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Knee Exam

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1041. The Effects of Aromatase Inhibition and Testosterone Replacement on Sex Steroids, Pituitary Hormones, Markers of Bone Turnover, Muscle Strength, and Cognition in Older Men

will require an overnight stay in the hospital so that an intravenous (IV) line can be placed in the arm to allow samples to be drawn throughout the night. Testing will include a cardiac stress test, a glucose tolerance test, bone and muscle tests, evaluation of memory function, etc. For the safety of the prostate, we will perform a prostate ultrasound at the start and end of the study and we will monitor urinary symptoms, prostate specific antigen (PSA) levels and the prostate exam throughout the study (...) to prevent completion of the strength testing, history of joint replacement of knees or hip. Inability to walk 50 meters Known disease of the bone and/or taking medications to treat osteoporosis, i.e. Fosamax, Evista, Miacalcin History of Gastric surgery History of prostate cancer or any other cancers, including blood dyscrasias History of severe benign prostatic hyperplasia (causing urinary problems) History of heart attack or open-heart surgery within the past 6 months Use of steroids within the past 3

2005 Clinical Trials

1042. Osteoarthritis: Weakness From Inflammation

a physical exam, a DEXA bone density scan, blood and urine testing, knee x-rays, strength testing and a surface electromyography (EMG). Samples of muscle, joint fluid and joint tissue will be collected during your planned surgery. Participation in this study is entirely voluntary. Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 88 participants Observational Model: Cohort Time Perspective: Cross-Sectional Official Title: Weakness From Inflammation (...) of this study is to understand the factors that lead to muscle weakness with arthritis and aging. Condition or disease Osteoarthritis Detailed Description: Through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. We hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure. This study requires 1 four-hour visit to Harbor Hospital. The visit involves

2005 Clinical Trials

1043. Low-Dose Alteplase to Treat Blood Clots in Deep Leg Veins

tube) is then inserted into a vein either behind the knee, in the groin, or in the neck, and advanced until it reaches the clots. When the catheter is in place, rtPA is injected while the radiologist watches the vein under the x-ray image. The amount of rtPa needed will depends on the size of the clot. Up to five venograms may be done if the clot requires the maximum four rtPA treatments allowed in this study. During the treatments, patients receive standard doses of heparin, given continuously (...) Function [ Time Frame: 6 months ] The outcome measures the ability of Alteplase to lyse acute and subacute deep venous thrombosis (DVT) of the lower extremities and/or pelvis and restore venous function, or blood flow, to these areas. Restored venous function is also known as patency. Patency is measured by venography and ultrasound exams. Secondary Outcome Measures : Number of Participants That Developed Hemorrhage [ Time Frame: 5 days ] The outcome measures the number of participants who developed

2004 Clinical Trials

1044. Testosterone Replacement in Older Men and Atherosclerosis Progression

indicates a worsening. Change From Baseline in Chest Press Strength and Leg Press Strength [ Time Frame: Baseline and Month 36 ] Maximal voluntary strength of the lower and upper extremities was assessed using the one repetition maximum (1-RM) method for the seated leg press and chest press exercises. Participants were positioned with standardized seat position and foot placement that allowed 90° of knee flexion for the leg press exercise. Seat height and handle position was standardized for the chest (...) or induration of digital rectal exam (DRE) Prostate specific antigen (PSA) greater than 4 unless participant has had a negative transrectal biopsy within last 3 months Limiting heart disease in including New York (NY) Class III or IV - congestive heart failure, unstable angina, or myocardial infarction (MI) in last 3 months Liver function tests [aspartate aminotransferase (AST) and alanine aminotransferase(ALT)] greater than 3 times the upper limit of the reference range Serum creatinine (Cr) greater than

2006 Clinical Trials

1045. Meniscal Repair: A Randomized Prospective Trial of FAST-FIX vs. Meniscal Suturing

information, Layout table for eligibility information Ages Eligible for Study: 16 Years to 50 Years (Child, Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: -** Canadians Only can be recruited for this trial History indicative of meniscal pathology (i.e. pain, locking, clicking or giving way of the knee) +/- ACL insufficiency On physical exam, evidence of a meniscal tear (i.e. a locked joint, joint line tenderness and pain on meniscal compression (...) rates. However, complications associated with the use of the inside-out technique (injury to the knee's neurovascular structures and infection) and the fact that it is a time consuming procedure have generated the development of alternative methods and devices. The FasT-Fix is reported to be quicker and safer. It is applicable to tears in most locations and requires no additional incisions or portals. Even though this and many similar devices are widely used with reported clinical healing rates

