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Lactose Breath Hydrogen Test

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181. Evaluation of Urinary Isoprostanes in the Assessment of Children With Inflammatory Bowel Disease

Eligible for Study: All Accepts Healthy Volunteers: Yes Sampling Method: Non-Probability Sample Study Population Patients with known or suspected IBD. Criteria Inclusion Criteria: Patients scheduled for endoscopic evaluation (upper endoscopy, colonoscopy or sigmoidoscopy) Patients currently completing lactose hydrogen breath tests (LHBT) Exclusion Criteria: Patients with a previous history of HIV and/or chronic Hepatitis (or active acute hepatitis B or C). Patients will be asked about potential blood (...) . Isoprostane levels will be compared across conditions (IBD vs. non-inflammatory, Crohn's disease vs. ulcerative colitis) and tested for statistical significance. Similarly, disease severity and urinary isoprostane levels will be assessed. The sensitivity, specificity, and positive and negative predictive values of elevated urinary isoprostane levels at discriminating pediatric patients with inflammatory and non-inflammatory gastrointestinal disease will be calculated. Condition or disease Inflammatory

2005 Clinical Trials

182. Recurrent Abdominal Pain in Children

that the child kept while on the special diet. The coordinators will explain how to collect some samples of urine, stool, and breath. These tests will evaluate the gastrointestinal (GI) tract for inflammation and transit time. If the special diet does not make the stomach pain go away, the child will be selected at random, like the flip of a coin, to be placed in one of two groups: one group that receives fiber or one group that receives a placebo or sugar pill. Fiber has been suggested to help children (...) somatization, coping, and illness interaction [ Time Frame: Four weeks prior to treatment and 6 months after treatment ] Changes in GI Transit time [ Time Frame: Prior to and after treatment ] Changes in Breath Hydrogen production [ Time Frame: Prior to and after treatment ] Changes in GI Permeability [ Time Frame: Prior to and after treatment ] Changes in fecal calprotectin concentration [ Time Frame: Prior to and after treatment ] Eligibility Criteria Go to Information from the National Library

2007 Clinical Trials

183. Transit Time and Bacterial Overgrowth Using SmartPill Capsule

. The ACT-1 (SmartPill) GI Monitoring System includes an ingestible capsule, a receiver and video display software. Procedure: Lactulose hydrogen breath test (H_2BT) A hydrogen breath test provides information about the digestion of certain sugars or carbohydrates, such as milk sugar (lactose) or fruit sugar (fructose). The test is also used for detecting abnormal growth of bacteria within the small bowel by having the patient ingest lactulose. Active Comparator: Symptomatic Participants Subjects (...) The SmartPill is a single-use, ingestible capsule that utilizes sensor technology to measure pressure, pH and temperature throughout the entire GI tract. The ACT-1 (SmartPill) GI Monitoring System includes an ingestible capsule, a receiver and video display software. Procedure: Lactulose hydrogen breath test (H_2BT) A hydrogen breath test provides information about the digestion of certain sugars or carbohydrates, such as milk sugar (lactose) or fruit sugar (fructose). The test is also used for detecting

2007 Clinical Trials

184. The Effect of Probioticson Bloating in IBS

: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: No Criteria Inclusion Criteria: - Female test persons with symptoms of meteorism, the age of > 18 years, completely integrated in the Danish society (including nutrition), and no previous abdominal surgery besides from appendicectomy (advertisement in a local newspaper for test persons). Exclusion Criteria: Lactose and sorbitol intolerant persons (based on hydrogen breath tests). Persons (...) Information provided by: Royal Veterinary and Agricultural University, Denmark Study Details Study Description Go to Brief Summary: The purpose of the study is to establish an in-vitro method to evaluate the effect of probiotics on gas production in feces (hydrogen and methane) Condition or disease Intervention/treatment Phase Irritable Bowel Syndrome Drug: Probiotic bacteria (Trevis R) Not Applicable Detailed Description: The objective of this study is to establish a model for screening probiotic

