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Lactose Breath Hydrogen Test

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81. Tovanor Breezhaler - glycopyrronium bromide

inhaler SLC Solute carrier uptake transporters SMQ Standardized MedDRA query SOC System organ class SGRQ St Gorge Respiratory Questionnaire SMETT Sub-max constant-load cycle ergometry test ss Steady state T½ Apparent elimination half-life TDI Transition dyspnea index Tg Transgenic Tmax Time to reach maximum concentration Tio Tiotropium ULN Upper limit normal URTI Upper respiratory tract infection V Volume of distribution WBC White blood cell Tovanor Breezhaler CHMP assessment report EMA/CHMP/508244 (...) of administrative information, complete quality data, non- clinical and clinical data based on applicants’ own tests and studies and bibliographic literature supporting certain tests or studies. Information on Paediatric requirements Pursuant to Article 7 of Regulation (EC) No 1901/2006, the application included an EMA Decision P/4/2008 on the granting of a product-specific waiver. Information relating to orphan market exclusivity Similarity Pursuant to Article 8 of Regulation (EC) No. 141/2000 and Article 3

2012 European Medicines Agency - EPARs

82. Effect of Genetic Variation in Starch-digesting Enzymes on Digestibility and Glycemic Index of Cold and Hot Rice

of breath hydrogen concentrations from the lowest value over 0-3 hours to 6 hours (termed "H"). For each subject the amount of hydrogen per gram malabsorbed carbohydrate (H/g) is calculated as (GL-G)/10 where GL is H after the glucose plus lactose meal and G is H after the glucose meal. The amount of carbohydrate malabsorbed after the hot and cold rice meals, respectively, are HR/Hg and CR/Hg, where HR and Cr are H after the hot and cold rice meals. Glycemic response [ Time Frame: 0-2 hours (...) ] The incremental area under the blood glucose response curve Breath hydrogen response [ Time Frame: 0-6 hours ] Sum of breath hydrogen concentrations from the lowest in the first 3 hours to 6 hours. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research

2018 Clinical Trials

83. Comparing the Digestion of Milk With Different Beta-casein Protein Content by Dairy Intolerant Persons

intolerance (e.g., Lactaid® Dietary Supplements) during study involvement Willing to return for all study visits and complete all study related procedures, including fasting before and during the hydrogen breath tests Qualifying Lactose Challenge Symptom Score: (4 symptom categories with severity measured on from 0 to 5) as defined by one of the following: At least one score of "moderately severe" or "severe" on a single symptom during the 6 hour HBT test; A score of "moderate" or greater for a single (...) symptom on at least two (2) time points during the 6 hour HBT test; At least one "moderate" score or greater on each of two symptoms during the 6 hour HBT test 7. Hydrogen concentration of at least 20 parts per million greater than baseline at least 2 time points during the screening hydrogren breath test 8. Able to understand and provide written informed consent in English Exclusion Criteria: Allergic to milk Currently pregnant Currently lactating Cigarette smoking or other use of tobacco or nicotine

2018 Clinical Trials

84. Dietary Fibers and Satiety in Bariatric Patients

(SCFA), breath hydrogen (as a marker of large intestinal fermentation), the secretion of gastrointestinal (GI) satiation hormones and glycaemia in morbidly obese patients before and 6 month after RYGB surgery. The primary study outcome measure is macronutrient and food intake (grams and kcal eaten) at the ad libitum buffet meal as well as time to complete the meal. Secondary outcome measures are 1) Appetite ratings (validated visual analogue scales, VAS) including hunger, fullness, thirst, desire (...) to eat, and amount of food desired to eat. 2) Plasma concentrations of SCFA (propionate, acetate, butyrate). 3) Breath hydrogen (as a marker of large intestinal fermentation) 4) Plasma concentrations of gastrointestinal hormones (ghrelin, cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), peptide YY (PYY) and potentially other, yet to be identified gut hormones). 4) Concentrations of plasma insulin and glucagon and blood glucose. Randomized, single-blinded cross-over trial in 24 morbidly obese