2006 Clinical Trials

1046. Sleep in Osteoarthritis Project

tests of physical function. Subjects will be also asked to complete additional questionnaire and diary items that ask them to rate their emotions during the pain testing procedures and during the days that they keep their electronic diary for the parent project. At Visit 2, participants will undergo pain testing, an in-home sleep study and optional procedures outlined above. At Visit 3, participants with knee osteoarthritis will have an exam by a rheumatologist. Participants in Phase 1 who have both (...) for insomnia in reducing sleep disturbances, thereby reducing clinical pain in people with knee OA. The study will test whether improvement in clinical pain are mediated by changes in certain types of pain processing. Condition or disease Intervention/treatment Phase Sleep Initiation and Maintenance Disorders Osteoarthritis Behavioral: Cognitive behavioral therapy (CBT) for insomnia Behavioral: Behavioral desensitization treatment for insomnia Phase 2 Detailed Description: Sleep disturbance and pain

2007 Clinical Trials

1047. Safety and Efficacy Study of ImCOOH Cream in Patients Suffering From Moderate Atopic Dermatitis

. Finally the Eczema Area and Severity Index (EASI) score will be determined for both target areas, predose on Day 1 of treatment and on Days 7 and 15 of treatment. Safety will be assessed by monitoring (S)AEs, performing clinical laboratory tests (hematology, biochemistry, urinalysis) and physical exams and by taking vital signs and recording ECGs on a regular basis. For pharmacokinetic analysis, plasma concentrations of ImCOOH will be determined on Days 1 and 15 up to 12 hours postdose. In addition (...) (armpits [axillas] are also allowed) or both target areas should be located at the hollows of the knee. Topical Atopic Dermatitis Severity Index (toADSI) score of at least 5 for both target areas and the severity of the 2 sites do not differ by more than 3 points. General medical condition, in the investigator's opinion, does not interfere with the assessments and the completion of the trial. Exclusion Criteria: Female subject of childbearing potential without use of effective birth control methods

2007 Clinical Trials

1048. Spinal Cord Plasticity

is given an electrical stimulation at the nerve at the back of the knee while pedaling on a stationary bicycle. The shock produces a jerky movement called the "H reflex." The muscular activity causing these reflexes is measured using electrodes (small metal disks) filled with a conductive gel and taped to the skin over the calf muscle. The nerve is stimulated at four different frequencies during the experiment. While cycling, pedal resistance changes, making it harder or easier to pedal. On study day 1 (...) information, Layout table for eligibility information Ages Eligible for Study: 21 Years to 65 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria INCLUSION CRITERIA: Healthy volunteers (age 21 to 65 years) who are willing to participate and who are considered able to cylce for 16 minutes based on neurological and physical exams will be eligible for the study. Reproductive age women with a negative pregnancy test. EXCLUSION CRITERIA: Subjects with history

2003 Clinical Trials

1049. Functional Brain Imaging

to understand the requirements of the study and complete the baseline studies in a reasonable time frame, as determined by the interviewer Exclusion criteria: Having had acupuncture before (must be acupuncture naïve) Any history of claustrophobia that could affect the subject's ability to tolerate the f-MRI study Hip or ankle disease by history or exam severe enough to cause pain >2/10 daily Bleeding disorder or current use of warfarin or heparin by patient history Other primary causes of chronic knee pain (...) (NIAMS) National Institute of Neurological Disorders and Stroke (NINDS) Information provided by: National Center for Complementary and Integrative Health (NCCIH) Study Details Study Description Go to Brief Summary: The goal of this study is to use single photon emission computed tomography (SPECT) and functional magnetic resonance imaging (f-MRI) of the brain to study the response of both normal participants and participants with Osteoarthritis (OA) of the knee to acupuncture. Condition or disease

2003 Clinical Trials

1050. Nervous System Function in Normal Volunteers During Cycling Training

and after training. Nerve conduction studies measure the speed with which nerves conduct electrical impulses and the strength of the connection between the nerve and the muscle. For these studies, a probe is placed on the skin over the calf muscles and the knee to deliver a small electrical stimulus, and wires are taped to the skin to record the impulses. SSEP recordings, which measure of the excitability of the brain to sensory stimuli, are collected from electrodes placed on the scalp. After (...) Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria INCLUSION CRITERIA: Normal volunteers (ages 18 and above) who are willing to participate and who are considered able to cycle for16 minutes based on neurological and physical exams. EXCLUSION CRITERIA: Subjects with history of heart condition, unresponsive arterial hypertension, diabetes, chronic back pain, sciatica, peripheral neuropathy, rheumatoid arthritis, active joint

