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Lactose Breath Hydrogen Test

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101. Whole Milk Intake and Cardio-metabolic Risk Factors

With or Without Lactose Maldigestion Study Start Date : May 2016 Estimated Primary Completion Date : August 2016 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: lactose digesters Participants in arm 1 are grouped as lactose digesters based on breath hydrogen test after a 25-g lactose load. The breath hydrogen excretion is less than 20 ppm. Dietary Supplement: full-fat milk intake 250ml full-fat milk per day (...) , do not intake any other dairy products Active Comparator: lactose maldigesters Participants in arm 2 are also grouped as lactose maldigesters based on breath hydrogen test after a 25-g lactose load. The breath hydrogen excretion is not less than 20 ppm. Dietary Supplement: full-fat milk intake 250ml full-fat milk per day, do not intake any other dairy products Outcome Measures Go to Primary Outcome Measures : Changes in body weight [ Time Frame: 4 weeks ] Change in body composition (body fat mass

2016 Clinical Trials

102. A Low FODMAPs Diet in Celiac Patients With Persistent Gastrointestinal Symptoms

criteria subjects with VAS>5 Exclusion Criteria: refractory celiac disease disaccharide intolerance (fructose an lactose breath test) abdominal surgery comorbidity patients recruited in other clinical trials positive patients at lactulose breath test (SIBO) Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study (...) FODMAPS causes a rapid increase in carbohydrate which can overwhelm the microbiota's ability to utilise substrate. The excess reducing equivalents will generate hydrogen or methane. The principal symptoms are diarrhoea and abdominal distension. Patients with irritable bowel syndrome appear to benefit by restricting intake, possibly because they are hypersensitive to intestinal distension. The focus of the study is to evaluate if in celiac patients with persistent abdominal symptoms and with a correct

2016 Clinical Trials

103. Concomitant Prevalence of Low Serum Diamine Oxidase Activity and Carbohydrate Malabsorption (PubMed)

Concomitant Prevalence of Low Serum Diamine Oxidase Activity and Carbohydrate Malabsorption The aim of this retrospective study was to analyze the concomitant prevalence rates for lactose malabsorption (LM), fructose malabsorption (FM), and histamine intolerance (HI) in patients with so far unexplained gastrointestinal (GI) symptoms. A total of 439 outpatients, who presented unclear abdominal discomfort, underwent lactose (50 g) and fructose (25 g) hydrogen (H2) breath tests. Additionally (...) malabsorption were also diagnosed with HI (LM + HI: 52 [11.8%], FM + HI: 23 [5.2%], and LM + FM + HI 14 [3.2%] individuals). In conclusion different combinations of LM, FM, and HI are present in individuals with unclear abdominal discomfort/pain. In clinical practice we suggest testing for LM, FM, and additional HI in the diagnostic work-up of these patients. Depending on these various diagnoses possible, patients should get an individualized dietary advice.

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2016 Canadian journal of gastroenterology & hepatology

104. Irritable bowel syndrome in adults: diagnosis and management

(https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 7 of 22antibody testing for coeliac disease (endomysial antibodies [EMA] or tissue transglutaminase [TTG]). [2008] [2008] The following tests are not necessary to confirm diagnosis in people who meet the IBS diagnostic criteria: ultrasound rigid/flexible sigmoidoscopy colonoscopy; barium enema thyroid function test faecal ova and parasite test faecal occult blood hydrogen breath test (for lactose intolerance and bacterial (...) and management (CG61) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 11 of 221.1.2.2 The following tests are not necessary to confirm diagnosis in people who meet the IBS diagnostic criteria: ultrasound rigid/flexible sigmoidoscopy colonoscopy; barium enema thyroid function test faecal ova and parasite test faecal occult blood hydrogen breath test (for lactose intolerance and bacterial overgrowth). [2008] [2008] 1.2

