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Lactose Breath Hydrogen Test

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101. Efficacy of Rifaximin to Treat Diarrhea-predominant Irritable Bowel Syndrome

and evaluate the efficacy of rifaximin for IBS-D in Chinese population. Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 120 participants Observational Model: Case Control Time Perspective: Prospective Official Title: Efficacy of Rifaximin for Diarrhea-predominant Irritable Bowel Syndrome With Positive Lactulose Hydrogen Breath Test Study Start Date : October 2015 Estimated Primary Completion Date : October 2017 Estimated Study Completion Date (...) of patients who with positive lactulose hydrogen breath test change to be negative [ Time Frame: 2 weeks ] the composition of patients's fecal microbiota [ Time Frame: 2 weeks ] Biospecimen Retention: Samples With DNA Faeces Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may

2015 Clinical Trials

102. Over-night Effect of Dietary Fiber on Glucose Metabolism and Satiety

] Insulin, levels of insulin in blood [ Time Frame: Postprandial 0-180 min after breakfast ] Appetite hormones, levels of Peptide YY (PYY) in blood [ Time Frame: Postprandial 0-180 min after breakfast ] Markers of colonic fermentation, levels of hydrogen in breath [ Time Frame: Postprandial 0-180 min after breakfast ] Inflammation markers, levels of Interleukin-6 (IL-6) in blood [ Time Frame: Postprandial 0-180 min after breakfast ] Secondary Outcome Measures : Subjective satiety, as measured by VAS (...) : + ind. CHO Test meals: intake of high levels of indigestible carbohydrates the evening prior to measurements of variables Other: High levels of indigestible carbohydrates Experimental: - ind. CHO Reference meal: scarce intake of indigestible carbohydrates the evening prior to measurements of variables Other: Low levels of indigestible carbohydrates Outcome Measures Go to Primary Outcome Measures : Blood Glucose, levels of glucose in blood [ Time Frame: Postprandial 0-180 min after breakfast

2015 Clinical Trials

103. Safety and Tolerability of Serum Derived Bovine Immunoglobulin in Children With Diarrhea Predominant IBS

Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Male or female patients > 8 years of age and < 18 years of age Patients with a diagnosis of IBS-D as per Rome III criteria Patients with normal laboratory work up (CBC, ESR, CRP, amylase, lipase, celiac panel, fecal occult blood) Patients with normal fecal calprotectin and lactose hydrogen breath test Patients off motility drugs, NSAIDs for at least 2 weeks prior to enrollment in the study Ability to complete the study

2014 Clinical Trials

104. Improving Bone Health in Adolescence Through Targeted Behavioral Intervention

in 6 states. The primary outcomes of bone mass and dietary calcium were assessed among Asian, Hispanic, or non-Hispanic white girls between 10 -13 y. Lactose maldigestion (LM) was determined by a breath hydrogen test (BHT). Perceived milk intolerance (PMI) and calcium intake were assessed by questionnaires and bone mineral content (BMC) was determined by dual energy X-ray absorptiometry (DXA). Data from 473 girls were used in a multiple linear regression to examine the impact of the intervention (...) months ] Baseline, 12 month and 18 month bone mineral content measured Dietary Calcium [ Time Frame: 18 months ] Dietary Calcium intake assessed by food frequency questionnaire Secondary Outcome Measures : Lactose maldigestion [ Time Frame: Baseline ] Measured by breath hydrogen testing Other Outcome Measures: Perceived lactose intolerance [ Time Frame: Baseline ] Measured by questionnaire Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study

2014 Clinical Trials

105. Effects of Resistant Starch in a Baked Snack Bar on a Post-prandial Glycemic and Insulinemic Response

will be consumed four hours later. Outcome Measures Go to Primary Outcome Measures : resistant starch effects [ Time Frame: 2 weeks ] effects of resistant starch consumption of area under the curve of blood serum glucose, insulin, and hydrogen breath testing Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about (...) , with a BMI between 20.0 and 29.9. Exclusion Criteria: Weight change > 3kg in the past 3 months Exercising vigorously over the past 3 months as well as no exercise 3 days prior to testing day Intestinal disorders including lipid mal-absorption or lactose intolerance Abnormal liver or kidney function tests; fasting blood glucose >100mg/dL Smoking Drinking more than 2 alcoholic drinks per day Taking lipid-lowering medications or dietary supplements affecting plasma cholesterol concentration. Subjects must

