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Ketamine Abuse

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1. Outcome Evaluation of a Short-Term Hospitalization and Community Support Program for People Who Abuse Ketamine (PubMed)

Outcome Evaluation of a Short-Term Hospitalization and Community Support Program for People Who Abuse Ketamine Ketamine is a popular recreational drug among young people in Hong Kong. Long-term abuse of ketamine can lead to acute urological and medical issues, which often require immediate care at emergency rooms. Many patients require short-term hospitalization for medical management. This opens a brief time window, within which mental health professionals could engage young people who abuses (...) ketamine in psychosocial, functional, and lifestyle interventions. The Crisis Accommodation Program (CAP) is a short-term hospitalization and community support program that addresses the health care needs of young people who abuse ketamine. During short-term hospitalization, the patient participates in a range of cognitive and psychosocial assessments, motivational interviewing, emotions management, and lifestyle re-design interventions. Upon discharge, social work professionals of non-government

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2018 Frontiers in Psychiatry

2. Successful Use of Ketamine for Burst Suppression in Super Refractory Status Epilepticus Following Substance Abuse (PubMed)

Successful Use of Ketamine for Burst Suppression in Super Refractory Status Epilepticus Following Substance Abuse Status epilepticus is frequently encountered in neuro Intensive Care Units. It is a medical emergency and if not treated promptly can lead to severe brain damage and even death. Here, we present the case of a 18-year-old male with uncontrolled and unrelenting seizures with a rare etiology requiring ketamine infusion for burst suppression as it was resistant to thiopentone

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2018 Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

3. Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse

Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03539887

2018 Clinical Trials

4. Effectiveness of a Brief Cognitive and Behavioral Skills Program on Stage Transitions for Chronic Ketamine Abusers

Effectiveness of a Brief Cognitive and Behavioral Skills Program on Stage Transitions for Chronic Ketamine Abusers Effectiveness of a Brief Cognitive and Behavioral Skills Program on Stage Transitions for Chronic Ketamine Abusers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Effectiveness of a Brief Cognitive and Behavioral Skills Program on Stage Transitions for Chronic Ketamine Abusers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03644719 Recruitment Status : Completed First Posted : August

2018 Clinical Trials

5. Ureteral Nephrogenic Adenoma in Chronic Recreational Ketamine Abuse (PubMed)

Ureteral Nephrogenic Adenoma in Chronic Recreational Ketamine Abuse 29204356 2019 02 26 2214-4420 16 2018 Jan Urology case reports Urol Case Rep Ureteral Nephrogenic Adenoma in Chronic Recreational Ketamine Abuse. 75-76 10.1016/j.eucr.2017.11.006 Lai Qingquan Q Department of Urology, Quanzhou Southeast Hospital, Quanzhou, Fujian, China. Zhuang Hainan H Department of Urology, Quanzhou Southeast Hospital, Quanzhou, Fujian, China. Xie Huifen H Department of Pathology, Quanzhou Southeast Hospital (...) , Quanzhou, Fujian, China. eng Case Reports 2017 11 21 United States Urol Case Rep 101626357 2214-4420 Ketamine Nephrogenic adenoma Nephrogenic metaplasia Ureter 2017 09 26 2017 10 11 2017 11 17 2017 12 6 6 0 2017 12 6 6 0 2017 12 6 6 1 epublish 29204356 10.1016/j.eucr.2017.11.006 S2214-4420(17)30261-9 PMC5709286 J Clin Pathol. 2011 Jun;64(6):551-2 21345876 Urology. 2016 Sep;95:29-33 27138263 Am J Surg Pathol. 2013 Apr;37(4):532-8 23426119 Arch Esp Urol. 1992 Jun;45(5):423-7 1510472 Br J Urol. 1985 Aug

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2017 Urology case reports

6. The Use of Continuous Ketamine for Analgesia and Sedation in Critically Ill Patients with Opioid Abuse: A Case Series (PubMed)

