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Laser Skin Procedure

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3261. Immediate Treatment vs Colposcopic Follow-up for Biopsy-Proven CIN 1

of Health Research (CIHR) Information provided by: Ontario Clinical Oncology Group (OCOG) Study Details Study Description Go to Brief Summary: This study looks at immediate treatment of a cervix with CIN 1 versus regular six-month follow-up with colposcopy and treatment if CIN 1 progresses. Condition or disease Intervention/treatment Phase Cervical Intraepithelial Neoplasia Procedure: loop electrosurgical excision procedure (LEEP) Phase 3 Detailed Description: In women who present with biopsy-proven CIN (...) ) Primary Purpose: Treatment Official Title: Randomized Trial of Immediate Treatment vs. Colposcopic Follow-up for Biopsy-Proven CIN 1 Study Start Date : November 2000 Actual Primary Completion Date : September 2007 Actual Study Completion Date : September 2007 Resource links provided by the National Library of Medicine related topics: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: 1 Immediate Treatment - LEEP - Loop electrosurgical excision procedure Procedure: loop

2005 Clinical Trials

3262. Androgen Suppression Combined With Elective Nodal and Dose Escalated Radiation Therapy

the post treatment prostate specific antigen (PSA) is > 2 ng/mL above the lowest level previously recorded. Condition or disease Intervention/treatment Phase Prostate Cancer Procedure: Androgen suppression, radiotherapy Procedure: Androgen suppression, radiotherapy, iodine 125 brachytherapy Phase 3 Detailed Description: Patients will be randomly assigned with equal probability to one or two treatment arms, Arm 1 or Arm 2, where the interventions associated with these Arms are as follows: Arm 1 (...) Procedure: Androgen suppression, radiotherapy Total of 12 months of androgen suppression. 8 months after the start of androgen suppression 4.2-5 weeks external beam radiation (46 Gy in 23 equal fractions) followed by an external beam radiation boost lasting 3.2-4 weeks (32 Gy in 16 equal fractions). Other Names: Androgen suppression: non-steroidal androgen (any of flutamide, nilutamide or bicalutamide (bicalutamide is almost always used). LHRH monotherapy: buserelin acetate or leuprolide acetate

2005 Clinical Trials

3263. A Study to Compare Ocular Safety and Tolerability of Eye Drops Containing Prednisolone Acetate in Patients With Intraocular Inflammation After Cataract Surgery

Operation not performed according to the standard procedures. Any eye condition which urgently requires treatment with NSAIDs or corticosteroids. History of intraocular surgery in the operated eye. Any laser therapy or cryotherapy in the operated eye in the 90 days preceding surgery. Any previous episode of uveitis in the operated eye. Clinically significant trichiasis or other clinically relevant concurrent inflammatory/ infective eye disorders (e.g. conjunctivitis, episcleritis) except mild forms (...) to Outcome Measures Go to Primary Outcome Measures : Primary efficacy parameter was the anterior chamber flare of the operated eye, measured by a KOWA laser cell flare meter. Secondary Outcome Measures : The secondary objectives were to demonstrate that two days treatment with 0.5 % prednisolone acetate eye drops: are superior to vehicle regarding corneal edema and bulbar conjunctival hyperemia, are safe regarding intraocular pressure (IOP), visual acuity and frequency of AEs and SAEs, are well tolerated

2005 Clinical Trials

3264. In vivo analysis of wound healing by optical methods Full Text available with Trip Pro

In vivo analysis of wound healing by optical methods The analysis of wound healing is important for the therapy control and for the development of drugs stimulating the healing process. Wounds cause damage to the skin barrier. A damaged stratum corneum leads to an increased water loss through the skin barrier. The standard measuring procedure for characterization of wound healing is the measurement of transepidermal water loss (TEWL). The disadvantage of this method is that it can be easily (...) disturbed by the perspiration of the volunteers and by topically applied substances, for instance wound healing creams. In the study presented, in vivo laser scanning microscopy and optical coherent tomography were compared concerning the application for their analysis of wound healing processes. The laser scanning microscopy allows the analysis of the healing process on a cellular level. The course of wound healing determined by laser scanning microscopy was correlated with numerical values, allowing

