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Ketamine

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141. The utility of intravenous ketamine for the management of intraoperative penile erection: a retrospective single-center analysis of endourological surgeries over a 4-year. Full Text available with Trip Pro

The utility of intravenous ketamine for the management of intraoperative penile erection: a retrospective single-center analysis of endourological surgeries over a 4-year. To assess the prevalence of intraoperative penile erection in our endourology practice and the utility of intravenous ketamine in the management of the condition.Of 402 endoscopic urological procedures performed in our clinic over a 4-year (2015-2019) period, a total of 9 cases with intraoperative penile erection impeding (...) received spinal anesthesia (n = 9) at T8-10 dermatome levels, for TURP in 7 (77.8%) cases and for TURBT in 2 (22.2%) cases. The onset of penile erection was post-urethroscope in 7 (77.8%) cases. The average total ketamine dose was 34.3 mg (range, 18.0-75.0 mg). The average duration of the operation was 91.7 min (range, 40.0-140.0 min). Ketamine treatment resulted in resolved erection with delayed procedure in 7 (77.8%) cases, while conversion to general anesthesia was required in 2 (22.5%) cases.In

2020 BMC Urology

142. Abnormal expression of rno_circRNA_014900 and rno_circRNA_005442 induced by ketamine in the rat hippocampus. Full Text available with Trip Pro

Abnormal expression of rno_circRNA_014900 and rno_circRNA_005442 induced by ketamine in the rat hippocampus. Recent studies have shown that circular RNA (circRNA) is rich in microRNA (miRNA) binding sites. We have previously demonstrated that the antidepressant effect of ketamine is related to the abnormal expression of various miRNAs in the brain. This study determined the expression profile of circRNAs in the hippocampus of rats treated with ketamine.The aberrantly expressed circRNAs in rat (...) hippocampus after ketamine injection were analyzed by microarray chip, and we further validated these circRNAs by quantitative reverse-transcription PCR (qRT-PCR). The target genes of the different circRNAs were predicted using bioinformatic analyses, and the functions and signal pathways of these target genes were investigated by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses.Microarray analysis showed that five circRNAs were aberrantly expressed in rat hippocampus

2020 BMC Psychiatry

143. Effect of caudal ketamine on minimum local anesthetic concentration of ropivacaine in children: a prospective randomized trial. Full Text available with Trip Pro

Effect of caudal ketamine on minimum local anesthetic concentration of ropivacaine in children: a prospective randomized trial. Caudal ketamine has been shown to provide an effective and prolonged post-operative analgesia with few adverse effects. However, the effect of caudal ketamine on the minimum local anesthetic concentration (MLAC) of ropivacaine for intra-operative analgesia is unclear.One hundred and sixty-nine children were randomized to five groups: Group C (caudal ropivacaine only (...) ), Group K0.25 (caudal ropivacaine plus 0.25 mg/kg ketamine), Group K0.5 (caudal ropivacaine plus 0.5 mg/kg ketamine), Group K0.75 (caudal ropivacaine plus 0.75 mg/kg ketamine), and Group K1.0 (caudal ropivacaine plus 1.0 mg/kg ketamine). The primary outcome was the MLAC values of ropivacaine with/without ketamine for caudal block.The MLAC values of ropivacaine were 0.128% (0.028%) in the control group, 0.112% (0.021%) in Group K0.25, 0.112% (0.018%) in Group K0.5, 0.110% (0.019%) in Group K0.75

2020 BMC Anesthesiology

144. A rapid positive influence of S-ketamine on the anxiety of patients in palliative care: a retrospective pilot study. Full Text available with Trip Pro

A rapid positive influence of S-ketamine on the anxiety of patients in palliative care: a retrospective pilot study. Patients in palliative care need rapid-acting pharmacological options for psychological distress. N-methyl-D-aspartate antagonist ketamine is known to have a fast onset of anti-depressant and anxiolytic action. Its S-enantiomer S-ketamine (or esketamine) is an analgesic used as a routine treatment for refractory pain as an intravenous infusion (0.25 mg/kg over 45 min). This study (...) investigates whether S-ketamine pain therapy has a positive impact on psychological distress caused by anxiety and depression in palliative care.Patient routine data from a palliative care unit of a tertiary care hospital were used in a retrospective analysis after positive ethics approval. Eight patients, who received analgesic S-ketamine treatment, were compared to a control group matched by gender and age. The main analysis was conducted using three-way mixed MANOVA followed by two-way mixed ANOVA

2020 BMC Palliative Care

145. Propofol versus placebo (with rescue with ketamine) before less invasive surfactant administration: study protocol for a multicenter, double-blind, placebo controlled trial (PROLISA). Full Text available with Trip Pro

