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Lactose Breath Hydrogen Test

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1. Data Mining Techniques Applied to Hydrogen Lactose Breath Test. (PubMed)

Data Mining Techniques Applied to Hydrogen Lactose Breath Test. Analyze a set of data of hydrogen breath tests by use of data mining tools. Identify new patterns of H2 production.Hydrogen breath tests data sets as well as k-means clustering as the data mining technique to a dataset of 2571 patients.Six different patterns have been extracted upon analysis of the hydrogen breath test data. We have also shown the relevance of each of the samples taken throughout the test.Analysis of the hydrogen (...) breath test data sets using data mining techniques has identified new patterns of hydrogen generation upon lactose absorption. We can see the potential of application of data mining techniques to clinical data sets. These results offer promising data for future research on the relations between gut microbiota produced hydrogen and its link to clinical symptoms.

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2017 PLoS ONE

2. Hydrogen breath test in patients with functional bowel disorders and suspected carbohydrate malabsorption

database. Citation HAYES, Inc. Hydrogen breath test in patients with functional bowel disorders and suspected carbohydrate malabsorption. Lansdale: HAYES, Inc. Directory Publication. 2017 Authors' conclusions Hydrogen breath tests (HBTs) may be used to identify carbohydrate malabsorption by assessing changes in hydrogen expiration following the administration of lactose, fructose, or other carbohydrates. Carbohydrate malabsorption may be suspected in patients with symptoms suggestive of or a diagnosis (...) of functional bowel disorders (FBDs), including irritable bowel disease. In these patients, HBTs may identify an underlying cause of the symptoms and thereby also potential treatments. However, the clinical utility and clinical validity of HBTs have not been firmly established. Rationale: Lactose or fructose hydrogen breath test (LHBT or FHBT, respectively) results are obtained quickly compared with genotyping techniques and are comparatively safer and less costly than more invasive techniques. Controversy

2017 Health Technology Assessment (HTA) Database.

3. HYBRID: Hydrogen Breath Test in Lactose Digestion

HYBRID: Hydrogen Breath Test in Lactose Digestion HYBRID: Hydrogen Breath Test in Lactose Digestion - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. HYBRID: Hydrogen Breath Test in Lactose Digestion (HYBRID (...) Criteria Inclusion Criteria: BMI between 18.5 and 24.9 kg/m2 inclusive Lactose intolerant The following criteria need to be checked at visit 2: Lactose intolerance confirmed by positive Hydrogen Breath Test (HBT) (i.e. if there are two or more samples with hydrogen level > 20 ppm increase compared to baseline sample between 90 mins and 240 min sampling time point). At least one sample with hydrogen level > 20 ppm increase compared to baseline between 90 mins and 180 mins sampling time point. Exclusion

2016 Clinical Trials

4. Lactose Breath Hydrogen Test

Lactose Breath Hydrogen Test Lactose Breath Hydrogen Test Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Lactose Breath Hydrogen Test (...) Lactose Breath Hydrogen Test Aka: Lactose Breath Hydrogen Test II. Indications testing III. Efficacy Preferred over : 90% IV. Technique Measure baseline breath hydrogen concentration Patient ingests lactose Classic: 25 to 50 grams lactose Physiologic: 12 grams lactose (same as in 8 oz milk) Measure breath hydrogen concentration in 3 to 8 hours Increase >20 ppm suggests V. False negative causes Gastrointestinal flora absent (e.g. recent antibiotics) VI. False positive causes Recent use smoking VII

2018 FP Notebook

5. Four-sample lactose hydrogen breath test for diagnosis of lactose malabsorption in irritable bowel syndrome patients with diarrhea (PubMed)