2008 National Institute for Health and Clinical Excellence - Clinical Guidelines

105. Efficacy of Rifaximin to Treat Diarrhea-predominant Irritable Bowel Syndrome

and evaluate the efficacy of rifaximin for IBS-D in Chinese population. Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 120 participants Observational Model: Case Control Time Perspective: Prospective Official Title: Efficacy of Rifaximin for Diarrhea-predominant Irritable Bowel Syndrome With Positive Lactulose Hydrogen Breath Test Study Start Date : October 2015 Estimated Primary Completion Date : October 2017 Estimated Study Completion Date (...) of patients who with positive lactulose hydrogen breath test change to be negative [ Time Frame: 2 weeks ] the composition of patients's fecal microbiota [ Time Frame: 2 weeks ] Biospecimen Retention: Samples With DNA Faeces Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may

2015 Clinical Trials

106. Safety, Pharmacokinetic (PK) and Pharmacodynamic (PD) Study of Repeat Doses of Inhaled GSK2269557 in Patients With APDS/PASLI

. On those days, they will be dosed at the clinic). The subject should hold their breath for 10 seconds before exhaling. Inhalations should be taken approximately 30 seconds apart. Outcome Measures Go to Primary Outcome Measures : Number of subjects with any adverse events (AE) [ Time Frame: Up to 6 months ] An AE is any untoward medical occurrence in a patient or clinical investigation subject, temporally associated with the use of a medicinal product, whether or not considered related to the medicinal (...) , Glucose, C-reactive protein (CRP), Potassium, Sodium, Calcium, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase, Total and direct bilirubin, Total Protein, and Albumin Composite of urinalysis parameters as a measure of safety [ Time Frame: Up to 7.5 months ] Specific gravity, power of hydrogen (pH), glucose, protein, blood and ketones measured by dipstick; and microscopic examination (if blood or protein is abnormal) Spirometry: Forced expiratory volume in one

2015 Clinical Trials

107. Diets in Symptom Relief and the Influence of Quality of Life in People With Irritable Bowel Syndrome

Sponsor: Hong Kong Sanatorium & Hospital Collaborator: The Hong Kong Society of Gastrointestinal Motility Information provided by (Responsible Party): Hong Kong Sanatorium & Hospital Study Details Study Description Go to Brief Summary: Subjects with confirmed diagnosis of Irritable Bowel Syndrome will be blinded and randomly assigned to one of two groups, the low FODMAP diet or the conventional IBS diet group. They will be referred to do three hydrogen breath tests prior to diet education. Upon (...) and randomly assigned to Conventional IBS diet group (A) or Low FODMAP diet group (B) 3 Breath tests (lactulose, fructose, lactose) will be carried out for all subjects before diet education Subjects will be asked to come to the dietitians clinic and receive the first one hour diet education (including diet assessment & diet education) and two times thirty minutes follow-up appointments with the dietitians at Week 0, 6 and 10, respectively Subjects will be asked to record their food intake and signs

2015 Clinical Trials

108. Over-night Effect of Dietary Fiber on Glucose Metabolism and Satiety

] Insulin, levels of insulin in blood [ Time Frame: Postprandial 0-180 min after breakfast ] Appetite hormones, levels of Peptide YY (PYY) in blood [ Time Frame: Postprandial 0-180 min after breakfast ] Markers of colonic fermentation, levels of hydrogen in breath [ Time Frame: Postprandial 0-180 min after breakfast ] Inflammation markers, levels of Interleukin-6 (IL-6) in blood [ Time Frame: Postprandial 0-180 min after breakfast ] Secondary Outcome Measures : Subjective satiety, as measured by VAS (...) : + ind. CHO Test meals: intake of high levels of indigestible carbohydrates the evening prior to measurements of variables Other: High levels of indigestible carbohydrates Experimental: - ind. CHO Reference meal: scarce intake of indigestible carbohydrates the evening prior to measurements of variables Other: Low levels of indigestible carbohydrates Outcome Measures Go to Primary Outcome Measures : Blood Glucose, levels of glucose in blood [ Time Frame: Postprandial 0-180 min after breakfast