Propofol versus placebo (with rescue with ketamine) before less invasive surfactant administration: study protocol for a multicenter, double-blind, placebo controlled trial (PROLISA). One major limitation for less invasive surfactant administration (LISA) is the difficulty in providing sedation before this procedure and the competitive risk of respiratory depression versus avoidance of intubation for most sedative or analgesic drugs used in this context. The objective of this study (...) is to compare the need for mechanical ventilation within 72 h of life following premedication with propofol, versus placebo (rescue with ketamine), for the LISA procedure in preterm neonates born before 32 weeks gestational age (wGA).ProLISA is a phase III, non-inferiority, multicenter, double blind, randomized, placebo controlled trial designed according to the SPIRIT Statement. Neonates born before 32 wGA in 12 geographically dispersed Neonatal Intensive Care Units in France needing surfactant

2020 BMC Pediatrics

146. A randomized, crossover comparison of ketamine and electroconvulsive therapy for treatment of major depressive episodes: a Canadian biomarker integration network in depression (CAN-BIND) study protocol. Full Text available with Trip Pro

A randomized, crossover comparison of ketamine and electroconvulsive therapy for treatment of major depressive episodes: a Canadian biomarker integration network in depression (CAN-BIND) study protocol. Recent evidence underscores the utility of rapid-acting antidepressant interventions, such as ketamine, in alleviating symptoms of major depressive episodes (MDE). However, to date, there have been limited head-to-head comparisons of intravenous (IV) ketamine infusions with other antidepressant (...) treatment strategies in large randomized trials. This study protocol describes an ongoing multi-centre, prospective, randomized, crossover, non-inferiority trial comparing acute treatment of individuals meeting diagnostic criteria for a major depressive episode (MDE) with ketamine and electroconvulsive therapy (ECT) on efficacy, speed of therapeutic effects, side effects, and health care resource utilization. A secondary aim is to compare a 6-month maintenance strategy for ketamine responders

2020 BMC Psychiatry

147. Ketamine-propofol (Ketofol) for procedural sedation and analgesia in children: a systematic review and meta-analysis. Full Text available with Trip Pro

Ketamine-propofol (Ketofol) for procedural sedation and analgesia in children: a systematic review and meta-analysis. The aim of this review is to elucidate the efficacy and side effects of ketofol in comparison to other anaesthetic agents during procedural sedation and analgesia.The Cochrane Central Register of Controlled Trials (1996 to Feb 2019) and MEDLINE (1966 to Feb 2019) were searched, including the related randomised control trials and reviewed articles to find unpublished trials (...) or trials not obtained via electronic searches. Inclusion criteria for the studies included comparing recovery time, recording clinician satisfaction, and assessing the adverse effects of ketofol.Eleven trials consisting of a total of 1274 patients met our criteria and were included in this meta-analysis. Five trials compared ketofol with a single agent, while six trials compared ketofol with combined agents. While comparing between ketofol and a single agent (either ketamine or propofol), ketofol

2020 BMC Emergency Medicine

148. Ketamine: a versatile tool for anesthesia and analgesia. (Abstract)

Ketamine: a versatile tool for anesthesia and analgesia. Ketamine has been used for decades for a variety of indications. Beyond the historical benefits and effects of ketamine, newer developments have occurred worthy of an update. This review will discuss common uses and indications for ketamine in the perioperative setting, as well as highlight newer indications in recent years.Multiple studies have examined the use of ketamine in a variety of environments, as ketamine has become more popular (...) in emergency rooms and ICUs. Ketamine may be particularly beneficial in management of burn patients, who often require multiple procedures over the course of their treatment. Ketamine's role in the ongoing opioid crisis has been of particular interest, with multiple studies evaluating its potential role in managing both acute and chronic pain conditions. Ongoing studies examining the role of ketamine in treatment of depressions show promise as well.Ketamine is regaining popularity in the field

2020 Current Opinion in Anaesthesiology

149. Analgesic effects of low-dose ketamine after spinal fusion in adults: A protocol of prospective randomized trial. Full Text available with Trip Pro

Analgesic effects of low-dose ketamine after spinal fusion in adults: A protocol of prospective randomized trial. Patients with spinal fusion often have opioid tolerance and chronic pain, which makes it difficult to control postoperative pain. In this double-blind, randomized, prospective study, we assessed the safety and efficacy of intravenous low-dose ketamine for the treatment of pain in patients undergoing the lumbar spinal fusion.This randomized, prospective, double-blind and placebo (...) -controlled study was approved via the hospital institutional review committee. Patients were registered with signed written consent. All the floor nurses, recovery room and surgeons, patients, statisticians as well as research assistants were unaware of the grouping. The patients were randomly divided into ketamine group and control group by random number table. Nausea, vomiting or vomiting, the intensity of pain, adverse events, cumulative morphine consumption, as well as the amount of extra antiemetics