2014 Clinical Trials

106. Effects of Resistant Starch in a Beverage on Post-prandial Glycemic and Insulinemic Responses

, and hydrogen breath testing. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years to 29 Years (Adult) Sexes (...) lipid mal-absorption or lactose intolerance Abnormal liver or kidney function tests; fasting blood glucose >100mg/dL Smoking Drinking more than 2 alcoholic drinks per day Taking lipid-lowering medications or dietary supplements affecting plasma cholesterol concentration. Subjects must not be pregnant or lactating. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact

2014 Clinical Trials

107. Intraepithelial giardia intestinalis: a case report and literature review. Full Text available with Trip Pro

for pathogens and lactose hydrogen breath test was positive. The presumptive clinical diagnosis was giardiasis and the patient was empirically treated with nitazoxanide. But, the patient persisted with abdominal pain and pasty stools. Endoscopy was indicated to search for Helicobacter and Giardia. Guardian and patient gave written informed consent. Hematological profile was normal. The endoscopy was performed under general anesthesia and the biopsies and duodenal aspirate were obtained. The microscopic (...) analyses of duodenal fluid showed Giardia trophozoites. Electron microscopic analysis was negative for Helicobacter pylori, but Giardia trophozoites with a typical crescent shape within the tissue were found. The patient was treated with tinidazole, subsequent tests showed that lactose absorption was normal, stool examinations were negative for Giardia and abdominal pain had stopped. This case suggest that intraepithelial giardiasis could be a common entity but unseen because the giardiasis diagnosis

2014 Medicine

108. Bacterial Overgrowth Syndrome (Follow-up)

of hydrogen breath tests in most patients with Crohn disease. [ ] Norfloxacin, cephalexin, trimethoprim-sulfamethoxazole, and levofloxacin have been recommended for the treatment of bacterial overgrowth syndrome. [ , ] The exact length of therapy is not clearly defined; length of therapy should be tailored to symptom improvement. A single 7-10 day course of antibiotic may improve symptoms in 46-90% of patients with bacterial overgrowth syndrome. [ ] . Recurrence following therapy is not uncommon (...) in Gastroenterology and Hepatology. 1998. Stotzer PO, Kilander AF. Comparison of the 1-gram (14)C-D-xylose breath test and the 50-gram hydrogen glucose breath test for diagnosis of small intestinal bacterial overgrowth. Digestion . 2000. 61(3):165-71. . Peralta S, Cottone C, Doveri T, Almasio PL, Craxi A. Small intestine bacterial overgrowth and irritable bowel syndrome-related symptoms: experience with Rifaximin. World J Gastroenterol . 2009 Jun 7. 15(21):2628-31. . Pimentel M. Review of rifaximin as treatment

2014 eMedicine.com

109. Malabsorption (Diagnosis)

Palmitate Test. Clin Chim Acta . 2015 Jan 1. 438:103-6. . Ghoshal UC, Kumar S, Chourasia D, Misra A. Lactose hydrogen breath test versus lactose tolerance test in the tropics: does positive lactose tolerance test reflect more severe lactose malabsorption?. Trop Gastroenterol . 2009 Apr-Jun. 30(2):86-90. . Casterton PL, Verbeke KA, Brouns F, Dammann KW. Evaluation of sucromalt digestion in healthy children using breath hydrogen as a biomarker of carbohydrate malabsorption. Food Funct . 2012 Apr. 3(4):410 (...) of LCT-13910C/T and LCT-22018G/A single nucleotide polymorphisms associated with adult-type hypolactasia/lactase persistence among Israelis of different ethnic groups. Gene . 2013 Apr 25. 519(1):67-70. . Santonocito C, Scapaticci M, Guarino D, et al. Lactose intolerance genetic testing: Is it useful as routine screening? Results on 1426 south-central Italy patients. Clin Chim Acta . 2015 Jan 15. 439:14-7. . Holt PR. Diarrhea and malabsorption in the elderly. Gastroenterol Clin North Am . 2001 Jun. 30