2008 GMS Krankenhaushygiene Interdisziplinar

3265. Percutaneous Window Chamber Method for Chronic Intravital Microscopy of Sensor–Tissue Interactions Full Text available with Trip Pro

previous animal models.A surgical procedure for implanting a sensor into the subcutis beneath an acrylic window (15 mm diameter) is presented. Methods to quantify changes in the microvascular network and red blood cell perfusion around the sensors using noninvasive intravital microscopy and laser Doppler flowmetry are described. The feasibility of combining interstitial glucose monitoring from an implanted sensor with intravital fluorescence microscopy was explored using a bolus injection (...) Percutaneous Window Chamber Method for Chronic Intravital Microscopy of Sensor–Tissue Interactions A dorsal, two-sided skin-fold window chamber model was employed previously by Gough in glucose sensor research to characterize poorly understood physiological factors affecting sensor performance. We have extended this work by developing a percutaneous one-sided window chamber model for the rodent dorsum that offers both a larger subcutaneous area and a less restrictive tissue space than

2008 Journal of diabetes science and technology (Online)

3266. A randomized, double-blind comparison of two topical anesthetic formulations prior to electrodesiccation of dermatosis papulosa nigra. (Abstract)

A randomized, double-blind comparison of two topical anesthetic formulations prior to electrodesiccation of dermatosis papulosa nigra. Liposomal lidocaine 4% (L.M.X.4 cream, Ferndale Laboratories Inc., Ferndale, MI, USA) has been proposed as a more rapidly acting topical anesthetic than the eutectic mixture of lidocaine 2.5% and prilocaine 2.5% (EMLA cream, AstraZeneca LP, Wilmington, DE, USA) for venipuncture and laser procedures. However, their anesthetic efficacy has not been previously (...) compared for electrosurgical destruction of superficial skin lesions.To test the hypothesis that L.M.X.4 and EMLA differ in anesthetic efficacy when applied under occlusion for 30 minutes prior to electrodesiccation of papules of dermatosis papulosa nigra.Forty adults were randomly assigned to treatment with either agent for 30 minutes under Tegaderm. The study drug was administered for an additional 30 minutes if the electrodesiccation of the first few papules was too painful.One subject treated

2006 Dermatologic Surgery Controlled trial quality: uncertain

3267. Efficacy of 1% 4-ethoxybenzaldehyde in reducing facial erythema. (Abstract)

Efficacy of 1% 4-ethoxybenzaldehyde in reducing facial erythema. Facial erythema is a common postsurgical and dermatologic problem. It is commonly the result of dermal inflammation arising from either a facial surgical procedure, such as laser resurfacing, dermabrasion, or a face peel, or from an underlying dermatologic condition, such as rosacea. Facial erythema is difficult for the dermatologist to treat in both settings because topical corticosteroids cannot be used long term on the thin (...) facial skin and anti-inflammatory oral or topical antibiotics have associated side effects.The goal of this pilot study was to evaluate the anti-inflammatory effect of 1% 4-ethoxybenzaldehyde in a rosacea model of facial erythema.Thirty subjects with mild to moderate stable rosacea were enrolled in this 4-week, double-blind, vehicle-controlled study. Photographs, investigator assessment, and subject assessment were the efficacy criteria.There was a statistically significant reduction in facial

2005 Dermatologic Surgery Controlled trial quality: uncertain

3268. Hemodynamic effects of intermittent pneumatic compression in patients with critical limb ischemia. Full Text available with Trip Pro

