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Lactation Suppression

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1. Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early stage breast cancer. Full Text available with Trip Pro

Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early stage breast cancer. Plasma arginine (ARG) levels are reduced in breast cancer, suggesting diminished systemic ARG availability. ARG and its product nitric oxide (NO) are important in early postoperative recovery due to its roles in immune function and wound healing. It remains unclear whether major surgery further diminishes systemic ARG availability due to enhanced (...) ARG catabolism and/or insufficient endogenous ARG synthesis negatively affecting NO synthesis in patients with early stage breast cancer.In 9 women with early stage breast malignancy and 9 healthy women with genetic predisposition to breast cancer, whole body ARG and citrulline (CIT) rates of appearances were measured to determine their production rates prior to and within 24 h after major breast surgery by stable isotope methodology in the postabsorptive and postprandial state. The conversions

2017 Clinical nutrition (Edinburgh, Scotland)

2. Reproductive Health Outcomes by Method of Breast Milk Feeding

, Davis Information provided by (Responsible Party): University of California, Davis Study Details Study Description Go to Brief Summary: The purpose of this research is to determine whether there are differences in ovarian suppression between women who are feeding at the breast compared with women who are pumping. In the main study, the aim is to compare reproductive health outcomes, including amenorrhea rates, duration of lactation, and resumption of sexual activity, between mothers who (...) are exclusively breastfeeding (i.e. feeding at the breast) and those who are pumping after a term or preterm delivery. In the sub-study, the aim is to determine the feasibility and acceptability of using urinary luteinizing hormone (LH) detection kits at home to detect ovulation in exclusively breastmilk feeding women. Condition or disease Breast Feeding Milk Expression, Breast Amenorrhea, Postpartum Detailed Description: Women will be recruited for this study during routine prenatal care. Interested

2018 Clinical Trials

3. Breastfeeding - Promoting and Supporting the Initiation, Exclusivity, and Continuation of Breastfeeding in Newborns, Infants and Young Children

) their partners G , family G , and support network G . The focus of this Guideline is breastfeeding which recognizes and includes the varied ways in which breast milk G may be fed to a newborn, infant, or young child. This includes direct breastfeeding, expressed breast milk (EBM) G , and/ or donor human milk. The use of formula supplementation or other manufactured infant and young child feeding products are included in the BPG only as clinically necessary and when breast or donor breast milk (...) Association ® IMS insufficient milk supply LATCH L = how well the baby latches A = audible number of swallows T = type of nipple C = comfort level with breastfeeding H = amount of assistance required when positioning the infant at the breast LC lactation consultant LEAARC Lactation Education Accreditation and Approval Review Committee LGBTQ lesbian, gay, bisexual, trans, and queer BACKGROUND7 BEST PRACTICE GUIDELINES • www.RNAO.ca BACKGROUND Breastfeeding - Promoting and Supporting the Initiation

2018 Registered Nurses' Association of Ontario

4. HIV viral suppression among pregnant and breastfeeding women in routine care in the Kinshasa province: a baseline evaluation of participants in CQI-PMTCT study. Full Text available with Trip Pro

HIV viral suppression among pregnant and breastfeeding women in routine care in the Kinshasa province: a baseline evaluation of participants in CQI-PMTCT study. Published data on viral suppression among pregnant and breastfeeding women in routine care settings are scarce. Here, we report provincial estimates of undetectable and suppressed viral load among pregnant or breastfeeding women in HIV care in Kinshasa, Democratic Republic of Congo (DRC) and associated risk factors.This cross-sectional (...) study was conducted as part of a baseline assessment for the CQI-PMTCT study: an ongoing cluster randomized trial to evaluate the effect of continuous quality interventions (CQI) on long-term ART outcomes among pregnant and breastfeeding women (NCT03048669). From November 2016 to June 2018, in each of the 35 Kinshasa provincial health zones (HZ), study teams visited the three busiest maternal and child health clinics, enrolled all HIV-positive pregnant or breastfeeding women (≤1 year post-delivery

