How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

791 results for

Klinefelter Syndrome

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

121. Neuroanatomical correlates of Klinefelter syndrome studied in relation to the neuropsychological profile (PubMed)

Neuroanatomical correlates of Klinefelter syndrome studied in relation to the neuropsychological profile Brain imaging in Klinefelter syndrome (47, XXY) (KS), a genetic disorder characterized by the presence of an extra X chromosome, may contribute to understanding the relationship between gene expression, brain structure, and subsequent cognitive disabilities and psychiatric disorders. We conducted the largest to date voxel-based morphometry study of 65 KS subjects and 65 controls matched

Full Text available with Trip Pro

2013 NeuroImage : Clinical

122. Birth of a healthy boy using fresh testicular sperm in a patient with Klinefelter syndrome combined with Kartagener syndrome. (PubMed)

Birth of a healthy boy using fresh testicular sperm in a patient with Klinefelter syndrome combined with Kartagener syndrome. To report a case of Klinefelter syndrome combined with Kartagener syndrome.Case report.Private IVF center.A 35-year-old man with Klinefelter syndrome combined with Kartagener syndrome causing primary infertility.Testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI).Sperm recovery, fertilization, and live birth.Ovulation induction of the female (...) partner, recovery of spermatozoa by TESE from the male partner and ICSI of 9 metaphase II oocytes resulted in two fertilized oocytes. The delivery of a healthy boy with normal anatomy and 46,XY karyotype was achieved after the transfer of only one 4-cell grade 1 embryo.To our knowledge, this case with nonmosaic Klinefelter syndrome combined with Kartagener's syndrome is unique and demonstrates the revolutionary aspects of assisted reproductive technologies (ART) concerning male factor

2011 Fertility and Sterility

123. Testicular sperm sampling by subcapsular orchiectomy in Klinefelter patients: A new simplified treatment approach. (PubMed)

Testicular sperm sampling by subcapsular orchiectomy in Klinefelter patients: A new simplified treatment approach. To evaluate subcapsular orchiectomy as a method to retrieve spermatozoa from minute testicular foci in men with Klinefelter syndrome (KS).Fourteen men with KS were consecutively recruited to unilateral subcapsular orchiectomy. Testicular tissue was dissected mechanically and enzymatically to identify possible sperm. Previous testosterone replacement therapy was interrupted for 10

Full Text available with Trip Pro

2015 Urology

124. Is serum estradiol (E2) really increased in patients with Klinefelter Syndrome (KS)? Results from a meta-analysis study

Is serum estradiol (E2) really increased in patients with Klinefelter Syndrome (KS)? Results from a meta-analysis study Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence

2016 PROSPERO

125. Clinical Presentation of Klinefelter's Syndrome: Differences According to Age (PubMed)

Clinical Presentation of Klinefelter's Syndrome: Differences According to Age The aim of the study was to establish the characteristics of presentation of 94 patients with Kinelfelter's syndrome (KS) referred to the endocrinologist at different ages. The diagnosis of KS was more frequent in the age group between 11 and 20 years (46.8%). Most of the patients (83.7%) showed the classic 47,XXY karyotype and 7.1% showed a 47,XXY/46,XY mosaicism. Half of the patients younger than 18 years presented (...) ≥25.0 kg/m(2). In conclusion, the diagnosis of Klinefelter syndrome seems to be made earlier nowadays probably because pediatricians are more aware that boys and adolescents with neuro-developmental disorders and cryptorchidism are at increased risk. The increasing use of prenatal diagnosis has also decreased the mean age at diagnosis and allowed to get insight into the evolution of previously undiagnosed cases, which probably represent the mildest forms. In adults average height and weight

Full Text available with Trip Pro

2012 International journal of endocrinology

126. Klinefelter Syndrome Associated With Goniodysgenesis. (PubMed)

Klinefelter Syndrome Associated With Goniodysgenesis. We report a case of a patient with Klinefelter syndrome and glaucoma.A 30-year-old patient with karyotype 47, XXY, presented with a known medical history of glaucoma. Besides reduced fertility, no characteristic physical or behavioral symptoms for Klinefelter syndrome were found on clinical examination. While both eyes were treated with topical intraocular pressure-lowering medications, an increased intraocular pressure, visual field losses (...) . However, the association between Klinefelter syndrome and ocular manifestations is rare.: Glaucoma or in fact any other ocular manifestations associated with Klinefelter syndrome are rarely described. Here, we report a case of glaucoma and its treatment combining trabeculotomy and trabeculectomy in a patient with Klinefelter syndrome.

