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Lacrimal Duct Obstruction

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1. Tobramycin/dexamethasone eye drops as a better choice for lacrimal duct probing in persistent congenital nasolacrimal duct obstruction: A consort study. Full Text available with Trip Pro

Tobramycin/dexamethasone eye drops as a better choice for lacrimal duct probing in persistent congenital nasolacrimal duct obstruction: A consort study. Congenital nasolacrimal duct obstruction (CNLDO) is common and. lacrimal duct probing is the major treatment. But persistent CNLDO in older children makes the success rate rapidly decreased due to long-term chronic inflammation. To improve the success rate, probing combined with tobramycin/dexamethasone ointment is considered effective (...) . But in practice, we found a lot of problems in using the ointment. So we tried tobramycin/dexamethasone eye drops as a replacement. The results is surprising, so we hope to do some further research in order to prove it is worth to clinical application.To evaluate the effect of lacrimal duct probing combined with tobramycin/dexamethasone eye drops or ointment on persistent CNLDO in children older than 1-year-old.This randomized controlled study included 409 subjects (496 eyes) older than 1-year-old

2019 Medicine Controlled trial quality: uncertain

2. Safety and Efficacy of the Slit Stent II Lacrimal Stent for the Treatment of Nasolacrimal Duct Obstruction

Safety and Efficacy of the Slit Stent II Lacrimal Stent for the Treatment of Nasolacrimal Duct Obstruction SLlt Stent II Lacrimal Stent for the Treatment of Nasolacrimal Duct Obstruction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. SLlt Stent II Lacrimal Stent for the Treatment of Nasolacrimal Duct Obstruction (SLINDO) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03705000 Recruitment Status : Recruiting First Posted

2018 Clinical Trials

3. Intervention using a novel biodegradable hollow stent containing polylactic acid-polyprolactone-polyethylene glycol complexes against lacrimal duct obstruction disease. Full Text available with Trip Pro

Intervention using a novel biodegradable hollow stent containing polylactic acid-polyprolactone-polyethylene glycol complexes against lacrimal duct obstruction disease. Lacrimal duct obstruction disease (LDOD) is a common ophthalmologic disease. Stent implantation surgery is one of the most effective therapies. In this study, we intended to find out the satisfactory biodegradable stents containing poly-L-lactic acid-polycaprolactone-polyethylene glycol (PLLA- PCL- PEG) complexes for therapeutic (...) application in LDOD. Stents made of PLLA- PCL- PEG complexes in various ratios, were prepared and used in vitro to determine stents with appropriate mechanical properties and shorter range of bio-degradation for study in vivo. Thirty-two rabbits were randomized into eight groups of four eyes each in advance for test in vivo. The selected stents were implanted into the left lacrimal ducts of 16 rabbits and silica gel stents as the control for the other 16 rabbits. At four points in time (1, 4, 10 and 16

2017 PLoS ONE

4. Probing for congenital nasolacrimal duct obstruction. Full Text available with Trip Pro

ranges from 5% to 20% and often resolves without surgery. Treatment options for this condition are either conservative therapy, including observation (or deferred probing), massage of the lacrimal sac and antibiotics, or probing the nasolacrimal duct to open the membranous obstruction at the distal nasolacrimal duct. Probing may be performed without anesthesia in the office setting or under general anesthesia in the operating room. Probing may serve to resolve the symptoms by opening the membranous (...) Probing for congenital nasolacrimal duct obstruction. Congenital nasolacrimal duct obstruction (NLDO) is a common condition causing excessive tearing in the first year of life. Infants present with excessive tearing or mucoid discharge from the eyes due to blockage of the nasolacrimal duct system, which can result in maceration of the skin of the eyelids and local infections, such as conjunctivitis, that may require antibiotics. The incidence of nasolacrimal duct obstruction in early childhood

