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Lactation Vitamin Supplementation

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1. Iron, Zinc, and Vitamin D Supplementation During Breastfeeding

of breastfeeding mothers and their infants: A 6-month follow-up pilot study. Breastfeed Med 2006;1:59–70. 39. HollisBW,WagnerCL,HowardCR,etal.Maternalversus infant vitamin D supplementation during lactation: A ran- domized controlled trial. Pediatrics 2015;136:625–634. 40. Oberhelman SS, Meekins ME, Fischer PR, et al. Maternal vitamin D supplementation to improve the vitamin D status of breast-fed infants: A randomized controlled trial. Mayo Clin Proc 2013;88:1378–1387. 41. March KM, Chen NN, Karakochuk CD, et (...) such as prematurity. In contemporary high- and low- resource settings, concern has been raised regarding iron, zinc, and vitamin D status of human milk-fed infants. This protocolreviewstheavailableevidenceregardingiron,zinc, and vitamin D supplementation of the breastfeeding dyad. Quality of evidence (levels of evidence [LOE] IA, IB, IIA, IIB, III, and IV) is provided and based on levels of evidence used for the National Guidelines Clearing House. 1 From currentlyavailable evidence,recommendationsareprovided

2018 Academy of Breastfeeding Medicine

2. Correlation of 25-Hydroxyvitamin D Levels in Serum vs. Breastmilk in Vitamin D-Supplementation Breastfeeding Women during Lactation: Randomized Double Blinded Control Trial. (Abstract)

status and breast-feeding milk.This was a randomized, placebo–controlled study of Thai pregnant women in their third trimester. A total of 76 Thai lactating mothers and their breast-fed infants were studied with maternal 25 Hydroxyvitamin D 25 (OH) D levels of 10-30 ng/ml determined using Liquid Chromatography Mass Spectrometry Tandem (LC-MS/MS). One group received vitamin D3 1,800 IU/d supplementation for 6 weeks, and members of the other group were given a placebo. 25 (OH) D level of colostum and 6 (...) -MS/MS) method. Breast-fed milk did not show any significant incremental change in 25 (OH) D levels measured by High Performance Liquid Chromatography (HPLC); however, the change in 25 (OH) D levels in breast milk in the VD group was significantly different from that of the placebo group (p = 0.005).`Vitamin D3 supplementation during lactation can increase 25 (OH) D levels in Thai breast-fed mothers. Further work is needed to determine the duration of vitamin D supplementation to normalize breast

2019 Journal of the Medical Association of Thailand = Chotmaihet thangphaet Controlled trial quality: predicted high

3. Randomized controlled trial: Maternal postpartum high-dose vitamin D3 supplementation (6400?IU/day) or conventional infant vitamin D3 supplementation (400?IU/day) lead to similar vitamin D status of healthy exclusively/fully breastfeeding infants by 7?mon

supplementation (400 IU/day) lead to similar vitamin D status of healthy exclusively/fully breastfeeding infants by 7 months of age Daniel E Roth Statistics from Altmetric.com Commentary on: Hollis BW , Wagner CL , Howard CR , et al . Maternal versus infant vitamin D supplementation during lactation: a randomized controlled trial . Context Routine vitamin D supplementation (400 IU/day) of breastfed infants has been recommended in North America for >50 years. 1 Historically, the practice was advocated (...) Randomized controlled trial: Maternal postpartum high-dose vitamin D3 supplementation (6400?IU/day) or conventional infant vitamin D3 supplementation (400?IU/day) lead to similar vitamin D status of healthy exclusively/fully breastfeeding infants by 7?mon Maternal postpartum high-dose vitamin D3 supplementation (6400 IU/day) or conventional infant vitamin D3 supplementation (400 IU/day) lead to similar vitamin D status of healthy exclusively/fully breastfeeding infants by 7 months of age | BMJ

2016 Evidence-Based Medicine

4. The Effect of High-Dose Postpartum Maternal Vitamin D Supplementation Alone Compared with Maternal Plus Infant Vitamin D Supplementation in Breastfeeding Infants in a High-Risk Population. A Randomized Controlled Trial. Full Text available with Trip Pro