2020 Medicine

150. Comparison of a new sublingual sedation troche with midazolam, ketamine, and ondansetron with intravenous sedation and the effects on vital signs. Full Text available with Trip Pro

Comparison of a new sublingual sedation troche with midazolam, ketamine, and ondansetron with intravenous sedation and the effects on vital signs. To compare effects of the MKO Melt (midazolam 3 mg, ketamine 25 mg, and ondansetron 2 mg) with intravenous (IV) sedation on vital signs of patients who underwent cataract surgery.Two private ophthalmology practices in Sioux Falls, South Dakota, USA.Retrospective analysis.Preoperative, intraoperative, and postoperative vital signs were compared

2020 Journal of cataract and refractive surgery

151. A randomized controlled trial for measuring effects on cognitive functions of adding ketamine to propofol during sedation for colonoscopy. Full Text available with Trip Pro

A randomized controlled trial for measuring effects on cognitive functions of adding ketamine to propofol during sedation for colonoscopy. The purpose of this study was to evaluate the effects of adding ketamine to propofol on cognitive functions in patients undergoing sedation for colonoscopy.In this randomized, double-blinded, and controlled study, 200 patients were randomly allocated to ketamine/propofol admixture group (Group KP, n = 100), and propofol group (Group P, n = 100). Patients (...) in Group KP received 0.25 mg/kg of ketamine and 0.5 mg/kg of propofol. Patients in Group P received 0.5 mg/kg propofol. Cognitive functions were measured using CogState battery before and after the colonoscopy procedure. Ninety five patients in Group KP and 92 patients in Group P had completed the CogStates tests and were included in the data analysis.Compared with before procedure baseline, the performance on detection and identification tasks were significantly impaired after the procedure in both

2020 Medicine

153. Intranasal ketamine versus intravenous morphine for pain management in patients with renal colic: a double-blind, randomized, controlled trial. (Abstract)

Intranasal ketamine versus intravenous morphine for pain management in patients with renal colic: a double-blind, randomized, controlled trial. Urinary stones are a common urologic problem that can be manifested as an intense pain, known as renal colic. Pain control is an important intervention for the emergency treatment of renal colic patients. Intranasal ketamine can form a crucial part of such interventions by offering a new route for a widely-used analgesic drug.In a double-blind (...) , randomized, clinical trial, adults with renal colic admitted to a tertiary hospital emergency department were examined. The intervention group received 1 mg/kg intranasal (IN) ketamine and 1 ml of saline as a placebo. The control group received 0.1 mg/kg intravenous (IV) morphine and four puffs of saline as the placebo. The pain score was measured on the Numerical Rating Scale (NRS) 0, 15, 30 and 60 min after the drug administration.A total of 184 patients enrolled in this study in two parallel groups

2020 World journal of urology

154. Effects of ketamine in electroconvulsive therapy for major depressive disorder: meta-analysis of randomised controlled trials Full Text available with Trip Pro

Effects of ketamine in electroconvulsive therapy for major depressive disorder: meta-analysis of randomised controlled trials Effects of ketamine in electroconvulsive therapy for major depressive disorder: meta-analysis of randomised controlled trials | General Psychiatry Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Effects of ketamine in electroconvulsive therapy for major depressive disorder: meta-analysis of randomised controlled trials Article Text Meta-analysis Effects of ketamine in electroconvulsive therapy for major depressive disorder: meta-analysis of randomised controlled trials Xiao-Mei Li , Zhan-Ming Shi , Pei-Jia Wang and Hua Hu This is an open access

2020 General psychiatry

155. 38. Ketamine for painful sickle cell vaso-occlusive crises: a systematic review and meta-analysis Full Text available with Trip Pro

38. Ketamine for painful sickle cell vaso-occlusive crises: a systematic review and meta-analysis 38. Ketamine for painful sickle cell vaso-occlusive crises:... : European Journal of Emergency Medicine ')} You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Your account has been temporarily locked Your account has been temporarily locked due to incorrect sign in attempts and will be automatically unlocked in 30 mins (...) Free Metrics Introduction: Vaso-occlusive crisis (VOC) is one of the main causes of hospital admission in patients with sickle cell disease (SCD). Ketamine is often used as adjuvant to opioids to control sickle cell crisis, however, there is a lack of class one evidence about its safety and efficacy for VOC in SCD patients. We conducted this systematic review and meta-analysis to synthesize evidence from published reports about the efficacy and safety of ketamine in the management of acute painful

2020 European Journal of Emergency Medicine

156. Ketamine for treatment-resistant depression: recent developments and clinical applicationsEditor's Choice FREE Full Text available with Trip Pro

