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Lactose Breath Hydrogen Test

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161. Statement on persistent diarrhea in the returned traveller

breath test can confirm a suspicion of lactose tolerance if the diagnosis is suspected and the clinical response to milk avoidance is inconclusive.) Specific therapy should be given using published guidelines ( or other sources) if likely pathogenic microorganisms are identified. A II Indications for GI endoscopy Among patients with persistent and substantial symptoms, GI endoscopy may contribute to management in the following circumstances. If sustained or progressive weight loss is a prominent (...) Stool examination for fecal leukocytes, lactoferrin, or even occult blood can also be helpful in identifying subjects with colitis of all etiologies . A II A complete blood count may be helpful if it reveals anemia, leukocytosis, thrombocytosis, or eosinophilia. While the results are awaited, advise the patient to avoid all dairy or lactose-containing products; a trial period of 3 to 5 days is often diagnostic (C III). Clinical improvement may avoid the need for further investigations. (A hydrogen

2006 CPG Infobase

162. Circadin (melatonin)

in clinical efficacy section. The new dossier includes all the data that were submitted in the first MAA and additional data extracted from the new studies performed during 2003-2005. ©EMEA 2007 4/52 1. Quality aspects Introduction Circadin is presented in the form of prolonged-release tablets containing 2 mg of melatonin for oral administration. The excipients used in the formulation of Circadin are ammonio methacrylate copolymer Type B, calcium hydrogen phosphate dihydrate, lactose monohydrate (...) established. A single-dose, two-way crossover comparative pharmacokinetic and food interaction study together with the corresponding in vitro dissolution study, were performed to establish an in vitro-in vivo correlation. The data showed linear correlation (level A), confirming that the proposed dissolution test may be considered a reliable marker for the in vivo performance. • Adventitious Agents Lactose monohydrate was of animal origin. A declaration from the lactose supplier was provided stating

2007 European Medicines Agency - EPARs

163. Transit Time and Bacterial Overgrowth Using SmartPill Capsule

. The ACT-1 (SmartPill) GI Monitoring System includes an ingestible capsule, a receiver and video display software. Procedure: Lactulose hydrogen breath test (H_2BT) A hydrogen breath test provides information about the digestion of certain sugars or carbohydrates, such as milk sugar (lactose) or fruit sugar (fructose). The test is also used for detecting abnormal growth of bacteria within the small bowel by having the patient ingest lactulose. Active Comparator: Symptomatic Participants Subjects (...) The SmartPill is a single-use, ingestible capsule that utilizes sensor technology to measure pressure, pH and temperature throughout the entire GI tract. The ACT-1 (SmartPill) GI Monitoring System includes an ingestible capsule, a receiver and video display software. Procedure: Lactulose hydrogen breath test (H_2BT) A hydrogen breath test provides information about the digestion of certain sugars or carbohydrates, such as milk sugar (lactose) or fruit sugar (fructose). The test is also used for detecting

2007 Clinical Trials

164. Non-Invasive Measurement of Gastrointestinal (GI) Motility in Patients With Amyotrophic Lateral Sclerosis (ALS)

or at your home). Before eating or drinking anything a baseline measurement will be taken by breathing into the hydrogen meter. This will be just normal breathing. You will then drink a test meal consisting of 250 ml (approximately 1 cup) of a lactose (type of sugar) free supplement (For example Ensure) that has 20 grams of Lactulose added. If you have a peg tube then the supplement will be given through the tube. After 10 minutes you will again be asked to breath into the machine to measure the hydrogen (...) instrument that measures hydrogen gas in your breath. Data collection will start after you sign this consent form. The only procedures that would be above and beyond routine care are indicated below: In order to prepare for the study you will be asked to be off all medications that affects the GI motility for 24 hours. You will also be asked to fast overnight (starting midnight) the day before the test. After fasting overnight, the test will be performed in the morning (at the Neurology Outpatient Clinic

