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21. The THINK (Treatment of Headache with Intranasal Ketamine) Trial: A Randomized Controlled Trial Comparing Intranasal Ketamine with Intravenous Metoclopramide. (Abstract)

The THINK (Treatment of Headache with Intranasal Ketamine) Trial: A Randomized Controlled Trial Comparing Intranasal Ketamine with Intravenous Metoclopramide. Headache is a common chief complaint in the emergency department (ED) setting.To compare analgesia with metoclopramide and diphenhydramine vs. intranasal ketamine among ED patients with primary headache.We enrolled a convenience sample of adults with a primary headache in a randomized, single-blind, placebo-controlled trial. We randomized (...) patients to either a control arm (intravenous metoclopramide and diphenhydramine) or intranasal ketamine. The primary outcome was change in pain 0-100 mm visual analog scale (VAS) score measured at study start and 30 min post completion of initial medication administration. Secondary outcomes included side effects, hospital admission, and return to care within 48-72 h.All 53 enrolled subjects completed the study, 26 of whom were allocated to the control arm and 27 to intranasal ketamine. The mean

2019 Journal of Emergency Medicine Controlled trial quality: predicted high

22. Effects of ketamine treatment on suicidal ideation: a qualitative study of patients' accounts following treatment for depression in a UK ketamine clinic. Full Text available with Trip Pro

Effects of ketamine treatment on suicidal ideation: a qualitative study of patients' accounts following treatment for depression in a UK ketamine clinic. It is recognised that ketamine treatment can reduce suicidal ideation (SI) in people with depression, at least in the short term. However, information is lacking on patients' perspectives on such effects. Studying these can contribute to greater understanding of the mechanisms underlying impact of ketamine treatment on SI. The aim (...) of this study was to investigate patients' reports of the impact of treatment on their SI, the duration of effects and possible mechanisms.This qualitative study consisted of semi-structured interviews with patients who had received ketamine treatment for depression. Interview data were analysed thematically.Fourteen patients (8 females, 6 males, aged 24-64 years) who had received treatment with ketamine for treatment-resistant depression, and had SI at the initiation of treatment. Two participants also had

2019 BMJ open

23. Comparison of Ketamine-Propofol and Ketamine-Thiopental on Bispectral Index Values during Monitored Anesthesia Care (MAC) in Minor Traumatic Orthopedic Surgery; A Randomized, Double-Blind, Clinical Trial. Full Text available with Trip Pro

Comparison of Ketamine-Propofol and Ketamine-Thiopental on Bispectral Index Values during Monitored Anesthesia Care (MAC) in Minor Traumatic Orthopedic Surgery; A Randomized, Double-Blind, Clinical Trial. To compare the effects of ketamine-propofol and ketamine-thiopental on bispectral index values during monitored anesthesia care in minor orthopedic surgeries.This randomized double-blind clinical trial was performed on 90 patients undergoing minor orthopedic surgeries. Participants were (...) randomly allocated to either groups of propofol or thiopental. Bispectral index (BIS), non-invasive arterial blood pressure, SpO2, and electrocardiogram were monitored every 5 minutes. Patients in propofol group received a bolus dose of 0.5 mg/kg ketamine, plus 0.5 mg/kg propofol. In thiopental group, patients received a bolus dose of 0.5 mg/kg ketamine, plus 50-75 mg thiopental. After the surgery, recovery duration, patients' pain score (VAS) and any intra-operative recall or awareness were recorded

2019 Bulletin of emergency and trauma Controlled trial quality: uncertain

24. Neurocognitive performance under combined regimens of ketamine-dexmedetomidine and ketamine-fentanyl in healthy adults: A randomised trial. Full Text available with Trip Pro