2003 Clinical Trials

1051. Safety and Preliminary Effectiveness of AV650 in Patients With Spasticity Due to Spinal Cord Injury

duration of 6 or more months. Muscle tone sufficient to score at least two (2) on the Ashworth Scale for at least one of the following lower muscle groups: ankle plantar flexors (gastrocnemius), knee extensors (quadriceps), knee flexors (hamstrings) and/or hip adductors (adductors) and seven (7) for the most spastic limb. ASIA Impairment Scale Exam score of B, C or D. Female subjects of childbearing potential must be either surgically sterile or using an effective method of contraception. Female (...) or spinous process. Subjects with corrective surgery to or contracture of the measurable hip, knee, or ankle joints. Subjects known to be Hepatitis B or HIV positive. Female subjects who are pregnant or nursing. Subjects who have received an investigational drug within 30 days before Screening visit. Subjects with any documented episodes of seizures. Subjects requiring use of clinically relevant 2C19 or 2D6 inhibitors, or concomitant use of lidocaine. Use of rescue medication(s) within 48 hours

2007 Clinical Trials

1052. Magnetic Resonance Imaging to Identify Characteristics of Plaque Build-Up in People With Peripheral Arterial Disease

through a series of timed walks, leg strength exercises, and muscle power exercises. Questionnaires to assess participants' medical history will be completed by each participant's primary care doctor, and study researchers will review participants' medical records. Participants with knee pain will have a knee x-ray, and participants may wear a small device called an accelerometer for 1 week to monitor physical activity levels. During the second and third study visits, occurring at one and two year (...) than 1 in participants Criteria Inclusion Criteria: For participants with PAD: lowest leg ankle-brachial index (ABI) less than or equal to 0.999 For participants in the control group: lowest ABI between 1.00 to 1.30 Exclusion Criteria: Foot amputation, leg amputation, or gangrene Recent liver transplantation Requires oxygen on ambulation End stage renal disease Confined to a wheelchair Lives in a nursing home Low life expectancy Mini-Mental Status Exam (MMSE) score of less than 23 out of 30

2007 Clinical Trials

1053. Rituximab for the Treatment of Early Rheumatoid Arthritis (RA)

, and 12. Systemic corticosteroid doses will be modified based on the participant's health while in the study. Use of nonsteroidal anti-inflammatory drugs (NSAIDs) is permitted, but NSAID doses should not be changed during the study, if at all possible. NSAIDs will not be provided by this study. There will be a maximum of 2 screening visits before study treatment, a baseline visit (Day 0), and 11 study visits. A physical exam, assessment for adverse events, and blood collection will occur at all study (...) visits. Kidney and liver function tests and rheumatologic evaluations will occur at most study visits; participants will also be asked to complete a questionnaire on their health at most study visits. Arthroscopy (knee biopsy) on the more inflamed knee will occur at baseline and Month 3. Participants will be contacted by telephone the day after each arthroscopy and rituximab infusion. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment

2006 Clinical Trials

1054. A Comparison of an Advanced Metal Hip System to a Resurfacing Hip System

for Noninflammatory Degenerative Joint Disease (NIDJD). Composite diagnoses of NIDJD include osteo/degenerative arthritis, traumatic arthritis, congenital hip dysplasia, and avascular necrosis. (3) Patients 18 years of age or older (skeletally mature). (4) Patients for whom there is a reasonable expectation that they will be available for each examination scheduled over a two year post-operative follow-up period and for annual exams until the last patient entered into the study has achieved two years of follow-up (...) . (5) Patients who agree to participate and sign the Informed Consent Form. (6) Patients who do not meet any of the exclusion criteria. Exclusion Criteria: (1) Patients with previous fusions, acute femoral neck fractures, above knee amputations, or significant arthritic changes to the knees. (2) Patients with evidence of active infection. (3) Patients with neurologic or musculoskeletal disease that may adversely affect gait or weight-bearing. (4) Patients who have previously undergone

2006 Clinical Trials

1055. Beta Blocker for Chronic Wound Healing

a physical exam have blood and urine tested have photographs taken of the wound apply medication to the leg ulcer as directed Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 40 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Care Provider, Investigator) Primary Purpose: Treatment Official Title: Beta Adrenergic Receptor Modulation of Burn Wound Healing Study Start Date : June (...) , Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Any race btwn 18 and 85 years of age, inclusive; Male or female, neither pregnant nor lactating. Informed consent; Have at least 1 lower extremity ulcer in the gaiter area (knee to ankle): Surface area of ≥2 sq. cm. to ≤20 sq. cm.; Ulcer with largest surface area meeting inclusion criteria will be selected. If 2 ulcers present with the same surface area, ulcer of longest duration selected. Study