2008 Clinical Trials

165. Effect of Fructose on Colonic Microflora

in water twice a day Dietary Supplement: Fructose powder 30g in 250ml water twice a day No Intervention: No Intervention Outcome Measures Go to Primary Outcome Measures : Statistically significant reduction in total sum breath hydrogen upon a 50g fructose challenge test. [ Time Frame: intervention for 2 weeks per participant ] Secondary Outcome Measures : A log 1 change in fecal bifidobacteria or lactobacilli species. [ Time Frame: stools retested 2 weeks apart ] Eligibility Criteria Go to Information (...) is achieved in both cases by short term regular consumption of the targeted sugar which is not digested by the host. The clinical definition of CA includes a measured change in breath hydrogen, reduction of clinical symptoms (Bloat, gas, cramps and at times diarrhea) and an associated increase of bacterial lactase(β-galactosidase. The putative mechanism is through bacterial action which results in enhanced metabolism or expanded bacterial population of specific genus and species of bacteria. The act of CA

2008 Clinical Trials

166. Recurrent Abdominal Pain in Children

that the child kept while on the special diet. The coordinators will explain how to collect some samples of urine, stool, and breath. These tests will evaluate the gastrointestinal (GI) tract for inflammation and transit time. If the special diet does not make the stomach pain go away, the child will be selected at random, like the flip of a coin, to be placed in one of two groups: one group that receives fiber or one group that receives a placebo or sugar pill. Fiber has been suggested to help children (...) somatization, coping, and illness interaction [ Time Frame: Four weeks prior to treatment and 6 months after treatment ] Changes in GI Transit time [ Time Frame: Prior to and after treatment ] Changes in Breath Hydrogen production [ Time Frame: Prior to and after treatment ] Changes in GI Permeability [ Time Frame: Prior to and after treatment ] Changes in fecal calprotectin concentration [ Time Frame: Prior to and after treatment ] Eligibility Criteria Go to Information from the National Library

2007 Clinical Trials

167. Evaluation of Urinary Isoprostanes in the Assessment of Children With Inflammatory Bowel Disease

Eligible for Study: All Accepts Healthy Volunteers: Yes Sampling Method: Non-Probability Sample Study Population Patients with known or suspected IBD. Criteria Inclusion Criteria: Patients scheduled for endoscopic evaluation (upper endoscopy, colonoscopy or sigmoidoscopy) Patients currently completing lactose hydrogen breath tests (LHBT) Exclusion Criteria: Patients with a previous history of HIV and/or chronic Hepatitis (or active acute hepatitis B or C). Patients will be asked about potential blood (...) . Isoprostane levels will be compared across conditions (IBD vs. non-inflammatory, Crohn's disease vs. ulcerative colitis) and tested for statistical significance. Similarly, disease severity and urinary isoprostane levels will be assessed. The sensitivity, specificity, and positive and negative predictive values of elevated urinary isoprostane levels at discriminating pediatric patients with inflammatory and non-inflammatory gastrointestinal disease will be calculated. Condition or disease Inflammatory

2005 Clinical Trials

168. The Effect of Probioticson Bloating in IBS

: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: No Criteria Inclusion Criteria: - Female test persons with symptoms of meteorism, the age of > 18 years, completely integrated in the Danish society (including nutrition), and no previous abdominal surgery besides from appendicectomy (advertisement in a local newspaper for test persons). Exclusion Criteria: Lactose and sorbitol intolerant persons (based on hydrogen breath tests). Persons (...) Information provided by: Royal Veterinary and Agricultural University, Denmark Study Details Study Description Go to Brief Summary: The purpose of the study is to establish an in-vitro method to evaluate the effect of probiotics on gas production in feces (hydrogen and methane) Condition or disease Intervention/treatment Phase Irritable Bowel Syndrome Drug: Probiotic bacteria (Trevis R) Not Applicable Detailed Description: The objective of this study is to establish a model for screening probiotic

