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Knee Exam

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961. Certolizumab and Lower Extremity Lymph Flow in Rheumatoid Arthritis (RA)

inflammation in one knee determined on physical exam and confirmed by Doppler ultrasound. We will include patients with bilateral knee inflammation only if one knee is more inflamed than the contralateral knee. The comparative level of inflammation will be determined by clinical examination and Doppler US. Patients must be willing to undergo a sulfur colloid technetium scan, knee ultrasound and MRI of the knee. Exclusion Criteria Contra-indication to anti-TNF agent. History of recurrent infections (...) ): Christopher Ritchlin, University of Rochester Study Details Study Description Go to Brief Summary: This open-label pilot study will select subjects who are inadequate responders to methotrexate. These subjects will receive certolizumab subcutaneously on a monthly basis for six months. The study is attempting to determine the following: Is lymphatic flow altered in the extremities of RA patients with an inflamed knee? Is resolution of synovitis associated with a restoration of lymphatic flow and lymph node

2010 Clinical Trials

962. Efficacy And Safety Study Of Tanezumab Subcutaneous Administration In Osteoarthritis

In Patients With Osteoarthritis Of The Knee Study Start Date : March 2010 Actual Primary Completion Date : November 2010 Actual Study Completion Date : November 2010 Resource links provided by the National Library of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment Placebo Comparator: Placebo Biological: Placebo IV 1 ml of placebo administered SC and IV once every 8 weeks. Biological: Placebo SC 1 ml of placebo administered SC and IV once every 8 weeks (...) , 2, 4, 8, 12, and 16 ] Cumulative distribution of percent change from Baseline in the WOMAC Pain subscale score to Weeks 1, 2, 4, 8, 12 and 16 (endpoint for summary only) [ Time Frame: Weeks 1, 2, 4, 8, 12 and 16 ] Treatment Response: Improvement of greater than or equal to 2 points in Patient Global Assessment of Osteoarthritis at Weeks 1, 2, 4, 8, 12, and 16 • [ Time Frame: Weeks 1, 2, 4, 8, 12, and 16 ] Average pain score in the index knee change from Baseline to Weeks 1, 2, 4, 8, 12, and 16

2010 Clinical Trials

963. Bias in the physical examination of patients with lumbar radiculopathy. (Full text)

% vs. 36%; p = 0.05). Sensitivities and specificities for exam components otherwise showed no statistically significant differences between groups.Prior knowledge of lumbar MRI results may introduce bias into the pinprick sensory testing component of the physical examination for lumbar radiculopathy. No statistically significant effect of bias was seen for other components of the physical examination. The effect of bias due to prior knowledge of lumbar MRI results should be considered when (...) an isolated sensory deficit on examination is used in medical decision-making. Further studies of bias should include surgical clinic populations and other common diagnoses including shoulder, knee and hip pathology.

2010 BMC Musculoskeletal Disorders

964. A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration

investigator and are based on exams of the Knee, Ankle, L3-L5 Dermatone, and S1 Dermatome. Tension signs are evaluated with a straight leg raise to determine at which point, if any, sciatic pain occurs. Treatment Emergent Adverse Events- Relationship to Study Drug [ Time Frame: Through a 12 month period and annual telephone contact at 24 and 36 months for subject health status follow-up. ] Number of patients with Treatment Emergent Adverse Events that were designated as related or possibly related to Study (...) ) and discography (a discogram performed within 12 months of the anticipated study treatment date is acceptable, as long as the subject has not had an accident or re-injury). Oswestry Disability Index (ODI) for low back pain of 30 or greater Low Back Pain score greater than or equal to 4 cm as measured by Visual Analog Scale (VAS) at Visit 1 Baseline Male or Female 18 years of age or older Exclusion Criteria: Persons unable to have an MRI Abnormal neurological exam at baseline (e.g., chronic radiculopathy

2010 Clinical Trials

965. Enhancement of Cerebral Vasoreactivity and Cognition by Intranasal Insulin in Type 2 Diabetes

or major illness and surgery within six months Liver or renal failure or transplant Uncontrolled hypertension (systolic BP >180 and/or diastolic BP >100 mm Hg or subjects taking more than 3 antihypertensive medications) Seizure disorders Malignant tumors Clinical dementia (by history) or inability to follow details of the protocol(MMSE (Mini Mental Status Exam) score (≥3 points below the Comparative Normal Value for the subject's age group and education level, or ≤ 24) Current recreational drug (...) or alcohol abuse Morbid obesity (BMI >40) Inability to obtain permission for participation from the primary care physician Transcranial Doppler (TCD) exclusion criterion - poor insonation window and TCD signal MR exclusion criteria - any metal or bioimplants not compatible with 3 Tesla MRI and claustrophobia Clinically significant and movement limiting hip, knee and/or back disorders or injury, and rheumatoid arthritis Contacts and Locations Go to Information from the National Library of Medicine