Neurocognitive performance under combined regimens of ketamine-dexmedetomidine and ketamine-fentanyl in healthy adults: A randomised trial. Analgesic doses of ketamine affects neurocognition; however, deficits under co-administration regimens are unknown. This study evaluated the effects of ketamine, alone and in combination with dexmedetomidine or fentanyl on neurocognition. Using a randomised, within-subjects gender stratified design, 39 participants (mean age = 28.4, SD ± 5.8) received (...) a ketamine bolus of 0.3 mg/kg followed by 0.15 mg/kg/h infusion of ketamine (3 h duration). At 1.5 h post-ketamine infusion commencement, participants received either: i) 0.7 μg/kg/h infusion of dexmedetomidine (n = 19) (KET/DEX) or (ii) three 25 μg fentanyl injections over 1.5 h (n = 20) (KET/FENT). Reaction and Movement time (RTI, Simple and 5Choice), Visuospatial Working Memory (SWM) and Verbal Recognition Memory (VRM) were assessed using the Cambridge Neuropsychological Test Automated Battery (CANTAB

2019 Progress in neuro-psychopharmacology & biological psychiatry Controlled trial quality: uncertain

25. Efficacy of Adding Low-Dose Ketamine to Dexmedetomidine Versus Low-Dose Ketamine and Propofol for Conscious Sedation in Patients Undergoing Awake Fiber-optic Intubation. Full Text available with Trip Pro

Efficacy of Adding Low-Dose Ketamine to Dexmedetomidine Versus Low-Dose Ketamine and Propofol for Conscious Sedation in Patients Undergoing Awake Fiber-optic Intubation. Conscious sedation is the key for successful AFOI. This trial was conducted to compare the effectiveness of dexmedetomidine and low dose of ketamine against propofol and low dose ketamine.Sixty patients subjected for general anesthesia were invited to participate in the study and randomly allocated into two equal groups: D-K (n (...) = 30) had been received a bolus dose of both ketamine 0.5mg /kg and dexmedetomidine 1ug/kg over 10 min. Then continuous infusion of ketamine 0.5mg /kg and dexmedetomidine 1ug/kg. The second group (P-K group) (n = 30): had been received a bolus dose of both ketamine 0.5mg/kg and propofol 1mg/kg over 10 min. Then continuous infusion of ketamine 0. 5mg/kg and propofol 1mg/kg.The intubation time was statistically significant shorter within the D-K group (58.9 ± 6.1) versus P-K group (63.4 ± 5.3) with p

2019 Anesthesia, essays and researches Controlled trial quality: uncertain

26. Ketamine-propofol (Ketofol) for Procedural Sedation and Analgesia in Children: A Systematic Review and Meta-Analysis Full Text available with Trip Pro

Ketamine-propofol (Ketofol) for Procedural Sedation and Analgesia in Children: A Systematic Review and Meta-Analysis Ketamine-propofol (Ketofol) for Procedural Sedation and Analgesia in Children: A Systematic Review and Meta-Analysis | Research Square Browse Tools & Services Your Cart See the published version of this article at . This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior (...) to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Research article Ketamine-propofol (Ketofol) for Procedural Sedation and Analgesia in Children: A Systematic Review and Meta-Analysis Tze Yong Foo, Norhayati Mohd Noor, Mohd Boniami Yazid, Mohd Hashairi Fauzi, Shaik Farid Abdull Wahab, Mohammad Zikri Ahmad Tze Yong Foo Universiti Sains

2020 Research Square

27. Ketamine-propofol (Ketofol) on Procedural Sedation and Analgesia in Children: A Systematic Review and Meta-Analysis Full Text available with Trip Pro

Ketamine-propofol (Ketofol) on Procedural Sedation and Analgesia in Children: A Systematic Review and Meta-Analysis Ketamine-propofol (Ketofol) on Procedural Sedation and Analgesia in Children: A Systematic Review and Meta-Analysis | Research Square Browse Tools & Services Your Cart See the published version of this article at . This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting (...) preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Research article Ketamine-propofol (Ketofol) on Procedural Sedation and Analgesia in Children: A Systematic Review and Meta-Analysis Tze Yong Foo, Norhayati Mohd Noor, Mohd Boniami Yazid, Mohd Hashairi Fauzi, Shaik Farid Abdull Wahab, Mohammad Zikri Ahmad Tze Yong Foo Universiti Sains Malaysia

