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Kernicterus

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1. Cost-effectiveness analysis of a system-based approach for managing neonatal jaundice and preventing kernicterus in Ontario

Cost-effectiveness analysis of a system-based approach for managing neonatal jaundice and preventing kernicterus in Ontario Cost-effectiveness analysis of a system-based approach for managing neonatal jaundice and preventing kernicterus in Ontario Cost-effectiveness analysis of a system-based approach for managing neonatal jaundice and preventing kernicterus in Ontario Xie B, Da Silva O, Zaric G Record Status This is a critical abstract of an economic evaluation that meets the criteria (...) are reasonable given the results obtained. However, they cannot be considered robust given the high level of uncertainty in the data. Type of economic evaluation Cost-effectiveness analysis, cost-utility analysis Study objective The aim was to examine the cost-effectiveness of a system approach for managing neonatal jaundice and preventing kernicterus. The study population was a hypothetical cohort of 300,000 term and late preterm neonates (≥35 weeks) representing the Canadian birth cohort. Interventions

2012 NHS Economic Evaluation Database.

2. MRI of bilirubin encephalopathy (kernicterus): A case series of 4 patients from Sub-Saharan Africa, May 2017 Full Text available with Trip Pro

MRI of bilirubin encephalopathy (kernicterus): A case series of 4 patients from Sub-Saharan Africa, May 2017 Characteristic magnetic resonance imaging (MRI) findings in patients with chronic kernicterus are bilateral and symmetric T2-weighted hyperintensities in the globus pallidus. We report 4 cases of infants with clinical, laboratory, and MRI findings of kernicterus in this case series. This is the first MRI report of kernicterus in Ethiopia. Awareness of the disease is raised in this report (...) , and the role of magnetic resonance in detecting signal abnormalities associated with kernicterus in the globus pallidi is underscored. We recommend MRI to be part of the investigation in neonates with jaundice.

2018 Radiology Case Reports

3. Learning from claims: hyperbilirubinaemia and kernicterus. Full Text available with Trip Pro

Learning from claims: hyperbilirubinaemia and kernicterus. We examined claims made against the National Health Service (NHS) involving neonatal jaundice in order to determine whether there were lessons that could be learnt from common themes.This was a retrospective anonymised study using information from the NHS Resolution database for 2001-2011.Twenty cases (16 males) had sufficient information for analysis. Fifteen had confirmed cerebral palsy and two young children had damage to the globus (...) was found in all but two; six had glucose-6-phosphatase deficiency (one also had Gilbert's syndrome); five were diagnosed with ABO incompatibility; three with Rh haemolytic disease; one with spherocytosis and three preterm. The total cost of these claims by August 2017 was almost £150.5 million. This figure is likely to rise.These data show that, in the group who litigate, babies who develop kernicterus generally have an underlying diagnosis. We recommend adherence to theNational Institute for Health

2018 Archives of Disease in Childhood. Fetal and Neonatal Edition

4. Extreme neonatal hyperbilirubinemia, acute bilirubin encephalopathy, and kernicterus spectrum disorder in children with galactosemia. Full Text available with Trip Pro

Extreme neonatal hyperbilirubinemia, acute bilirubin encephalopathy, and kernicterus spectrum disorder in children with galactosemia. Galactosemia has not been recognized as a cause of extreme neonatal hyperbilirubinemia, although growing evidence supports this association.In a retrospective cohort study, we identified children with galactosemia due to GALT deficiency using the Danish Metabolic Laboratory Database. Among these, we identified children with extreme neonatal hyperbilirubinemia

2018 Pediatric Research

5. Kernicterus

Kernicterus Kernicterus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Kernicterus Kernicterus Aka: Kernicterus , Bilirubin Toxicity (...) , Bilirubin Encephalopathy , Acute Bilirubin Encephalopathy , Chronic Bilirubin Encephalopathy From Related Chapters II. Epidemiology: Incidence Acute Bilirubin Encephalopathy: 1 infant in 10,000 Progresses to Kernicterus in 5% of infants Chronic Bilirubin Encephalopathy (Kernicterus): 1 infant in 100,000 III. Risk Factors See Severe (>20 mg/dl) alone does not predict Bilirubin Encephalopathy For healthy infants at term with >30 mg/dl, only 5% develop Bilirubin Encephalopathy Earlier IV. Pathophysiology