2015 Clinical Trials

109. Improving Bone Health in Adolescence Through Targeted Behavioral Intervention

in 6 states. The primary outcomes of bone mass and dietary calcium were assessed among Asian, Hispanic, or non-Hispanic white girls between 10 -13 y. Lactose maldigestion (LM) was determined by a breath hydrogen test (BHT). Perceived milk intolerance (PMI) and calcium intake were assessed by questionnaires and bone mineral content (BMC) was determined by dual energy X-ray absorptiometry (DXA). Data from 473 girls were used in a multiple linear regression to examine the impact of the intervention (...) months ] Baseline, 12 month and 18 month bone mineral content measured Dietary Calcium [ Time Frame: 18 months ] Dietary Calcium intake assessed by food frequency questionnaire Secondary Outcome Measures : Lactose maldigestion [ Time Frame: Baseline ] Measured by breath hydrogen testing Other Outcome Measures: Perceived lactose intolerance [ Time Frame: Baseline ] Measured by questionnaire Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study

2014 Clinical Trials

110. Safety and Tolerability of Serum Derived Bovine Immunoglobulin in Children With Diarrhea Predominant IBS

Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Male or female patients > 8 years of age and < 18 years of age Patients with a diagnosis of IBS-D as per Rome III criteria Patients with normal laboratory work up (CBC, ESR, CRP, amylase, lipase, celiac panel, fecal occult blood) Patients with normal fecal calprotectin and lactose hydrogen breath test Patients off motility drugs, NSAIDs for at least 2 weeks prior to enrollment in the study Ability to complete the study

2014 Clinical Trials

111. Effects of Resistant Starch in a Baked Snack Bar on a Post-prandial Glycemic and Insulinemic Response

will be consumed four hours later. Outcome Measures Go to Primary Outcome Measures : resistant starch effects [ Time Frame: 2 weeks ] effects of resistant starch consumption of area under the curve of blood serum glucose, insulin, and hydrogen breath testing Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about (...) , with a BMI between 20.0 and 29.9. Exclusion Criteria: Weight change > 3kg in the past 3 months Exercising vigorously over the past 3 months as well as no exercise 3 days prior to testing day Intestinal disorders including lipid mal-absorption or lactose intolerance Abnormal liver or kidney function tests; fasting blood glucose >100mg/dL Smoking Drinking more than 2 alcoholic drinks per day Taking lipid-lowering medications or dietary supplements affecting plasma cholesterol concentration. Subjects must

2014 Clinical Trials

112. Effects of Resistant Starch in a Beverage on Post-prandial Glycemic and Insulinemic Responses

, and hydrogen breath testing. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years to 29 Years (Adult) Sexes (...) lipid mal-absorption or lactose intolerance Abnormal liver or kidney function tests; fasting blood glucose >100mg/dL Smoking Drinking more than 2 alcoholic drinks per day Taking lipid-lowering medications or dietary supplements affecting plasma cholesterol concentration. Subjects must not be pregnant or lactating. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact

2014 Clinical Trials

113. Intraepithelial giardia intestinalis: a case report and literature review. (PubMed)

for pathogens and lactose hydrogen breath test was positive. The presumptive clinical diagnosis was giardiasis and the patient was empirically treated with nitazoxanide. But, the patient persisted with abdominal pain and pasty stools. Endoscopy was indicated to search for Helicobacter and Giardia. Guardian and patient gave written informed consent. Hematological profile was normal. The endoscopy was performed under general anesthesia and the biopsies and duodenal aspirate were obtained. The microscopic (...) analyses of duodenal fluid showed Giardia trophozoites. Electron microscopic analysis was negative for Helicobacter pylori, but Giardia trophozoites with a typical crescent shape within the tissue were found. The patient was treated with tinidazole, subsequent tests showed that lactose absorption was normal, stool examinations were negative for Giardia and abdominal pain had stopped. This case suggest that intraepithelial giardiasis could be a common entity but unseen because the giardiasis diagnosis