2019 Journal of the International AIDS Society

5. Tenofovir concentrations in hair strongly predict virologic suppression in breastfeeding women. (Abstract)

Tenofovir concentrations in hair strongly predict virologic suppression in breastfeeding women. Antiretroviral treatment (ART) adherence is often suboptimal in the perinatal period. We measured hair tenofovir (TFV) concentrations as a metric of adherence in postpartum women to understand patterns and predictors of adherence throughout this critical period. Additionally, we examined the association between hair TFV concentrations and virologic outcomes.Between 12/2012-09/2016, hair samples were (...) collected longitudinally from delivery through breastfeeding from women on ART in the PROMISE study (NCT01061151) in sub-Saharan Africa. Hair TFV levels were measured using validated methods. Using generalized estimating equations, we estimated the association between hair TFV levels and virologic suppression (<400 copies/mL) over time and assessed predictors of hair TFV levels.Hair TFV levels were measured at 370 visits in 71 women from delivery through a median of 14 months (IQR 12-15

2019 AIDS

6. NHERF1 is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland. (Abstract)

NHERF1 is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland. Prior studies have demonstrated that the calcium pump, plasma membrane calcium ATPase 2 (PMCA2), mediates calcium transport into milk and prevents mammary epithelial cell death during lactation. PMCA2 also regulates cell proliferation and cell death in breast cancer cells, in part by maintaining the receptor tyrosine kinase ErbB2/HER2 within specialized plasma membrane domains (...) . Furthermore, the regulation of PMCA2 membrane localization and activity in breast cancer cells requires its interaction with the PDZ domain-containing scaffolding molecule sodium-hydrogen exchanger regulatory factor (NHERF) 1. In this study, we asked whether NHERF1 also interacts with PMCA2 in normal mammary epithelial cells during lactation. Our results demonstrate that NHERF1 expression is upregulated during lactation and that it interacts with PMCA2 at the apical membrane of secretory luminal

2019 Endocrinology

7. Guidelines for the management of pregnant and breastfeeding women in the context of Ebola virus disease

temperature full-cream (or whole) cow’s milk along with complementary feeding (this food can be supplemented with micronutrient powders if the nutrient content is expected to be inadequate). 3. Rapid testing of breast milk of women with recovered EVD, who would like to continue to breastfeed, should be prioritized. 4. Women’s choices related to stopping breastfeeding, or continuing after EVD recovery and testing of breast-milk, should be respected and supported by health care workers to facili- tate (...) or laboratory-confirmed EVD, with a mortality rate of 82%. Eight infants were breastfed by EVD-positive women but did not become ill (31–38). Other studies of four breast- fed infants did not identify if the mother or infant developed EVD first (31,33,34). However, Bower et al (35) found that of 14 mothers who clearly acquired EVD prior to their breastfed infants, 86% (n=12) of the exposed infants contracted EVD, with EVD status proving to be the greatest risk. Breastfeeding alone was not identified

2020 World Health Organisation Guidelines

8. Somatostatin-somatostatin receptor 2 signaling mediates LH pulse suppression in lactating rats. Full Text available with Trip Pro

Somatostatin-somatostatin receptor 2 signaling mediates LH pulse suppression in lactating rats. Follicular development and ovulation are profoundly suppressed during lactation in mammals. This suppression is suggested to be mainly due to the suckling-induced inhibition of kisspeptin gene (Kiss1) expression in the arcuate nucleus (ARC) and consequent inhibition of pulsatile GnRH/LH release. We examined whether central somatostatin (SST) signaling mediates the suckling-induced suppression (...) in the ARC. Furthermore, a central injection of an SSTR2 antagonist caused a significant increase in pulsatile LH release in lactating rats. Double labeling of Sstr2 and the neurokinin B gene, as a marker for ARC KNDy neurons, showed Sstr2 expression was abundantly detected in the ARC, but few KNDy neurons coexpressed Sstr2 in lactating rats. Taken together, these findings suggest the suckling-induced activation of SST-SSTR2 signaling mediates, at least in part, the suppression of pulsatile LH secretion

2018 Endocrinology

9. Inhibiting Glycine Decarboxylase Suppresses Pyruvate-to-Lactate Metabolism in Lung Cancer Cells Full Text available with Trip Pro