. This prospective study was designed to determine if the use of IPC increases popliteal, gastrocnemial, collateral arterial, and skin blood flow in patients with CLI.Twenty limbs with CLI in 20 patients (mean age, 74 years) were evaluated with duplex ultrasound scans and laser Doppler fluxmetry in the semi-erect position before, during, and after IPC. One pneumatic cuff was applied on the foot and the other on the calf. The maximum inflation pressure was 120 mm Hg and was applied for 3 seconds at three cycles (...) Hemodynamic effects of intermittent pneumatic compression in patients with critical limb ischemia. Traditional teaching assumes that the distal arterial tree is maximally dilated in patients with critical limb ischemia (CLI). Endovascular or arterial bypass procedures are the commonly used interventions to increase distal perfusion. However, other forms of treatment such as spinal cord stimulation or intermittent pneumatic compression (IPC) have been shown to improve limb salvage rates

2005 Journal of Vascular Surgery

3269. Long-term effects of endovascular angioplasty on orthostatic vasocutaneous autoregulation in patients with peripheral atherosclerosis. Full Text available with Trip Pro

angioplasty of femoropopliteal lesions. In all subjects, foot skin blood flow was assessed by laser Doppler flowmetry in the horizontal (HBF) and sitting (SBF) positions. VAR was calculated as (HBF - SBF)/HBF x 100.In patients with peripheral arterial disease, mean HBF (in arbitrary units [AU]; mean +/- SD) was similar before (25.6 +/- 15.3 AU) and after (27.0 +/- 16.4 AU) angioplasty (P = .67), whereas SBF was significantly lower after than before the endovascular procedure (11.6 +/- 7.7 AU to 18.4

2006 Journal of Vascular Surgery

3270. Prevalence of somatic small fiber neuropathy in obesity. Full Text available with Trip Pro

the hairy skin of the forearm. In fact, a neurological examination revealed that 37 subjects were asymptomatic in the legs and only four complained of a neuropathic pain in the foot. Virtually all subjects were exposed to a set of capsaicin-sensitive tests and measures which were identified by capsaicin desensitization procedures. These tests, conducted while in a supine position in bed at the Banner Good Samaritan Medical Center, Phoenix, examined the two principle roles of cutaneous SSFs, namely (...) conveying pain signals to the CNS and controlling local neurogenic vasodilatation (flare; axon-reflex).Heat-induced pain was assessed by verbal reports of sensation after accommodation and heat-, capsaicin-, and transcutneous stimulation- induced blood flow was measured by laser Doppler flowmetry with probes placed at the site of stimulation and 1 cm remote from the site, the latter to evaluate flare latency and intensity of flare.Significant depression of pain and flare responses were observed

2007 International Journal of Obesity

3271. Dew point effect of cooled hydrogel pads on human stratum corneum biosurface. (Abstract)

Dew point effect of cooled hydrogel pads on human stratum corneum biosurface. Cooled hydrogel pads are used to prevent overheating effects of laser therapy. They do not induce cold injuries to the skin, but their more subtle physiological effects have not been thoroughly studied.To describe the changes in transepidermal water loss and electrometric properties of the skin surface following application of cooled hydrogel pads. Measurements were performed on normal forearm skin of 27 healthy (...) hydrogel pads during laser therapy is different from the effect of a cryogenic spray cooling procedure. The better preservation of the water balance in the stratum corneum by the cooled hydrogel pads could have a beneficial esthetic effect on laser treated areas.(c) 2008 S. Karger AG, Basel.

2008 Dermatology

3272. Identification of dermatophyte species causing onychomycosis and tinea pedis by MALDI-TOF mass spectrometry. Full Text available with Trip Pro

Identification of dermatophyte species causing onychomycosis and tinea pedis by MALDI-TOF mass spectrometry. Identification of dermatophytes is currently performed based on morphological criteria and is increasingly supported by genomic sequence comparison. The present study evaluates an alternative based on the analysis of clinical fungal isolates by mass spectrometry. Samples originating from skin and nail were characterized morphologically and by sequencing the internal transcribed spacer 1 (...) (ITS1), ITS2 and the 5.8S rDNA regions of the rDNA clusters. In a blind comparative study, samples were analyzed by matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF MS). The mass spectra were compared to a database comprising of the spectral data of reference strains by applying the saramis software package. All fungal isolates belonging to the taxa Trichophyton rubrum, T. interdigitale, T. tonsurans, Arthroderma benhamiae and Microsporum canis were correctly identified