2010 Clinical Trials

966. A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration

investigator and are further classified by grade: 0= No Movement, 1= Flicker/trace of contraction, 2=Active movement when gravity removed, 3= Active movement against gravity, 4= Active Movement against gravity and resistance. For Reflexes/Sensory, Clinically Significant Abnormal results are determined by the surgeon investigator and are based on exams of the Knee, Ankle, L3-L5 Dermatone, and S1 Dermatome. Tension signs are evaluated with a straight leg raise to determine at which point, if any, sciatic (...) , with an expiry of 12 months from the date performed. Oswestry Disability Index (ODI) for low back pain of 30 or greater Low Back Pain score greater than or equal to 4 cm as measured by Visual Analog Scale (VAS) at Visit 1 Baseline Male or Female 18 years of age or older Exclusion Criteria: Persons unable to have a discogram, CT, or MRI Abnormal neurological exam at baseline (e.g., chronic radiculopathy) Active radicular pain due to anatomical compression such as stenosis or disc herniation (radicular pain

2010 Clinical Trials

967. A Multicenter, Randomized, Double-blind, Placebo Controlled, Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of 2 Doses of Intradiscal rhGDF-5 (Single Administration) for the Treatment of Early Stage Lumbar Disc Degenerat

and resistance. For Reflexes/Sensory, Clinically Significant Abnormal results are determined by the surgeon investigator and are based on exams of the Knee, Ankle, L3-L5 Dermatone, and S1 Dermatome. Tension signs are evaluated with a straight leg raise to determine at which point, if any, sciatic pain occurs. Treatment Emergent Adverse Events- Relationship to Study Drug [ Time Frame: Through a 12 month period and annual telephone contact at 24 and 36 months for subject health status follow-up. ] Number (...) calendar months, a new discogram will be required. Oswestry Disability Index (ODI) for low back pain of 30 or greater Low Back Pain score greater than or equal to 4 cm as measured by Visual Analog Scale (VAS) at Visit 1 Baseline Exclusion Criteria: Persons unable to have a discogram, CT, or MRI Abnormal neurological exam at baseline (e.g., chronic radiculopathy) Active radicular pain due to anatomical compression such as stenosis or disc herniation (radicular pain is defined as pain below the knee

2010 Clinical Trials

968. Safety and Efficacy Study of MSB-CAR001 in Subjects 6 Weeks Post an Anterior Cruciate Ligament Reconstruction

-CAR001 plus Hyaluronan at one of two doses or Hyaluronan alone will be injected into the knee joint. After the screening and injection visits, each subject will be evaluated clinically within 3 days and 28 days after surgery, and at 2, 3, 6, 9, 12, 18, and 24 months after surgery. The radiographical exams will be performed at 6, 12, 18, and 24 months after surgery. Subjects will be evaluated at 24 months after surgery for safety. Study Design Go to Layout table for study information Study Type (...) 1 Phase 2 Detailed Description: This is a prospective, single center, randomized, double blind, controlled Phase 1b/2a study designed to evaluate the safety and tolerability of a single injection into the knee joint of two different doses of MPCs combined with Hyaluronan compared to Hyaluronan alone in patients who have recently undergone an Anterior Cruciate Ligament Reconstruction. All subjects in this study have undergone unilateral ACL reconstruction surgery within six months of injury. MSB

2010 Clinical Trials

969. Utility of a Urine Screening Tool for Vitamin D Deficiency in Infants and Toddlers

of infants and toddlers at increased risk for vitamin D deficiency. We will recruit 150 healthy children, 6 to 36 months of age, with risk factors for vitamin D deficiency (premature birth, breast feeding, dairy product avoidance, etc.). Based on previous studies in the US, we anticipate about 12% of these subjects will have vitamin D deficiency. Subjects will have a physical exam targeted to signs of rickets. Laboratories will include a random urine sample for calcium-to-creatinine ratio and blood (...) for calcium, creatinine, alkaline phosphatase, phosphorus, magnesium, intact PTH, and 25-hydroxy vitamin D. Subjects with biochemical evidence of rickets will have x-rays done of the left wrist and knees that will be scored according to previously published rickets scores. Potential Impact. Vitamin D deficiency is increasingly recognized as a common source of morbidity in both developed and undeveloped countries. The validation of a noninvasive and inexpensive screening tool for vitamin D deficiency would