Four-sample lactose hydrogen breath test for diagnosis of lactose malabsorption in irritable bowel syndrome patients with diarrhea To validate 4-sample lactose hydrogen breath testing (4SLHBT) compared to standard 13-sample LHBT in the clinical setting.Irritable bowel syndrome patients with diarrhea (IBS-D) and healthy volunteers (HVs) were enrolled and received a 10 g, 20 g, or 40 g dose lactose hydrogen breath test (LHBT) in a randomized, double-blinded, controlled trial. The lactase gene (...) promoter region was sequenced. Breath samples and symptoms were acquired at baseline and every 15 min for 3 h (13 measurements). The detection rates of lactose malabsorption (LM) and lactose intolerance (LI) for a 4SLHBT that acquired four measurements at 0, 90, 120, and 180 min from the same data set were compared with the results of standard LHBT.Sixty IBS-D patients and 60 HVs were studied. The genotype in all participants was C/C-13910. LM and LI detection rates increased with lactose dose from 10

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2015 World journal of gastroenterology : WJG Controlled trial quality: uncertain

6. Hydrogen and Methane-Based Breath Testing in Gastrointestinal Disorders: The North American Consensus. (PubMed)

Hydrogen and Methane-Based Breath Testing in Gastrointestinal Disorders: The North American Consensus. Breath tests (BTs) are important for the diagnosis of carbohydrate maldigestion syndromes and small intestinal bacterial overgrowth (SIBO). However, standardization is lacking regarding indications for testing, test methodology and interpretation of results. A consensus meeting of experts was convened to develop guidelines for clinicians and research.Pre-meeting survey questions encompassing (...) five domains; indications, preparation, performance, interpretation of results, and knowledge gaps, were sent to 17 clinician-scientists, and 10 attended a live meeting. Using an evidence-based approach, 28 statements were finalized and voted on anonymously by a working group of specialists.Consensus was reached on 26 statements encompassing all five domains. Consensus doses for lactulose, glucose, fructose and lactose BT were 10, 75, 25 and 25 g, respectively. Glucose and lactulose BTs remain

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2017 American Journal of Gastroenterology

7. Small intestinal bacterial overgrowth as an uncommon cause of false positive lactose hydrogen breath test among patients with diarrhea-predominant irritable bowel syndrome in Asia. (PubMed)

Small intestinal bacterial overgrowth as an uncommon cause of false positive lactose hydrogen breath test among patients with diarrhea-predominant irritable bowel syndrome in Asia. It has been reported that small intestinal bacterial overgrowth (SIBO) may lead to false positive diagnoses of lactose malabsorption (LM) in irritable bowel syndrome patients. The aim of this study was to determine the influence of SIBO on lactose hydrogen breath test (HBT) results in these patients.Diarrhea (...) -predominant irritable bowel syndrome patients with abnormal lactose HBTs ingested a test meal containing (99m) Tc and lactose. The location of the test meal and the breath levels of hydrogen were recorded simultaneously by scintigraphic scanning and lactose HBT, respectively. The increase in hydrogen concentration was not considered to be caused by SIBO if ≥ 10% of (99m) Tc accumulated in the cecal region at the time or before of abnormal lactose HBT.LM was present in 84% (31/37) of irritable bowel

2015 Journal of gastroenterology and hepatology

8. Hydrogen excretion in pediatric lactose malabsorbers: relation to symptoms and the dose of lactose (PubMed)

Hydrogen excretion in pediatric lactose malabsorbers: relation to symptoms and the dose of lactose Lactose malabsorption arises from lactase deficiency and may lead to lactose intolerance - gastrointestinal symptoms after lactose ingestion. Occurrence and severity of the symptoms are influenced by many factors, including the dose of lactose and the intensity of its colonic fermentation to short chain fatty acids and gases.The hydrogen breath test (HBT) after 30 g or 50 g of lactose (...) was performed in 387 children. Further analysis included children who had a positive HBT result. The HBT parameters were net hydrogen concentration in each breath and total net hydrogen concentration during the HBT. The time of the first hydrogen rise was also calculated. HBT parameters were analyzed according to symptoms occurrence (lack or present), symptoms severity (lack, moderate or severe) and the dose of lactose (30 g or 50 g).One hundred and six children (12.1 years, 46 boys) had a positive HBT