Inhibiting Glycine Decarboxylase Suppresses Pyruvate-to-Lactate Metabolism in Lung Cancer Cells Glycine decarboxylase (GLDC) gene is frequently upregulated in various types of cancer including lung, prostate and brain. It catabolizes glycine to yield 5,10-methylenetetrahydrofolate, an important substrate in one-carbon metabolism for nucleotide synthesis. In this study, we used exon splicing modulating steric hindrance antisense oligonucleotide (shAON) to suppress GLDC expression (...) and investigated its effect on pyruvate metabolism via hyperpolarized carbon-13 magnetic resonance spectroscopy (MRS). The MRS technique allows us to study in vivo metabolic flux in tumor tissues with/without GLDC-shAON intervention. Here, we show that GLDC-shAON treatment is able to suppress lung cancer cell growth and tumorigenesis, both in vitro and in vivo. The carbon-13 MRS results indicated that the conversion of pyruvate into lactate in GLDC-shAON-treated tumor tissues was significantly reduced, when

2018 Frontiers in oncology

10. D-lactic Acidosis: Successful Suppression of D-lactate-Producing <i>Lactobacillus</i> by Probiotics. Full Text available with Trip Pro

D-lactic Acidosis: Successful Suppression of D-lactate-Producing Lactobacillus by Probiotics. Intestinal microbiota composition in children with short bowel syndrome (SBS) is an important factor influencing the clinical outcome. An increase of D-lactate-producing bacteria can lead to D-lactic acidosis, also referred to as D-lactate encephalopathy, with severe neurologic impairment. Antibiotic treatments for D-lactic acidosis in children with SBS offer often only short-term relief. Here (...) , we present the case of a boy with SBS who developed recurrent episodes of D-lactic acidosis even under continuous cycling antibiotic treatment. Microbiological analyses were used to detect the presence of D-lactate-producing Lactobacillus species in the stool samples. A probiotic cocktail was introduced to alter the intestinal microbiota. During follow-up under treatment with probiotics, the patient remained stable, and there was no additional need for antibiotic therapy for more than a year

2018 Pediatrics

11. Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16INK4a inactivation Full Text available with Trip Pro

Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16INK4a inactivation The preferential use of aerobic glycolysis by tumor cells lead to high accumulation of lactate in tumor microenvironment. Clinical evidence has linked elevated lactate concentration with cancer outcomes. However, the role and molecular mechanisms of lactate in cellular senescence and tumor progression remain elusive.The function of Snail in lactate-induced EMT in lung cancer (...) cells was explored by wound healing assay and cell invasion assay. The qRT-PCR and dual luciferase reporter assay were performed to investigate how lactate regulates Snail expression. The level of TGF-β1 in culture supernatant of cells was measured by ELISA for its correlation with extracellular levels of lactate. Ras activity assay and SA-β-gal activity assay were established to determine the effect of lactate on oncogene-induced senescence in human lung epithelial cells. ChIP assays were conducted

2018 Journal of experimental & clinical cancer research : CR

12. Breast feeding: Guidance for staff assisting the mother

regarding the process of breastfeeding and confidence in their ability to breastfeed. Rationale 3: Sufficient rest, fluid and a balanced diet create the optimum conditions for the initiation and maintenance of lactation. Rationale 4: Comfort, privacy and a calm, supportive environment facilitate the let down reflex. Rationale 5: To initiate and maintain lactation if the baby is unable to suckle. Rationale 6: Incorrect use of the breast pump may result in breast and nipple trauma. Rationale 7: Correct (...) accommodation to prevent them having to walk to the hospital in the middle of the night. Rationale 18: Expression during the night is important for the maintenance of a healthy lactation. Rationale 19: Difficulties in establishing breastfeeding may stem from a lack of confidence, anxiety or physical discomfort. Rationale 20: Ineffective positioning will lead to a poor latch and ineffective breast feeding. Poor positioning is a common predisposing factor for sore nipples. Rationale 21: Engorged breasts

2009 Publication 1593

13. "I beg you…breastfeed the baby, things changed": infant feeding experiences among Ugandan mothers living with HIV in the context of evolving guidelines to prevent postnatal transmission. Full Text available with Trip Pro