95 exclusively breastfeeding mother-infant pairs with high prevalence of vitamin D deficiency was to compare the effect of six-month post-partum vitamin D3 maternal supplementation of 6000 IU/day alone with maternal supplementation of 600 IU/day plus infant supplementation of 400 IU/day on the vitamin D status of breastfeeding infants in Doha, Qatar. Serum calcium, parathyroid hormone, maternal urine calcium/creatinine ratio and breast milk vitamin D content were measured. At baseline, the mean (...) The Effect of High-Dose Postpartum Maternal Vitamin D Supplementation Alone Compared with Maternal Plus Infant Vitamin D Supplementation in Breastfeeding Infants in a High-Risk Population. A Randomized Controlled Trial. In view of continuing reports of high prevalence of severe vitamin D deficiency and low rate of infant vitamin D supplementation, an alternative strategy for prevention of vitamin D deficiency in infants warrants further study. The aim of this randomized controlled trial among

2019 Nutrients Controlled trial quality: uncertain

5. Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth. Full Text available with Trip Pro

Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth. It is unclear whether maternal vitamin D supplementation during pregnancy and lactation improves fetal and infant growth in regions where vitamin D deficiency is common.We conducted a randomized, double-blind, placebo-controlled trial in Bangladesh to assess the effects of weekly prenatal vitamin D supplementation (from 17 to 24 weeks of gestation until birth) and postpartum vitamin D supplementation on the primary outcome (...) of infants' length-for-age z scores at 1 year according to World Health Organization (WHO) child growth standards. One group received neither prenatal nor postpartum vitamin D (placebo group). Three groups received prenatal supplementation only, in doses of 4200 IU (prenatal 4200 group), 16,800 IU (prenatal 16,800 group), and 28,000 IU (prenatal 28,000 group). The fifth group received prenatal supplementation as well as 26 weeks of postpartum supplementation in the amount of 28,000 IU (prenatal

2018 NEJM Controlled trial quality: predicted high

6. Influence of daily 10-85 μg vitamin D supplements during pregnancy and lactation on maternal vitamin D status and mature milk antirachitic activity. Full Text available with Trip Pro

Influence of daily 10-85 μg vitamin D supplements during pregnancy and lactation on maternal vitamin D status and mature milk antirachitic activity. Pregnant and lactating women and breastfed infants are at risk of vitamin D deficiency. The supplemental vitamin D dose that optimises maternal vitamin D status and breast milk antirachitic activity (ARA) is unclear. Healthy pregnant women were randomised to 10 (n 10), 35 (n 11), 60 (n 11) and 85 (n 11) µg vitamin D3/d from 20 gestational weeks (...) (GW) to 4 weeks postpartum (PP). The participants also received increasing dosages of fish oil supplements and a multivitamin. Treatment allocation was not blinded. Parent vitamin D and 25-hydroxyvitamin D (25(OH)D) were measured in maternal plasma at 20 GW, 36 GW and 4 weeks PP, and in milk at 4 weeks PP. Median 25(OH)D and parent vitamin D at 20 GW were 85 (range 25-131) nmol/l and 'not detectable (nd)' (range nd-40) nmol/l. Both increased, seemingly dose dependent, from 20 to 36 GW

2019 The British journal of nutrition Controlled trial quality: uncertain

7. Combined consumption of a single high-dose vitamin A supplement with provision of vitamin A fortified oil to households maintains adequate milk retinol concentrations for 6 months in lactating Moroccan women. (Abstract)