The Use of Continuous Ketamine for Analgesia and Sedation in Critically Ill Patients with Opioid Abuse: A Case Series Managing pain and agitation in patients with opioid abuse is becoming more common in intensive care units. Tolerance to commonly used agents is often observed, leading to inadequate pain control and increased agitation. Ketamine's unique mechanism of action and opioid-sparing effects make it an ideal agent for patients with suboptimal response to opioid therapy. This report (...) describes our experience using continuous ketamine infusions for analgesia and sedation in four mechanically ventilated patients with histories of opioid abuse that had suboptimal response to standard therapy. Ketamine was successful in improving analgesia and sedation in three patients while reducing the need for other analgesics and sedatives with minimal adverse effects. Continuous ketamine infusions may be useful to facilitate mechanical ventilation in patients with histories of opioid abuse

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2017 The Journal of Critical Care Medicine

7. Crossover Study to Evaluate the Abuse Potential of Intranasal Esketamine Compared to Racemic Intravenous Ketamine in Nondependent, Recreational Drug Users

Crossover Study to Evaluate the Abuse Potential of Intranasal Esketamine Compared to Racemic Intravenous Ketamine in Nondependent, Recreational Drug Users Crossover Study to Evaluate the Abuse Potential of Intranasal Esketamine Compared to Racemic Intravenous Ketamine in Nondependent, Recreational Drug Users - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail (...) Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Crossover Study to Evaluate the Abuse Potential of Intranasal Esketamine Compared to Racemic Intravenous Ketamine in Nondependent, Recreational Drug Users The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government

2016 Clinical Trials

8. Mania following ketamine abuse (PubMed)

Mania following ketamine abuse Ketamine, a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, has multiple clinical uses. On the other hand, ketamine abuse or recreational use has been gaining increasing attention. Induction of mania and psychotic symptoms has been reported in a patient receiving IV ketamine therapy for reflex sympathetic dystrophy. We here report a 26 year-old man who abused ketamine by inhalation for 12 months and developed manic-like symptoms after (...) ketamine use. This case suggests a possible relationship between manic symptoms and ketamine abuse. To the best of our knowledge, this may be the first report regarding mania after recreational use of ketamine.

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2016 Neuropsychiatric disease and treatment

9. Ketamine Abuse

Ketamine Abuse Ketamine Abuse Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Ketamine Abuse Ketamine Abuse Aka: Ketamine Abuse II (...) not available may cause positive PCP on VI. References Fontes (2014) Crit Dec Emerg Med 28(1): 14-24 Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Ketamine Abuse." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Pharmacology About FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians

2018 FP Notebook

10. Chronic biliary colic associated with ketamine abuse (PubMed)

Chronic biliary colic associated with ketamine abuse Biliary colic is a common clinical presentation, with the majority of cases being related to gallstone disease. However, rarely, patients may present with biliary symptoms without evidence of gallbladder stones - referred to as acalculous gallstone disease. This case report details a rare case of chronic biliary colic associated with ketamine abuse.A 24-year-old Caucasian female presented to the emergency department with a history (...) with the current rise of recreational hallucinogenic drug abuse.

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2016 International medical case reports journal

11. Major Depressive Disorder Induced by Chronic Ketamine Abuse: A Case Report (PubMed)

Major Depressive Disorder Induced by Chronic Ketamine Abuse: A Case Report 27722024 2017 03 06 2018 11 13 2155-7780 18 3 2016 The primary care companion for CNS disorders Prim Care Companion CNS Disord Major Depressive Disorder Induced by Chronic Ketamine Abuse: A Case Report. 10.4088/PCC.15l01881 Chang Huming H Taipei City Psychiatric Center, Taipei City Hospital, Songde Branch, Taipei City, Taiwan. Huang Ming-Chi MC Taipei Medical University, Department of Psychiatry, Taipei City, Taiwan (...) . Chen Lian-Yu LY Taipei City Psychiatric Center, Taipei City Hospital, Songde Branch, Taipei City, Taiwan. eng Case Reports Journal Article 2016 06 23 United States Prim Care Companion CNS Disord 101547532 2155-7780 0 Anesthetics, Dissociative 690G0D6V8H Ketamine IM Adult Anesthetics, Dissociative adverse effects toxicity Depressive Disorder, Major etiology therapy Humans Ketamine administration & dosage toxicity Male Substance-Related Disorders complications therapy 2016 10 11 6 0 2016 10 11 6 0

