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Knee Exam

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981. Feasibility Study of Exercise in Patients With Leg Blood Clots

and a screening treadmill test prior to enrollment between two and four weeks post DVT diagnosis. All patients will be provided and asked to wear class II (30 to 40mmHg) knee length compression hose daily during the entire trial. The formal exercise training includes both a supervised walking program and a home-based walking program for 12 weeks with follow-up at 26 weeks. Blood tests will be taken to measure levels of indicators of inflammation at baseline, week 4, week 12, and week 26. The primary outcomes (...) of DVT with systemic or catheter-directed thrombolysis Contraindications to exercise training according to the American College of Sports Medicine (e.g., acute myocardial infarction, unstable angina, etc.,). Life expectancy < 1 year. Pregnancy. Geographic inaccessibility. Screening (pre-randomization) exercise stress test demonstrating contraindication to exercise training (see exclusion #2). Cognitive dysfunction assessed by mini-mental status exam (score < 24). Inability to walk. Contacts

2009 Clinical Trials

982. Melatonin for Circadian Sleep Disorders in the Blind

light exposed daily behind the knee can regulate the body clock. Sub-study 5 is an optional longitudinal study, an extension of the first study stage, for subjects whose rhythms are not clearly free-running. Condition or disease Intervention/treatment Phase Insomnia Blindness Daytime Sleepiness Drug: Melatonin Behavioral: Regular Sleep Schedule Behavioral: Light Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 40 (...) Accepts Healthy Volunteers: No Criteria Inclusion criteria: blindness for at least one year, verified by an ophthalmologic exam ability to comply with the requirements of the experimental protocol competency to sign informed consent Exclusion criteria (as determined by medical history and/or physical examination): abnormal heart, liver or kidney function a current Axis I psychiatric or substance abuse disorder according to the DSM-IV Manual possibly external demands that limit the ability to maintain

2009 Clinical Trials

983. Repair of a complete anterior cruciate tear using prolotherapy: a case report (Full text)

prolotherapy and at-home exercise. CLINICAL PRESENTATION AND INTERVENTION: The 18 year old female patient sustained a right knee injury during a downhill skiing accident. Magnetic Resonance Imaging (MRI) revealed a high-grade partial versus complete rupture; Lachman exam findings suggested a complete rupture. She deferred surgical treatment. At 21 weeks post-injury, with unstable gait, inability to climb stairs and more than 1 cm anterior drawer test, she consented to undergo prolotherapy injections. She

2009 International musculoskeletal medicine

984. Lateral compartment translation predicts the grade of pivot shift: a cadaveric and clinical analysis. (PubMed)

translations and amount of knee rotation could not distinguish between clinical grades. Finally, a threshold of 6-7 mm of anterior tibial translation in the lateral compartment was necessary to produce a positive pivot shift. Taken together, these data suggest that monitoring lateral compartment translations during a pivot shift exam may be a convenient means to evaluate the outcomes of ACL surgery and that requisite increases in anterior translation of the lateral compartment are necessary for each (...) examinations were performed on cadavers with various degrees of instability, and 24 pivot shift exams were performed on patients under anesthesia before and after ACL reconstruction. In all positive pivot shift exams, anterior tibial translations were found to be higher on in the lateral compartment compared to the medial compartment. In addition, an excellent correlation was found between the amount of lateral compartment translation and the clinical grade of the pivot shift; medial compartment

2010 Knee Surgery, Sports Traumatology, Arthroscopy

985. Accessory Plantaris Muscle: Anatomy and Prevalence (Full text)

review of 1,000 consecutive MRI exams of the knee performed on patients presenting with acute or chronic knee symptoms revealed an accessory plantaris muscle in 63 of the 1,000 patients (6.3%)-38 males (7.5%) and 25 females (5.1%). Origin of 62 of 63 of the accessory plantaris muscles merged with the origin of the normal plantaris muscle, and one of 63 merged with the origin of the lateral head of the gastrocnemius muscle. These accessory plantaris muscles inserted into the iliotibial band (...) Accessory Plantaris Muscle: Anatomy and Prevalence Accessory and anomalous muscles have been described in humans, but only a few at the level of the knee. The aim of this retrospective cohort analysis was to determine the prevalence of a new accessory muscle located at the level of the knee detected with magnetic resonance imaging (MRI). The accessory muscle is designated an accessory plantaris muscle in this study due to its intimate origin with the normal plantaris muscle. Retrospective