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2016 Archives of medical science : AMS

9. Meta-analysis: the diagnostic accuracy of lactose breath hydrogen or lactose tolerance tests for predicting the North European lactase polymorphism C/T-13910. (PubMed)

Meta-analysis: the diagnostic accuracy of lactose breath hydrogen or lactose tolerance tests for predicting the North European lactase polymorphism C/T-13910.   The diagnostic accuracy of two indirect tests of lactose digestion, lactose breath hydrogen and lactose tolerance tests, have not been systematically reviewed for comparison with available publications on genotype.  To perform a meta-analysis of available studies that compares the north-European genetic polymorphism C/T-13910 (...) with the lactose breath hydrogen and the lactose tolerance tests, to determine their ability to predict geno/phenotype relationships. We examine the effects of lactose loading dose, inclusion of children and latitudes of study centre on comparative outcome.  An electronic database of the literature as well as individual references in articles were searched with the theme of genetics of lactase and comparisons with breath or lactose tolerance tests were carried out. Random effect and fixed effect models were

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2012 Alimentary pharmacology & therapeutics

10. Breath hydrogen test for detecting lactose malabsorption in infants and children. Prevalence of lactose malabsorption in Japanese children and adults. (PubMed)

Breath hydrogen test for detecting lactose malabsorption in infants and children. Prevalence of lactose malabsorption in Japanese children and adults. The breath hydrogen test (BHT) was adapted for use in young infants and children. The diagnostic criterion of sugar malabsorption in the BHT was determined by oral administration of 0.5 g/kg of unabsorbable sugar (lactulose) to 21 healthy infants and children. A maximum increase in breath hydrogen less than 0.05 ml/min per m2 was observed in all (...) subjects. A good correlation between results by the BHT and by the ordinary lactose tolerance test was obtained after oral administration of 2 g/kg lactose to 21 healthy infants and children, 2 congenital lactase-deficient infants, and 7 adults. Using this test, 80 healthy Japanese infants and children (aged between one month and 15 years) and 18 adults were examined for lactose malabsorption after a dose of 1 g/kg lactose. All infants and children under 2-years old absorbed lactose completely

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1979 Archives of Disease in Childhood

11. Lactose Breath Hydrogen Test

Lactose Breath Hydrogen Test Lactose Breath Hydrogen Test Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Lactose Breath Hydrogen Test (...) Lactose Breath Hydrogen Test Aka: Lactose Breath Hydrogen Test II. Indications testing III. Efficacy Preferred over : 90% IV. Technique Measure baseline breath hydrogen concentration Patient ingests lactose Classic: 25 to 50 grams lactose Physiologic: 12 grams lactose (same as in 8 oz milk) Measure breath hydrogen concentration in 3 to 8 hours Increase >20 ppm suggests V. False negative causes Gastrointestinal flora absent (e.g. recent antibiotics) VI. False positive causes Recent use smoking VII

2015 FP Notebook

12. Lactose intolerance, detected by the hydrogen breath test, in infants and children with chronic diarrhoea (PubMed)

Lactose intolerance, detected by the hydrogen breath test, in infants and children with chronic diarrhoea 931422 1978 01 27 2018 11 13 1468-2044 52 10 1977 Oct Archives of disease in childhood Arch. Dis. Child. Lactose intolerance, detected by the hydrogen breath test, in infants and children with chronic diarrhoea. 766-71 Maffei H V HV Metz G G Bampoe V V Shiner M M Herman S S Brook C G CG eng Journal Article England Arch Dis Child 0372434 0003-9888 7YNJ3PO35Z Hydrogen IM Adolescent Breath (...) Tests methods Celiac Disease complications Child Child, Preschool Chronic Disease Diarrhea complications Humans Hydrogen analysis Infant Intestinal Mucosa pathology Jejunum pathology Lactose Intolerance complications diagnosis Prognosis 1977 10 1 1977 10 1 0 1 1977 10 1 0 0 ppublish 931422 PMC1544801 Lancet. 1964 May 2;1(7340):981 14121364 N Engl J Med. 1964 Nov 12;271:1033-7 14195755 Pediatrics. 1964 Jul;34:38-50 14181983 Lancet. 1976 Mar 27;1(7961):668-9 73641 Lancet. 1976 Sep 18;2(7986):636 61374