2018 Clinical Trials

85. Slowly Digestible Carbohydrates and the Ileal Brake

feelings of hunger and stronger feelings of fullness indicate better outcomes. Breath hydrogen (fermentability) [ Time Frame: Acute study; 4 hours of measurement after consumption of test food ] Breath samples were collected in 15-minute intervals for 4 hours after consumption of test food and analyzed for hydrogen levels using a breath analyzer. Breath hydrogen levels are indicative of a food's fermentability. Eligibility Criteria Go to Information from the National Library of Medicine Choosing (...) response were measured using a 13C-labeled octanoic acid breath test and continuous glucose monitors, respectively. Glucose readings were continuously monitored 24 h prior to and 48 h after test meal consumption, and breath samples were collected for a 4 h period following test meal consumption. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 20 participants Allocation: Randomized Intervention Model: Crossover Assignment Masking

2018 Clinical Trials

86. Coping with Common GI Symptoms in the Community: A Global Perspective on Heartburn, Constipation, Bloating, and Abdominal Pain/Discomfort

of esophageal acid exposure and assessment of the temporal association between heartburn symptoms and acidic reflux episodes • Manometry o Esophageal motility study, high-resolution manometry o Anorectal manometry • Imaging o Gastrointestinal barium series—air contrast swallow, meal and follow- through, enteroclysis o Double-contrast barium enema o Abdominal ultrasonography o Abdominal computed tomography (CT), magnetic resonance imaging (MRI) of the abdomen • Miscellaneous o Breath tests: lactose, glucose (...) , fructose [32] o Dietary exclusion, followed by challenge with specific dietary components, may be considered a diagnostic test o Therapeutic trial of acid suppression (the “proton-pump inhibitor test”) in patients with heartburn or other symptoms that might be related to acid reflux o Food allergy or intolerance, lactose intolerance, eosinophilic infiltrates 3 Heartburn It should be noted that not all common GI symptoms are functional. This concept is particularly relevant for the symptom of heartburn

2013 World Gastroenterology Organisation

87. Gastro-oesophageal reflux in children - what's the worry?

based on the clinical assessment of the patient as differential diagnosis can vary significantly with different age groups. Noninvasive test for lactose intolerance (malabsorption) using lactose hydrogen breath test can be ordered, however, accessibility can be difficult. Stool reducing substances are unreliable and nonspecific for lactose intolerance and therefore are no longer recommended. Food specific serum IgE antibody (cap-FEIA testing) always requires clinical history for the appropriate (...) from endoscopic biopsies showed a mixture of neutrophils and mild eosinophilia in the lower oesophagus and duodenum. Oesophageal eosinophilia was less than 15 per high power field with no basal cell proliferation, ruling out eosinophilic oesophagitis. The other biopsies were unremarkable with normal small intestinal disaccharidases, ruling out lactose intolerance. These findings were consistent with GORD. Due to the timing of symptom development, the possibility of cow’s milk protein allergy

2012 Clinical Practice Guidelines Portal

88. β-thalassemia minor, carbohydrate malabsorption and histamine intolerance Full Text available with Trip Pro

with β-thalassemia minor suffering nonspecific abdominal symptoms due to a carbohydrate and histamine malabsorption. Design/methods: The diagnosis of β-thalassemia minorwas done with peripheral blood smear and cellulose acetate electrophoresis. Carbohydrate malabsorption was diagnosed with hydrogen breath tests and, histamine intolerance (HIT) with a serum diamine oxidase value <10 U/ml and more than two gastrointestinal symptoms described for HIT. Conclusion: The symptoms of gastrointestinal (...) β-thalassemia minor, carbohydrate malabsorption and histamine intolerance Background: β-thalassemia minor is characterized by reduced β-haemoglobin chain synthesis and sometimes mild anaemia, although carriers of β-thalassemia minorare usually clinically asymptomatic.Nonspecific abdominal complaints may be caused by gastrointestinal carbohydrate malabsorption (lactose and fructose) and/or malabsorption of biogenic amines (histamine), or proteins (gluten). Objectives: We report on two patients

