This may be an effective treatment against skin cancer. PURPOSE: This phase II trial is studying the side effects of photodynamic therapy (...) York Laser and Skin Surgery Center of New York Recruiting New York, New York, United States, 10016 Contact: Roy G. Geronemus, MD 212-686-7306 Sponsors and Collaborators Laser and Skin Surgery Center of New York Investigators Layout table for investigator information OverallOfficial: Diana Santanello Laser and Skin Surgery Center of New York More Information Go to Layout table for additonal information Responsible Party: Roy G. Geronemus, Laser and Skin Surgery Center of New York ClinicalTrials.gov

2008 Clinical Trials

3344. An Evaluation of Kinerase Pro+Therapy Regimen Vs. Kinerase Vs. Control for the Treatment of Skin Aging

aging Written informed consent Likely to complete all study visits and follow study protocol Exclusion Criteria: Any dermatological or medical condition which would make patient participation unsafe or interfere with study outcomes or measurements Known hypersensitivity to any study product or their components Recent (within 4 weeks of baseline) surgical treatment to face (including IPL and other laser procedures) Prior use of anti-aging treatments for 30 days prior to study entry (physician (...) An Evaluation of Kinerase Pro+Therapy Regimen Vs. Kinerase Vs. Control for the Treatment of Skin Aging An Evaluation of Kinerase Pro+Therapy Regimen Vs. Kinerase Vs. Control for the Treatment of Skin Aging - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2007 Clinical Trials

3345. Clinical Usefulness of Optical Skin Biopsy

the harmonics optical biopsy of a human skin sample using a femtosecond Cr:forsterite laser centered at 1230 nm. Higher harmonics generation is known to leave no energy deposition to the interacted matters due to their energy-conservation characteristic. This energy-conservation characteristic provides the “noninvasive” nature desirable for clinical imaging. In our study, we will evaluate the clinical applications of optical skin biopsy using harmonic generation microscopy. Condition or disease Skin (...) Neoplasms Detailed Description: Traditional biopsy requires the removal, fixation, and staining of tissues from the human body. Its procedure is invasive and painful. Non-invasive in vivo optical biopsy is thus required, which should provide non-invasive, highly penetrative, three-dimensional (3D) imaging with sub-micron spatial resolution. Optical biopsy based on scanning two-photon fluorescence microscopy (TPFM) is a good method for biopsy of skin due to its high lateral resolution, low out-of-focus

2005 Clinical Trials

3346. Operative treatment of functional facial skin disorders Full Text available with Trip Pro

, and the use of growth factors. Age-related skin changes with impairment of cosmetic function are characterized by the development of creases and looseness of skin. Rejuvenation has become an important segment of skin surgery. For surface treatment, especially of creases and acne scars, various types of laser treatment are employed. Deeper lines can be filled with filler materials. The integration of the superficial musculoaponeurotic system (SMAS) into face lift procedures has lead to more viable (...) Operative treatment of functional facial skin disorders The skin is the principal interface between the body and the surrounding world and thus serves as a protective barrier against trauma, temperature extremes and radiation. With receptors for pressure, movement, heat and cold, it also acts as sensory organ and through sweat secretion plays a role in thermoregulation and electrolyte metabolism. Not all of these functions are relevant to facial skin, however, cosmetic aspects are of vital

2005 GMS current topics in otorhinolaryngology, head and neck surgery

3347. Patterns of reinnervation and blood flow in split-skin grafts Full Text available with Trip Pro

and the blood flow pattern of skin grafts. The present study uses Laser Doppler flowmetry and the immunohistochemical stains protein gene product 9.5, calcitonin gene-related peptide and substance P to identify nerve fibres, and antibodies to CD31 and von Willebrand factor to identify endothelial tissues. The aim of the present study was to investigate the patterns of blood flow and nerve tissue regeneration in split-skin grafts up to 15 years following the original procedure. Thirty-two split-skin grafts (...) and called A1, A2 and A3, respectively. In the Laser Doppler flowmetry arm of the study, the grafts were assessed at various stages after heating, cooling and further reheating. The Laser Doppler flowmetry studies showed that, on subjecting the skin grafts in both groups I and II to heating and cooling followed by reheating, the overall response of the blood flow to changes in the temperature was slower. The immunohistochemical analysis showed that in all graft types and graft ages, protein gene product