2012 Journal of Glaucoma

127. The genetic origin of Klinefelter syndrome and its effect on spermatogenesis. (PubMed)

The genetic origin of Klinefelter syndrome and its effect on spermatogenesis. Klinefelter syndrome is the most prevalent chromosome abnormality and genetic cause of azoospermia in males. The availability of assisted reproductive technology (ART) has allowed men with Klinefelter syndrome to father their own genetic offspring. When providing ART to men with Klinefelter syndrome, it is important to be able to counsel them properly on both the chance of finding sperm and the potential effects (...) on their offspring. The aim of this review is twofold: [1] to describe the genetic etiology of Klinefelter syndrome and [2] to describe how spermatogenesis occurs in men with Klinefelter syndrome and the consequences this has for children born from men with Klinefelter syndrome.Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

2012 Fertility and Sterility

128. Klinefelter Syndrome--A Clinical Update. (PubMed)

Klinefelter Syndrome--A Clinical Update. Recently, new clinically important information regarding Klinefelter syndrome (KS) has been published. We review aspects of epidemiology, endocrinology, metabolism, body composition, and neuropsychology with reference to recent genetic discoveries.PubMed was searched for "Klinefelter," "Klinefelter's," and "XXY" in titles and abstracts. Relevant papers were obtained and reviewed, as well as other articles selected by the authors.KS is the most common sex (...) chromosome disorder in males, affecting one in 660 men. The genetic background is the extra X-chromosome, which may be inherited from either parent. Most genes from the extra X undergo inactivation, but some escape and serve as the putative genetic cause of the syndrome. KS is severely underdiagnosed or is diagnosed late in life, roughly 25% are diagnosed, and the mean age of diagnosis is in the mid-30s. KS is associated with an increased morbidity resulting in loss of approximately 2 yr in life span

Full Text available with Trip Pro

2012 Journal of Clinical Endocrinology and Metabolism

129. Klinefelter syndrome: how, what, and why? (PubMed)

Klinefelter syndrome: how, what, and why? Klinefelter syndrome is commonly encountered by the physician dealing with male infertility. Despite the success of sperm retrieval and ICSI, there remain many areas of controversy about the mechanisms and natural history of spermatogenesis, as well as the appropriate management of these patients. This collection of articles provides a state of the art review of what is known and what is unknown about this syndrome and reports a variety of management

2012 Fertility and Sterility

130. Study of Psychological and Motor Effects of Testosterone in Adolescents With XXY/Klinefelter Syndrome

Study of Psychological and Motor Effects of Testosterone in Adolescents With XXY/Klinefelter Syndrome Study of Psychological and Motor Effects of Testosterone in Adolescents With XXY/Klinefelter Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Study of Psychological and Motor Effects of Testosterone in Adolescents With XXY/Klinefelter Syndrome (TestoXXY/KS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01585831 Recruitment Status : Completed First Posted : April 26, 2012 Last Update Posted

2012 Clinical Trials

131. Epigenetics and Metabolic Disorders in Men With the Klinefelter Syndrome

Epigenetics and Metabolic Disorders in Men With the Klinefelter Syndrome Epigenetics and Metabolic Disorders in Men With the Klinefelter Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Epigenetics (...) and Metabolic Disorders in Men With the Klinefelter Syndrome (IZKF-CRA03-09) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01703676 Recruitment Status : Completed First Posted : October 10, 2012 Last Update Posted : October 15, 2012 Sponsor: University Hospital Muenster Information provided by (Responsible

2012 Clinical Trials

132. Life Quality and Health in Patients With Klinefelter Syndrome

Life Quality and Health in Patients With Klinefelter Syndrome Life Quality and Health in Patients With Klinefelter Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Life Quality and Health (...) in Patients With Klinefelter Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01690013 Recruitment Status : Completed First Posted : September 21, 2012 Last Update Posted : June 2, 2015 Sponsor: University of Aarhus Collaborator: Aarhus University Hospital Information provided by (Responsible Party

2012 Clinical Trials

133. Subcapsular Orchiectomy in Men With Klinefelter Syndrome

Subcapsular Orchiectomy in Men With Klinefelter Syndrome Subcapsular Orchiectomy in Men With Klinefelter Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Subcapsular Orchiectomy in Men (...) With Klinefelter Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01750632 Recruitment Status : Completed First Posted : December 17, 2012 Last Update Posted : October 4, 2016 Sponsor: Odense University Hospital Collaborators: University of Copenhagen Aarhus University Hospital Information provided

2012 Clinical Trials

134. Klinefelter's syndrome associated with progressive muscular atrophy simulating Kennedy's disease (PubMed)

Klinefelter's syndrome associated with progressive muscular atrophy simulating Kennedy's disease Kennedy's disease, an X-linked spinal and bulbar muscular atrophy, is characterized by loss of lower motor neurons. Mild sensory deficits, gynecomastia and infertility may be observed. Klinefelter's syndrome is a variation of sex chromosome disorder characterized by hypogonadism, gynecomastia and azoospermia, and the most frequent karyotype is XXY. A 55-year-old man who presented with slowly (...) progressive and diffuse neurogenic muscle atrophy without bulbar or sensory symptoms. He also had Klinefelter's syndrome. Genetic study of Kennedy's disease was normal. Our patient differs from those with Kennedy's disease in the absence of bulbar and sensory symptoms. It is suggested that the X chromosome plays an important role in the biology of motor neurons.