Combined consumption of a single high-dose vitamin A supplement with provision of vitamin A fortified oil to households maintains adequate milk retinol concentrations for 6 months in lactating Moroccan women. In Morocco, post-partum women systematically receive a single high-dose of vitamin A (VA) (200 000 IU) within the first month of giving birth and vegetable oil is fortified to increase the VA intake. The efficacy of this combined approach of supplementation and fortification for increasing (...) maternal VA status during lactation is not known. The purpose of the study is to evaluate the effect of post-partum high dose VA supplementation and provision of VA fortified oil for household consumption on plasma and milk retinol concentrations of lactating Moroccan women during the first 6 mo post-partum. Post-partum women aged 19-40 y received a VA supplement and thereafter were randomly assigned to one of two groups to receive weekly vitamin A Fortified Oil (FO) or Non-Fortified Oil (NFO) for 6

2019 Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme Controlled trial quality: uncertain

8. Breastfeeding and vitamin D supplementation reduce the risk of Kawasaki disease in a German population-based case-control study. Full Text available with Trip Pro

Breastfeeding and vitamin D supplementation reduce the risk of Kawasaki disease in a German population-based case-control study. In Kawasaki disease (KD), a vasculitis of unknown etiology, the most serious complication is the development of coronary artery aneurysm (CAA). To date, the exact pathomechanism of KD is unknown. Both environmental and genetic factors seem to be associated with the development of the disease.Data on KD patients recruited from the population-based German Pediatric (...) Surveillance Study during 2012-2014 were used to evaluate the impact of various factors from the perinatal and infancy period on the development of KD. The study design was a matched case-control study with respect to age, sex and place of residence (n = 308 KD cases, n = 326 controls). All KD patients were individually re-evaluated; all fulfilled the international diagnostic KD criteria. A standardized questionnaire was used to review breastfeeding practices, vitamin D supplementation and birth

2019 BMC Pediatrics

9. Longitudinal study on the effectiveness of vitamin D supplements in exclusively breast-fed infants Full Text available with Trip Pro

Longitudinal study on the effectiveness of vitamin D supplements in exclusively breast-fed infants Vitamin D deficiency is a common health problem in infancy. Breast-fed infants are at a higher risk of rickets than formula-fed infants. We observed fluctuations in vitamin D levels in infancy (phase I, 2009-2010) and considered the benefits of vitamin D supplementation specifically in exclusively breast-fed infants in Japan (phase II, 2015). Infants born at our hospital were enrolled (...) in this study. In phase I, we measured 25-hydroxyvitamin D [25(OH)D] levels at 1- to 6-mo intervals from birth. In phase II, we measured 25(OH)D levels before and after supplementation. Vitamin D deficiency was defined as 25(OH)D levels of < 20 ng/mL. All 38 infants in phase I were deficient at birth, and none of the exclusively breast-fed infants achieved 25(OH)D sufficiency by 5 mo of age. Formula-fed infants achieved 25(OH)D sufficiency earlier. The majority of the 71 infants in phase II were deficient

2017 Clinical Pediatric Endocrinology

10. Adult scurvy associated with psychiatric disorders and breast feeding Full Text available with Trip Pro

and ongoing breast feeding, presented with a 10-day history of spontaneous haematomas in the lower limbs, gingivorrhagia and fatigue. The examination was remarkable for signs of minor bleeding without haemodynamic compromise, gonalgia and pale skin. Work-up studies revealed the presence of anaemia. Direct anamnesis identified a diet based solely of tea and carbohydrates due to distorted body image. With the working diagnosis of scurvy, nutritional support and oral vitamin C supplementation was initiated (...) Adult scurvy associated with psychiatric disorders and breast feeding Scurvy is a nutritional disease caused by ascorbic acid deficiency and is potentially fatal. It was originally described in the 18th century by James Lind and associated with long sea voyages and insufficient citrus consumption. Its prevalence has declined markedly over the years but has still been described sporadically in certain countries. A 22-year-old woman with an anxiety disorder and anorexia nervosa, recent pregnancy

2018 BMJ case reports

11. Community pharmacists' services for women during pregnancy and breast feeding in Kuwait: a cross-sectional study. Full Text available with Trip Pro