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2016 The Primary Care Companion for CNS Disorders

12. Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Chronic Pain

and abuse potential, studies comparing the different enantiomers have also produced mixed results. For depression, 2 animal studies demonstrated more sustained antidepressant effects for the R(−) stereoisomer, but there are no clinical studies to guide treatment. Ketamine exhibits a unique combination of hypnotic, analgesic, and amnestic effects, which makes it ideal for treating posttraumatic and procedure-related pain. The hypnotic effects are likely secondary to inhibition HCN1 nonspecific cation (...) abusers. Animal studies have demonstrated the potential of ketamine to cause hepatotoxicity as well as cystitis. In humans, the incidence of hepatotoxicity and cystitis may be increased

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2018 American Society of Regional Anesthesia and Pain Medicine

13. Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Acute Pain Management

differ from those for ketamine used to treat chronic conditions, with the exception of the use of ketamine in active substance abusers (Grade C relative contraindication for chronic pain, not a contraindication for acute pain) and poorly controlled cardiovascular disease (Grade B relative contraindication for chronic pain, Grade C for acute pain). These differences were attributed to the more urgent nature of treating acute pain, and for substance abuse, the fact that in most cases the drug of abuse (...) Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Acute Pain Management Consensus Guidelines on the Use of Intravenous Ketamine Infu... : Regional Anesthesia and Pain Medicine You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login No user account? Lippincott Journals Subscribers , use your username or email along with your password to log in. Remember me on this computer Register for a free account

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2018 American Society of Regional Anesthesia and Pain Medicine

14. Repeated ketamine administration alters N-methyl-D-aspartic acid receptor subunit gene expression: Implication of genetic vulnerability for ketamine abuse and ketamine psychosis in humans (PubMed)

Repeated ketamine administration alters N-methyl-D-aspartic acid receptor subunit gene expression: Implication of genetic vulnerability for ketamine abuse and ketamine psychosis in humans For more than 40 years following its approval by the Food and Drug Administration (FDA) as an anesthetic, ketamine, a non-competitive N-methyl-D-aspartic acid (NMDA) receptor antagonist, has been used as a tool of psychiatric research. As a psychedelic drug, ketamine induces psychotic symptoms, cognitive (...) where up-regulation of NMDA receptors could produce cognitive deficits in chronic ketamine abuse patients. In other studies, NMDA receptor gene variants are associated with addictive behavior. Here, we focus on the roles of NMDA receptor gene subunits in ketamine abuse and ketamine psychosis and propose that full sequencing of NMDA receptor genes may help explain individual vulnerability to ketamine abuse and ketamine-associated psychosis.© 2014 by the Society for Experimental Biology and Medicine.

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2014 Experimental biology and medicine (Maywood, N.J.)

15. CRACKCast E186 – Substance Abuse

CRACKCast E186 – Substance Abuse CRACKCast E186 - Substance Abuse - CanadiEM CRACKCast E186 – Substance Abuse In , by Chris Lipp June 14, 2018 This episode of CRACKCast covers Rosen’s Chapter 140 (9th Edition), Substance Abuse. This chapter gives a brief overview regarding the burden of substance abuse from adolescent to elderly patients. An important consideration in the emergency department is self-awareness and advocacy for these patients that often are challenging to interact with and can (...) provoke countertransference. Shownotes – Key Concepts Substance abuse can affect people from all socioeconomic groups and all ages. For the majority of patients with toxin-induced violent behavior, intramuscular butyrophenones (such as, haloperidol) are safe and rapidly effective sedating agents. With suspected sympathomimetic (eg, cocaine and amphetamines) intoxication, benzodiazepines (such as, lorazepam) should be used. Presentation to an ED with a complication of substance abuse may be a “teaching

2018 CandiEM

16. "THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"

"THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department" "THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department" - Full Text View (...) - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. "THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary

2017 Clinical Trials

17. Opioid-sparing effect of preemptive bolus low-dose ketamine for moderate sedation in opioid abusers undergoing extracorporeal shock wave lithotripsy: a randomized clinical trial (PubMed)