2010 Clinical Trials

970. The LIFE Study

of the household is a participant in the Life Study Residence too far from the intervention site Residence in a nursing home Difficulty in communication with study personnel due to speech or hearing problems Modified Mini-Mental State Exam (3MSE) score below the cutoff for education: African American, 9+ yrs 76, <9 yrs 70; English Speaking Non-African American, 9+ yrs 80, <9 yrs 76; Spanish Speaking, 9+ yrs 80, <9 yrs 70 Participation in LIFE-Pilot study Other medical, psychiatric, or behavioral factors (...) , hip fracture, hip or knee replacement, or spinal surgery in the past 6 months. Serious conduction disorder (e.g., 3rd degree heart block), uncontrolled arrhythmia, or new Q waves or ST-segment depressions (>3 mm) on ECG. Myocardial infarction, major heart surgery (i.e., valve replacement or bypass surgery), stroke, deep vein thrombosis or pulmonary embolus in the past 6 months. Undergoing physical therapy or cardiopulmonary rehabilitation Currently enrolled in another randomized trial involving

2010 Clinical Trials

971. Using Three-Dimensional Gait Data for Foot/Ankle Orthopaedic Surgery (Full text)

Using Three-Dimensional Gait Data for Foot/Ankle Orthopaedic Surgery We present the case of a forty year old male who sustained a torn carotid during strenuous physical activity. This was followed by a right hemispheric stroke due to a clot associated with the carotid. Upon recovery, the patient's gait was characterized as hemiparetic with a stiff-knee pattern, a fixed flexion deformity of the toe flexors, and a hindfoot varus. Based on clinical exams and radiographs, the surgical treatment

2009 The open orthopaedics journal

972. A Clinical Study to Assess the Effects of SRT2104 Upon Immobilization-Induced Skeletal Muscle Atrophy in Healthy Human Volunteers

after receiving 2.0 g of SRT2104 or placebo given in capsule form once a day for 28 days including a 14 day knee and lower leg immobilisation period during the final 14 days of dosing. Imaging methods, muscle biopsies and exercise tests will be used in the study to see whether the following measurements change after taking SRT2104 for 28 days, including an immobilised knee and lower leg for the final 14 days of dosing. i) energy reaching the muscles ii) muscle strength iii) changes in the structure (...) will be monitored by AEs, VS, physical exam, labs and ECGs. ] To investigate the effect of 14 day administration of SRT2104, using the above mentioned primary and secondary analyses, on normal/mobile muscle function. [ Time Frame: Normal/mobile muscle function will be assessed on Day -1, Day 15, and Day 28. ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about

2009 Clinical Trials

973. Effect of Robot-assisted Gait Training on Freezing of Gait in Parkinson's Disease

will be conducted. Participants will also be asked to return for 1- and 3-month post-intervention assessments to see if the training has any lasting effects. Approximately 10-20 subjects will be enrolled, and the study will last up to 6 months. Robot-assisted gait training will be conducted with the Lokomat (a treadmill with supplemental robot-assistance for moving the hip and knee). We will monitor changes in freezing by conducting various assessments. There are approximately 1 million Americans with PD (...) . This is accomplished by utilizing high quality computer-controlled motors that are precisely synchronized with the speed of the treadmill. The hip and knee joint angles are controlled in real time by software to achieve kinematically correct stepping behaviors. Each of the four motor-driven joints is individually controlled to correspond precisely to the desired joint angle trajectories. This system assures a precise match between the speed of the limb trajectory and the treadmill. In addition, sensors

2009 Clinical Trials

974. Review for the generalist: evaluation of pediatric hip pain. (Full text)

Review for the generalist: evaluation of pediatric hip pain. Hip pathology may cause groin pain, referred thigh or knee pain, refusal to bear weight or altered gait in the absence of pain. A young child with an irritable hip poses a diagnostic challenge. Transient synovitis, one of the most common causes of hip pain in children, must be differentiated from septic arthritis. Hip pain may be caused by conditions unique to the growing pediatric skeleton including Perthes disease, slipped capital (...) femoral epiphysis and apophyseal avulsion fractures of the pelvis. Hip pain may also be referred from low back or pelvic pathology. Evaluation and management requires a thorough history and physical exam, and understanding of the pediatric skeleton. This article will review common causes of hip and pelvic musculoskeletal pain in the pediatric population.