Community pharmacists' services for women during pregnancy and breast feeding in Kuwait: a cross-sectional study. This study was designed to identify the services provided by community pharmacists in Kuwait and their views regarding self-care in pregnancy and lactation. In addition, it determined the pharmacists' recommendations for treatment of pregnancy-related and breast feeding-related ailments.Cross-sectional questionnaire-based survey.Community pharmacies in Kuwait.207 pharmacies were (...) randomly selected from the Ministry of Health database. One registered pharmacist was approached from each pharmacy. One hundred and ninety-two (92.8%) pharmacists agreed to participate and completed a self-administered questionnaire.The proportions of pharmacists offering particular advice for health conditions in pregnancy and lactation, pharmacists' recommendations for common and specific ailments during pregnancy and breast feeding, and pharmacists' views about self-care in pregnancy and breast

2018 BMJ open

12. Risk of postneonatal mortality, hospitalisation and suboptimal breast feeding practices in low birthweight infants from rural Haryana, India: findings from a secondary data analysis. Full Text available with Trip Pro

infancy.Data from a large randomised controlled trial of neonatal vitamin A supplementation (Neovita) trial were used. Log binomial model was applied to assess association between birth weight and mortality, hospitalisation and breast feeding practices.Rural Haryana, North India.Newborns recruited in the primary intervention trial that aimed to evaluate the effect of single-dose oral vitamin A supplementation on mortality in the first 6 months of life.We recruited a total of 44 984 infants, of which 10 658 (...) Risk of postneonatal mortality, hospitalisation and suboptimal breast feeding practices in low birthweight infants from rural Haryana, India: findings from a secondary data analysis. Low birth weight (LBW) is a risk factor for neonatal mortality and morbidity. It is important to examine whether this risk persists beyond neonatal period. The current secondary data analysis aimed to examine association of birth weight with mortality, hospitalisation and breast feeding practices during

2018 BMJ open Controlled trial quality: predicted high

13. Hollis BW, Wagner CL, Howard CR, et al. Maternal Versus Infant Vitamin D Supplementation During Lactation: A Randomized Controlled Trial. Full Text available with Trip Pro

Hollis BW, Wagner CL, Howard CR, et al. Maternal Versus Infant Vitamin D Supplementation During Lactation: A Randomized Controlled Trial. 31253738 2019 07 23 1098-4275 144 1 2019 Jul Pediatrics Pediatrics Hollis BW, Wagner CL, Howard CR, et al. Maternal Versus Infant Vitamin D Supplementation During Lactation: A Randomized Controlled Trial. Pediatrics. 2015;136(4):625-634. e20191063 10.1542/peds.2019-1063 eng Journal Article Published Erratum United States Pediatrics 0376422 0031-4005

2019 Pediatrics Controlled trial quality: predicted high

14. Do Current Fortification and Supplementation Programs Assure Adequate Intake of Fat-Soluble Vitamins in Belgian Infants, Toddlers, Pregnant Women, and Lactating Women? Full Text available with Trip Pro

Do Current Fortification and Supplementation Programs Assure Adequate Intake of Fat-Soluble Vitamins in Belgian Infants, Toddlers, Pregnant Women, and Lactating Women? Abstracts: Adequate intakes of fat-soluble vitamins are essential to support the growth and development of the foetus, the neonate, and the young child. By means of an online self-administered frequency questionnaire, this study aimed to evaluate the intake of vitamins A, D, E, and K in Belgian infants (n = 455), toddlers (n (...) = 265), pregnant women (n = 161), and lactating women (n = 165). The contribution of foods, fortified foods, and supplements on the total intake was quantified. 5% of toddlers, 16% of pregnant women, and 35% of lactating women had an inadequate vitamin A intake. Conversely, excessive vitamin A intakes were associated with consumption of liver (products). Furthermore, 22% of infants were at risk for inadequate vitamin D intake due to the lack of prophylaxis, while consumption of highly dosed

2018 Nutrients

15. Psoriasis in those planning a family, pregnant or breast-feeding. The Australasian Psoriasis Collaboration. (Abstract)