Opioid-sparing effect of preemptive bolus low-dose ketamine for moderate sedation in opioid abusers undergoing extracorporeal shock wave lithotripsy: a randomized clinical trial Ketamine has been used as part of a multimodal analgesia regime in opioid abusers undergoing general anesthesia. We studied the opioid-sparing effect of a very low-dose bolus of ketamine as part of moderate sedation for opioid abuse patients undergoing extracorporeal shock wave lithotripsy.In this randomized, placebo (...) -controlled clinical trial, 190 opioid abusers were enrolled. They were stratified into 2 blocks based on their daily opioid consumption. Both blocks were then randomized to receive 0.1 mg/kg IV ketamine (group K) or placebo (group P). Lithotripsy was performed under moderate sedation with intermittent bolus doses of remifentanil (0.2 µg/kg) to alleviate pain. The total remifentanil dose (primary outcome) and respiratory adverse events (secondary outcome) were compared in the 2 groups.Remifentanil

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2013 EvidenceUpdates

18. Ketamine for treatment-resistant depression: recent developments and clinical applicationsEditor's Choice FREE

explored repeated self-administration of IN S-ketamine over a 2-week period ( ). Additional clinical trials are currently underway ( ) to study the long-term effects of repeated administration in addition to ongoing antidepressant treatment. The effects of self-administration and repeated-administration will also require further study since this promising intervention has the potential for greater accessibility but is also increasing the risk of diversion (as ketamine is a drug of abuse). Ketamine's (...) that clinical presentations including severe depression, anhedonia, SI and/or cognitive deficits have been associated with positive outcomes after IV ketamine. Safety and potential for abuse Ketamine has been shown to be safe and effective as an anaesthetic in children and adults at doses ranging from 1 to 3 mg/kg. When used for treating pain and depression, ketamine has been administered at doses ranging from 0.1 to 1 mg/kg. These subanaesthetic doses can be associated with short-lasting neuropsychiatric

2016 Evidence-Based Mental Health

19. Ketamine Abuse Syndrome: Hepatobiliary and Urinary Pathology Among Adolescents in Flushing, NY. (PubMed)

Ketamine Abuse Syndrome: Hepatobiliary and Urinary Pathology Among Adolescents in Flushing, NY. Ketamine is a recreational drug widely abused in East Asia and also in certain subpopulations of the United States. Many US clinicians are unaware of abuse symptoms, leading to misdiagnosis and missed opportunities for intervention. We will discuss clinical patterns that should alert a clinician to the possibility of ketamine abuse.We present 6 adolescent patients who presented to the pediatric (...) emergency department and inpatient wards with urinary and hepatobiliary symptoms in the setting of ketamine abuse.We identified 6 patients with confirmed ketamine abuse who presented with epigastric pain or urinary pain. All had laboratory and radiographic evidence of disease.Ketamine abuse is associated with a distinctive pattern of symptoms involving the urinary and hepatobiliary systems.

2015 Pediatric Emergency Care

20. Relationship of serum levels of TNF-α, IL-6 and IL-18 and schizophrenia-like symptoms in chronic ketamine abusers. (PubMed)

Relationship of serum levels of TNF-α, IL-6 and IL-18 and schizophrenia-like symptoms in chronic ketamine abusers. Exposing to NMDAR receptor antagonists, such as ketamine, produces schizophrenia-like symptoms in humans and deteriorates symptoms in schizophrenia patients. Meanwhile, schizophrenia is associated with alterations of cytokines in the immune system. This study aims to examine the serum TNF-α, IL-6 and IL-18 levels in chronic human ketamine users as compared to healthy subjects (...) . The correlations between the serum cytokines levels with the demographic, ketamine use characteristics and psychiatric symptoms were also assessed.155 subjects who fulfilled the criteria of ketamine dependence and 80 healthy control subjects were recruited. Serum TNF-α, IL-6 and IL-18 levels were measured using an enzyme-linked immunosorbent assay (ELISA). The psychiatric symptoms of the ketamine abusers were assessed using the Positive and Negative Syndrome Scale (PANSS).Serum IL-6 and IL-18 levels were

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2015 Schizophrenia Research

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