2006 Clinical Trials

169. Beneficial effects of oral tilactase on patients with hypolactasia. (Abstract)

levels (P < 0.005) than intolerants. After tilactase ingestion, integrated H(2) levels were decreased by 75% (low dose) and 87% (standard dose) in malabsorbers, and by 74% (low dose) and 88% (standard dose) in intolerants. In the latter group, total symptom score were decreased by 76% (low dose) and by 88% (standard dose) (P < 0.0001).A single oral administration of tilactase is highly effective in decreasing symptoms and hydrogen excretion of hypolactasia assessed by lactose H(2)-breath test (...) Beneficial effects of oral tilactase on patients with hypolactasia. A lactose-free diet is commonly prescribed to subjects with hypolactasia. We tested the effectiveness of a single ingestion of tilactase (a beta-D-galactosidase from Aspergillus oryzae) in adults with hypolactasia, previously assessed by lactose H(2)-breath test.After measurement of orocecal transit time (OCTT, by lactulose H(2)-breath test) and lactose H(2)-breath testing plus placebo, a total of 134 subjects were positive

2008 European journal of clinical investigation

170. Perceived milk intolerance is related to bone mineral content in 10- to 13-year-old female adolescents. Full Text available with Trip Pro

Perceived milk intolerance is related to bone mineral content in 10- to 13-year-old female adolescents. The purpose of this study was to determine associations among lactose maldigestion status, perceived milk intolerance, dietary calcium intake, and bone mineral content in early adolescent girls.Subjects were 291 girls who participated in a substudy of the multiple-site project Adequate Calcium Today. Lactose maldigestion status was determined with hydrogen breath testing, and questionnaires (...) and were classified as lactose maldigesters. Of the 246 participants who completed useable perceived milk intolerance questionnaires, 47 considered themselves to be milk intolerant. Of the 47 girls self-reporting perceived milk intolerance, 40 completed breath hydrogen testing and 22 were not maldigesters. Girls with perceived milk intolerance consumed an average of 212 mg of total food calcium per day less than girls without perceived milk intolerance. Spinal bone mineral content was significantly

2007 Pediatrics Controlled trial quality: uncertain

171. Decline of Lactase Activity and C/T-13910 Variant in Sardinian Childhood. (Abstract)

Decline of Lactase Activity and C/T-13910 Variant in Sardinian Childhood. Our study aims to determine the age of onset of adult-type hypolactasia in Sardinians, and to establish the age at which genotyping of the C/T-13910 variant can be used reliably in the diagnosis of lactose malabsorption.A lactose breath hydrogen test was given to 383 randomly selected patients, from 3 to 19 years old.The C/C-13910 genotype was found in 90% of patients; the frequency of the positive lactose breath hydrogen (...) test increased with age and reached a prevalence of 85% at 9 years.In Sardinians, adult-type hypolactasia becomes phenotypically evident in all individuals older than 9 years, suggesting that this should be considered the minimum age at which the genetic test for lactase nonpersistence should be applied.

2007 Journal of Pediatric Gastroenterology and Nutrition

172. Pilot study on the effect of reducing dietary FODMAP intake on bowel function in patients without a colon. Full Text available with Trip Pro

. Carbohydrate malabsorption was evaluated by breath tests. Pouchitis was assessed clinically/endoscopically or by fecal lactoferrin.Of 8 patients with a breath hydrogen response to lactulose, 7 had fructose malabsorption, 3 with lactose malabsorption, and 1 had lactose malabsorption alone. Five of 7 studied retrospectively improved stool frequency (from median 8 to 4 per day; P = 0.02), this being sustained over 0.5-3 years of follow-up. Five of 8 patients completed a prospective arm of the study. One