2009 Pediatric Rheumatology

975. BioCleanse Tibialis Tendon Anterior Cruciate Ligament (ACL) Study

replacement will be evaluated Outcome Measures Go to Primary Outcome Measures : Objective International Knee Documentation Committee (IKDC) Exam [ Time Frame: pre-op, 2 months, 4 months, 6 months, 12 months, 24 months ] The International Knee Documentation Committee (IKDC) is a knee-specific patient-reported outcome measure. This is an indexed score form 0-100, with 0 being the worst possible status and 100 indicating no dysfunction, disability or pain. Secondary Outcome Measures : Subjective quality (...) of the inclusion criteria listed above. Autograft anterior cruciate ligament surgery on either knee. Anterior cruciate ligament injury on contra-lateral leg at any time Multi-ligament reconstruction Inability to comply with all requirements of this investigation, as well as follow the instructions of the physician. Significant systemic disease or conditions which impact overall health or well being or which necessitate chronic medication use. Revision anterior cruciate ligament surgery to either knee

2009 Clinical Trials

976. The Arthritis, Diet, and Activity Promotion Trial

Forest University Health Sciences Study Details Study Description Go to Brief Summary: The primary purpose of this study was to determine the effect of dietary weight-loss, exercise training, or a combination of both on physical function in overweight and obese adults with knee osteoarthritis (OA). In secondary analyses, the effect of weight-loss and/or exercise on OA progression, self-reported pain and inflammation were examined. In post-trial analyses, the effect of dietary weight-loss on total (...) mortality was determined. Condition or disease Intervention/treatment Phase Knee Osteoarthritis Behavioral: Dietary Weight-loss Behavioral: Exercise Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 318 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Outcomes Assessor) Primary Purpose: Treatment Official Title: The Arthritis, Diet, and Activity Promotion Trial Study Start Date

2009 Clinical Trials

977. Functional and Physiological Responses to Lokomat Therapy (Pilot Study)

) Body Composition [dual energy x-ray absorptiometry (DEXA) ) - [scans include total body, dual femur, and the knee], partial body potassium counting (PBKleg), bioelectrical impedance analysis (BIA), anthropometric and skin fold measurements] Fasting blood draw for plasma glucose and insulin (FPG, FPI), lipid profile, testosterone, sex hormone binding globulin (SHBG), insulin-like growth factor 1 (IGF-1), bone markers, coagulation factors, platelet aggregation, 2 hour standard oral glucose tolerance (...) testing (OGTT) with insulin levels. Autonomic and blood pressure regulation studies [resting and tilt table provocation, for heart rate and blood pressure variability (HRV, BPV), arterial blood flow, and venous occlusion] Disability-specific quality of life (QOL) and activities of daily living surveys [GI-Bowel survey, brief pain inventory (BPI), fatigue survey, spasticity scale, mini mental status exam (MMSE)]. These disease-specific QOLs will include the question "How do you rate your general health

2009 Clinical Trials

978. Comparison of Therapeutic Regimens for Scleroderma Interstitial Lung Disease (The Scleroderma Lung Study II)

that will include pulmonary function tests, blood and urine sampling, a physical exam, and questionnaires about current health and medications. At the final study visit, participants will also undergo a high resolution computerized tomography (HRCT) scan and possibly a punch biopsy. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 142 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant (...) provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: The presence of either limited (cutaneous thickening distal but not proximal to elbows and knees, with or without facial involvement) or diffuse (cutaneous thickening proximal to elbows and knees, often involving the chest or abdomen) scleroderma, as determined

2009 Clinical Trials

979. Feasibility Study of Radiofrequency Heating of Cardiac Infarction Scar to Treat Heart Failure

-cause hospitalizations, days alive out of the hospital, and neurological assessments (NIH Stroke Scale and Mini-Mental Status Exam) [ Time Frame: 6 and 12 months ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts (...) insufficiency of any severity due to hepato-renal syndrome Only for patients undergoing MR (rather than CT) imaging: Known allergy or reaction to Gadolinium Atrial fibrillation Prior cardiac surgery (including coronary artery bypass grafting, valve replacement or repair, aortic root replacement) or anticipated during the 6 months following enrollment Major non-cardiac surgery (e.g. knee or hip replacement, laparotomy, carotid endarterectomy, etc.) ≤ 3 months prior to enrollment or planned during the 6

2009 Clinical Trials

980. Muscle Perfusion and Protein Metabolism in Elderly

. Availability of transportation (i.e., subjects must be able to provide their own transportation to UTMB). Ability to sign informed consent (score >24 on 30 item mini-mental status exam and no errors on assessment of judgment). Exclusion Criteria: None of the following exclusion criteria should be present at enrollment or throughout the study: Patients with limiting or unstable angina or who demonstrate cardiac abnormalities such as > 0.2 mV horizontal or downsloping ST segment depression, frequent (...) -converting enzyme inhibitors, calcium channel blockers, or alpha blockers. Any patient with uncontrolled metabolic diseases including any patient with liver or renal disease. Glucose intolerance: fasting plasma glucose concentration 110-126 mg/dL (6.1-7 mmol/L) and/or 2-h plasma glucose 140-200 mg/dL (7.8-11.1 mmol/L) during oral glucose tolerance test (OGTT). Currently in muscle strengthening program. Total knee replacement or moderate to severe degenerative joint disease of knees. Anemia (hemoglobin

2009 Clinical Trials

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