2007 Experimental Dermatology

3273. Non-surgical treatment modalities of facial photodamage: practical knowledge for the oral and maxillofacial professional. (Abstract)

to use albeit with appropriate precautions and professional guidance. As a second-level option, facial rejuvenation procedures such as botulinum toxin injection, soft tissue augmentation with collagen or hyaluronic acid gel, skin resurfacing, use of chemical peels, dermabrasion and laser resurfacing procedures can be used but require administration by qualified practitioners. Overall, these treatments may be used to complement rehabilitative, reconstructive, or cosmetic oral and maxillofacial surgery (...) Non-surgical treatment modalities of facial photodamage: practical knowledge for the oral and maxillofacial professional. With the increasing interest in cosmetic procedures, oral and maxillofacial surgeons are being asked not only to improve oral health and aesthetics but to extend their expertise to provide advice on improving the overall appearance of the face. For the discerning patient, improving overall facial skin appearance is becoming an integral part of the process of surgical

2006 International Journal of Oral and Maxillofacial Surgery

3274. Pharmacologic approaches for reducing venous access pain in children. Full Text available with Trip Pro

Pharmacologic approaches for reducing venous access pain in children. A variety of pharmacologic options are available to clinicians who want to provide effective and safe topical local anesthesia to children undergoing venous access procedures. These options can be distinguished on the basis of how they deliver active drug through the impermeable outer layer of skin, the stratum corneum, to pain receptors located in the dermis and epidermis. Three general methodologies are typically used (...) be distinguished on the basis of the time to onset of full anesthetic effect. Several available agents induce significant local anesthesia within 1 to 3 minutes of administration, or faster, allowing easy integration into the skin preparation and subsequent venous access procedure. In combination with nonpharmacologic approaches, these agents can be used to dramatically lessen this significant source of pediatric pain.

2008 Pediatrics

3275. Minimally invasive techniques in the treatment of saphenous varicose veins. (Abstract)

in the development of these new therapies of truncal varicose veins. Of the new therapies, ultrasound-guided foam sclerotherapy, endovenous laser therapy, and radiofrequency ablation are the most common and challenge surgery as the "gold standard" of care for patients with varicose veins. The objective of this review is to inform clinicians about these 3 therapeutic options for truncal varicose veins and to describe and compare the procedures, indications, efficacy, and safety profile. (...) Minimally invasive techniques in the treatment of saphenous varicose veins. Lower extremity venous insufficiency is common and increases with age. In addition to classical symptoms, it may result in skin changes and venous ulcers. Chronic venous insufficiency has a great impact on patients' health-related quality of life and is associated with considerable health care costs. Surgical ligation of the junction with or without stripping has been the standard of care in the treatment

2008 Journal of American Academy of Dermatology

3276. Evaluation of barrier creams - introduction and comparison of 3 in vivo methods. (Abstract)

and glycerol trinitrate acted as hydrophilic model-penetrating substances. By means of these methods, 3 different BC were tested and compared for their potency. The investigations showed that primarily the tape-stripping procedure and also the laser scanning microscopy are promising tools for the evaluation of BC. In contrast, the laser doppler flowmetry represents a less feasible technique. In addition, the evaluation of BC showed that Vaseline enfolds a 100% barrier on the skin surface (...) Evaluation of barrier creams - introduction and comparison of 3 in vivo methods. Often barrier creams (BC) do not fulfil their protecting behaviour, even when promised by the manufacturers. Therefore, it is of great importance to develop standardized in vivo techniques to prove the potency of BC in humans. In the present study, 3 promising techniques for the analysis of BC were evaluated: laser scanning microscopy, laser doppler flowmetry, and the tape-stripping procedure. Sodium fluorescein