2006 Clinical Trials

185. Pilot study on the effect of reducing dietary FODMAP intake on bowel function in patients without a colon. (PubMed)

. Carbohydrate malabsorption was evaluated by breath tests. Pouchitis was assessed clinically/endoscopically or by fecal lactoferrin.Of 8 patients with a breath hydrogen response to lactulose, 7 had fructose malabsorption, 3 with lactose malabsorption, and 1 had lactose malabsorption alone. Five of 7 studied retrospectively improved stool frequency (from median 8 to 4 per day; P = 0.02), this being sustained over 0.5-3 years of follow-up. Five of 8 patients completed a prospective arm of the study. One

2007 Inflammatory Bowel Diseases

186. Systematic evaluation of the causes of chronic watery diarrhea with functional characteristics. (PubMed)

follow-through; and (d) hydrogen breath test (lactose, fructose + sorbitol). Gluten- or sugar-free diet, or cholestyramine was administered according to results. Functional disease was diagnosed if all tests performed were normal or if either there was no response to specific therapy or diarrhea relapsed during a 12-month follow-up.Bile acid malabsorption was considered to be the cause of diarrhea in 28 (45.2%) patients, sugar malabsorption in 10 (16.1%), gluten-sensitive enteropathy in 10 (16.1 (...) watery diarrhea of obscure origin fulfilling Rome II criteria of functional disease.A total of 62 patients with chronic watery diarrhea, defined as more than 3 loose or liquid bowel movements a day for at least 4 wk and a stool weight >200 g/day were included. The following tests were performed: (a) HLA-DQ2/DQ8 genotyping, and if positive, endoscopic biopsies from distal duodenum were obtained, and intestinal damage assessed; (b) SeHCAT (Se-homotaurocholate) abdominal retention test; (c) small bowel

2007 American Journal of Gastroenterology

187. Fructose intolerance: an under-recognized problem. (PubMed)

Fructose intolerance: an under-recognized problem. Although the role of lactose intolerance in the pathogenesis of abdominal symptoms is well known, the role of fructose intolerance is unclear. Our aims were 1) to examine the prevalence of fructose intolerance in patients with unexplained abdominal symptoms, and 2) to explore whether fructose concentration influences fructose breath test.Over 2 yr, patients with unexplained symptoms answered questionnaires and underwent fructose breath tests (...) . Patients received 50 g fructose in 150 ml water (33% solution). Breath samples were collected for hydrogen and methane. In a second study, breath test was performed after giving either 10%, 20%, or 33% fructose solution. Data were analyzed retrospectively.A total of 183 patients (50 male, 133 female) had breath tests, of whom 134 (73%) were positive. Among these, 119 (89%) had elevated H(2), and 15 (11%) had elevated CH(4) or both gases. Questionnaires showed that flatus (83%), pain (80%), bloating (78

2003 American Journal of Gastroenterology

188. Decline of Lactase Activity and C/T-13910 Variant in Sardinian Childhood. (PubMed)

Decline of Lactase Activity and C/T-13910 Variant in Sardinian Childhood. Our study aims to determine the age of onset of adult-type hypolactasia in Sardinians, and to establish the age at which genotyping of the C/T-13910 variant can be used reliably in the diagnosis of lactose malabsorption.A lactose breath hydrogen test was given to 383 randomly selected patients, from 3 to 19 years old.The C/C-13910 genotype was found in 90% of patients; the frequency of the positive lactose breath hydrogen (...) test increased with age and reached a prevalence of 85% at 9 years.In Sardinians, adult-type hypolactasia becomes phenotypically evident in all individuals older than 9 years, suggesting that this should be considered the minimum age at which the genetic test for lactase nonpersistence should be applied.