2014 eMedicine.com

110. Irritable Bowel Syndrome (Diagnosis)

pathogens, leukocytes, Clostridium difficile toxin, and possibly Giardia antigen History-specific studies include the following: Hydrogen breath testing to exclude bacterial overgrowth in patients with diarrhea and to screen for lactose and/or fructose intolerance Tissue transglutaminase antibody testing and small bowel biopsy in IBS-D to diagnose celiac disease. Thyroid function tests Serum calcium testing to screen for hyperparathyroidism Erythrocyte sedimentation rate and C-reactive protein (...) , Morch K, Eide GE, Rortveit G. Irritable bowel syndrome and chronic fatigue 3 years after acute giardiasis: historic cohort study. Gut . 2012 Feb. 61 (2):214-9. . Lacy BE. The science, evidence, and practice of dietary interventions in irritable bowel syndrome. Clin Gastroenterol Hepatol . 2015 Nov. 13 (11):1899-906. . Pimentel M, Chow EJ, Lin HC. Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome. a double-blind, randomized, placebo-controlled

2014 eMedicine.com

111. Disorders of Carbohydrate Metabolism (Treatment)

minutes of oxygen deprivation, it can withstand only about 40-45 minutes without fuel. Most physicians, as medical students or interns, have had experience treating diabetic ketoacidosis. Although the experience tends to cast ketone bodies as toxins, they are not. The acidosis produced by ketone bodies is toxic and is the direct cause of the Kussmaul breathing typical of patients with diabetic ketoacidosis. Patients with diabetes in this state usually have had normal to elevated blood glucose (...) for the previous days or weeks. Enough glucose enters the brain cells during this time to inhibit synthesis of beta-hydroxybutyrate dehydrogenase and acetoacetyl CoA synthetase. Again, the ketone-utilizing enzymes in the brain are not working at effective levels. By the time frank ketoacidosis sets in, too little insulin is left for the blood glucose to be able to sustain the high metabolic activity of the brain. The ketone bodies accumulate but cannot provide energy or carbon for the brain. The hydrogen ion

2014 eMedicine.com

112. Bacterial Overgrowth Syndrome (Treatment)

of hydrogen breath tests in most patients with Crohn disease. [ ] Norfloxacin, cephalexin, trimethoprim-sulfamethoxazole, and levofloxacin have been recommended for the treatment of bacterial overgrowth syndrome. [ , ] The exact length of therapy is not clearly defined; length of therapy should be tailored to symptom improvement. A single 7-10 day course of antibiotic may improve symptoms in 46-90% of patients with bacterial overgrowth syndrome. [ ] . Recurrence following therapy is not uncommon (...) in Gastroenterology and Hepatology. 1998. Stotzer PO, Kilander AF. Comparison of the 1-gram (14)C-D-xylose breath test and the 50-gram hydrogen glucose breath test for diagnosis of small intestinal bacterial overgrowth. Digestion . 2000. 61(3):165-71. . Peralta S, Cottone C, Doveri T, Almasio PL, Craxi A. Small intestine bacterial overgrowth and irritable bowel syndrome-related symptoms: experience with Rifaximin. World J Gastroenterol . 2009 Jun 7. 15(21):2628-31. . Pimentel M. Review of rifaximin as treatment

2014 eMedicine.com

113. Malabsorption (Treatment)

Hepatol . 2012 Feb. 24(2):109-16. . Raman M, Fenton T, Crotty P, Ghosh S, Rioux K, Hundal R. A novel method to identify fat malabsorption: The Serum Retinyl Palmitate Test. Clin Chim Acta . 2015 Jan 1. 438:103-6. . Ghoshal UC, Kumar S, Chourasia D, Misra A. Lactose hydrogen breath test versus lactose tolerance test in the tropics: does positive lactose tolerance test reflect more severe lactose malabsorption?. Trop Gastroenterol . 2009 Apr-Jun. 30(2):86-90. . Casterton PL, Verbeke KA, Brouns F (...) , Dammann KW. Evaluation of sucromalt digestion in healthy children using breath hydrogen as a biomarker of carbohydrate malabsorption. Food Funct . 2012 Apr. 3(4):410-3. . Hope HB, Tveito K, Aase S, et al. Small intestinal malabsorption in chronic alcoholism determined by (13)C-D-xylose breath test and microscopic examination of the duodenal mucosa. Scand J Gastroenterol . 2010. 45(1):39-45. . Dutta AK, Sajith KG, Shah G, et al. Duodenal villous morphology assessed using magnification narrow band