2017 Cochrane

5. Endonasal versus external dacryocystorhinostomy for nasolacrimal duct obstruction. Full Text available with Trip Pro

Endonasal versus external dacryocystorhinostomy for nasolacrimal duct obstruction. A dacryocystorhinostomy (DCR) procedure aims to restore drainage of tears by bypassing a blockage in the nasolacrimal duct, through the creation of a bony ostium that allows communication between the lacrimal sac and the nasal cavity. It can be performed using endonasal or external approaches. The comparative success rates of these two approaches have not yet been established and this review aims to evaluate (...) GRADE.We included two trials in this review. One trial from Finland compared laser-assisted endonasal DCR with external DCR, and one trial from India compared mechanical endonasal DCR (using punch forceps) with external DCR. The trials were poorly reported and it was difficult to judge the extent to which bias had been avoided.Anatomic success was defined as the demonstration of a patent lacrimal passage on syringing, or endoscopic visualisation of fluorescein dye at the nasal opening

2017 Cochrane

6. A case of neglected silicone tube in lacrimal duct for 20 years Full Text available with Trip Pro

duct was observed under lacrimal micro-endoscopy, subjective and objective resolution of symptoms, including granulated tissue formation, was achieved after removal of the silicone tube and conservative medical treatment. Follow-up examinations performed over a 12-month period post treatment revealed no recurrence of epiphora or anatomical obstruction. Inspection of the lacrimal tube using the tension test revealed minimal changes in the tube in situ for 20 years.The findings in this case suggest (...) both the lacrimal system and the silicone tube are tolerant to prolonged intubation, as long as the tube had been placed properly with careful observation. Our findings may encourage physicians to consider prolonged intubation for select cases of nasolacrimal duct obstruction.

2018 American journal of ophthalmology case reports

7. Cytokine Profiles of Tear Fluid From Patients With Pediatric Lacrimal Duct Obstruction. Full Text available with Trip Pro

Cytokine Profiles of Tear Fluid From Patients With Pediatric Lacrimal Duct Obstruction. This study evaluated the cytokine levels in unilateral tear samples from both sides in patients with pediatric lacrimal duct obstruction.Fifteen cases of unilateral lacrimal duct obstruction (mean, 26.9 ± 28.7 months old) were enrolled in this study. Tear samples were collected separately from the obstructed side and the intact side in each case before surgery, which was performed under general anesthesia (...) or sedation. The levels of IL-2, IL-4, IL-6, IL-10, TNF, IFN-γ, and IL-17A then were measured in each tear sample. A receiver operating characteristic (ROC) curve was constructed for the IL-6 levels in the tears. We also measured the postoperative tear fluid levels of IL-6 in those cases from which tear fluid samples could be collected after the surgery.Only the IL-6 concentration was significantly higher on the lacrimal duct-obstructed sides, compared to the control sides (P < 0.001). An ROC curve

2017 Investigative Ophthalmology & Visual Science

8. An insertion mutation in HOXC13 underlies pure hair and nail ectodermal dysplasia with lacrimal duct obstruction. (Abstract)

An insertion mutation in HOXC13 underlies pure hair and nail ectodermal dysplasia with lacrimal duct obstruction. 29278420 2018 04 18 1365-2133 178 4 2018 Apr The British journal of dermatology Br. J. Dermatol. An insertion mutation in HOXC13 underlies pure hair and nail ectodermal dysplasia with lacrimal duct obstruction. e265-e267 10.1111/bjd.16276 Humbatova A A Institute of Human Genetics, University Hospital Bonn, Bonn, Germany. Institute of Genetic Resources, Azerbaijan, National Academy

2017 British Journal of Dermatology

9. Congenital nasolacrimal duct obstruction: Should we continue lacrimal massage till 1 year or perform an office probing at 6 months? A clinical decision analysis approach Full Text available with Trip Pro