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2007 Journal of Pediatric Gastroenterology and Nutrition

189. Perceived milk intolerance is related to bone mineral content in 10- to 13-year-old female adolescents. (PubMed)

Perceived milk intolerance is related to bone mineral content in 10- to 13-year-old female adolescents. The purpose of this study was to determine associations among lactose maldigestion status, perceived milk intolerance, dietary calcium intake, and bone mineral content in early adolescent girls.Subjects were 291 girls who participated in a substudy of the multiple-site project Adequate Calcium Today. Lactose maldigestion status was determined with hydrogen breath testing, and questionnaires (...) and were classified as lactose maldigesters. Of the 246 participants who completed useable perceived milk intolerance questionnaires, 47 considered themselves to be milk intolerant. Of the 47 girls self-reporting perceived milk intolerance, 40 completed breath hydrogen testing and 22 were not maldigesters. Girls with perceived milk intolerance consumed an average of 212 mg of total food calcium per day less than girls without perceived milk intolerance. Spinal bone mineral content was significantly

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2007 Pediatrics Controlled trial quality: uncertain

190. Distribution of adult lactase phenotypes in the Tuareg of Niger. (PubMed)

Distribution of adult lactase phenotypes in the Tuareg of Niger. The adult lactase phenotype, lactose absorber or malabsorber, was determined using the lactose tolerance test with breath hydrogen assay in a group of Tuareg, a traditionally nomadic pastoralist population in the central Sahara. Out of a total of 118 subjects, 103 (87.3%) were lactose absorbers and 15 (12.7%) lactose malabsorbers. The frequency of the "lactase suppression gene" in this population sample was .357 (SD .043). The low

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1986 American Journal of Human Genetics

191. Honey may have a laxative effect on normal subjects because of incomplete fructose absorption. (PubMed)

of a glucose and fructose mixture. The breath-hydrogen concentration was measured every 15 min for 6 h. Semiquantitative estimates of carbohydrate malabsorption were assessed with lactose as a nonabsorbable standard. Breath-hydrogen concentrations increased by 52 +/- 6, 30 +/- 4, 20 +/- 3, and 4 +/- 1 ppm (mean +/- SEM) after each of the four test solutions, respectively. The estimated carbohydrate malabsorption was 10.3 +/- 1.8, 5.9 +/- 1.2, and 0.5 +/- 0.2 g after 100 g honey, 50 g honey, and the glucose

1996 The American journal of clinical nutrition Controlled trial quality: uncertain

192. [Clinical consequences of replacing milk with yogurt in persistent infantile diarrhea]. (PubMed)

hydrogen breath test results. Clinical treatment failure (weight loss greater than 5% in one day or persistent diarrhea after 5 days) was significantly less common in children fed yogurt (15 +/- 6%) than in children fed milk (45 +/- 8%). The beneficial effects of feeding yogurt were apparent within 48 hours in 67 +/- 8% of infants. In conclusion, these data confirm the clinical efficacy of substituting yogurt for milk in young children with persistent diarrhea. They also suggest that yogurt may (...) for milk, as the only treatment. After a one to two-day observation period during which a standard milk diet was given, 78 children aged 3 to 36 months with confirmed persistent diarrhea of more than 15 days but less than one month duration and negative tests for fecal blood were fed either milk (infant formula) or yogurt (infant formula fermented with Lactobacillus bulgaricus and Streptococcus thermophilus). At inclusion both groups were comparable for age, nutritional status, diarrhea, and lactose

