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Lactose Breath Hydrogen Test

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41. Prevalence of Lactose Intolerance in Chile: A Double-Blind Placebo Study. (PubMed)

Prevalence of Lactose Intolerance in Chile: A Double-Blind Placebo Study. Lactase non-persistence (LNP), or primary hypolactasia, is a genetic condition that mediates lactose malabsorption and can cause lactose intolerance. Here we report the prevalence of lactose intolerance in a double-blind placebo study.The LCT C>T-13910 variant was genotyped by RT-PCR in 121 volunteers and lactose malabsorption was assessed using the hydrogen breath test (HBT) after consuming 25 g of lactose. Lactose (...) intolerance was assessed by scoring symptoms (SS) using a standardized questionnaire following challenge with a lactose solution or saccharose placebo.The LNP genotype was observed in 57% of the volunteers, among whom 87% were HBT⁺. In the HBT⁺ group the median SS was 9 and in the HBT⁻ group the median SS was 3 (p < 0.001). No difference was observed in the SS when both groups were challenged with the placebo. The most common symptoms included audible bowel sounds, abdominal pain and meteorism. In the ROC

2014 Digestion Controlled trial quality: uncertain

42. Effect of raw milk on lactose intolerance: a randomized controlled pilot study. (PubMed)

Effect of raw milk on lactose intolerance: a randomized controlled pilot study. This pilot study aimed to determine whether raw milk reduces lactose malabsorption and/or lactose intolerance symptoms relative to pasteurized milk.We performed a crossover trial involving 16 adults with self-reported lactose intolerance and lactose malabsorption confirmed by hydrogen (H2) breath testing. Participants underwent 3, 8-day milk phases (raw vs 2 controls: pasteurized, soy) in randomized order separated (...) by 1-week washout periods. On days 1 and 8 of each phase, milk consumption was 473 mL (16 oz); on days 2 to 7, milk dosage increased daily by 118 mL (4 oz), beginning with 118 mL (4 oz) on day 2 and reaching 710 mL (24 oz) on day 7. Outcomes were area under the breath H2 curve (AUC H2) and self-reported symptom severity (visual analog scales: flatulence/gas, audible bowel sounds, abdominal cramping, diarrhea).AUC H2 (mean ± standard error of the mean) was higher for raw vs pasteurized on day 1 (113

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2014 Annals of family medicine Controlled trial quality: uncertain

43. Lactose Intolerance (Overview)

A, Ballou S. Irritable bowel syndrome and diet. Gastroenterol Rep (Oxf) . 2017 Feb. 5 (1):11-9. . . Beyerlein L, Pohl D, Delco F, et al. Correlation between symptoms developed after the oral ingestion of 50 g lactose and results of hydrogen breath testing for lactose intolerance. Aliment Pharmacol Ther . 2008 Apr. 27(8):659-65. . Hermans MM, Brummer RJ, Ruijgers AM, et al. The relationship between lactose tolerance test results and symptoms of lactose intolerance. Am J Gastroenterol . 1997 Jun. 92(6 (...) of intestinal lactase prevents hydrolysis of ingested lactose. The osmotic load of the unabsorbed lactose causes secretion of fluid and electrolytes until osmotic equilibrium is reached. Dilation of the intestine caused by the osmosis induces an acceleration of small intestinal transit, which increases the degree of maldigestion. Within the large intestine, free lactose is fermented by colonic bacteria to yield short-chain fatty acids and hydrogen gas. [ ] The combined increase in fecal water, intestinal

2014 eMedicine.com

44. Lactose Intolerance (Treatment)

. . . Beyerlein L, Pohl D, Delco F, et al. Correlation between symptoms developed after the oral ingestion of 50 g lactose and results of hydrogen breath testing for lactose intolerance. Aliment Pharmacol Ther . 2008 Apr. 27(8):659-65. . Hermans MM, Brummer RJ, Ruijgers AM, et al. The relationship between lactose tolerance test results and symptoms of lactose intolerance. Am J Gastroenterol . 1997 Jun. 92(6):981-4. . Arola H. Diagnosis of hypolactasia and lactose malabsorption. Scand J Gastroenterol Suppl (...) , George P. A simple gene test for lactose intolerance/adult hypolactasia. N Z Med J . 2007 Nov 9. 120(1265):U2817. . Corgneau M, Scher J, Ritie-Pertusa L, et al. Recent advances on lactose intolerance: tolerance thresholds and currently available answers. Crit Rev Food Sci Nutr . 2017 Oct 13. 57 (15):3344-56. . Xiong L, Wang Y, Gong X, Chen M. Prevalence of lactose intolerance in patients with diarrhea-predominant irritable bowel syndrome: data from a tertiary center in southern China. J Health Popul