2007 Inflammatory Bowel Diseases

173. Systematic evaluation of the causes of chronic watery diarrhea with functional characteristics. (Abstract)

follow-through; and (d) hydrogen breath test (lactose, fructose + sorbitol). Gluten- or sugar-free diet, or cholestyramine was administered according to results. Functional disease was diagnosed if all tests performed were normal or if either there was no response to specific therapy or diarrhea relapsed during a 12-month follow-up.Bile acid malabsorption was considered to be the cause of diarrhea in 28 (45.2%) patients, sugar malabsorption in 10 (16.1%), gluten-sensitive enteropathy in 10 (16.1 (...) watery diarrhea of obscure origin fulfilling Rome II criteria of functional disease.A total of 62 patients with chronic watery diarrhea, defined as more than 3 loose or liquid bowel movements a day for at least 4 wk and a stool weight >200 g/day were included. The following tests were performed: (a) HLA-DQ2/DQ8 genotyping, and if positive, endoscopic biopsies from distal duodenum were obtained, and intestinal damage assessed; (b) SeHCAT (Se-homotaurocholate) abdominal retention test; (c) small bowel

2007 American Journal of Gastroenterology

174. Irritable Bowel Syndrome (IBS)

. CRP. Coeliac screen. CA 125 for women with symptoms which could be ovarian cancer [ ] . Faecal calprotectin for those with symptoms which could be IBD [ ] . The following tests are NOT required to confirm IBS in those who meet the diagnostic criteria: TFTs. Ultrasound. Colonoscopy/sigmoidoscopy/barium enema. Faecal occult blood. Faecal ova and parasite tests. Hydrogen breath tests. Referral criteria Refer patients in the event of diagnostic uncertainty, alarm symptoms, or severe resistant symptoms (...) in causing symptoms of IBS. Foods high in FODMAPs, such as apples, cherries, peaches, nectarines, artificial sweeteners, most lactose-containing foods, legumes, and many green vegetables (broccoli, Brussels sprouts, cabbage, and peas) may have fermentation and osmotic effects, increasing symptoms. Diets low in FODMAPs have therefore been advocated in helping symptoms. There is evidence to support this approach [ , , ] . Up to 86% of people with IBS are said to report an improvement in symptoms

2008 Mentor

175. Chronic Diarrhoea in Adults

hydrogen breath test, jejunal aspirate and culture. Pancreatic: CT scan of pancreas. Faecal elastase or chymotrypsin. Further structural tests: endoscopic retrograde cholangiopancreatography or magnetic resonance cholangiopancreatography. History or findings suggestive of colonic or terminal ileal disease. Flexible sigmoidoscopy if aged under 45 years (the diagnostic yield is not different to colonoscopy in this group). If aged over 45 years, colonoscopy is preferred to barium enema. Terminal ileum (...) , tropical sprue, amyloid, intestinal lymphangiectasia. Bile acid malabsorption - eg, Crohn's disease affecting the terminal ileum, after ileal resection, cholecystectomy, coeliac disease, bacterial overgrowth and pancreatic insufficiency. Disaccharidase deficiency. Lactose intolerance. Small bowel bacterial overgrowth. Mesenteric ischaemia. Radiation enteritis. Lymphoma. Pancreatic: Chronic pancreatitis. Pancreatic carcinoma. Cystic fibrosis. Endocrine: Hyperthyroidism. Diabetes mellitus (and other

2008 Mentor

176. Flatulence and Wind

dioxide, hydrogen and methane are responsible for the main volume of intestinal gas and sulfur-containing gases for malodour. [ ] The volume and composition of gas depends both on diet and on colonic flora. [ , ] Peope with irritable bowel syndrome (IBS) are likely to produce a greater volume of gas than people who do not have IBS. IBS is also associated with a positive lactulose breath test (a test that assesses the amount of fermented gas generated by bacteria in the bowel) and an increase in gas (...) syndrome): [ ] FBC. ESR or CRP. Antibody testing for coeliac disease. Breath tests may be used to assess intestinal flora and small intestinal bacterial overgrowth, usually in the context of research studies. [ ] Management Belching Explanation of normal physiology and reassurance may be sufficient. Investigate/treat and symptoms if relevant. [ ] Speech therapy or behavioural therapy may be used. [ , ] Flatulence Note that most of the research and literature on this topic relates to patients diagnosed