Congenital nasolacrimal duct obstruction: Should we continue lacrimal massage till 1 year or perform an office probing at 6 months? A clinical decision analysis approach 28345576 2017 11 13 2018 12 02 1998-3689 65 2 2017 02 Indian journal of ophthalmology Indian J Ophthalmol Congenital nasolacrimal duct obstruction: Should we continue lacrimal massage till 1 year or perform an office probing at 6 months? A clinical decision analysis approach. 167-169 10.4103/ijo.IJO_245_16 Kothari Mihir M (...) of Pediatric Oculoplasty Services, Jyotirmay Eye Clinic and Ocular Motility Laboratory, Thane, Maharashtra, India. Singhania Renu R Department of Pediatric Oculoplasty Services, Jyotirmay Eye Clinic and Ocular Motility Laboratory, Thane, Maharashtra, India. eng Letter Comment India Indian J Ophthalmol 0405376 0301-4738 IM Indian J Ophthalmol. 2015 Oct;63(10 ):759-62 26654998 Dacryocystorhinostomy Decision Support Techniques Humans Infant Lacrimal Duct Obstruction congenital Massage Nasolacrimal Duct

2017 Indian journal of ophthalmology

10. High-resolution dacryoendoscopy for observation for pediatric lacrimal duct obstruction Full Text available with Trip Pro

High-resolution dacryoendoscopy for observation for pediatric lacrimal duct obstruction The aim of this study was to describe high-resolution dacryoendoscopy findings for nasolacrimal duct obstruction (NLDO) in three representative pediatric cases with different etiologies.In a case of congenital NLDO, a mucosal membranous obstruction was observed at the distal end of the nasolacrimal duct (NLD), and a slit-shaped opening of the NLD was observed after perforation. In a case of acquired NLDO (...) secondary to an adenoviral infection, a membranous obstruction was observed at the proximal NLD. In a case of NLDO with chronic dacryocystitis in a patient with Down syndrome, diffuse fibrous obstruction was observed.High-resolution dacryoendoscopy enables a clearer visualization of pediatric lacrimal duct obstructions, leading to an improved understanding of their features.

2016 American journal of ophthalmology case reports

11. Lacrimal Gland Repair after Short-term Obstruction of Excretory Duct in Rabbits Full Text available with Trip Pro

Lacrimal Gland Repair after Short-term Obstruction of Excretory Duct in Rabbits Aqueous tear-deficient dry eye is a multifactorial chronic disorder in which the lacrimal glands fail to produce enough tears to maintain a healthy ocular surface. The existence of lacrimal gland stem/progenitor cells was proposed in several species, yet their origin and characteristics are not very clear. Here, we investigated the presence of resident progenitor cells and their regenerative potential in a rabbit (...) model with lacrimal gland main excretory duct ligation-induced injury. The ligation-injured lacrimal glands temporarily decreased in weight and had impaired tear secretion. Protein expression profiles and transcriptional profiles were obtained from injured tissue. Isolated lacrimal gland progenitor cells were tested and characterized by stem cell-related marker evaluation, single cell clonal assay and three-dimensional (3-D) culture. The results of our study indicate that lacrimal glands are capable

2017 Scientific reports

12. Indian survey on practice patterns of lacrimal & eyelid disorders (iSUPPLE): Report 3 – Cataract and nasolacrimal duct obstruction Full Text available with Trip Pro

Indian survey on practice patterns of lacrimal & eyelid disorders (iSUPPLE): Report 3 – Cataract and nasolacrimal duct obstruction To assess the practice patterns pertaining to pre-cataract screening for nasolacrimal duct obstruction (NLDO) among oculoplastic surgeons in India. The survey was aimed at obtaining data on the current screening and treatment strategies for NLDO and the interval between lacrimal surgery and subsequent cataract surgery.An online survey was sent to all members (...) of Oculoplastic Association of India. All valid responses were tabulated and analyzed.Majority of the respondents (92%) felt that nasolacrimal duct patency should be checked prior to performing cataract surgery: 59.6% felt that checking for regurgitation on pressure over the lacrimal sac (ROPLAS) was sufficient and 32.6% preferred to perform lacrimal irrigation to check for NLD patency. Dacryocystorhinostomy (DCR) was the preferred surgery for NLDO thus detected. The preferred interval between a DCR