Ketamine for treatment-resistant depression: recent developments and clinical applicationsEditor's Choice FREE Ketamine for treatment-resistant depression: recent developments and clinical applications | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal (...) accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Ketamine for treatment-resistant depression: recent developments and clinical applications Article Text Clinical review Ketamine for treatment-resistant depression: recent developments

2016 Evidence-Based Mental Health

157. Intravenous Ketamine for the Treatment of Pain Syndromes

Intravenous Ketamine for the Treatment of Pain Syndromes TITLE: Intravenous Ketamine for the Treatment of Pain Syndromes: Clinical Effectiveness DATE: 07 June 2013 RESEARCH QUESTIONS 1. What is the clinical effectiveness of intravenous (IV) ketamine for the treatment of recalcitrant chronic regional pain syndrome? 2. What is the clinical effectiveness of IV ketamine for the treatment of fibromyalgia? 3. What is the clinical effectiveness of IV ketamine for the treatment of reflex sympathetic (...) dystrophy? KEY MESSAGE One systematic review, two randomized controlled trials, and four non-randomized studies were identified regarding the clinical effectiveness of intravenous (IV) ketamine for the treatment of chronic regional pain syndrome. No health technology assessments, systematic reviews, randomized controlled trials, or non-randomized studies were identified regarding the clinical effectiveness of IV ketamine for the treatment of fibromyalgia or reflex sympathetic dystrophy. METHODS

2013 Canadian Agency for Drugs and Technologies in Health - Rapid Review

158. Is Ketamine Effective for the Management of Acute Asthma Exacerbations in Children?

Is Ketamine Effective for the Management of Acute Asthma Exacerbations in Children? Systematic Review Snapshot TAKE-HOME MESSAGE Limited data from a single randomized controlled trial do not support the routine use of ketamine for children with acute asthma exacerbations that are unresponsive to initial aerosolized b 2 -agonist or steroids. Is Ketamine Effective for the Management of Acute Asthma Exacerbations in Children? EBEM Commentators Randolph P. Maddox, MD Rawle A. Seupaul, MD Department (...) of Emergency Medicine University of Arkansas for Medical Sciences Little Rock, AR Results Estimated bene?t of ketamine compared to placebo for children with acute asthma exacerbation that fail standard therapy based on a single trial (N¼68). Time Pulmonary Index Score (Mean Difference) 95% Con?dence Interval 2 h 0.40 (–0.4 to 1.3) The search identi?ed 5 potential studies; only 1 trial 2 met inclusion criteria so a meta-analysis could not be performed. This trial was appro- priately powered to detect

2013 Annals of Emergency Medicine Systematic Review Snapshots

159. Serum concentration of ketamine and antinociceptive effects of ketamine and ketamine-lidocaine infusions in conscious dogs. Full Text available with Trip Pro

Serum concentration of ketamine and antinociceptive effects of ketamine and ketamine-lidocaine infusions in conscious dogs. Central sensitization is a potential severe consequence of invasive surgical procedures. It results in postoperative and potentially chronic pain enhancement. It results in postoperative pain enhancement; clinically manifested as hyperalgesia and allodynia. N-methyl-D-aspartate (NMDA) receptor plays a crucial role in the mechanism of central sensitisation. Ketamine is most (...) commonly used NMDA-antagonist in human and veterinary practice. However, the antinociceptive serum concentration of ketamine is not yet properly established in dogs. Six dogs were used in a crossover design, with one week washout period. Treatments consisted of: 1) 0.5 mg/kg ketamine followed by continuous rate infusion (CRI) of 30 μg/kg/min; 2) 0.5 mg/kg ketamine followed by CRI of 30 μg/kg/min and lidocaine (2 mg/kg followed by CRI of 100 μg/kg/min); and 3) 0.5 mg/kg ketamine followed by CRI of 50 μg

2017 BMC veterinary research Controlled trial quality: uncertain

160. Ketamine infusion for pain control in adult patients with multiple rib fractures: Results of a randomized control trial. (Abstract)

Ketamine infusion for pain control in adult patients with multiple rib fractures: Results of a randomized control trial. Rib fractures occur in up to 40% of trauma patients and are associated with increased mortality. Opiate-based pain regimens remain the cornerstone of rib fracture management; however, concerns around opioids have fostered interest in alternative analgesics. Ketamine is currently being used in lieu of opioids, but little evidence exists supporting its use within the trauma (...) population.A prospective, randomized, double-blind placebo-controlled trial of adult patients with three or more rib fractures admitted to a Level I trauma center was conducted. Exclusion criteria included age older than 64 years, Glasgow Coma Scale score less than 13, and chronic opiate use. The experimental arm received low-dose ketamine (LDK) at 2.5 μg·kg·min while the placebo cohort received an equivalent rate of 0.9% normal saline. All infusions were continued for 48 hours. The primary outcome

2019 The journal of trauma and acute care surgery Controlled trial quality: predicted high

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