Full Text available with Trip Pro

2012 Annals of Indian Academy of Neurology

135. Klinefelter Syndrome

Klinefelter Syndrome Klinefelter Syndrome Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Klinefelter Syndrome Klinefelter Syndrome (...) Aka: Klinefelter Syndrome From Related Chapters II. Epidemiology Most common major sexual differentiation abnormality of Klinefelter Syndrome in specific cohorts Newborn males: 1 in 500 to 1000 Male : 7.5% Infertile males: 3% Mild : 1% III. Pathophysiology Results in testicular dysgenesis Chromosomal abnormality with 47,XXY karyotype Abnormality of nondisjunction during meiosis Maternal or paternal origin Most of additional X is inactivated Functioning extra genes confer More severe cases

2015 FP Notebook

136. Spermatogonial stem cell preservation in boys with Klinefelter syndrome: to bank or not to bank, that's the question. (PubMed)

Spermatogonial stem cell preservation in boys with Klinefelter syndrome: to bank or not to bank, that's the question. Although early development of testis appears normal in boys with Klinefelter syndrome (KS), spermatogonial stem cell (SSC) depletion occurs in midpuberty, leading to infertility. Therefore, freezing of semen samples or testicular tissue sampling could be offered to boys with KS at onset of puberty. However, only in about half of patients with KS, adult or prepubertal

2012 Fertility and Sterility

137. The natural history of endocrine function and spermatogenesis in Klinefelter syndrome: what the data show. (PubMed)

The natural history of endocrine function and spermatogenesis in Klinefelter syndrome: what the data show. Once thought to be a chromosomal aberration associated with absolute sterility, Klinefelter syndrome may now be potentially treatable by testicular sperm retrieval coupled with intracytoplasmic sperm injection. With these therapeutic advances, azoospermic 47,XXY men now may have an opportunity for biological paternity. However, our knowledge of the basic mechanisms underlying germ cell (...) loss and Leydig cell compromise is lagging, and is just now beginning to evolve and provide answers to some of the field's most vexing questions: how to maximize and preserve fertility in Klinefelter males many years or even decades before they wish to actively pursue fatherhood. This article reviews the development of the androgenic and spermatogenic compartments of the Klinefelter testis through puberty, and recommends that it is only with a clear understanding of the basic facts that a rational

2012 Fertility and Sterility

138. A myotonic syndrome associated with Klinefelter's syndrome. (PubMed)

A myotonic syndrome associated with Klinefelter's syndrome. 6082911 1968 04 20 2018 11 13 0022-2593 4 4 1967 Dec Journal of medical genetics J. Med. Genet. A myotonic syndrome associated with Klinefelter's syndrome. 299-301 Woollacott S S Pearce J J eng Case Reports Journal Article England J Med Genet 2985087R 0022-2593 IM Adult Humans Klinefelter Syndrome complications Male Myotonia complications diagnosis genetics Myotonia Congenita diagnosis Myotonic Dystrophy diagnosis 1967 12 1 1967 12 1 0

Full Text available with Trip Pro

1967 Journal of Medical Genetics

139. XYY syndrome, and XYY-XXYY mosaicism also showing features of Klinefelter's syndrome. (PubMed)

XYY syndrome, and XYY-XXYY mosaicism also showing features of Klinefelter's syndrome. 5801462 1969 09 30 2018 11 13 0022-2593 6 2 1969 Jun Journal of medical genetics J. Med. Genet. XYY syndrome, and XYY-XXYY mosaicism also showing features of Klinefelter's syndrome. 159-65 Spencer D A DA Eyles J W JW Mason M K MK eng Journal Article England J Med Genet 2985087R 0022-2593 IM Adult Antisocial Personality Disorder Body Height Cheek cytology Humans Intellectual Disability genetics Jaw (...) Abnormalities genetics Karyotyping Klinefelter Syndrome Male Mandible abnormalities Mosaicism Sex Chromosome Aberrations 1969 6 1 1969 6 1 0 1 1969 6 1 0 0 ppublish 5801462 PMC1468843 Nature. 1965 Dec 25;208(5017):1351-2 5870205 Nature. 1966 Feb 5;209(5023):641-2 5921206 Lancet. 1961 Aug 26;2(7200):488-9 13746118 Exp Cell Res. 1960 Sep;20:613-6 13772379 Ann Hum Genet. 1961 Oct;25:145-51 13889991 JAMA. 1963 Apr 20;184:179-82 14015109 Am J Hum Genet. 1964 Sep;16:284-91 14204778 Ann Med Nancy. 1964 Aug-Sep;42

Full Text available with Trip Pro

1969 Journal of Medical Genetics

140. European Society of Endocrinology Clinical practice guidelines for the care of girls and women with Turner syndrome

European Society of Endocrinology Clinical practice guidelines for the care of girls and women with Turner syndrome Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting in: European Journal of Endocrinology Volume 177 Issue 3 Year 2017 This site uses cookies, tags, and tracking settings to store information that help give you the very best browsing experience. If you don't change your (...) settings, we'll assume you're happy with this. Google Translate to save searches and organize your favorite content. Not registered? Search Recently viewed (1) Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting in Authors: , , , , , , , , , , , , , , , , , , , , and View More View Less 1 Departments of Endocrinology and Internal Medicine 2 Departments of Molecular Medicine 3 Departments

2017 European Society of Endocrinology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>