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2014 Medicine

114. Aubagio (teriflunomide)

inhibitory concentration IFN: interferon IgG: immunoglobin G IgM: immunoglobin M ILD: interstitial lung disease IV: intravenous IVIVC: in vitro/in vivo correlation LS: least-squares MAA: Marketing Authorisation Application MEB: Medicines Evaluation Board MedDRA: Medical Dictionary for Regulatory Activities MRI: magnetic resonance imaging MS: multiple sclerosis MSFC: multiple sclerosis functional composite Assessment report EMA/529295/2013 Page 4/150 NCT: nerve-conduction test NOAEL: no-observable-adverse (...) -effect level OAT: organic anion transporter OATP: organic anion transporting polypeptide PCSA: potentially clinically significant abnormality PDCO: Paediatric Development Committee PFT: pulmonary function testing PIP: paediatric investigation plan PML: progressive multifocal leukoencephalopathy PPMS: primary progressive multiple sclerosis PRMS: progressive-relapsing multiple sclerosis PT: preferred term QD: once a day QOL: quality of life RA: rheumatoid arthritis RBC: red blood cell RRMS: relapsing

2013 European Medicines Agency - EPARs

115. Safety of Probiotics to Reduce Risk and Prevent or Treat Disease

, Streptococcus, Enterococcus, and Bacillus differ by product and delivery characteristics? The lack of detail in the description of administered probiotic organisms in most studies hindered evaluations of the safety. Many studies did not specify which probiotic strains were investigated, nor was there indication that intervention preparations were tested for identity of the included organisms, quantity, viability, or contaminants. Stratified analyses by probiotic genus showed no increased risk of adverse (...) are safe in the short term? Long term? a. What safety parameters are collected in clinical studies (Phases I-IV)? b. What harms are reported in clinical studies (Phases I-IV)? c. What harms are reported in case reports? d. What safety parameters are collected in population surveillance studies and other observational studies, and do these include only standard clinical safety parameters (e.g., standard blood chemistry profiles) or also expanded laboratory or clinical testing unique to the use

2011 EvidenceUpdates

116. Bacterial Overgrowth Syndrome (Follow-up)

of hydrogen breath tests in most patients with Crohn disease. [ ] Norfloxacin, cephalexin, trimethoprim-sulfamethoxazole, and levofloxacin have been recommended for the treatment of bacterial overgrowth syndrome. [ , ] The exact length of therapy is not clearly defined; length of therapy should be tailored to symptom improvement. A single 7-10 day course of antibiotic may improve symptoms in 46-90% of patients with bacterial overgrowth syndrome. [ ] . Recurrence following therapy is not uncommon (...) in Gastroenterology and Hepatology. 1998. Stotzer PO, Kilander AF. Comparison of the 1-gram (14)C-D-xylose breath test and the 50-gram hydrogen glucose breath test for diagnosis of small intestinal bacterial overgrowth. Digestion . 2000. 61(3):165-71. . Peralta S, Cottone C, Doveri T, Almasio PL, Craxi A. Small intestine bacterial overgrowth and irritable bowel syndrome-related symptoms: experience with Rifaximin. World J Gastroenterol . 2009 Jun 7. 15(21):2628-31. . Pimentel M. Review of rifaximin as treatment

2014 eMedicine.com

117. Fructose 1-Phosphate Aldolase Deficiency (Fructose Intolerance) (Diagnosis)

. An inborn defect of hepatic fructose-1-phosphate splitting aldolase. Am J Med . 1963 Feb. 34:151-67. . Levin B, Oberholzer VG, Snodgrass GJAI, Stimmler L, Wilmers MJ. Fructosaemia. An inborn error of fructose metabolism. Arch Dis Child . 1963 Jun. 38:220-30. . Mass RE, Smith WR, Walsh JR. The association of hereditary fructose intolerance and renal tubular acidosis. Am J Med Sci . 1966 May. 251(5):516-23. . Muller P, Meier C, Bohme HJ. Fructose breath hydrogen test - is it really a harmless diagnostic (...) , jaundice, coagulopathy, coma, renal , and severe (in part due to lactic acidosis). See the image below. Pathophysiologic classification of lactic acidosis. Next: Pathophysiology Affected individuals are completely asymptomatic until they ingest fructose. Thus, homozygous neonates remain clinically well until confronted with dietary sources of fructose. Although lactose is the carbohydrate base in most infant formulas, some (eg, soy formulas) contain sucrose, a fructose-glucose disaccharide that may