2014 eMedicine.com

114. Malabsorption (Overview)

Palmitate Test. Clin Chim Acta . 2015 Jan 1. 438:103-6. . Ghoshal UC, Kumar S, Chourasia D, Misra A. Lactose hydrogen breath test versus lactose tolerance test in the tropics: does positive lactose tolerance test reflect more severe lactose malabsorption?. Trop Gastroenterol . 2009 Apr-Jun. 30(2):86-90. . Casterton PL, Verbeke KA, Brouns F, Dammann KW. Evaluation of sucromalt digestion in healthy children using breath hydrogen as a biomarker of carbohydrate malabsorption. Food Funct . 2012 Apr. 3(4):410 (...) of LCT-13910C/T and LCT-22018G/A single nucleotide polymorphisms associated with adult-type hypolactasia/lactase persistence among Israelis of different ethnic groups. Gene . 2013 Apr 25. 519(1):67-70. . Santonocito C, Scapaticci M, Guarino D, et al. Lactose intolerance genetic testing: Is it useful as routine screening? Results on 1426 south-central Italy patients. Clin Chim Acta . 2015 Jan 15. 439:14-7. . Holt PR. Diarrhea and malabsorption in the elderly. Gastroenterol Clin North Am . 2001 Jun. 30

2014 eMedicine.com

115. Irritable Bowel Syndrome (Overview)

pathogens, leukocytes, Clostridium difficile toxin, and possibly Giardia antigen History-specific studies include the following: Hydrogen breath testing to exclude bacterial overgrowth in patients with diarrhea and to screen for lactose and/or fructose intolerance Tissue transglutaminase antibody testing and small bowel biopsy in IBS-D to diagnose celiac disease. Thyroid function tests Serum calcium testing to screen for hyperparathyroidism Erythrocyte sedimentation rate and C-reactive protein (...) , Morch K, Eide GE, Rortveit G. Irritable bowel syndrome and chronic fatigue 3 years after acute giardiasis: historic cohort study. Gut . 2012 Feb. 61 (2):214-9. . Lacy BE. The science, evidence, and practice of dietary interventions in irritable bowel syndrome. Clin Gastroenterol Hepatol . 2015 Nov. 13 (11):1899-906. . Pimentel M, Chow EJ, Lin HC. Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome. a double-blind, randomized, placebo-controlled

2014 eMedicine.com

116. Disorders of Carbohydrate Metabolism (Overview)

minutes of oxygen deprivation, it can withstand only about 40-45 minutes without fuel. Most physicians, as medical students or interns, have had experience treating diabetic ketoacidosis. Although the experience tends to cast ketone bodies as toxins, they are not. The acidosis produced by ketone bodies is toxic and is the direct cause of the Kussmaul breathing typical of patients with diabetic ketoacidosis. Patients with diabetes in this state usually have had normal to elevated blood glucose (...) for the previous days or weeks. Enough glucose enters the brain cells during this time to inhibit synthesis of beta-hydroxybutyrate dehydrogenase and acetoacetyl CoA synthetase. Again, the ketone-utilizing enzymes in the brain are not working at effective levels. By the time frank ketoacidosis sets in, too little insulin is left for the blood glucose to be able to sustain the high metabolic activity of the brain. The ketone bodies accumulate but cannot provide energy or carbon for the brain. The hydrogen ion