"I beg you…breastfeed the baby, things changed": infant feeding experiences among Ugandan mothers living with HIV in the context of evolving guidelines to prevent postnatal transmission. For women living with HIV (WLWH) in low- and middle-income countries, World Health Organization (WHO) infant feeding guidelines now recommend exclusive breastfeeding until six months followed by mixed feeding until 24 months, alongside lifelong maternal antiretroviral therapy (ART). These recommendations (...) for all pregnant and breastfeeding women (Option B+). Content analysis was used to identify major themes. Infant feeding experiences was an emergent theme. NVivo 10 software was used to organize analyses.Among 20 women, median age was 33 years [IQR: 28-35], number of livebirths was 3 [IQR: 2-5], years on ART was 2.3 [IQR: 1.5-5.1], and 95% were virally suppressed. Data revealed that women valued opportunities to reduce postnatal transmission. However, women made infant feeding choices that differed

2018 BMC Public Health

14. Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity Full Text available with Trip Pro

Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity Naïve T cells are poorly studied in cancer patients. We report that naïve T cells are prone to undergo apoptosis due to a selective loss of FAK family-interacting protein of 200 kDa (FIP200) in ovarian cancer patients and tumor-bearing mice. This results in poor antitumor immunity via autophagy deficiency, mitochondria overactivation, and high reactive oxygen species (...) production in T cells. Mechanistically, loss of FIP200 disables the balance between proapoptotic and antiapoptotic Bcl-2 family members via enhanced argonaute 2 (Ago2) degradation, reduced Ago2 and microRNA1198-5p complex formation, less microRNA1198-5p maturation, and consequently abolished microRNA1198-5p-mediated repression on apoptotic gene Bak1 Bcl-2 overexpression and mitochondria complex I inhibition rescue T cell apoptosis and promoted tumor immunity. Tumor-derived lactate translationally

2017 Science immunology

15. Immune Modulating Therapies in Pregnancy and Lactation

not be used during pregnancy because of its teratogenic effects, after reports of associated facial malformations ( ). The metabolite of leflunomide (teriflunomide) remains detectable as long as 2 years after drug discontinuation. Breastfeeding and Infant Considerations The amount of medication transmitted into breast milk and the potential effect on the neonate are important considerations when the use of immunomodulating drugs is being considered for women who are lactating. In general, immunomodulating (...) drugs that are not contraindicated in pregnancy are compatible with breastfeeding. A multicenter prospective cohort study of breastfeeding women who received immunomodulating therapies for inflammatory bowel disease demonstrated low drug concentrations in breast milk and no evidence of increased risk of infection or adverse neurodevelopment in the infant ( ). Although some expert opinions recommend limiting exposure to these medications during lactation, data to support that practice are limited

2019 American College of Obstetricians and Gynecologists

16. Lactation Suppression

in suppressing the flow of her milk when breast-feeding is not desired. Service is billed in 15-minute increments. Concepts Therapeutic or Preventive Procedure ( T061 ) SnomedCT 43141007 English Therapeutic suppression of lactation , Lactation Suppression , Inhibition of lactation procedure , Suppressing milk , Suppression of lactation , Lactation suppression , Inhibition of lactation procedure (procedure) , Lactation suppression each 15 minutes , lact.suprxn ea.15min Spanish procedimiento de inhibición de (...) from a Bing search on the term "Lactation Suppression." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Therapeutic suppression of lactation (C0546981) Definition (NCI) Active suspension of lactation using a medical or physical intervention.(NICHD) Definition (NIC) Facilitating the cessation of milk production and minimizing breast engorgement after giving birth Definition (ALT) Assisting a client/patient

2018 FP Notebook

17. Effect of lactate administration on brain lactate levels during hypoglycemia in patients with type 1 diabetes. Full Text available with Trip Pro