2010 HSS Journal

986. Classification-Directed Treatment of Low Back Pain

in performance of modified versions of the direction-specific impairment tests from the exam, with an emphasis on impairments that can be modified to eliminate symptoms. Behavioral: Classification-directed treatment People in the Classification-directed treatment will be treated based on their direction-specific LBP classification. Treatment will consist of 3 primary components. The first component of treatment will be analysis and instruction in modification of the person's direction-specific alignment (...) and movement strategies during symptomatic functional activities and activities in which the person uses similar strategies to those displayed with symptomatic functional activities. The second component is education about the principles of tissue injury and healing and the need to keep active. The third component is exercise prescription that consists of practice in performance of modified versions of the direction-specific impairment tests from the exam, with an emphasis on impairments that can

2008 Clinical Trials

987. Ultrasound and X-ray in Detecting Articular Cartilage Calcification

of ultrasound with a probe superficial performance. 166 patients will be enrolled in this trial and an echography and a radiography of the 2 knees (front and profile) will be done for each patient. Ih the echography show a calcification, further exams with wrists, hips shoulders echographies will be conducted. In case of liquid epanchement, analysis of the liquid will be carried in order to eliminate the differential diagnostic including septic arthritis Study Design Go to Layout table for study information (...) Study Details Study Description Go to Brief Summary: Prospective study with an echography of the 2 knees and radiography of the 2 knees (front and profile) for each patient. If found calcification on ultrasound further examination with ultrasound wrists, hips and shoulders. Condition or disease Intervention/treatment Phase Chondrocalcinosis Articular Cartilage Calcification Procedure: Echography Not Applicable Detailed Description: Osteo-articular echography is currently recognized as an important

2008 Clinical Trials

988. Long-Term Analgesic Efficacy And Safety Of Tanezumab Alone Or In Combination With Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Versus NSAIDs Alone In Patients With Osteoarthritis Of The Knee Or Hip

: Weeks 2, 4, 8, 12, 24,32, 40, 48 and 56 ] Time to discontinuation [ Time Frame: All weeks ] Radiographic assessment of index joint (knee or hip) [ Time Frame: Screening period and Week 56 ] Safety (laboratories for chemistry, hematology urinalysis, ECGs, physical exams, vital signs, neurologic exams, serum anti-drug antibody assessments [ Time Frame: All weeks ] Pregnancy tests (where applicable) [ Time Frame: Weeks 8, 16, 24, 32, 40, 48 and 56 ] Work Productivity and Activity Impairment (...) Long-Term Analgesic Efficacy And Safety Of Tanezumab Alone Or In Combination With Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Versus NSAIDs Alone In Patients With Osteoarthritis Of The Knee Or Hip Long-Term Analgesic Efficacy And Safety Of Tanezumab Alone Or In Combination With Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Versus NSAIDs Alone In Patients With Osteoarthritis Of The Knee Or Hip - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer

2008 Clinical Trials

989. Intradiscal rhGDF-5 Phase I/II Clinical Trial

, Clinically Significant Abnormal results are determined by the surgeon investigator and are based on exams of the Knee, Ankle, L3-L5 Dermatone, and S1 Dermatome. Tension signs are evaluated with a straight leg raise to determine at which point, if any, sciatic pain occurs. Treatment Emergent Adverse Events- Relationship to Study Drug [ Time Frame: Through a 12 month period and annual telephone contact at 24 and 36 months for subject health status follow-up ] Number of patients with Treatment Emergent (...) to have a discogram, CT or an MRI Abnormal neurological exam at baseline (e.g., radiculopathy) Radicular pain Leak of contrast agent during the discogram, into the epidural space (does not include leak of contrast agent along the needle track) MRI findings demonstrate any of the following:· Suspected disc appears normal· >50% decrease in disc height· Modic changes, and/or· Presence of osteophytes or significant facet arthrosis Contacts and Locations Go to Information from the National Library

2008 Clinical Trials

990. Seniors Health and Activity Research Program-Pilot

for less than 8 years of education) and 95 on the Modified Mini-Mental Exam Sedentary lifestyle, i.e., not actively participating in a formal exercise program within the past 3 months (defined as 30 minutes or more of formal exercise at least once a week; brisk walks will be considered formal exercise, leisurely walks will not) Fluency in standard American English (to limit staffing and translation costs in this pilot) Willingness to be randomized to any of the four intervention conditions Exclusion (...) months Serious conduction disorder (e.g., 3rd degree heart block), uncontrolled arrhythmia Pulmonary embolism or deep venous thrombosis within past 6 months Stroke, hip fracture, hip or knee replacement, or spinal surgery within past 4 months Receiving physical therapy for gait, balance, or other lower extremity training Severe hypertension, e.g., systolic blood pressure over 160 mmHg, diastolic blood pressure over 110 mmHg Other temporary intervening events, such as sick spouse, bereavement