1992 Annales de pédiatrie Controlled trial quality: uncertain

193. [Effects of neomycin on intestinal digestion, absorption and fermentation of carbohydrates in patients with liver cirrhosis: evidence for an alternative therapeutic mechanism in hepatic encephalopathy]. (PubMed)

malabsorption.To investigate the effects of neomycin on intestinal digestion, absorption and fermentation of carbohydrates in patients with liver cirrhosis.Thirty eight Child B or C cirrhotic patients separated in three groups; subjects within each group were randomized to receive neomycin (2/g/day for 10 days, n = 8) or placebo (n = 4). Absorption of lactose and d-xylose and fermentation of d-xylose, lactose and lactulose (measured using hydrogen breath tests) were studied before and after the treatment (...) period.Neomycin did not change lactose fermentation but reduced plasma glucose rise after lactose ingestion (38.8 +/- mg/dl to 22 +/- 6 mg/dl p < 0.05). Plasma d-xylose levels at 30 min and its 5 h urinary excretion were reduced by neomycin from 19 +/- 3 to 9 +/- 2 mg/dl and from 4.9 +/- 0, 8 to 2.6 +/- 0.3 g/5h respectively (p < 0.05). Fermentation of d-xylose, lactose and lactulose was not reduced by neomycin. No significant changes were observed after placebo treatment.Neomycin therapy is associated

1994 Revista médica de Chile Controlled trial quality: uncertain

194. Is it worth investigating patients with apparent irritable bowel syndrome for lactose intolerance and if so what is the most practical way of doing so?

intolerance and if so what is the most practical way of doing so? eMedicine, an American online textbook, holds an article on irritable bowel syndrome(1). This states that a lactose tolerance test or hydrogen breath test should be directed by history. It also suggests that inconsistent symptoms should alert to the possibility of an organic pathology and lists lactose intolerance as a differential diagnosis. A 2001 study describes a cohort of 17 IBS subsequently identified as having lactose malabsorbtion (...) (2). The authors state that after 6 weeks on a lactose restricted diet symptoms were markedly improved in the lactose malabsorbtion-positive patients. They add that after 5 years, one patient was lost to follow up and 14 of the remaining 16 still had no complaints during the lactose restricted diet. Another 2001 study examined a low-lactose diet in 33 patient with a positive lactose hydrogen breath test (3). They report that only 39% of patients improved on the low lactose diet and the authors

2003 TRIP Answers

195. Do probiotics reduce adult lactose intolerance? A systematic review. (PubMed)

Do probiotics reduce adult lactose intolerance? A systematic review. To assess the efficacy of oral probiotics in adults with lactose intolerance through a systematic review of its effects on symptoms and breath hydrogen tests, and whether adding probiotics to nonfermented dairy products decreases lactose intolerance at that meal.We searched randomized controlled trials published between 1966 and December 2002. Databases in the search strategy included Medline and AMED. We reviewed references (...) of clinical trials and contacted authors of major articles and manufacturers of probiotic commercial products. Quality assessment was based on the McMaster guides and was performed by 5 independent reviewers. Data extraction was performed by 2 reviewers.A master list of 90 articles was compiled. Ten articles met inclusion and exclusion criteria and were consistent with our clinical question. Of the 9 studies that measured breath hydrogen, 3 were positive, 3 were negative, and 3 had both positive

2005 Journal of Family Practice

196. Review article: lactose intolerance in clinical practice - myths and realities. (PubMed)

of lactose intolerance include abdominal pain, bloating, flatulence and diarrhoea. Diagnosis is most commonly by the lactose hydrogen breath test. However, most people with hypolactasia, if given appropriate advice, can tolerate some lactose-containing foods without symptoms.In clinical practice, some people with lactose intolerance can consume milk and dairy foods without developing symptoms, whereas others will need lactose restriction. (...) Review article: lactose intolerance in clinical practice - myths and realities. Approximately 70% of the world population has hypolactasia, which often remains undiagnosed and has the potential to cause some morbidity. However, not everyone has lactose intolerance, as several nutritional and genetic factors influence tolerance.To review current clinical practice and identify published literature on the management of lactose intolerance.PubMed was searched using the terms lactose, lactase

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2007 Alimentary Pharmacology & Therapeutics