2007 Contact Dermatitis

3277. Treatment of port wine stains with intense pulsed light: a prospective study. (Abstract)

Treatment of port wine stains with intense pulsed light: a prospective study. Recent studies have shown that intense pulsed light can be useful in treating port wine stains that were resistant to previous pulsed dye laser therapy. Asian persons with high epidermal melanin context can be at a higher risk of complication.The aim of this study was to conduct a prospective trial to assess the efficacy and complication of intense pulsed light in the treatment of port wine stains in Chinese (...) patients.Twenty-two Chinese patients with port wine stains without previous treatment were recruited to receive intense pulsed light source therapy for five to seven treatments at intervals of 3 to 4 weeks. Patient demographics, skin type, characteristics of port wine stains including color and location, treatment parameters, degree of pain caused by intense pulsed light treatment, percentage of clearing, and treatment complications were recorded and entered into a database. A questionnaire was conducted

2004 Dermatologic Surgery

3278. Update on the use of antibiotics in cutaneous surgery. (Abstract)

sources from the past 30 years, especially focusing on sources from the past 5 to 10 years. Data were examined for a variety of cutaneous surgical procedures, routes of antibiotic administration, and consideration of both cutaneous and distant infections.The literature suggests that, for most routine skin procedures, antibiotic use is probably not warranted for the prevention of surgical wound infection, endocarditis, and late prosthetic joint infections. During prolonged Mohs procedures, delayed (...) repairs, grafts, takedowns of interpolation flaps, or any procedure that breaches a mucosal surface, the evidence is less clear, and decisions should be made on a case-by-case basis. Topical antibiotics are probably overused, although silver sulfadiazine may have an undeserved negative reputation among dermatologists. Systemic prophylactic antibiotics for laser resurfacing and liposuction appear not to be routinely necessary, although patients with known prior herpes infection likely should receive

2005 Dermatologic Surgery

3279. Treatment of actinic cheilitis using photodynamic therapy with methyl aminolevulinate: report of three cases. (Abstract)

Treatment of actinic cheilitis using photodynamic therapy with methyl aminolevulinate: report of three cases. Patients with actinic cheilitis should be treated to prevent transformation into invasive squamous cell carcinoma. Treatment options comprise, for instance, destructive approaches, such as vermilionectomy and carbon dioxide laser ablation. Photodynamic therapy (PDT) has demonstrated high efficacy in patients with epithelial skin cancers, but there is only one report on PDT with free (...) treatment.A good clinical response with an excellent cosmetic outcome was observed in all three patients. Moderate to severe pain was associated with the application of the red light, and mild inflammation with edema of the lower lip occurred.This is the first use of PDT with MAOP and 634 mm wavelength red light in patients with actinic cheilitis. The clinical results demonstrate that PDT might be an alternative for patients who refuse surgical procedures. However, further studies are needed to compare

2005 Dermatologic Surgery

3280. CPT coding and reimbursement issues in dermatology. (Abstract)

CPT coding and reimbursement issues in dermatology. In the past 6 years, significant changes have been made in Current Procedural Terminology codes, descriptors, and guidelines affecting dermatologists. These changes involved excision, repair, measuring excised diameter, measuring flap defects, skin biopsy and Mohs surgery guidelines, KOH examination, and fungus cultures. New codes were introduced for photodynamic therapy, laser treatment, and whole-body photography. Reimbursement issues (...) affecting dermatologists are also discussed, including inappropriate bundling of separate services, failure to recognize modifiers, and unfair multiple procedure reduction. The successes of the American Academy of Dermatology Association advocacy efforts with insurance carriers are summarized, with an update on the current status of these issues. Physician responsibilities, documentation requirements, and expectations are also outlined.

2005 Seminars in Cutaneous Medicine and Surgery

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