2008 Clinical Trials

991. Cannabis for Spasticity in Multiple Sclerosis

-controlled torque motor system (Lido WorkSet II) was designed for this study to analyze the resistance to passive movement of the knee. It determines the amount of torque required to move the knee joint (without voluntary resistance) at high velocities (up to 200 degrees per second) and at slow velocities (as low as 10 degrees per second). The slow displacement torque is a measure of the passive resistance to movement (from the connective tissue and the non-contracting muscle) and the rapid displacement (...) Frame: Week 0, Week 3 ] A modified servo-controlled torque motor system (Lido WorkSet II) was designed for this study to analyze the resistance to passive movement of the knee. It determines the amount of torque required to move the knee joint (without voluntary resistance) at high velocities (up to 200 degrees per second) and at slow velocities (as low as 10 degrees per second). The slow displacement torque is a measure of the passive resistance to movement (from the connective tissue and the non

2008 Clinical Trials

992. Effect of Combined Use of Naloxone and Tramacet on Postop Analgesia in Elderly Patients Having Joint Replacement Surgery

use of oral tramacet and naloxone infusion perioperatively in elderly patients (70 yrs and older) having elective knee/ hip arthroplasty under spinal anesthesia. Secondary objectives are to determine the incidence VAS scores ≥4 and adverse effects such as nausea, vomiting, sedation, respiratory depression, pruritus, confusion, and time of independent mobilization. Hypothesis: Perioperative naloxone infusion and tramacet provides adequate analgesia in elderly patients undergoing total knee/hip (...) arthroplasty and is associated with 80% reduction in opioid use and reduced opioid-induced side effects. Condition or disease Intervention/treatment Phase Hip Arthroplasty Knee Arthroplasty Spinal Anesthesia Drug: tramacet, naloxone Drug: tramacet Drug: Acetaminophen Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 45 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant

2008 Clinical Trials

993. The Effects of Bariatric Surgery Weight Loss on Knee Pain in Patients With Osteoarthritis of the Knee

positions are filled. At their next pre-bariatric surgery visit, the study participants will have a basic knee exam performed by Kevin P. Black, M.D. in order to evaluate the structural integrity and alignment of the knee joint. The information gathered from the exam will serve as a baseline measure of knee function for the study. Prior to undergoing surgery, each of the 25 patients will be asked to complete a full version of the WOMAC survey and a separate, related survey the Knee and Osteoarthritis (...) The Effects of Bariatric Surgery Weight Loss on Knee Pain in Patients With Osteoarthritis of the Knee The Effects of Bariatric Surgery Weight Loss on Knee Pain in Patients With Osteoarthritis of the Knee - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2008 Clinical Trials

994. Tanezumab in Osteoarthritis of the Knee

Tanezumab in Osteoarthritis of the Knee Tanezumab in Osteoarthritis of the Knee - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Tanezumab in Osteoarthritis of the Knee The safety and scientific validity (...) of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00733902 Recruitment Status : Completed First Posted : August 13, 2008 Last Update Posted : January 7, 2011 Sponsor: Pfizer Information provided by: Pfizer Study Details Study Description Go to Brief Summary: Test the efficacy and safety of 3 doses in Osteoarthritis of the knee in patients

2008 Clinical Trials

995. A Clinical Investigation of the M2a-Magnumâ„¢ Hip System

the function and survivorship of the M2a-Magnum™ Hip System. Patients are required to come in for preoperative, operative, one year follow-up, three year follow-up, five year follow-up, and ten year follow-up exams. This product was FDA cleared in 2004. Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 249 participants Observational Model: Cohort Time Perspective: Prospective Official Title: A Prospective, Non-controlled, Clinical Investigation of the M2a (...) Identifier: Other Study ID Numbers: Biomet 12380-82 First Posted: June 17, 2008 Last Update Posted: June 21, 2017 Last Verified: June 2017 Keywords provided by Zimmer Biomet ( Biomet Orthopedics, LLC ): Total Knee Replacement Total Knee Arthroplasty Hip Arthritis Additional relevant MeSH terms: Layout table for MeSH terms Arthritis Osteoarthritis Arthritis, Rheumatoid Bone Diseases Joint Diseases Osteoarthritis, Hip Musculoskeletal Diseases Rheumatic Diseases Connective Tissue Diseases Autoimmune