2005 The Canadian Journal of Plastic Surgery

3348. Collagen alpha5 and alpha2(IV) chain coexpression: analysis of skin biopsies of Alport patients. Full Text available with Trip Pro

Collagen alpha5 and alpha2(IV) chain coexpression: analysis of skin biopsies of Alport patients. Alport syndrome is a collagen type IV disease caused by mutations in the COL4A5 gene with the X-linked form being most prevalent. The resultant alpha5(IV) collagen chain is a component of the glomerular and skin basement membranes (SBMs). Immunofluorescent determination of the alpha5(IV) chain in skin biopsies is the procedure of choice to identify patients. In 30% of patients, however, the mutant (...) protein is still found in the SBM resulting in a normal staining pattern. In order to minimize or eliminate false results, we compared the distribution of the alpha2(IV) chain (another SBM component) and the alpha5(IV) chain by standard double label immunofluorescence (IF) and by confocal laser scanning microscopy. The study was performed on 55 skin biopsies of patients suspected of Alports and five normal control specimens. In normal skin, IF showed the classical linear pattern for both collagens

2007 Kidney International

3349. Palmar skin blood flow and temperature responses throughout endoscopic sympathectomy. (Abstract)

temporal resolution relative to monitoring palmar skin temperature. In 11 patients with palmar and/or axillary hyperhidrosis, we measured palmar skin temperature and blood flow (via laser Doppler flowmetry) throughout the sympathectomy procedure. Five minutes after the initial cautery, skin blood flow increased from 48 +/- 7 perfusion units to 121 +/- 17 perfusion units (P <0.001), whereas no significant change in temperature was observed (31.0 degrees C +/- 0.5 degrees C to 31.3 degrees C +/- 0.5 (...) Palmar skin blood flow and temperature responses throughout endoscopic sympathectomy. Thoracic surgical sympathectomy is often performed to treat primary palmar and axillary hyperhidrosis. An increase in palmar skin temperature is frequently used to identify the success of the procedure. Because changes in palmar skin temperature occur secondary to changes in skin blood flow, the objective of this study was to test the hypothesis that monitoring palmar skin blood flow would provide greater

2005 Anesthesia and Analgesia

3350. The use of hybrid radiofrequency device for the treatment of rhytides and lax skin. Full Text available with Trip Pro

The use of hybrid radiofrequency device for the treatment of rhytides and lax skin. Recently, radiofrequency (RF) devices have been introduced and commercialized for nonablative procedures in dermatology and plastic surgery for the treatment of age-related rhytides and lax skin.The objective was to assess the efficacy and safety of a novel RF device (Accent, Alma Lasers, Ltd, Caesarea, Israel) for the treatment of rhytides and lax skin.Sixteen female patients (age range, 29-66 years; mean, 47 (...) +/-6 years; skin phototypes II to IV) were treated with Accent system. Patients were treated on the chin (n=5), forehead (n=8), cheeks (n=12), jowl lines (n=9), periorbital area (n=7), marionette line (n=3), and nasolabial folds (n=6) for wrinkles (n=27 cases) and skin laxity (n=23 cases). Patients received two to six treatments (mean, 4.3+/-1.1), with the time interval of 2 to 3 weeks. Photographs were assessed 1 month after the last treatment. RESULTS For wrinkles and skin laxity, in 5 patients

2007 Dermatologic Surgery

3351. Microdermabrasion as a novel tool to enhance drug delivery via the skin: an animal study. (Abstract)

Microdermabrasion as a novel tool to enhance drug delivery via the skin: an animal study. Microdermabrasion is a widely performed skin rejuvenation procedure. It can partly ablate and homogenize the stratum corneum (SC) layers.The effect of microdermabrasion treatment on the skin permeation of hydrophilic and lipophilic drugs was examined in this study.5-Fluorouracil (5-FU) and clobetasol 17-propionate were used as the hydrophilic and lipophilic permeants, respectively. In vitro skin delivery (...) enhancement of 5-FU delivery via the skin. In contrast to the results for 5-FU, microdermabrasion reduced the skin permeation and deposition of topically applied clobetasol. The partitioning effect of clobetasol from the vehicle to the SC may have predominated this result. Microdermabrasion also enhanced the skin delivery of the hydrophilic 5-aminolevulinic acid (ALA). Confocal laser scanning microscopy (CLSM) of microdermabrasion-treated skin revealed intense red fluorescence of ALA-transformed

