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221. Lichen Planus

to induce a lichenoid drug eruption, such as 29,43 : ? Antihypertensives – ACE inhibitors, beta-blockers, nifedipine, methyldopa 44 ? Diuretics 45 – hydrochlorothiazide, furosemide, spironolactone ? Non-steroidal anti-in ?ammatory drugs (NSAIDs) 44 ? Phenothiazine derivatives 46 ? Anti-convulsants – carbamazapine 47 , phenytoin ? Drugs to treat tuberculosis 48 ? Antifungal drug – ketoconazole ? Chemotherapeutic agents – hydroxyurea, 5- ?uorouracil, imatinib 49 ? Antimalarial agents

2018 European Dermatology Forum

224. Castration-Resistant Prostate Cancer

developed to provide a rational basis for treatment based on currently available published data. [pdf] [pdf] [pdf] Note to the Reader: On July 21, 2014, the FDA issued a recommendation that health care professionals should consider the alcohol content of docetaxel when prescribing or administering the drug to patients. On July 26, 2013, the FDA issued a safety announcement related to the use of ketoconazole in the form of oral tablets. Side effects can include hepatotoxicity, adrenal insufficiency (...) ; Evidence Level Grade C) Index Patient 2 5. Clinicians should offer abiraterone plus prednisone, enzalutamide, docetaxel, or sipuleucel-T to patients with asymptomatic or minimally symptomatic mCRPC with good performance status and no prior docetaxel chemotherapy. (Standard; Evidence Level Grade A [abiraterone plus prednisone and enzalutamide] /B [docetaxel and sipuleucel-T]) 6. Clinicians may offer first- generation anti-androgen therapy, ketoconazole plus steroid or observation to patients

2018 American Urological Association

227. Antiocoagulation - oral

and clinically relevant bleeding risk. A prosthetic heart valve. Apixaban is also contraindicated in: People who are taking any other anticoagulants, except when switching to or from warfarin treatment. People who are taking strong inhibitors of cytochrome P3A4 enzyme and P-glycoprotein, such as ketoconazole, or HIV protease inhibitors such as ritonavir. For more information, see . Women who are pregnant or breastfeeding. The safety of apixaban has not been established in pregnant or breastfeeding women (...) warfarin treatment. For more information on how to switch to or from warfarin, see . Antiplatelets such as low dose aspirin, clopidogrel, ticlopidine, glycoprotein IIb/IIIa-receptor antagonists, sulfinpyrazone, and ticagrelor — there is an increased risk of bleeding with concomitant therapy; avoid concomitant use with apixaban, except on specialist advice. Itraconazole, ketoconazole, voriconazole, posaconazole, and HIV protease inhibitors (e.g. ritonavir) — the plasma concentration of apixaban

2017 Prodigy

228. Blood and Clots Series: Which antithrombotic therapy should I start for my patient with acute VTE? Full Text available with Trip Pro

-glycoprotein and CYP3A 4 may interact with Rivaroxaban and Apixaban. A table of common interactions can be found 1 . A few common drugs to look out for: some Antifungals (particularly Ketoconazole and Voriconazole) increase DOAC effect, Antiepileptics (particularly Phenytoin, Carbamazepine, Phenobarbitol) reduce DOAC effect, and tuberculosis medications (Rifampin) reduce DOAC effect. Is there sufficient renal and hepatic function ? The DOACs are reliant to a variable extent on renal clearance. These drugs

2018 CandiEM

230. CRACKCast E184 – The Solid Organ Transplant Donor

, Diltiazem, Fluconazole, Fluoroquinolones, Ketoconazole, Macrolide antibiotics, Oral contraceptives, Verapamil Interact at a glomerular or tubular level (increased nephrotoxicity). E.g., Aminoglycosides, Amphotericin B, Cimetidine, Nonsteroidals, Sulfur This post was copyedited and uploaded by Samuel Hogman (Visited 577 times, 1 visits today) Chris Lipp is one of the founding Fathers for CrackCast. He currently divides his time as an EM Physician in Calgary (SHC/FMC) and in Sports Medicine. His interests

2018 CandiEM

231. Kaiser Permanente National Dyslipidemia Clinician Guide

or rosuvastatin up to 5 mg Avoid simvastatin, atorvastatin, and lovastatin Danazol Use atorvastatin up to 20 mg or rosuvastatin any dose Avoid simvastatin and lovastatin Diltiazem, dronedarone, or verapamil Use atorvastatin up to 40 mg and 80 mg with caution Avoid simvastatin > 10 mg Avoid lovastatin > 20 mg Gemfibrozil Stop gemfibrozil in those on statins or needing statins. For TG = 500 mg/dL, add EPA/DHA 2-4 g/day and retest. If TG remain elevated, see TG algorithm (Fig 2) Itraconazole, ketoconazole

2017 Kaiser Permanente National Guideline Program

233. Edoxaban (Roteas) - anticoagulant

, ketoconazole, quinidine, or verapamil. 2.2. Quality aspects Since this application is an informed consent of the Lixiana, the quality data in support of the Roteas application are identical to the up-to-date quality data of the Lixiana dossier, which has been assessed and approved (including all post-marketing procedures). Assessment report EMA/158410/2017 Page 9/13 2.3. Non-clinical aspects 2.3.1. Introduction Roteas is submitted under an informed consent application, article 10(c) of directive 2001/83/EC

2017 European Medicines Agency - EPARs

237. Solithromycin Triskel - community-acquired pneumonia, anthrax and tularaemia

In-vivo studies CYP3A inhibition by ketoconazole (107) Fasting subjects received solithromycin 400 mg (2×200 mg capsules) on Day 1, ketoconazole 400 mg once daily on Days 7 through 10 and both agents together on Day 11. Solithromycin plasma concentrations were substantially higher on co-administration. Cmax increased 1.6-fold (56%) with 90% CI 1.39-1.76 while AUC inf increased by 2.6-fold (155%) with 90% CI 2.24-2.91. Changes in N-acetyl-solithromycin PK were proportional to parent drug concentration (...) changes and were considered likely due to changes in parent drug kinetics, since ketoconazole is not known to affect N- acetylation. Formation of the metabolite CEM-214 was decreased by ketoconazole. A population-based PK (PBPK) model was constructed based on in-vitro and in-vivo data in an attempt to understand the possible consequences of concomitant administration of a CYP3A4 inhibitor with solithromycin in patients with severe renal impairment. The predicted exposure of solithromycin after

2017 European Medicines Agency - EPARs

240. Apixaban (Eliquis)

of apixaban and drugs that inhibit or induce both P- glycoprotein (P-gp) and CYP3A4 should be avoided. Patients taking strong inhibitors of both CYP3A4 and P-gp are at an increased risk of bleeding. Examples of inhibitors include azole antifungals (e.g. itraconazole, ketoconazole, voriconazole, and posaconozole), macrolide antibiotics (e.g. clarithromycin, erythromycin) and HIV protease inhibitors (e.g. ritanovir). Alternatively, concomitant use of strong inducers (e.g. rifampin, carbamazepine, phenytoin

2017 Thrombosis Interest Group of Canada

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