Psoriasis in those planning a family, pregnant or breast-feeding. The Australasian Psoriasis Collaboration. The Australasian Psoriasis Collaboration has reviewed the evidence for managing moderate to severe psoriasis in those who are pregnant or are breast-feeding, or planning a family. The severity of the psoriasis, associated comorbidities and specific anti-psoriasis treatment, along with other exposures, can have a deleterious effect on pregnancy outcomes. Psoriasis itself increases the risk (...) of preterm and low birthweight babies, along with spontaneous and induced abortions, but no specific birth defects have been otherwise demonstrated. The baseline risk for a live born baby to have a major birth defect is 3%, and significant neuro-developmental problem is 5%. In Australia, pregnant women with psoriasis are more likely to be overweight or obese, depressed, or smoke in their first trimester, and are also less likely to take prenatal vitamins or supplements. Preconception counselling

2017 Australasian Journal of Dermatology

16. Vitamin D supplementation in pregnant or breastfeeding women or young children for preventing asthma [Cochrane protocol]

Vitamin D supplementation in pregnant or breastfeeding women or young children for preventing asthma [Cochrane protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

17. Vitamin D: increasing supplement use in at-risk groups

Vitamin D: supplement use in specific population groups (PH56) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 5 of 54This guideline partially replaces PH11 and CG62. Ov Overview erview This guideline covers vitamin D supplement use. It aims to prevent vitamin D deficiency among specific population groups including infants and children aged under 4, pregnant and breastfeeding women, particularly teenagers and young (...) whether there are any risks to infants from taking a supplement containing the RNI when they are consuming more than 500 ml of infant formula per day. Be aware that the complexity of existing advice (based on feeding type and maternal supplementation) may hinder uptake. Make it clear which type of supplement most people would benefit from. Be aware that people may be more likely to take a vitamin D-only supplement than one that is combined with calcium. Supplements containing vitamin D and calcium may

2014 National Institute for Health and Clinical Excellence - Clinical Guidelines

19. Breastfeeding woman are at higher risk of vitamin D deficiency than non-breastfeeding women - insights from the German VitaMinFemin study Full Text available with Trip Pro

to non-pregnant and non-breastfeeding (NPNB) women.This cross-sectional study investigated 124 breastfeeding women and 124 age and season matched NPNB women from the German "Vitamin and mineral status among German women" study. The study participants were recruited from April 2013 to March 2015 and did not take vitamin D supplements. Serum 25(OH)D was analyzed by chemiluminescent immunoassay.Vitamin D deficiency (<25.0 nmol/L) was prevalent in 26.6% of the breastfeeding women. The majority of women (...) Breastfeeding woman are at higher risk of vitamin D deficiency than non-breastfeeding women - insights from the German VitaMinFemin study Despite increased awareness of the adverse health effects of vitamin D deficiency, only a few studies have evaluated the vitamin D status (25-hydroxyvitamin D [25(OHD)]) of breastfeeding women and up to now, no information exits for German breastfeeding women. Therefore, the aim of study was to determine the vitamin D status of breastfeeding women compared

2017 International Breastfeeding Journal

20. Breastfeeding Programs and Policies, Breastfeeding Uptake, and Maternal Health Outcomes in Developed Countries

staff in skills necessary to implement this policy. 3. Inform all pregnant women about the benefits and management of breastfeeding. 4. Help mothers initiate breastfeeding within 1 hour of birth. 5. Show mothers how to breastfeed and how to maintain lactation even if they should be separated from their infants. 6. Give infants no food or drink other than breast milk, unless medically indicated. 7. Practice rooming in—allow mothers and infants to remain together 24 hours a day. 8. Encourage (...) and policies, breastfeeding uptake, and maternal health outcomes in developed countries 4 Appendixes Appendix A. Literature Search Strategies and Yields Appendix B. PRISMA Appendix C. Relevance and Risk of Bias Assessments Appendix D. Strength of Evidence Tables Appendix E. Excluded Studies Appendix F. Breast Cancer Evidence Tables Appendix G. References for All Appendixes ES-1 Evidence Summary Background In reproductive physiology, lactation follows pregnancy; a growing body of evidence supports

2018 Effective Health Care Program (AHRQ)

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