2017 Saudi Journal of Ophthalmology

13. Lacrimal Duct Obstruction

Lacrimal Duct Obstruction Lacrimal Duct Obstruction Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Lacrimal Duct Obstruction Lacrimal (...) Duct Obstruction Aka: Lacrimal Duct Obstruction , Dacryostenosis , Nasolacrimal Duct Obstruction From Related Chapters II. Definitions: Dacryostenosis Blocked tear ducts III. Signs Common in infants, with a build-up of yellow, sticky, non-purulent secretions IV. Management Infants respond to warm washcloth massage of inner canthus Adults should be evaluated by ophthalmology V. Complications See Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search

2018 FP Notebook

14. Long-term outcome of lacrimal stent intubation for complete acquired lacrimal drainage obstructions. (Abstract)

Long-term outcome of lacrimal stent intubation for complete acquired lacrimal drainage obstructions. To investigate long-term outcome and report reoperation rate of non-infected, complete acquired lacrimal drainage obstruction (ALDO) treated with canaliculodacryocystoplasty (CDCP) depending on site of stenosis.Consecutive adult patients with non-infected, complete ALDO treated with CDCP were followed for 76 months. Location of stenosis at preoperative visit and intraoperative probing (...) was recorded, and during follow-up, recurrence of stenosis prompting additional surgery and complications were noted. Survival analysis was applied to compare reoperation rate depending on site of stenosis. A follow-up questionnaire was sent to patients not requiring reoperation asking to grade current epiphora problems.Among 85 included cases (71 patients), 57 were classified as canalicular stenosis and 28 as nasolacrimal duct obstruction (NLDO) preoperatively. At the end of follow-up, 39% (33/85

2019 Acta ophthalmologica

15. Aquaporin expression in the lacrimal sac of patients with primary and functional nasolacrimal duct obstruction. (Abstract)

Aquaporin expression in the lacrimal sac of patients with primary and functional nasolacrimal duct obstruction. To compare the expression profile of aquaporins (AQPs), a family of membrane proteins that function as selective pores in the epithelium of the lacrimal sac in patients with primary or functional nasolacrimal duct obstruction.Forty lacrimal sacs were obtained from 20 patients with primary nasolacrimal duct obstruction (group 1) and 20 patients with functional nasolacrimal duct (...) =0.429 for AQP 5 by Mann-Whitney U test). Immunohistochemical analyses revealed AQPs 1, 3, 5, 7 and 10. Expression of AQP 1, 3, 5, 7 and 10 was statistically significantly greater in group 2 than in group 1 (p=0.022 for AQP 1, p=0.028 for AQP 3, p=0.002 for AQP 5, p=0.041 for AQP 7 and p=0.001 for AQP 10 by Mann-Whitney U test).AQP expression in functional nasolacrimal duct obstruction had a tendency towards being higher than in primary nasolacrimal duct obstruction, although this was only

2016 British Journal of Ophthalmology

16. Interactive navigation-guided ophthalmic plastic surgery: the utility of 3D CT-DCG-guided dacryolocalization in secondary acquired lacrimal duct obstructions Full Text available with Trip Pro

Interactive navigation-guided ophthalmic plastic surgery: the utility of 3D CT-DCG-guided dacryolocalization in secondary acquired lacrimal duct obstructions The aim of this study was to report the preliminary experience with the techniques and utility of navigation-guided, 3D, computed tomography-dacryocystography (CT-DCG) in the management of secondary acquired lacrimal drainage obstructions.Stereotactic surgeries using CT-DCG as the intraoperative image-guiding tool were performed in 3 (...) patients. One patient had nasolacrimal duct obstruction (NLDO) following a complete maxillectomy for a sinus malignancy, and the other 2 had NLDO following extensive maxillofacial trauma. All patients underwent a 3D CT-DCG. Image-guided dacryolocalization (IGDL) was performed using the intraoperative image-guided StealthStation™ system in the electromagnetic mode. All patients underwent navigation-guided powered endoscopic dacryocystorhinostomy (DCR). The utility of intraoperative dacryocystographic