2020 Research Square

28. Ketamine-propofol (Ketofol) on Procedural Sedation and Analgesia in Children: A Systematic Review and Meta-Analysis Full Text available with Trip Pro

Ketamine-propofol (Ketofol) on Procedural Sedation and Analgesia in Children: A Systematic Review and Meta-Analysis Ketamine-propofol (Ketofol) on Procedural Sedation and Analgesia in Children: A Systematic Review and Meta-Analysis | Research Square Browse Tools & Services Your Cart See the published version of this article at . This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting (...) preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Research article Ketamine-propofol (Ketofol) on Procedural Sedation and Analgesia in Children: A Systematic Review and Meta-Analysis Tze Yong Foo, Norhayati Mohd Noor, Mohd Boniami Yazid, Mohd Hashairi Fauzi, Shaik Farid Abdull Wahab, Mohammad Zikri Ahmad Tze Yong Foo Universiti Sains Malaysia

2020 Research Square

29. Faculty Opinions recommendation of The efficacy of ketamine supplementation on pain management for knee arthroscopy: A meta-analysis of randomized controlled trials. Full Text available with Trip Pro

Faculty Opinions recommendation of The efficacy of ketamine supplementation on pain management for knee arthroscopy: A meta-analysis of randomized controlled trials. The efficacy of ketamine supplementation on pain... | Faculty Opinions On April 12th, 2020, F1000Prime became Faculty Opinions. See our to learn more. Welcome Guest 1 Recommendations info_outline Systematic Review / Meta-analysis New Finding close Classified As New Finding 1 Article Type Systematic Review / Meta-analysis More (...) more_vert close Download article Export article Sciwheel Download citation BibTeX RIS Share Email The efficacy of ketamine supplementation on pain management for knee arthroscopy: A meta-analysis of randomized controlled trials. ARTICLE PUBLISHED: 2019 Jul CITE AS: Medicine (Baltimore). 2019 Jul ; 98 ( 27 ): e16138 Recommendations Abstract Comments You have reached your article limit. Register for 30-day free trial Registration is free and only takes a moment, or subscribe for unlimited access. Already

2020 Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

30. Clinical effects of low-dose intravenous ketamine in obstetrics: a systematic review Full Text available with Trip Pro

Clinical effects of low-dose intravenous ketamine in obstetrics: a systematic review Clinical effects of low-dose intravenous ketamine in obstetrics: a systematic review Vestnik intensivnoj terapii = Annals of Critical Care Search for: N.V. Shindyapina 1 , D.V. Marshalov 1 , E.M. Shifman 2 , A.V. Kuligin 1 1 Saratov State Medical University, Saratov, Russia 2 M.F. Vladimirskiy Moscow Regional Research Clinical Institute, Moscow, Russia For correspondence: Nataliya V. Shindyapina — assistant (...) at the of Department of Emergency Medicine, Anesthesiology and Resuscitation, Medical Faculty, Saratov State Medical University named after V.I.Razumovsky, Saratov; e-mail: Natalek-1111@mail.ru For citation : Shindyapina N.V., Marshalov D.V., Shifman E.M., Kuligin A.V. Clinical effects of low-dose intravenous ketamine in obstetrics: a systematic review. Annals of Critical Care. 2020;2:104–121. DOI: 10.21320/1818-474X-2020-2-104-121 Abstract Introduction . Over the past decade, there has been increased attention

2020 Alexander Saltanov Intensive Care Herald

31. Effectiveness of ketamine-propofol sedation for reducing respiratory adverse events compared to propofol sedation: A Meta-Analysis of randomized controlled trials Full Text available with Trip Pro

Effectiveness of ketamine-propofol sedation for reducing respiratory adverse events compared to propofol sedation: A Meta-Analysis of randomized controlled trials Effectiveness of ketamine-propofol sedation for reducing respiratory adverse events compared to propofol sedation: A Meta-Analysis of randomized controlled trials | Research Square Browse Tools & Services Your Cart This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research (...) Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Original research Effectiveness of ketamine-propofol sedation for reducing respiratory adverse events compared to propofol sedation: A Meta-Analysis of randomized controlled trials Ting Wen, Shibiao Chen, Lili Zhao, Yang Zhang Ting Wen First