197. Lactose intolerance in infants, children, and adolescents. (PubMed)

Lactose intolerance in infants, children, and adolescents. The American Academy of Pediatrics Committee on Nutrition presents an updated review of lactose intolerance in infants, children, and adolescents. Differences between primary, secondary, congenital, and developmental lactase deficiency that may result in lactose intolerance are discussed. Children with suspected lactose intolerance can be assessed clinically by dietary lactose elimination or by tests including noninvasive hydrogen (...) breath testing or invasive intestinal biopsy determination of lactase (and other disaccharidase) concentrations. Treatment consists of use of lactase-treated dairy products or oral lactase supplementation, limitation of lactose-containing foods, or dairy elimination. The American Academy of Pediatrics supports use of dairy foods as an important source of calcium for bone mineral health and of other nutrients that facilitate growth in children and adolescents. If dairy products are eliminated, other

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2006 Pediatrics

198. Genotyping of the lactase-phlorizin hydrolase -13910 polymorphism by LightCycler PCR and implications for the diagnosis of lactose intolerance. (PubMed)

Genotyping of the lactase-phlorizin hydrolase -13910 polymorphism by LightCycler PCR and implications for the diagnosis of lactose intolerance. Hypolactasia and lactose intolerance are common conditions worldwide. Hypolactasia seems to be strongly correlated with genotype C/C of the genetic variant C-->T(-13910) upstream of the lactase phlorizin hydrolase (LPH) gene. We developed a rapid genotyping assay for LPH C-->T(-13910) and investigated the relationship of positive lactose breath hydrogen (...) test (LBHT) results suggesting lactose intolerance with LPH C-->T(-13910) genotype.Using automated DNA purification on the MagNA Pure LC and real-time PCR on the LightCycler, we examined samples from 220 individuals to estimate genotype frequencies; we then determined LPH C-->T(-13910) genotype in samples from 54 Caucasian patients with a positive LBHT result and symptoms of lactose intolerance.Genotyping of 220 individuals revealed frequencies of 21.4%, 41.8%, and 36.8% for genotypes C/C, C/T

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2006 Clinical Chemistry

199. Effect of post-prandial posture on orocecal transit time and digestion of milk lactose in humans. (PubMed)

Effect of post-prandial posture on orocecal transit time and digestion of milk lactose in humans. We examined the effect of post-prandial body posture on orocecal transit time and absorption of milk lactose using the breath hydrogen test. In this experiment, subjects ingested a cup of commercially available milk to which we had added a small amount of lactosucrose (an indigestible trisaccharide), and then they lay on their backs or sat on a chair for the first 4 hr (from 08:00 to 12:00). After (...) longer than that under the sitting condition. In addition, the amount of breath hydrogen excretion under the supine condition was significantly lower than under the sitting condition, indicating that the unabsorbed milk lactose moved into cecum under the supine condition is smaller than that under the sitting condition. These findings provide evidence that postprandial supine posture works more beneficially to digest and absorb milk lactose when compared to the sitting posture.

2004 Journal of physiological anthropology and applied human science Controlled trial quality: uncertain

200. Rifaximin in patients with lactose intolerance. (PubMed)

Rifaximin in patients with lactose intolerance. Abdominal symptoms linked to lactose malabsorption may be caused by metabolic activity of colonic bacteria. Rifaximin, a non-absorbable rifampycin derivative, is active against colonic bacteria, it may be useful in the treatment of lactose intolerance.The aim of this study has been to evaluate short-term rifaximin therapy in patients with lactose intolerance.Thirty-two patients with lactose intolerance diagnosed using the hydrogen lactose breath (...) test were studied. Fourteen patients received rifaximin 800 mg/day for 10 days, 13 patients followed a diet without milk for 40 days and 5 patients received a placebo for 10 days. Total breath H(2) excretion expressed as area under the curve, and the symptom score were evaluated in all patients at the start, and subsequently after 10 and 40 days.In the 14 patients who received rifaximin for 10 days, area under the curve at day 10 and day 40 was statistically significantly lower than the one

2005 Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Controlled trial quality: uncertain

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