2016 Clinical ophthalmology (Auckland, N.Z.)

17. Risk and Importance of Peroperative Nasal Hemorrhage in the Treatment of Lacrimal Duct Obstruction in Young Children

Risk and Importance of Peroperative Nasal Hemorrhage in the Treatment of Lacrimal Duct Obstruction in Young Children Risk and Importance of Peroperative Nasal Hemorrhage in the Treatment of Lacrimal Duct Obstruction in Young Children - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Risk and Importance of Peroperative Nasal Hemorrhage in the Treatment of Lacrimal Duct Obstruction in Young Children (CANALHEMO) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2016 Clinical Trials

18. Indian survey on practice patterns of lacrimal and eyelid disorders (iSUPPLE) report 1: Congenital nasolacrimal duct obstruction. (Abstract)

Indian survey on practice patterns of lacrimal and eyelid disorders (iSUPPLE) report 1: Congenital nasolacrimal duct obstruction. To assess the preferred practice patterns in the management of congenital nasolacrimal duct obstruction (CNLDO) among oculoplastic surgeons in India. The survey was aimed at obtaining data on the timing of intervention, procedure of choice, and the use of adjunctive techniques such as silicone intubation and nasal endoscopy.An anonymized survey that included (...) questions on the management of lacrimal disorders was sent in April 2015 to members of the Oculoplastic Association of India (OPAI), through an e-mail communication. The results were tabulated and analyzed.A large proportion (84%) of respondents indicated that they advise lacrimal sac compression up to 1 year of age. Fourteen percent (12/87) indicated 2 years as their upper age limit for advising sac compression. One year is the preferred minimum age for advising primary nasolacrimal duct (NLD) probing

2016 International Journal of Pediatric Otorhinolaryngology

19. Cost-effectiveness of 2 approaches to managing nasolacrimal duct obstruction in infants: the importance of the spontaneous resolution rate Full Text available with Trip Pro

MeSH Ambulatory Surgical Procedures; Catheterization /economics; Cost-Benefit Analysis; Dacryocystorhinostomy; Decision Trees; Health Care Costs; Humans; Infant; Intubation /economics; Lacrimal Duct Obstruction /congenital /economics; Models, Economic; Nasolacrimal Duct /surgery; Ophthalmologic Surgical Procedures /economics; Probability; Remission, Spontaneous; Treatment Outcome AccessionNumber 22011001371 Date bibliographic record published 21/09/2011 Date abstract record published 21/12/2011 NHS (...) Cost-effectiveness of 2 approaches to managing nasolacrimal duct obstruction in infants: the importance of the spontaneous resolution rate Cost-effectiveness of 2 approaches to managing nasolacrimal duct obstruction in infants: the importance of the spontaneous resolution rate Cost-effectiveness of 2 approaches to managing nasolacrimal duct obstruction in infants: the importance of the spontaneous resolution rate Frick KD, Hariharan L, Repka MX, Chandler D, Melia BM, Beck RW, Pediatric Eye

2012 NHS Economic Evaluation Database.

20. Combined Lacrimal Passage Probing and Tobramycin/Dexamethasone Ophthalmic Ointment Infiltration: A Minimally Invasive Surgical Procedure for Incomplete Nasolacrimal Duct Obstruction. Full Text available with Trip Pro

Combined Lacrimal Passage Probing and Tobramycin/Dexamethasone Ophthalmic Ointment Infiltration: A Minimally Invasive Surgical Procedure for Incomplete Nasolacrimal Duct Obstruction. The optimal treatment strategy for an incomplete nasolacrimal duct obstruction (INDO) is still being debated. The aim of this study is to evaluate the treatment results of combined lacrimal passage probing and tobramycin/dexamethasone ophthalmic ointment infiltration (PIO, Probing and Injection) for INDO.In (...) this retrospective, noncomparative case series, 397 consecutive adult patients with INDO treated at Shanghai Eye, Ear, Nose and Throat Hospital were enrolled. Records of the patients were reviewed. With the help of a modified 23-gauge lacrimal cannula, the PIO surgery was performed for the INDO-identified patients. The main outcome measures were resolution of tearing and complications. The relationship between successful outcome and clinical characteristics was analyzed.The surgery was performed successfully

2015 Medicine

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