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1977 Archives of Disease in Childhood

13. Significance of hydrogen breath tests in children with suspected carbohydrate malabsorption. (PubMed)

Significance of hydrogen breath tests in children with suspected carbohydrate malabsorption. Hydrogen breath tests are noninvasive procedures frequently applied in the diagnostic workup of functional gastrointestinal disorders. Here, we review hydrogen breath test results and the occurrence of lactose, fructose and sorbitol malabsorption in pediatric patients; and determine the significance of the findings and the outcome of patients with carbohydrate malabsorption.We included 206 children (88 (...) male, 118 female, median age 10.7 years, range 3-18 years) with a total of 449 hydrogen breath tests (lactose, n = 161; fructose, n = 142; sorbitol, n = 146) into a retrospective analysis. Apart from test results, we documented symptoms, the therapeutic consequences of the test, the outcome and the overall satisfaction of the patients and families.In total, 204 (46%) of all breath tests were positive. Long-term follow-up data could be collected from 118 patients. Of 79 patients (67%) who were put

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2014 BMC Pediatrics

14. Investigate the Breath Hydrogen Exhalation After a Test Meal Containing Isomaltulose or Sucrose in Infants

Investigate the Breath Hydrogen Exhalation After a Test Meal Containing Isomaltulose or Sucrose in Infants Investigate the Breath Hydrogen Exhalation After a Test Meal Containing Isomaltulose or Sucrose in Infants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Investigate the Breath Hydrogen Exhalation After a Test Meal Containing Isomaltulose or Sucrose in Infants The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02247102 Recruitment Status : Unknown Verified December 2014 by Tel-Aviv Sourasky Medical

2014 Clinical Trials

15. Efficacy of Hydrogen Breath Test in the Patients With Irritable Bowel Syndrome

. The breath sample will be analyzed for hydrogen or methane content to determine if you are able to properly break down the lactose, fructose or sucrose, or if you have bacterial overgrowth. irritable bowel syndrome group Device: Glucose breath test (hydrogen breath test) Glucose breath test (hydrogen breath test) is the current gold standard for diagnosis of irritable bowel syndrome. Glucose is a sugar that will be broken down by bacteria if present in the small bowel with hydrogen or methane gas (...) as a by-product. The breath sample will be analyzed for hydrogen or methane content to determine if you are able to properly break down the lactose, fructose or sucrose, or if you have bacterial overgrowth. Outcome Measures Go to Primary Outcome Measures : The difference of H2 elevation level through the hydrogen breath test between the irritable bowel syndrome patients and the normal people [ Time Frame: Within the 24 hours after 8-12 hours fasting ] The difference of H2 elevation level through the hydrogen

2014 Clinical Trials

16. Clinical Utility of Breath Tests in GI

Study Details Study Description Go to Brief Summary: Bloating, gas, pain and diarrhea are common complaints. Routine investigations are negative; these patients are labeled as IBS. In these patients, whether testing for carbohydrate malabsorption or small intestinal bacterial overgrowth (SIBO) is useful is unclear. We aim to assess the prevalence of SIBO, fructose and lactose intolerance, the usefulness of breath tests, and predictive value of pre-test symptoms. Condition or disease Small Intestinal (...) unknown. Also may the clinical utility of performing a single breath test versus a cumulative battery of breath tests, such as glucose, lactose or fructose breath test, in a patient with unexplained GI symptoms is also not known. The aims of our study are to investigate a consecutive series of patients with unexplained chronic GI symptoms and examine; 1) the prevalence of SIBO answered by the glucose breath test, fructose and lactose intolerance answered by the fructose y lactose breath test, ; 2