Effect of lactate administration on brain lactate levels during hypoglycemia in patients with type 1 diabetes. Administration of lactate during hypoglycemia suppresses symptoms and counterregulatory responses, as seen in patients with type 1 diabetes and impaired awareness of hypoglycemia (IAH), presumably because lactate can substitute for glucose as a brain fuel. Here, we examined whether lactate administration, in a dose sufficient to impair awareness of hypoglycemia, affects brain lactate (...) to hypoglycemia were considerably suppressed in NAH. Infusion of lactate increased brain lactate levels modestly, but comparably, in both groups (mean increase in NAH w|lac: 0.12 ± 0.05 µmol/g and in IAH w|lac: 0.06 ± 0.04 µmol/g). The modest increase in brain lactate may suggest that the excess of lactate is immediately metabolized by the brain, which in turn may explain the suppressive effects of lactate on awareness of hypoglycemia observed in patients with NAH.

2018 Journal of Cerebral Blood Flow and Metabolism Controlled trial quality: uncertain

18. Breastfeeding Healthy Term Infants

. Intrapartum Care 9 V aginal Birth 9 Cesarean Birth 10 C. Postpartum Care 10 Key Points 10 2 to 24 hours 11 Guidelines to Assist Mothers to Breastfeed 12 Breastfeeding Positions and Preparation for Feeding .. 12 Infant Attachment on the Breast (Latch) 12 Attachment and Suckling Pattern 13 24 to 72 hours 13 Guidelines to Assess Breastfeeding 14 Breastfeeding Process 14 Maternal Assessment 14 Infant Assessment 14 Infant Weight Loss and Gain 15 Hand Expression 15 Pacifiers 16 Preparation for Hospital (...) duration but assist mothers to recognize the signs of milk transfer and their infant’s satiety 24 to 72 hours • Help mothers to recognize later infant feeding cues, i.e., fussing, squeaky noises, restlessness, progressing to soft intermittent crying 60 • Increase breastfeeding frequency to 8 or more times in 24 hours and offer both breasts per feeding to stimulate breastmilk production; breastfeed infant until satiated (may be 20 to 50 minutes) 38 • Assess a breastfeeding session until mother

2015 British Columbia Perinatal Health Program

19. Correlates of HIV detection among breastfeeding postpartum Kenyan women eligible under Option B. Full Text available with Trip Pro

), and detection in breast milk (>150 copies/mL) and endocervical secretions (>100 copies/mL) at 2 postpartum timepoints. Correlates of virologic failure were assessed using univariate tests and multivariate logistic regression.Of 42 women at 6-14 weeks postpartum, 21.4% of women had HIV RNA detected in plasma; 14.3% in breast milk, and 23.7% in endocervical secretions. At 18-24 weeks postpartum, the percentages were 21.1%, 7.1%, and 14.3%, respectively. Younger maternal age, intent to breastfeed for longer (...) Correlates of HIV detection among breastfeeding postpartum Kenyan women eligible under Option B. The Option B+ strategy streamlines delivery of HIV antiretroviral therapy (ART) to pregnant women, but concerns remain about ART treatment adherence and long term outcomes.We conducted a retrospective analysis of a cohort of HIV-positive, postpartum breastfeeding women receiving ART via Option B+ in Nairobi, Kenya. The primary outcome was virologic failure in plasma (HIV RNA >1000 copies/mL

2019 PLoS ONE

20. Safety in Lactation: Diuretics

Safety in Lactation: Diuretics Safety in Lactation: Diuretics – SPS - Specialist Pharmacy Service – The first stop for professional medicines advice Menu · · Published 24th February 2017 , updated 28th November 2018 Additional information relating to breastfeeding To be used in conjunction with individual drug entries for specific information and guidance . Thiazides and related diuretics (includes bendroflumethiazide, chlortalidone, cyclopenthiazide, hydrochlorothiazide, indapamide, metolazone (...) , short half life, high protein binding) . Loop diuretics (includes bumetanide, furosemide, torasemide) Loop diuretics may suppress lactation, although this is largely theoretical. Levels in milk of currently available loop diuretics have not been determined, but are likely to be too low to affect the infant. Monitor infant’s weight to determine adequate milk production. Furosemide preferred (most experience of use, short half life, high protein binding, low oral bioavailability) . Potassium-sparing

2017 Specialist Pharmacy Services

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