2014 eMedicine Pediatrics

118. Disorders of Carbohydrate Metabolism (Diagnosis)

minutes of oxygen deprivation, it can withstand only about 40-45 minutes without fuel. Most physicians, as medical students or interns, have had experience treating diabetic ketoacidosis. Although the experience tends to cast ketone bodies as toxins, they are not. The acidosis produced by ketone bodies is toxic and is the direct cause of the Kussmaul breathing typical of patients with diabetic ketoacidosis. Patients with diabetes in this state usually have had normal to elevated blood glucose (...) for the previous days or weeks. Enough glucose enters the brain cells during this time to inhibit synthesis of beta-hydroxybutyrate dehydrogenase and acetoacetyl CoA synthetase. Again, the ketone-utilizing enzymes in the brain are not working at effective levels. By the time frank ketoacidosis sets in, too little insulin is left for the blood glucose to be able to sustain the high metabolic activity of the brain. The ketone bodies accumulate but cannot provide energy or carbon for the brain. The hydrogen ion

2014 eMedicine.com

119. Bacterial Overgrowth Syndrome (Diagnosis)

A,editors. Clinical Application of Breath Tests in Gastroenterology and Hepatology. 1998. Stotzer PO, Kilander AF. Comparison of the 1-gram (14)C-D-xylose breath test and the 50-gram hydrogen glucose breath test for diagnosis of small intestinal bacterial overgrowth. Digestion . 2000. 61(3):165-71. . Peralta S, Cottone C, Doveri T, Almasio PL, Craxi A. Small intestine bacterial overgrowth and irritable bowel syndrome-related symptoms: experience with Rifaximin. World J Gastroenterol . 2009 Jun 7. 15(21 (...) on the population studied and the diagnostic methods used. In healthy people, BOS has been described in 0-12.5% by the glucose breath test, 20-22% by the lactulose breath test, and 0-35% when the 14 C D-xylose breath test is used. [ ] Bacterial overgrowth syndrome is more prevalent in elderly population because of diminished gastric acid secretion and consumption of a large number of medications that can cause hypomotility. BOS has also been described as a cause of occult malabsorption in elderly patients

2014 eMedicine.com

120. Malabsorption (Diagnosis)

Palmitate Test. Clin Chim Acta . 2015 Jan 1. 438:103-6. . Ghoshal UC, Kumar S, Chourasia D, Misra A. Lactose hydrogen breath test versus lactose tolerance test in the tropics: does positive lactose tolerance test reflect more severe lactose malabsorption?. Trop Gastroenterol . 2009 Apr-Jun. 30(2):86-90. . Casterton PL, Verbeke KA, Brouns F, Dammann KW. Evaluation of sucromalt digestion in healthy children using breath hydrogen as a biomarker of carbohydrate malabsorption. Food Funct . 2012 Apr. 3(4):410 (...) of LCT-13910C/T and LCT-22018G/A single nucleotide polymorphisms associated with adult-type hypolactasia/lactase persistence among Israelis of different ethnic groups. Gene . 2013 Apr 25. 519(1):67-70. . Santonocito C, Scapaticci M, Guarino D, et al. Lactose intolerance genetic testing: Is it useful as routine screening? Results on 1426 south-central Italy patients. Clin Chim Acta . 2015 Jan 15. 439:14-7. . Holt PR. Diarrhea and malabsorption in the elderly. Gastroenterol Clin North Am . 2001 Jun. 30

2014 eMedicine.com

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