2020 Research Square

32. Prehospital Use of Ketamine: A Systematic Review Full Text available with Trip Pro

Prehospital Use of Ketamine: A Systematic Review Prehospital Use of Ketamine: A Systematic Review Volume 7 - Issue 1 Archive Volume 7 - Issue 1 Article Citation Leonard Ranasinghe, Prehospital Use of Ketamine: A Systematic Review. Am J Biomed Sci & Res. 2020 - 7(1). AJBSR. MS.ID.001112. DOI: Navigation Menu Share this article Review Article Creative Commons, Prehospital Use of Ketamine: A Systematic Review *Corresponding author: Leonard Ranasinghe, Professor of Medical Education and Emergency (...) is not desirable and side effects at effective doses (e.g. CNS depression) can be potentially harmful to the patients. In recent years, ketamine has been used as a safer alternative for prehospital analgesia and sedation in the military setting, but has not been studied sufficiently in the civilian setting to be a part of standard protocol nationwide [ ] . Ketamine’s primary action is to block glutamate from acting on the n-Methyl-d-Aspartate (NMDA) receptor resulting in a “dissociative anesthesia” state

2020 American Journal of Biomedical Science & Research

33. Does intramuscular ondansetron have an effect on intramuscular ketamine-associated vomiting in children? A prospective, randomized, double blind, controlled study

Does intramuscular ondansetron have an effect on intramuscular ketamine-associated vomiting in children? A prospective, randomized, double blind, controlled study Does Intramuscular Ondansetron Have an Effect on Intramuscular Ketamine-Associated Vomiting in Children? A Prospective, Randomized, Double Blind, Controlled Study - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go (...) your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation Am J Emerg Med Actions 2019 Sep 12 [Online ahead of print] Does Intramuscular Ondansetron Have an Effect on Intramuscular Ketamine-Associated Vomiting in Children? A Prospective, Randomized, Double Blind, Controlled Study

2020 EvidenceUpdates

34. Effect on Opioids Requirement of Early Administration of Intranasal Ketamine for Acute Traumatic Pain Full Text available with Trip Pro

Effect on Opioids Requirement of Early Administration of Intranasal Ketamine for Acute Traumatic Pain Effect on Opioids Requirement of Early Administration of Intranasal Ketamine for Acute Traumatic Pain - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center (...) Link Copy Actions Cite Share Permalink Copy Page navigation Clin J Pain Actions . 2020 Jun;36(6):458-462. doi: 10.1097/AJP.0000000000000821. Effect on Opioids Requirement of Early Administration of Intranasal Ketamine for Acute Traumatic Pain , , , , , , , , , , , Affiliations Expand Affiliations 1 Emergency Department, Fattouma Bourguiba University Hospital. 2 Research Laboratory LR12SP18, University of Monastir. 3 Emergency Department, Farhat Hached University Hospital. 4 Emergency Department

2020 EvidenceUpdates

35. Efficacy of ketamine for initial control of acute agitation in the emergency department: A randomized study

Efficacy of ketamine for initial control of acute agitation in the emergency department: A randomized study Efficacy of Ketamine for Initial Control of Acute Agitation in the Emergency Department: A Randomized Study - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National (...) RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Am J Emerg Med Actions . 2020 Apr 11;S0735-6757(20)30241-2. doi: 10.1016/j.ajem.2020.04.013. Online ahead of print. Efficacy of Ketamine for Initial Control of Acute Agitation in the Emergency Department: A Randomized Study , , , , , , , Affiliations Expand Affiliations 1 Scripps Mercy Hospital Department of Pharmacy, 4077 5th Ave, MER 52, San Diego, CA 92103, United States of America. Electronic address: Lin.Justin

2020 EvidenceUpdates

36. Is ketamine sedation without local anesthesia sufficient for pediatric laceration repair? A double-blind randomized clinical trial