2014 eMedicine.com

45. Lactose Intolerance (Follow-up)

. . . Beyerlein L, Pohl D, Delco F, et al. Correlation between symptoms developed after the oral ingestion of 50 g lactose and results of hydrogen breath testing for lactose intolerance. Aliment Pharmacol Ther . 2008 Apr. 27(8):659-65. . Hermans MM, Brummer RJ, Ruijgers AM, et al. The relationship between lactose tolerance test results and symptoms of lactose intolerance. Am J Gastroenterol . 1997 Jun. 92(6):981-4. . Arola H. Diagnosis of hypolactasia and lactose malabsorption. Scand J Gastroenterol Suppl (...) , George P. A simple gene test for lactose intolerance/adult hypolactasia. N Z Med J . 2007 Nov 9. 120(1265):U2817. . Corgneau M, Scher J, Ritie-Pertusa L, et al. Recent advances on lactose intolerance: tolerance thresholds and currently available answers. Crit Rev Food Sci Nutr . 2017 Oct 13. 57 (15):3344-56. . Xiong L, Wang Y, Gong X, Chen M. Prevalence of lactose intolerance in patients with diarrhea-predominant irritable bowel syndrome: data from a tertiary center in southern China. J Health Popul

2014 eMedicine.com

46. Lactose Intolerance (Diagnosis)

A, Ballou S. Irritable bowel syndrome and diet. Gastroenterol Rep (Oxf) . 2017 Feb. 5 (1):11-9. . . Beyerlein L, Pohl D, Delco F, et al. Correlation between symptoms developed after the oral ingestion of 50 g lactose and results of hydrogen breath testing for lactose intolerance. Aliment Pharmacol Ther . 2008 Apr. 27(8):659-65. . Hermans MM, Brummer RJ, Ruijgers AM, et al. The relationship between lactose tolerance test results and symptoms of lactose intolerance. Am J Gastroenterol . 1997 Jun. 92(6 (...) of intestinal lactase prevents hydrolysis of ingested lactose. The osmotic load of the unabsorbed lactose causes secretion of fluid and electrolytes until osmotic equilibrium is reached. Dilation of the intestine caused by the osmosis induces an acceleration of small intestinal transit, which increases the degree of maldigestion. Within the large intestine, free lactose is fermented by colonic bacteria to yield short-chain fatty acids and hydrogen gas. [ ] The combined increase in fecal water, intestinal

2014 eMedicine.com

47. Breath-analysis tests in gastroenterology. (PubMed)

Breath-analysis tests in gastroenterology. 4600336 1974 08 28 2018 11 13 0017-5749 15 4 1974 Apr Gut Gut Breath-analysis tests in gastroenterology. 308-23 Newman A A eng Journal Article Review England Gut 2985108R 0017-5749 0 Bile Acids and Salts 0 Carbon Radioisotopes 0 Dietary Fats 0 Oxalates 0 Proteins 0 Radioisotopes 142M471B3J Carbon Dioxide 3OWL53L36A Mannitol 5I8I620HVX Krypton 7U1EE4V452 Carbon Monoxide 7YNJ3PO35Z Hydrogen 97C5T2UQ7J Cholesterol J2B2A4N98G Lactose OP0UW79H66 Methane AIM (...) IM Animals Bile Acids and Salts metabolism Blind Loop Syndrome diagnosis Breath Tests Carbon Dioxide analysis Carbon Monoxide analysis Carbon Radioisotopes adverse effects Celiac Disease metabolism Cholesterol metabolism Dietary Fats metabolism Digestive System metabolism physiopathology Dogs Flatulence Gastrointestinal Diseases diagnosis Guinea Pigs Humans Hydrogen analysis Ileum surgery Intestinal Absorption Intestine, Small microbiology Krypton Lactose metabolism Lactose Intolerance diagnosis