2006 Clinical Trials

1056. A Study to Evaluate 90-Day Safety of Tapentadol(CG5503) Immediate Release (IR) or Oxycodone Immediate Release in Patients With Chronic Pain

or Osteoarthritis of the Hip or Knee Study Start Date : July 2006 Actual Primary Completion Date : June 2007 Actual Study Completion Date : July 2007 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Outcome Measures Go to Primary Outcome Measures : The primary outcomes include incidence of adverse events, changes in laboratory measures, results of physical exams, and results of 12-Lead ECG. Secondary Outcome Measures (...) chronic (for at least 3 months) low-back pain or chronic pain from osteoarthritis of the hip or knee, and who require daily analgesic medication. In this double blind study (neither patients nor investigators will know what treatment is given), patients will be randomly (patients are assigned different treatments based on chance) assigned to receive either CG5503 base IR or oxycodone IR to begin a 90 day treatment during which each patient will return to the medical facility every 2 weeks

2006 Clinical Trials

1057. Smoking and osteoarthritis: is there an association? The Clearwater Osteoarthritis Study. (PubMed)

Smoking and osteoarthritis: is there an association? The Clearwater Osteoarthritis Study. To evaluate the association between cigarette smoking and the subsequent development of osteoarthritis (OA) at four separate sites: knee, hand, foot and cervical spine.This cohort study examined 2505 men and women aged 40 years and older participating in the longitudinal Clearwater Osteoarthritis Study (1988-current). Biennial physical exams, including serial radiographs, as well as historical information (...) , were collected. The Lawrence and Kellgren ordinal scale was used to determine radiological evidence of the study outcome, OA. Self-reported history of smoking behavior was used to determine the study exposure. Smoking was classified using four approaches: (1) ever/never, (2) former/never, (3) current/never, and (4) dose.Among the individuals at study entry, radiologically confirmed incident OA was detected during the follow-up period at four sites: knee (32%), hand (49%), foot (28%), and cervical

2003 Osteoarthritis and Cartilage

1058. MRI of bone marrow edema-like signal in the pathogenesis of subchondral cysts. (Full text)

-up exams were reviewed for presence, location, size and changes of marrow edema-like signal, subarticular cysts and cartilage abnormality. All locations in the knee were aggregated for analysis with descriptive statistics.The mean time interval between exams was 17.52 months (range 2.1-40.1 months). There were 23 cysts: 11 (47.8%) new, 6 (26.1%) increased size, 1 (4.4%) decreased size, and 5 (21.7%) no change in pre-existing lesions. Cysts always arose from regions of marrow edema-like signal (...) MRI of bone marrow edema-like signal in the pathogenesis of subchondral cysts. To determine if a relationship exists between bone marrow edema-like signal and subchondral cysts on magnetic resonance imaging (MRI).Retrospective cohort of 32 patients with two sequential knee MRI. Patients with acute trauma, infection, neoplasm, or osteonecrosis were excluded. The degree of osteoarthritis was assessed using an adaptation of the Baltimore Longitudinal Study of Aging (BLSA) scale. Initial and follow

2006 Osteoarthritis and Cartilage

1059. Complex regional pain syndrome-like symptoms during herpes zoster. (PubMed)

(screening) visit included a neurological and physical examination that was updated at each subsequent visit. Assessments included ratings of pain intensity, allodynia severity, and rash severity. The neurological exam included determination of presence or absence of the following CRPS-like symptoms: (1) increased sweating, (2) color changes, (3) skin temperature changes, (4) weakness of the affected area based on physical exam, (5) edema, and (6) extension of CRPS-like symptoms outside the affected (...) dermatome. For subjects with HZ in dermatomes that can include the limbs (C4-T2 and L1-S2), extremity involvement was considered present if allodynia or rash extended beyond the neck of the humerus (upper extremity), the inguinal ligament (anterior lower extremity), or gluteal sulcus (posterior lower extremity). Involvement of the extremity was considered proximal if neither HZ rash nor allodynia extended past the elbow (upper extremity) or knee (lower extremity). Of the first 75 subjects recruited, 25

2004 Pain

1060. The Effect of Botox on Children With Cerebral Palsy

be seizure-free or seizure controlled Children must have visuoperceptual skills and cognitive/communication skills sufficient to follow multiple step commands and to attend to tasks associated with data collection Children's passive range of motion in lower extremity joints must be less than 20 degrees of flexion contracture at the hips as measured by the Thomas Test, at least 20 degrees of hip abduction bilaterally, les than 0 degrees of knee flexion contracture, popliteal angle less than 55 degrees (...) , and at least 0 degrees of ankle dorsiflexion with the knee extended while the foot is in varus Children who are planning to undergo botulinum toxin injections of the gastrocnemius and/or soleus muscles without serial casting as clinically dictated for the treatment of muscle spasticity Exclusion Criteria: Children who have a diagnosis of "mixed" types of CP (i.e. athetosis) or other movement disorders (i.e. ataxia) Children who have had a selective dorsal rhizotomy, are presently are receiving intrathecal

2007 Clinical Trials

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