2006 Dermatologic Surgery

3352. Noninvasive lower eyelid blepharoplasty: a new technique using nonablative radiofrequency on periorbital skin. (Abstract)

Noninvasive lower eyelid blepharoplasty: a new technique using nonablative radiofrequency on periorbital skin. Laxity and rhytids of the lower eyelids are common cosmetic concerns. Historically, correction has either been surgical through either transcutaneous or transconjunctival blepharoplasty or ablative through laser resurfacing or chemical peeling. Therapeutic options usually require significant postoperative healing and have the potential risk of scarring ectropion or pigmentary loss.To (...) approximately 10 minutes. No postoperative care was required.All of the nine patients in the study achieved cosmetic improvement of the eyelids ostensibly through skin contraction. All patients were able to return to their normal routines immediately. Although the results were gradual, patient satisfaction was remarkable. No complications were seen in this study.This new procedure using NARF was successful in providing a safe, noninvasive, cosmetic improvement in these patients with excessive skin laxity

2004 Dermatologic Surgery

3353. Towards a more specific therapy: targeting nonmelanoma skin cancer cells. (Abstract)

Towards a more specific therapy: targeting nonmelanoma skin cancer cells. Epithelial cancers of the skin, e.g. basal cell carcinoma and squamous cell carcinoma, are the most common tumours in humans with increasing incidence. Hence the development of new therapeutic strategies is of utmost interest. For many years the most often used conventional therapies for these diseases were surgical procedures such as curettage and electrodesiccation, excision or, with so far the best outcome in terms (...) of remission rates, micrographic surgery. Other ablative treatment modalities are cryotherapy, radiation therapy or the use of lasers (Er:YAG, CO(2)). All those above-mentioned treatments have in common that they are quite unspecific and do not target the tumour itself or its environment, thus leading to unwanted effects in the surrounding tissue such as scar formation or other cosmetically disfiguring events. Therefore, the development of novel, more pathogenesis-based therapies such as the use

2006 British Journal of Dermatology

3354. Effect of nitric-oxide-generating system on microcirculatory blood flow in skin of patients with severe Raynaud's syndrome: a randomised trial. (Abstract)

cm2), and then mixed with a sterile cotton bud. A similar procedure was done simultaneously on the other arm with KY jelly only (placebo). The procedure was then repeated on the finger pulps. Changes in skin microcirculatory volume and flux were measured bilaterally by infrared photoplethysmography and laser doppler fluxmetry, respectively.In the forearm, blood flow increased significantly after application of the active gel both in patients with Raynaud's syndrome (microcirculatory volume from (...) Effect of nitric-oxide-generating system on microcirculatory blood flow in skin of patients with severe Raynaud's syndrome: a randomised trial. Patients with Raynaud's syndrome have abnormal digital vasoconstriction, which may be secondary to impaired synthesis of, or impaired sensitivity to, nitric oxide. We studied the effect on microcirculation of a nitric-oxide-generating system applied topically to the finger and forearm of healthy volunteers and patients with primary Raynaud's syndrome.We

1999 Lancet Controlled trial quality: uncertain

3355. Prospective Randomized Trial Comparing the New Endovenous Procedures Versus Conventional Surgery for Varicose Veins Due to Great Saphenous Vein Incompetence

, endovenous laser and foam sclerotherapy) versus high ligation and stripping. Procedure (proof-of-concept) and patient related (clinical outcome) factors will be studied. Condition or disease Intervention/treatment Phase Varicose Veins Procedure: High Ligation of the GSV Procedure: Endovenous Laser Ablation Procedure: Radiofrequency ablation Procedure: Foam Sclerotherapy Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment (...) direction. Active Comparator: Endovenous Laser Ablation Procedure: Endovenous Laser Ablation Laser ablation is performed in tumescence anesthesia which is performed with a 150-200 ml (sometimes more is required, up to 400ml in patients with a poorly formed saphenous sheath) solution of lidocaine with adrenaline supplement. General sedation can be administrated as a supplement (with intravenous Propofol or Dormicum when needed). Laser is performed under duplex guidance and the catheter is inserted

2008 Clinical Trials

3356. The lidocaine/tetracaine peel: a novel topical anesthetic for dermatologic procedures in adult patients. Full Text available with Trip Pro