2008 Clinical Trials

996. An Interventional Study of Geriatric Frailty, Osteoporosis, and Depression

phenotypes, and interventions of these three geriatric syndromes are often related. Frailty is often defined as accumulations of multi-system deficiencies with increased vulnerability to multiple worse outcomes. Multifactorial, interdisciplinary integrated care models targeting frail older adults may have positive impacts on measurements associated with not only frailty, but also depression, or osteoporosis. The objective of this proposed study is to conduct a randomized control trial (RCT) to exam (...) physical activity, Slow walking speed, Weak grip strength timed up and go [ Time Frame: baseline, 3, 6, and 12 months ] one leg stand time [ Time Frame: baseline, 3, 6, and 12 months ] dominant hand grip strength [ Time Frame: baseline, 3, 6, and 12 months ] dominant knee extension power [ Time Frame: baseline, 3, 6, and 12 months ] vitamin B12 in blood [ Time Frame: pilot study: baseline and 12 month, 2009 study: baseline and 6 months ] vitamin D in blood [ Time Frame: pilot study: baseline and 12

2008 Clinical Trials

997. Surgical Treatment for Acute Patella Tendon Rupture

, Emory University Study Details Study Description Go to Brief Summary: We will compare two groups for acute patella tendon repair: one treated with surgical anchors and the second, with transpatellar tunnels. Condition or disease Intervention/treatment Phase Acute Patella Tendon Rupture Procedure: Repair with transpatellar tunnels Procedure: Repair with suture anchors. Phase 4 Detailed Description: The patella tendon is located in the knee, and is attached to the leg bone and the patella bone (knee (...) from distal to proximal and tied over the superior pole. The knee will be flexed to 45 degrees. The tendon will be repaired adjacent to the articular surface and not to the anterior surface of the patella. Procedure: Repair with transpatellar tunnels Repair with transpatellar tunnels: We will make a small horizontal trough at the inferior pole of the patella. Multiple, braided Krackow sutures will then be placed through the substance of the tendon using no. 5 Fiberwire (Arthrex, Naples FL) suture

2008 Clinical Trials

998. A Trial of Custom Foot Orthoses for the Treatment of Plantar Heel Pain

to calcaneal tubercle and/or pain distal from tubercle along plantar fascial band Typical post-static dyskinesia. Pain first steps in morning or when getting up after being seated for a period of time Patients will be ambulatory with an age range of 18-75 with plantar heel pain present for no more than one year. They will not have previous injection within 6 months or currently use prescription custom foot orthoses. Patient history, exam, x-rays, and ultrasound will rule out other etiologies of heel pain (...) including proximal or local nerve entrapment, arthritis, bone cyst or tumor, or stress fracture. Since most patients will likely self-treat this condition prior to seeking care, the investigators will allow a washout period (appendix) and acetaminophen rescue analgesia provision. Exclusion Criteria: Proximal musculoskeletal pathology (i.e., knee or hip arthritis, sciatica secondary to back pathology, significant limb length discrepancy. Use of gait assistive devices (crutches, canes, walkers). Inability

2008 Clinical Trials

999. Compression Aided Management of Edema in Patients With C3 Venous Disease

and edema and non-venous edema will be evaluated by clinical exam and venous duplex ultrasound. Patients eligible for the study will be randomized to knee-high 20-30 Hg graded compression stockings or anti-embolism (13-18 mm Hg) compression stockings. Patients will have limb quantitative edema assessment, a severity score and quality of life determination. Compression will be assigned to each treatment group with instruction on proper wear and duration, and the interface pressure of compression (...) : BSN Medical Inc Information provided by: BSN Medical Inc Study Details Study Description Go to Brief Summary: Objectives: To quantify the clinical improvement and quality of life between patients wearing compression stockings versus anti-embolism stockings in patients with varicose veins and limb edema. Condition or disease Intervention/treatment Phase Chronic Venous Disease Device: Anti-embolism Knee High Stocking Device: 20-30 Knee High Compression Stocking Phase 4 Detailed Description: Research

2008 Clinical Trials

1000. Effects of Lumbosacral Joint Mobilization/Manipulation on Lower Extremity Muscle Neuromuscular Response

of quadriceps muscles following lumbopelvic joint manipulation. Determine the effects of lumbopelvic joint manipulation on temporospatial parameters of gait such cadence, step length, velocity and mean peak lower extremity joint moments. Determine if a correlation exists between patellofemoral joint pain and lumbopelvic joint dysfunction. Determine the amount of change in clinical outcome measure scores following lumbopelvic joint manipulation. Condition or disease Intervention/treatment Phase Knee Pain Hip (...) of muscle inhibition is multifaceted. Utilization of manual therapy techniques such as joint manipulation or mobilization directed at the lumbopelvic region have been shown to be successful in disinhibiting lower extremity muscles. Previous studies have demonstrated sacroiliac joint manipulation disinhibited the quadriceps muscle in individuals with anterior knee pain. One of the limitations was these studies only observed an immediate decrease of quadriceps inhibition and the duration of the treatment

2008 Clinical Trials

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