2014 eMedicine.com

117. Malabsorption (Follow-up)

Hepatol . 2012 Feb. 24(2):109-16. . Raman M, Fenton T, Crotty P, Ghosh S, Rioux K, Hundal R. A novel method to identify fat malabsorption: The Serum Retinyl Palmitate Test. Clin Chim Acta . 2015 Jan 1. 438:103-6. . Ghoshal UC, Kumar S, Chourasia D, Misra A. Lactose hydrogen breath test versus lactose tolerance test in the tropics: does positive lactose tolerance test reflect more severe lactose malabsorption?. Trop Gastroenterol . 2009 Apr-Jun. 30(2):86-90. . Casterton PL, Verbeke KA, Brouns F (...) , Dammann KW. Evaluation of sucromalt digestion in healthy children using breath hydrogen as a biomarker of carbohydrate malabsorption. Food Funct . 2012 Apr. 3(4):410-3. . Hope HB, Tveito K, Aase S, et al. Small intestinal malabsorption in chronic alcoholism determined by (13)C-D-xylose breath test and microscopic examination of the duodenal mucosa. Scand J Gastroenterol . 2010. 45(1):39-45. . Dutta AK, Sajith KG, Shah G, et al. Duodenal villous morphology assessed using magnification narrow band

2014 eMedicine.com

118. Bacterial Overgrowth Syndrome (Overview)

A,editors. Clinical Application of Breath Tests in Gastroenterology and Hepatology. 1998. Stotzer PO, Kilander AF. Comparison of the 1-gram (14)C-D-xylose breath test and the 50-gram hydrogen glucose breath test for diagnosis of small intestinal bacterial overgrowth. Digestion . 2000. 61(3):165-71. . Peralta S, Cottone C, Doveri T, Almasio PL, Craxi A. Small intestine bacterial overgrowth and irritable bowel syndrome-related symptoms: experience with Rifaximin. World J Gastroenterol . 2009 Jun 7. 15(21 (...) on the population studied and the diagnostic methods used. In healthy people, BOS has been described in 0-12.5% by the glucose breath test, 20-22% by the lactulose breath test, and 0-35% when the 14 C D-xylose breath test is used. [ ] Bacterial overgrowth syndrome is more prevalent in elderly population because of diminished gastric acid secretion and consumption of a large number of medications that can cause hypomotility. BOS has also been described as a cause of occult malabsorption in elderly patients

2014 eMedicine.com

119. Disorders of Carbohydrate Metabolism (Follow-up)

minutes of oxygen deprivation, it can withstand only about 40-45 minutes without fuel. Most physicians, as medical students or interns, have had experience treating diabetic ketoacidosis. Although the experience tends to cast ketone bodies as toxins, they are not. The acidosis produced by ketone bodies is toxic and is the direct cause of the Kussmaul breathing typical of patients with diabetic ketoacidosis. Patients with diabetes in this state usually have had normal to elevated blood glucose (...) for the previous days or weeks. Enough glucose enters the brain cells during this time to inhibit synthesis of beta-hydroxybutyrate dehydrogenase and acetoacetyl CoA synthetase. Again, the ketone-utilizing enzymes in the brain are not working at effective levels. By the time frank ketoacidosis sets in, too little insulin is left for the blood glucose to be able to sustain the high metabolic activity of the brain. The ketone bodies accumulate but cannot provide energy or carbon for the brain. The hydrogen ion

2014 eMedicine.com

120. Bacterial Overgrowth Syndrome (Diagnosis)

A,editors. Clinical Application of Breath Tests in Gastroenterology and Hepatology. 1998. Stotzer PO, Kilander AF. Comparison of the 1-gram (14)C-D-xylose breath test and the 50-gram hydrogen glucose breath test for diagnosis of small intestinal bacterial overgrowth. Digestion . 2000. 61(3):165-71. . Peralta S, Cottone C, Doveri T, Almasio PL, Craxi A. Small intestine bacterial overgrowth and irritable bowel syndrome-related symptoms: experience with Rifaximin. World J Gastroenterol . 2009 Jun 7. 15(21 (...) on the population studied and the diagnostic methods used. In healthy people, BOS has been described in 0-12.5% by the glucose breath test, 20-22% by the lactulose breath test, and 0-35% when the 14 C D-xylose breath test is used. [ ] Bacterial overgrowth syndrome is more prevalent in elderly population because of diminished gastric acid secretion and consumption of a large number of medications that can cause hypomotility. BOS has also been described as a cause of occult malabsorption in elderly patients

2014 eMedicine.com

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