Is ketamine sedation without local anesthesia sufficient for pediatric laceration repair? A double-blind randomized clinical trial Is Ketamine Sedation Without Local Anesthesia Sufficient for Pediatric Laceration Repair? A Double-Blind Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes (...) Share Permalink Copy Page navigation Am J Emerg Med Actions . 2020 Mar 19;S0735-6757(20)30172-8. doi: 10.1016/j.ajem.2020.03.030. Online ahead of print. Is Ketamine Sedation Without Local Anesthesia Sufficient for Pediatric Laceration Repair? A Double-Blind Randomized Clinical Trial , , , Affiliations Expand Affiliations 1 Department of Emergency Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea. 2 Department of Emergency Medicine, Seoul National University Bundang

2020 EvidenceUpdates

37. Intranasal ketamine for acute pain management in children: A systematic review and meta-analysis

Intranasal ketamine for acute pain management in children: A systematic review and meta-analysis Intranasal ketamine for acute pain management in children: A systematic review and meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest public health (...) at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Review Am J Emerg Med Actions . 2020 Jun 1;38(9):1860-1866. doi: 10.1016/j.ajem.2020.05.094. Online ahead of print. Intranasal ketamine for acute pain management

2020 EvidenceUpdates

38. A systematic review of ketamine for the treatment of depression among older adults

A systematic review of ketamine for the treatment of depression among older adults A systematic review of ketamine for the treatment of depression among older adults - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest public health information from CDC: Get the latest (...) : Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Int Psychogeriatr Actions . 2020 Jun 30;1-13. doi: 10.1017/S1041610220000903. Online ahead of print. A systematic review of ketamine for the treatment of depression

2020 EvidenceUpdates

39. Dexamethasone Versus Ketamine in the Interscalene Block in Patients Undergoing Arthroscopic Shoulder Surgery: A Randomized Double-Blinded Study. (Abstract)

Dexamethasone Versus Ketamine in the Interscalene Block in Patients Undergoing Arthroscopic Shoulder Surgery: A Randomized Double-Blinded Study. Arthroscopic shoulder surgery (ASS) is often followed by severe pain. Interscalene brachial plexus block (ISB) was used to relieve such pain. The aim of the study was to compare the effect of adding either dexamethasone or ketamine to ISB on time to the fi rst request for analgesia.Sixty patients scheduled for ASS were enrolled in this study. Before (...) induction of general anaesthesia, patients were randomly allocated to two groups; in Group D, patients received ISB with bupivacaine 0.3%, 5 mL lidocaine 2% plus 8 mg dexamethasone. Whereas in Group K, patients received ISB with bupivacaine 0.3%, 5 mL lidocaine 2% plus 50 mg ketamine. Time to the fi rst administration of supplemental analgesic postoperative was our primary concern. Secondary outcomes included pain score, patient satisfaction, and side effects of either block or drugs. Student's t-test

2019 Asian journal of anesthesiology Controlled trial quality: uncertain

40. Effects of Ketamine on Brain Activity During Emotional Processing: Differential Findings in Depressed Versus Healthy Control Participants. Full Text available with Trip Pro

Effects of Ketamine on Brain Activity During Emotional Processing: Differential Findings in Depressed Versus Healthy Control Participants. In the search for novel treatments for depression, ketamine has emerged as a unique agent with rapid antidepressant effects. Experimental tasks involving emotional processing can be used during functional magnetic resonance imaging scanning to investigate ketamine's effects on brain function in major depressive disorder (MDD). This study examined ketamine's (...) effects on functional magnetic resonance imaging activity during an emotional processing task.A total of 33 individuals with treatment-resistant MDD and 24 healthy control participants (HCs) took part in this double-blind, placebo-controlled crossover study. Participants received ketamine and placebo infusions 2 weeks apart, and functional magnetic resonance imaging scans were conducted at baseline and 2 days after each infusion. Blood oxygen level-dependent signal was measured during an emotional

2019 Biological psychiatry. Cognitive neuroscience and neuroimaging Controlled trial quality: uncertain

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