2017 Clinical Trials

17. The First Report about the Laparoscopic Sleeve Gastrectomy-Induced Lactose Intolerance. (PubMed)

The First Report about the Laparoscopic Sleeve Gastrectomy-Induced Lactose Intolerance. The impact of laparoscopic sleeve gastrectomy (LSG) on the lactose intolerance (LI) remains unclear. We checked 8 men and 34 women with mean body mass index (BMI) of 43.94 ± 5.89 kg/m2 for LI using hydrogen breath test and clinical examination before LSG and at 3 months postoperation. In addition to appropriate weight loss (34.30 ± 5.51 kg/m2), 1 man and 3 women, who had not LI at starting, were suffered

2019 Obesity Surgery

18. Evaluation of the Efficacy, Durability, Safety, and Tolerability of RP-G28 in Patients With Lactose Intolerance

periods and consuming dairy in other periods; Patient meets the defined minimum lactose intolerance symptom composite score; and Patient has positive Hydrogen Breath Test (HBT) results for lactase deficiency. Exclusion Criteria: Patient has a disorder associated with abnormal gastrointestinal motility such as gastroparesis (from any cause), amyloidosis, neuromuscular diseases (including Parkinson's disease), collagen vascular diseases, uremia, or malnutrition; Patient has undergone bowel preparation (...) Evaluation of the Efficacy, Durability, Safety, and Tolerability of RP-G28 in Patients With Lactose Intolerance Evaluation of the Efficacy, Durability, Safety, and Tolerability of RP-G28 in Patients With Lactose Intolerance - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2018 Clinical Trials

19. Effect of Probiotic Supplementation on Lactose Maldigestion Induced by Fat-free Milk

Information provided by (Responsible Party): Danisco Study Details Study Description Go to Brief Summary: The main objective of the study is to investigate the effect of probiotic supplementation on lactose maldigestion. Condition or disease Intervention/treatment Phase Gastrointestinal Symptoms Breath Test Dietary Supplement: Probiotic Dietary Supplement: Lactrase Other: Placebo Not Applicable Detailed Description: Primary endpoint is defined as the difference in breath hydrogen concentration (BHC, ppm (...) ) in lactase and probiotic groups compared to placebo and non-inferiority in breath hydrogen concentration (BHC, ppm) in probiotic group compared to lactase group, measured by the incremental area under curve (iAUC) analysis. To characterize the benefit of the investigational product (IP) the following secondary endpoints will be analyzed: Breath test: Breath hydrogen peak value (ppm) in lactase and probiotic groups compared to placebo Cumulative breath hydrogen (ppm) in lactase and probiotic groups

2018 Clinical Trials

20. [Effects of milk with inulin and vitamin D_3 on bone health and gastrointestine symptoms in lactose intolerance population]. (PubMed)

[Effects of milk with inulin and vitamin D_3 on bone health and gastrointestine symptoms in lactose intolerance population]. To investigate the effects of milk with inulin and vitamin D3 on bone health and gastrointestinal symptoms in lactose intolerance( LI) population.A total of 42 volunteers diagnosed as LI by breath hydrogen test were randomized into A or B group. Whole milk supplemented with inulin( 150 mg /100 g), vitamin D3( 2. 0μg /100 g), casein phosphopeptides( 5. 0 mg /100 m L), milk (...) minerals( 40 mg /100 g), and low-lactose whole milk were given to A or B groups respectively. Bone mass density( BMD), calcium absorption and gastrointestinal symptoms were measured at the 0th and6 th week of the intervention.After 6 weeks, BMD increased significantly in group A( P = 0. 013). In group B, BMD also increased but the trend was not significant. Calcium absorption increased in group A but decreased slightly in group B, the trends in both groups lacked of statistic significant

2018 Wei sheng yan jiu = Journal of hygiene research Controlled trial quality: uncertain

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