2017 Journal of community hospital internal medicine perspectives

89. Rapid Orocecal Transit Time and Fermentation in IBS.

: Lactulose breath test Lactulose 0.67 mg/mL, dose 15 mL (10 grams). No contaminants of lactose. Pharmacy quality. Outcome Measures Go to Primary Outcome Measures : Orocecal transit time [ Time Frame: 0-240 minutes ] The transit rate of lactulose (foods) through the small intestine Secondary Outcome Measures : Fermentation of lactulose of the cecal microbiota measured as increase of hydrogen in exhaled breath. [ Time Frame: 0-240 minutes ] The rise of hydrogen (beyond 10 and 20 ppm) after lactulose (...) by (Responsible Party): Per Hellström, Uppsala University Study Details Study Description Go to Brief Summary: Orocecal transit time is studied in individuals with irritable bowel syndrome (IBS) of both the constipation-dominant, diarrhea-dominant, and mixed form using the lactulose hydrogen breath test for orocecal transit time through the gut. Data are compared to those of healthy volunteers. The peak value of fermentation as read by hydrogen levels is captured after passage of the orocecal segment

2017 Clinical Trials

90. Chronic Watery Diarrhea

. Causes: Functional Diarrhea Findings: Small volume (<350 ml/day) watery stools, better at night and with g V. Labs Fecal electrolytes (fecal , fecal ) Electrolytes increased in Secretory Diarrhea Electrolytes negligible in Osmotic Diarrhea Small osmotic gap <50 mOsm/kg in Secretory Diarrhea pH pH <6 in carbohydrate malabsorption VI. Evaluation Osmotic Diarrhea: Fecal osmotic gap >125 mOsm/kg If g improves , consider breath hydrogen test for (or empiric avoidance) Secretory Diarrhea: Fecal osmotic gap (...) Diarrhea Aka: Chronic Watery Diarrhea , Secretory Diarrhea , Osmotic Diarrhea From Related Chapters II. Causes: Osmotic Diarrhea Findings: fecal osmotic gap >125 mOsm/kg Malabsorption Lactose malabsorption ( ) Fructose malabsorption malabsorption Galactose malabsorption Gluten-sensitive ( ) ( s) s s Excessive High sugar juice intake Apple juice Pear juice Sugar s Mannitol ingestion ingestion (chewing gum ) Xylitol s phosphate citrate therapy Sulfate (Glauber's Salt) III. Causes: Secretory Diarrhea

2018 FP Notebook

91. Flatulence

, Burping) No testing is typically needed, as this is nearly always aerophagia Gastric Bloating (symptoms begin <30 minutes after eating) Upper endoscopy Gastric Emptying Study Bloating (symptoms begin >30 minutes after eating) : IgA Tissue Transglutaminase (TTG) and Total IgA (if low, obtain IgG Gliadin instead of TTG) Hydrogen Breath Test Bloating with Rectal Exam (impaction, pelvic floor dysfunction) (TSH) Colon transit study Anorectal manometry XI. Management ral Avoid discounting patient concerns (...) fruit, honey, fruit juice, high fructose corn syrup) Fructans (fructo-oligosaccharides, inulins, levans - e.g. high fiber bars, onions, leeks, zucchini) Disaccharides (Lactose): Dairy, cheese, milk Polyols: cots, peaches Sugar s (esp. common in sugar-free gum): , xylitol, mannitol, malitol) Galactooligosaccharides or Raffinose (brussel sprouts, cabbage, green beans, lentils, legumes, chick peas) VI. Exam ral examination Focused abdominal exam Rectal exam VII. Findings: Red Flag Symptoms and signs

2018 FP Notebook

92. Lactase Deficiency

eating foods with lactose in them, you may feel sick to your stomach. You may also have Gas Diarrhea Swelling in your stomach Your doctor may do a blood, breath or stool test to find out if your problems are due to lactose intolerance. Lactose intolerance is not serious. Eating less food with lactose, or using pills or drops to help you digest lactose usually helps. You may need to take a calcium supplement if you don't get enough of it from your diet, since milk and foods made with milk are the most (...) ) Bloating or gas Cramping Foul smelling stools Large dairy intake or severe intolerance More significant symptoms of those listed above VI. Signs No weight loss associated with malabsorption VII. Differential Diagnosis (See secondary causes above) sis VIII. Evaluation Consider empiric trial off dairy products Also Consider (replaced by hydrogen test) IX. Management See Do not completely eliminate dairy products Risk of Lactase enzyme replacement (e.g. Lactaid, Dairy Ease) X. References Melrad in Goldman