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1974 Gut

48. Lactose intolerance in irritable bowel syndrome patients with diarrhoea: the roles of anxiety, activation of the innate mucosal immune system and visceral sensitivity. (PubMed)

and 18 healthy controls (HCs) with lactase deficiency underwent a 20-g lactose hydrogen breath test (LHBT). Patients were categorised as lactose malabsorption (LM; malabsorption only) or LI [malabsorption plus increase in total symptom score (TSS). Measurements included (i) psychological status; (ii) enteric biopsies with quantification of mast cells (MCs), T-lymphocytes and enterochromaffin cells; (iii) serum cytokines; (iv) rectal sensitivity before and after lactose ingestion.LI was more prevalent (...) Lactose intolerance in irritable bowel syndrome patients with diarrhoea: the roles of anxiety, activation of the innate mucosal immune system and visceral sensitivity. Irritable bowel syndrome patients with diarrhoea (IBS-D) often report intolerance to milk; however, the mechanism underlying these symptoms is unknown.To assess the role of psychological factors, immune activation and visceral sensitivity on the development of lactose intolerance (LI) in IBS-D patients.Fifty-five IBS-D patients

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2013 Alimentary Pharmacology & Therapeutics

49. Bloating and Distention in Irritable Bowel Syndrome: The Role of Gas Production and Visceral Sensation After Lactose Ingestion in a Population With Lactase Deficiency. (PubMed)

) underwent a 20-g lactose hydrogen breath test (LHBT) with evaluation of hydrogen gas production and lactose intolerance (LI) symptoms. Abdominal distention (199 IBS, 40 HCs) was measured during LHBT. Rectal sensitivity (74 IBS, 64 HCs) was assessed by barostat studies.Hydrogen production and distention were similar in IBS patients and HCs during LHBT; however, LI was more frequent in IBS (53.8 vs. 28.1%, P<0.001), especially bloating (39.0% vs. 14.1%, P<0.001) and borborygmi (39.0 vs. 21.9%, P=0.010 (...) Bloating and Distention in Irritable Bowel Syndrome: The Role of Gas Production and Visceral Sensation After Lactose Ingestion in a Population With Lactase Deficiency. Bloating and distention are often attributed to dietary factors by patients with irritable bowel syndrome (IBS). This study examined the effects of gas production and visceral hypersensitivity on digestive symptoms after lactose ingestion in a population with lactase deficiency.IBS patients (n=277) and healthy controls (HCs, n=64

2013 American Journal of Gastroenterology

50. Lactose malabsorption diagnosed by 50-g dose is inferior to assess clinical intolerance and to predict response to milk withdrawal than 25-g dose in an endemic area. (PubMed)

Lactose malabsorption diagnosed by 50-g dose is inferior to assess clinical intolerance and to predict response to milk withdrawal than 25-g dose in an endemic area. Lactose malabsorption (LM), diagnosed currently using lactose hydrogen breath and tolerance tests (LHBT, LTT) with a high, nonphysiological dose (50-g), may mimic irritable bowel syndrome (IBS). In LM-endemic areas, clinically significant malabsorption (lactose intolerance) may be better diagnosed using a lesser dose, and positive (...) using 25-g lactose, and 14/50 (28%) and 29/50 (58%) using 12-g lactose, respectively. Sensitivity and specificity of LHBT using 50-g, 25-g, and 12-g lactose were 92.6%, 52.0%, and 94%, 60%, and 36.4%, 88.2%, and those of LTT, 92%, 80.0%, and 84.8%, 82.4%, and 66.7%, 58.8%, respectively. Breath hydrogen correlated with lactose dose. Though patients developing symptoms with 50-g lactose exhaled more hydrogen than those remaining asymptomatic, hydrogen levels did not differ following 25-g and 12-g

2013 Journal of gastroenterology and hepatology

51. Secondary Lactose Intolerance Due to Chronic Norovirus Infection

genotype of the DNA variant -13910 T/C upstream in the LCT gene. After obtaining written and oral informed consent, the investigators perform a lactose hydrogen breath (LH2BT) test and a lactose tolerance test (LTT) in all eligible RTRs with proven chronic norovirus infection irrespective of current abdominal symptoms. The study population (N=10) is divided into two groups according to the gastrointestinal symptoms (asymptomatic versus symptomatic, such as chronic diarrhoea or diffuse abdominal (...) discomfort). The investigators chose the cut-off three or more stools per day as indicative of diarrhoea for the purpose of this study. RTRs with otherwise unexplainable chronic diarrhoea but absent norovirus infection serve as control group (N=10). Condition or disease Intervention/treatment Phase Chronic Diarrhea Behavioral: Lactose H2 breath test (LH2BT) Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 15 participants