2008 Mentor

177. Honey may have a laxative effect on normal subjects because of incomplete fructose absorption. (Abstract)

of a glucose and fructose mixture. The breath-hydrogen concentration was measured every 15 min for 6 h. Semiquantitative estimates of carbohydrate malabsorption were assessed with lactose as a nonabsorbable standard. Breath-hydrogen concentrations increased by 52 +/- 6, 30 +/- 4, 20 +/- 3, and 4 +/- 1 ppm (mean +/- SEM) after each of the four test solutions, respectively. The estimated carbohydrate malabsorption was 10.3 +/- 1.8, 5.9 +/- 1.2, and 0.5 +/- 0.2 g after 100 g honey, 50 g honey, and the glucose

1996 The American journal of clinical nutrition Controlled trial quality: uncertain

178. Distribution of adult lactase phenotypes in the Tuareg of Niger. Full Text available with Trip Pro

Distribution of adult lactase phenotypes in the Tuareg of Niger. The adult lactase phenotype, lactose absorber or malabsorber, was determined using the lactose tolerance test with breath hydrogen assay in a group of Tuareg, a traditionally nomadic pastoralist population in the central Sahara. Out of a total of 118 subjects, 103 (87.3%) were lactose absorbers and 15 (12.7%) lactose malabsorbers. The frequency of the "lactase suppression gene" in this population sample was .357 (SD .043). The low

1986 American Journal of Human Genetics

179. [Effects of neomycin on intestinal digestion, absorption and fermentation of carbohydrates in patients with liver cirrhosis: evidence for an alternative therapeutic mechanism in hepatic encephalopathy]. (Abstract)

malabsorption.To investigate the effects of neomycin on intestinal digestion, absorption and fermentation of carbohydrates in patients with liver cirrhosis.Thirty eight Child B or C cirrhotic patients separated in three groups; subjects within each group were randomized to receive neomycin (2/g/day for 10 days, n = 8) or placebo (n = 4). Absorption of lactose and d-xylose and fermentation of d-xylose, lactose and lactulose (measured using hydrogen breath tests) were studied before and after the treatment (...) period.Neomycin did not change lactose fermentation but reduced plasma glucose rise after lactose ingestion (38.8 +/- mg/dl to 22 +/- 6 mg/dl p < 0.05). Plasma d-xylose levels at 30 min and its 5 h urinary excretion were reduced by neomycin from 19 +/- 3 to 9 +/- 2 mg/dl and from 4.9 +/- 0, 8 to 2.6 +/- 0.3 g/5h respectively (p < 0.05). Fermentation of d-xylose, lactose and lactulose was not reduced by neomycin. No significant changes were observed after placebo treatment.Neomycin therapy is associated

1994 Revista médica de Chile Controlled trial quality: uncertain

180. [Clinical consequences of replacing milk with yogurt in persistent infantile diarrhea]. (Abstract)

hydrogen breath test results. Clinical treatment failure (weight loss greater than 5% in one day or persistent diarrhea after 5 days) was significantly less common in children fed yogurt (15 +/- 6%) than in children fed milk (45 +/- 8%). The beneficial effects of feeding yogurt were apparent within 48 hours in 67 +/- 8% of infants. In conclusion, these data confirm the clinical efficacy of substituting yogurt for milk in young children with persistent diarrhea. They also suggest that yogurt may (...) for milk, as the only treatment. After a one to two-day observation period during which a standard milk diet was given, 78 children aged 3 to 36 months with confirmed persistent diarrhea of more than 15 days but less than one month duration and negative tests for fecal blood were fed either milk (infant formula) or yogurt (infant formula fermented with Lactobacillus bulgaricus and Streptococcus thermophilus). At inclusion both groups were comparable for age, nutritional status, diarrhea, and lactose

1992 Annales de pédiatrie Controlled trial quality: uncertain

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