The lidocaine/tetracaine peel: a novel topical anesthetic for dermatologic procedures in adult patients. The 7% lidocaine and 7% tetracaine (LT) peel is a self-occlusive, topical local anesthetic that has been proven safe and effective for use in conjunction with many dermatologic procedures, including cryotherapy, collagen injections, and various laser treatments. The product is applied directly to the skin as a cream that dries within 20 to 30 minutes of air exposure to form a flexible film (...) to have superior anesthetic efficacy in adult patients undergoing a variety of cutaneous procedures. The LT peel is safe and well tolerated, with side effects limited to localized, transient skin reactions that do not appear to interfere with clinical outcome. It is an effective topical anesthetic for dermatologic procedures that is convenient to use and promotes a positive patient experience.

2007 Dermatologic Surgery

3357. A review of minimally invasive cosmetic procedures. (Abstract)

A review of minimally invasive cosmetic procedures. In today's society the desire to maintain a youthful appearance has driven the development of minimally invasive dermatological procedures that are designed to rejuvenate the ageing face. The aim of this review is to present evidence for the use of techniques which can easily be incorporated into outpatient dermatology practice with low overhead expenditure. For this reason, laser and light-based treatments have been omitted. This review (...) will instead focus on chemical peels, intradermal fillers and botulinum toxin. These techniques address the main aspects of facial ageing, namely photodamage, volume loss and dynamic lines, which correlate anatomically to skin, subcutaneous fat and muscle. A combination of such techniques will provide the practitioner with a reasonable portfolio of treatments for a balanced, holistic result.

2008 British Journal of Dermatology

3358. Pemphigus foliaceus masquerading as postoperative wound infection: report of a case and review of the Koebner and related phenomenon following surgical procedures. (Abstract)

Pemphigus foliaceus masquerading as postoperative wound infection: report of a case and review of the Koebner and related phenomenon following surgical procedures. The Koebner phenomenon, also known as the isomorphic response, is the development of preexisting skin disease following trauma to uninvolved skin. Various cutaneous disorders have been described to arise at surgical wounds and scars. Moreover, dermatologic procedures, such as cold-steel and laser surgery, can evoke koebnerization.To (...) , this is the first reported case of pemphigus foliaceus erupting at surgical and cryotherapy wounds. The clinical appearance can mimic wound infection. In addition to inducing preexisting disease, cutaneous procedures can also trigger the onset of new disease, which can either be limited only to the surgical site or subsequently become generalized.Postoperative Koebner or related responses should be included in the differential diagnosis of poorly healing surgical wounds. Skin biopsies for histopathology

2005 Dermatologic Surgery

3359. Topical Imiquimod in Conjunction With Nd:YAG Laser for Tattoo Removal

Pharmaceuticals, LLC Information provided by (Responsible Party): Keyvan Nouri, University of Miami Study Details Study Description Go to Brief Summary: The purpose of this study is to evaluate the efficacy of tattoo removal using topical imiquimod, 5% cream in conjunction with the 1064nm Nd:YAG laser. This procedure for tattoo removal will be compared to a laser removal alone. Condition or disease Intervention/treatment Phase Healthy Device: 1064 nm Nd:YAG laser Drug: Imiquimod, 5% cream Phase 1 Detailed (...) Actual Primary Completion Date : August 2014 Actual Study Completion Date : August 2014 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: 1 The tattoo will be treated with laser and imiquimod 5% cream Device: 1064 nm Nd:YAG laser The laser used will be a 1064 nm Nd:YAG, with a 10ns pulse, 3mm spot size and 4 joules of energy Drug: Imiquimod, 5% cream 2 weeks after the laser procedure the imiquimod

2008 Clinical Trials

3360. Validation of Laser Doppler Flowmetry to Identify Allergic Rhinitis Patients With Pharmacogenetic Alterations in Histamine Metabolism

of systemic corticosteroids or tricyclic antidepressants 30 days prior to skin testing, presence of condition that would cause difficulty in adherence with study procedure. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00362999 Contacts Layout table (...) Validation of Laser Doppler Flowmetry to Identify Allergic Rhinitis Patients With Pharmacogenetic Alterations in Histamine Metabolism Validation of Laser Doppler Flowmetry to Identify Allergic Rhinitis Patients With Pharmacogenetic Alterations in Histamine Metabolism - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You

2006 Clinical Trials

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