2013 Clinical Trials

52. Prevalence and presentation of lactose intolerance and effects on dairy product intake in healthy subjects and patients with irritable bowel syndrome. (PubMed)

at the Sir Run Run Shaw Hospital, Hangzhou, China and 60 controls were given hydrogen breath tests to detect malabsorption and intolerance after administration of 10, 20, and 40 g lactose in random order 7-14 days apart; participants and researchers were blinded to the dose. We assessed associations between the results and self-reported lactose intolerance (LI).Malabsorption of 40 g lactose was observed in 93% of controls and 92% of patients with D-IBS. Fewer controls than patients with D-IBS were (...) not correlate with results from hydrogen breath tests.The risk of LI is related to the dose of lactose ingested and intestinal gas production and is increased in patients with D-IBS. Self-reported LI, but not objective results from hydrogen breath tests, was associated with avoidance of dairy products.Copyright © 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.

2013 Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Controlled trial quality: uncertain

53. Corticotropin-releasing factor increases ascending colon volume after a fructose test meal in healthy humans: a randomized controlled trial. (PubMed)

was assessed with the use of the lactose [(13)C]ureide breath test and the adrenal response to CRF was assessed by serial salivary cortisol measurements.CRF injection caused a significant increase in salivary cortisol, which lasted for 135 min. Small bowel water content (SBWC) rose from baseline, peaking at 45 min after fructose ingestion, whereas breath hydrogen peaked later, at 75 min. The area under the curve for SBWC from -15 min to 135 min was significantly lower after CRF compared with saline [mean (...) investigated the effect of an intravenous injection of corticotropin-releasing factor (CRF) on fructose malabsorption and the resulting volume of water in the small bowel.We performed a randomized, placebo-controlled crossover study of CRF compared with saline injection in 11 male and 10 female healthy subjects, examining the effect on the malabsorption of a 40-g fructose test meal and its transit through the gut, which was assessed by serial MRI and breath hydrogen measurement. Orocecal transit

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2016 The American journal of clinical nutrition Controlled trial quality: uncertain

54. Lactose malabsorption is a risk factor for decreased bone mineral density in pancreatic insufficient cystic fibrosis patients. (PubMed)

liver cirrhosis, steatosis and cholestasis, diabetes mellitus, systemic glucocorticoid therapy), lumbar BMD, the nutritional status, pulmonary function, vitamin D3 concentration, calcium intake and single-nucleotide polymorphism upstream of the lactase gene were assessed. In subjects with the -13910 C/C genotype predisposing to ATH, the presence of LM was determined with the use of a hydrogen-methane breath test (BT). BMD and calcium intake were significantly lower in patients with the C/C genotype (...) Lactose malabsorption is a risk factor for decreased bone mineral density in pancreatic insufficient cystic fibrosis patients. As decreased bone mineral density (BMD) is a common problem in cystic fibrosis (CF) and milk products may have pivotal dietary role affecting BMD, we aimed to assess the potential influence of adult-type hypolactasia (ATH) and lactose malabsorption (LM) on BMD in adolescent and young adult patients. In 95 CF pancreatic-insufficient patients aged 10-25 years (without

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2012 European Journal of Human Genetics

55. Is the subjective perception of lactose intolerance influenced by the psychological profile? (PubMed)

intolerance.One hundred and two consecutive patients underwent a 15 g lactose hydrogen breath test to assess lactose malabsorption. The patients recorded the presence and severity of symptoms of lactose intolerance during the breath test using visual analogue scales. The psychological profile was assessed using a psychological symptom checklist, and health-related quality of life by means of the short-form health survey.Lactose malabsorption and intolerance were diagnosed in, respectively, 18% and 29 (...) , but not in those with lactose malabsorption.The symptoms of lactose intolerance during hydrogen breath testing at a low physiological lactose load, are unrelated to lactose malabsorption, but may reveal a tendency towards somatisation that could impair the quality of life.© 2012 Blackwell Publishing Ltd.