2018 FP Notebook

93. Malabsorption, Orocecal Transit Time and Small Intestinal Bacterial Overgrowth in Type 2 Diabetic Patients: A Connection Full Text available with Trip Pro

, and most fluids are absorbed in small intestine. Malabsorption may occurs when proper absorption of nutrients does not take place due to bacterial overgrowth or altered gut motility. The present study was planned to measure various malabsorption parameters in type 2 diabetic patients. 175 patients and 175 age and sex matched healthy controls attending Endocrinology Clinic in PGI, Chandigarh were enrolled. Lactose intolerance was measured by using non-invasive lactose hydrogen breath test. Urinary d (...) -xylose and fecal fat were estimated using standard methods. Orocecal transit time and small intestinal bacterial overgrowth were measured using non-invasive lactulose and glucose breath test respectively. Out of 175 diabetic patients enrolled, 87 were males while among 175 healthy subjects 88 were males. SIBO was observed in 14.8 % type 2 diabetic patients and in 2.8 % of controls. There was statistically significant increase (p < 0.002) in OCTT in type 2 diabetic patients compared with controls

2016 Indian Journal of Clinical Biochemistry

94. Concomitant Prevalence of Low Serum Diamine Oxidase Activity and Carbohydrate Malabsorption Full Text available with Trip Pro

Concomitant Prevalence of Low Serum Diamine Oxidase Activity and Carbohydrate Malabsorption The aim of this retrospective study was to analyze the concomitant prevalence rates for lactose malabsorption (LM), fructose malabsorption (FM), and histamine intolerance (HI) in patients with so far unexplained gastrointestinal (GI) symptoms. A total of 439 outpatients, who presented unclear abdominal discomfort, underwent lactose (50 g) and fructose (25 g) hydrogen (H2) breath tests. Additionally (...) malabsorption were also diagnosed with HI (LM + HI: 52 [11.8%], FM + HI: 23 [5.2%], and LM + FM + HI 14 [3.2%] individuals). In conclusion different combinations of LM, FM, and HI are present in individuals with unclear abdominal discomfort/pain. In clinical practice we suggest testing for LM, FM, and additional HI in the diagnostic work-up of these patients. Depending on these various diagnoses possible, patients should get an individualized dietary advice.

2016 Canadian journal of gastroenterology & hepatology

95. A Low FODMAPs Diet in Celiac Patients With Persistent Gastrointestinal Symptoms

criteria subjects with VAS>5 Exclusion Criteria: refractory celiac disease disaccharide intolerance (fructose an lactose breath test) abdominal surgery comorbidity patients recruited in other clinical trials positive patients at lactulose breath test (SIBO) Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study (...) FODMAPS causes a rapid increase in carbohydrate which can overwhelm the microbiota's ability to utilise substrate. The excess reducing equivalents will generate hydrogen or methane. The principal symptoms are diarrhoea and abdominal distension. Patients with irritable bowel syndrome appear to benefit by restricting intake, possibly because they are hypersensitive to intestinal distension. The focus of the study is to evaluate if in celiac patients with persistent abdominal symptoms and with a correct

2016 Clinical Trials

96. Effect of Oat Bran on Bowel Function and Appetite

chromatography Fecal total bile acids [ Time Frame: 2 weeks and 4 weeks ] Fecal enzymes [ Time Frame: 2 weeks and 4 weeks ] fecal beta-glucoronidase Fecal ammonia [ Time Frame: 2 weeks and 4 weeks ] Intestinal gas production [ Time Frame: 2 weeks and 4 weeks ] using breath hydrogen production Appetite [ Time Frame: 2 weeks and 4 weeks ] Appetite will be measured via visual analogue score (VAS) Ad libitum energy intake [ Time Frame: 2 weeks and 4 weeks ] Ad libitum energy intake is measured by serving (...) Not Applicable Detailed Description: The study is a randomized, double-blind, placebo-controlled crossover study it involves a total of 8 visits with a 14 day run-in period for total study duration of 84 days. A washout period of 2 weeks will occur in between the 2, 28 day treatment periods. The effects of an oat bran beverage for breakfast on bowel function will be tested after 2 week and 4 weeks of intake. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial

2016 Clinical Trials

97. Whole Milk Intake and Cardio-metabolic Risk Factors

With or Without Lactose Maldigestion Study Start Date : May 2016 Estimated Primary Completion Date : August 2016 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: lactose digesters Participants in arm 1 are grouped as lactose digesters based on breath hydrogen test after a 25-g lactose load. The breath hydrogen excretion is less than 20 ppm. Dietary Supplement: full-fat milk intake 250ml full-fat milk per day (...) , do not intake any other dairy products Active Comparator: lactose maldigesters Participants in arm 2 are also grouped as lactose maldigesters based on breath hydrogen test after a 25-g lactose load. The breath hydrogen excretion is not less than 20 ppm. Dietary Supplement: full-fat milk intake 250ml full-fat milk per day, do not intake any other dairy products Outcome Measures Go to Primary Outcome Measures : Changes in body weight [ Time Frame: 4 weeks ] Change in body composition (body fat mass

2016 Clinical Trials

98. An Exploratory Study on the Effects of Repeat Doses of Albiglutide Compared to Exenatide on Gastric Myoelectrical Activity and Gastric Emptying in Type 2 Diabetes Mellitus Subjects

of nausea. The intensity of upper gastrointestinal symptom of nausea was measured using VAS ranging from 0 (no nausea) to 100 (severe nausea) immediately before (pre-WL) and 10, 20, 30 minutes post-WL. Individual Par. responses to VAS score scale has been presented. Part A: Time to Half-gastric Emptying [ Time Frame: Up to Day 5 ] Breath samples were collected to assess the time to half gastric emptying using gastric emptying breath test (GEBT) containing 13 Carbon (13C)-Spirulina pre-meal and post GEBT (...) emptying. This analysis was planned but not performed for Part B as the study was terminated during Part A. Part B: Rate of [13]C Dose Excreted in Breath [ Time Frame: Up to 8 weeks ] The rate of [13]C dose excreted in breath was assessed to study gastric empting using GEBT. This analysis was planned but not performed for Part B as the study was terminated during Part A. Part B: The Volume of Water Ingested During EGG [ Time Frame: Up to 8 weeks ] EGG with WLT is a standardized test to induce gastric

2016 Clinical Trials

99. Diets in Symptom Relief and the Influence of Quality of Life in People With Irritable Bowel Syndrome

Sponsor: Hong Kong Sanatorium & Hospital Collaborator: The Hong Kong Society of Gastrointestinal Motility Information provided by (Responsible Party): Hong Kong Sanatorium & Hospital Study Details Study Description Go to Brief Summary: Subjects with confirmed diagnosis of Irritable Bowel Syndrome will be blinded and randomly assigned to one of two groups, the low FODMAP diet or the conventional IBS diet group. They will be referred to do three hydrogen breath tests prior to diet education. Upon (...) and randomly assigned to Conventional IBS diet group (A) or Low FODMAP diet group (B) 3 Breath tests (lactulose, fructose, lactose) will be carried out for all subjects before diet education Subjects will be asked to come to the dietitians clinic and receive the first one hour diet education (including diet assessment & diet education) and two times thirty minutes follow-up appointments with the dietitians at Week 0, 6 and 10, respectively Subjects will be asked to record their food intake and signs

2015 Clinical Trials

100. Safety, Pharmacokinetic (PK) and Pharmacodynamic (PD) Study of Repeat Doses of Inhaled GSK2269557 in Patients With APDS/PASLI

. On those days, they will be dosed at the clinic). The subject should hold their breath for 10 seconds before exhaling. Inhalations should be taken approximately 30 seconds apart. Outcome Measures Go to Primary Outcome Measures : Number of subjects with any adverse events (AE) [ Time Frame: Up to 6 months ] An AE is any untoward medical occurrence in a patient or clinical investigation subject, temporally associated with the use of a medicinal product, whether or not considered related to the medicinal (...) , Glucose, C-reactive protein (CRP), Potassium, Sodium, Calcium, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase, Total and direct bilirubin, Total Protein, and Albumin Composite of urinalysis parameters as a measure of safety [ Time Frame: Up to 7.5 months ] Specific gravity, power of hydrogen (pH), glucose, protein, blood and ketones measured by dipstick; and microscopic examination (if blood or protein is abnormal) Spirometry: Forced expiratory volume in one

2015 Clinical Trials

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