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2012 Alimentary Pharmacology & Therapeutics

56. The Effect of Probiotics on Lactose Intolerance

these symptoms are not specific and may differ from one patient to another. Breath hydrogen test have been advocated as the best diagnostic tool for the assessment of LI (15-16). During the test, subjects are sampled for hydrogen levels of breath samples at base line and every 30 minutes after the administration of 50 grams of oral lactose, for a total period of 180 minutes. A breath sample with > 20 ppm above baseline is considered positive for LI (15-16). There are no established treatments for LI, other (...) Intervention/treatment Phase Lactose Intolerance Dietary Supplement: Bio-25 Not Applicable Detailed Description: lactose hydrogen breath test (LHBT) will be performed at base line and at each visit (total of 7 breath samples from each patient). All subjects will be presented for the lactose hydrogen breath test after 8 hours fast. At the initial stage, the subjects will take a base reading at time 0. Subjects will then receive 50 g of lactose dissolved in a 100 ml of plain water and will perform further

2012 Clinical Trials

57. Lactose malabsorption, calcium intake and bone mass in children and adolescents. (PubMed)

Lactose malabsorption, calcium intake and bone mass in children and adolescents. The objective of the present study was to evaluate the calcium intake and bone mass in children and early adolescents in accordance with their absorption capacity to lactose.A transversal study was conducted on a sample composed of 76 individuals. Lactose malabsorption status was determined with hydrogen breath test. The hydrogen breath test was applied using 2  g of lactose per kilogram of weight up to a maximum (...) of 50  g. A hydrogen increment ≥20  pm in relation to fasting was used to characterize lactose malabsorption. Two 24-hour recalls were applied for the evaluation of food consumption. Bone mineral content and bone mineral density were evaluated in the lumbar spine by dual-energy x-ray absorptiometry.The prevalence of lactose malabsorption was 61.8%. The participants were divided into 2 groups: lactose malabsorbers (n = 47) and lactose absorbers (n = 29). There was no statistically significant

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2011 Journal of Pediatric Gastroenterology and Nutrition

58. The Effects of Lactose Intolerance on Gastrointestinal Function and Symptoms in a Chinese Population

Supplement: dietary restriction Not Applicable Detailed Description: Study #1: Questionnaire study in general Chinese population (n=2000). Study #2: Physiologic study in patients attending gastroenterology clinic (n=600) including in subgroups assessment of genetic factors,tolerance to lactose challenge and assessment of visceral sensitivity. Study #3: Assessment of appropriate dosage of lactose hydrogen breath test in a population with high-prevalence of lactase deficiency. Study #4: Impact (...) Outcome Measures Go to Primary Outcome Measures : To assess the effects of lactose intolerance on gastrointestinal function and symptoms [ Time Frame: Three years ] Secondary Outcome Measures : To measure the intake of dietary lactose in the adult general population and in patients with IBS [ Time Frame: three years ] To assess genetic factors, tolerance to lactose challenge and visceral sensitivity. [ Time Frame: three years ] To assess appropriate dosage of lactose hydrogen breath test [ Time Frame

2011 Clinical Trials

59. Disaccharide Absorption Test

Disaccharide Absorption Test Lactose Tolerance Tests Produced by In partnership with User Top Links Menu Search User Top Links Search Lactose Tolerance Tests Also Known As Hydrogen Breath Test Lactose Breath Test Disaccharide Absorption Test Oral Lactose Tolerance Formal Name Hydrogen Breath Test; Lactose Tolerance Test This article was last reviewed on 27 March 2019. This article was last modified on 27 March 2019. At a Glance Why Get Tested? To help diagnose in individuals who have (...) reference ranges for the majority of tests described on this web site. The lab report containing your test results should include the relevant reference range for your test(s). Please consult your doctor or the laboratory that performed the test(s) to obtain the reference range if you do not have the lab report. For more information on reference ranges, please read . What is being tested? Lactose tolerance tests measure hydrogen in the breath or changes in the level of glucose in the blood after

2012 Lab Tests Online UK

60. Lactose malabsorption and intolerance: a systematic review on the diagnostic value of gastrointestinal symptoms and self-reported milk intolerance. (PubMed)

absorbers reported symptoms during the lactose hydrogen breath test.Our review shows that high-quality studies on the diagnosis of lactose malabsorption and intolerance in primary care are urgently needed. An important prerequisite would be to clearly define the concept of lactose intolerance, as well as how it should be assessed. (...) on the diagnostic performance of gastrointestinal symptoms and self-reported milk (lactose) intolerance in primary care, and the relationship between lactose malabsorption and intolerance.PubMed, EMBASE and reference screening.Studies were selected if the design was a primary diagnostic study; the patients were adults consulting because of non-acute abdominal symptoms; the diagnostic test included gastrointestinal symptoms and/or self-reported milk intolerance. A total of 26 primary diagnostic studies were

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2010 QJM : monthly journal of the Association of Physicians

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