2018 FP Notebook

6. Does Maternal Instruction Prevent Kernicterus in Nigeria?

Does Maternal Instruction Prevent Kernicterus in Nigeria? Does Maternal Instruction Prevent Kernicterus in Nigeria? - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Does Maternal Instruction Prevent (...) Kernicterus in Nigeria? The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02713464 Recruitment Status : Completed First Posted : March 18, 2016 Last Update Posted : March 18, 2016 Sponsor: Bilimetrix s.r.l. Collaborators: Jos University Teaching Hospital Bayern University Teaching Hospital Ahmadu Bello

2016 Clinical Trials

7. Brain Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy Findings of Children with Kernicterus Full Text available with Trip Pro

Brain Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy Findings of Children with Kernicterus The term kernicterus, or bilirubin encephalopathy, is used to describe pathological bilirubin staining of the basal ganglia, brain stem, and cerebellum, and is associated with hyperbilirubinemia. Kernicterus generally occurs in untreated hyperbilirubinemia or cases where treatment is delayed. Magnetic resonance imaging (MRI)-based studies have shown characteristic findings in kernicterus (...) . The objective of our study was to describe the role of (1)H magnetic resonance spectroscopy (MRS) in demonstrating these metabolic changes and to review conventional MRI findings of kernicterus.Forty-eight pediatric cases with kernicterus were included in this study. MRI and MRS examinations were performed on variable dates (10-29 days after birth). NAA, Cr, Cho, NAA/Cr, NAA/Cho, and Cho/Cr values were evaluated visually and by computer analysis.There was no statistically significant difference between

2015 Polish Journal of Radiology

8. Why is kernicterus still a major cause of death and disability in low-income and middle-income countries? (Abstract)

Why is kernicterus still a major cause of death and disability in low-income and middle-income countries? Neonatal jaundice is predominantly a benign condition that affects 60%-80% of newborns worldwide but progresses to potentially harmful severe hyperbilirubinaemia in some. Despite the proven therapeutic benefits of phototherapy for preventing extreme hyperbilirubinaemia, acute bilirubin encephalopathy or kernicterus, several low-income and middle-income countries (LMIC) continue to report (...) high rates of avoidable exchange transfusions, as well as bilirubin-induced mortality and neurodevelopmental disorders. Considering the critical role of appropriate timing in treatment effectiveness, this review set out to examine the contributory factors to the burden of severe hyperbilirubinaemia and kernicterus based on the 'three delays model' described by Thaddeus and Maine in the 91 most economically disadvantaged LMICs with Gross National Income per capita ≤US$6000 and median human

2014 Archives of Disease in Childhood

9. Kernicterus (Overview)

Kernicterus (Overview) Kernicterus: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTc1Mjc2LW92ZXJ2aWV3 processing > Kernicterus Updated: Apr 02, 2014 Author: Shelley C (...) Springer, JD, MD, MSc, MBA, FAAP; Chief Editor: Ted Rosenkrantz, MD Share Email Print Feedback Close Sections Sections Kernicterus Overview Background The term kernicterus literally means "yellow kern," with kern indicating the most commonly afflicted region of the brain (ie, the nuclear region). Historically, the term refers to an anatomic diagnosis made at autopsy based on a characteristic pattern of staining found in babies who had marked hyperbilirubinemia before they died. Hervieux first described

2014 eMedicine Pediatrics

10. Kernicterus (Treatment)

Kernicterus (Treatment) Kernicterus Treatment & Management: Medical Care, Surgical Care, Diet Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTc1Mjc2LXRyZWF0bWVudA== processing > Kernicterus Treatment & Management (...) Updated: Apr 02, 2014 Author: Shelley C Springer, JD, MD, MSc, MBA, FAAP; Chief Editor: Ted Rosenkrantz, MD Share Email Print Feedback Close Sections Sections Kernicterus Treatment Medical Care The cornerstone of management of hyperbilirubinemia is prevention of neurotoxicity. The definitive method of removing bilirubin from the blood is via exchange transfusion. This is currently the indicated approach in the presence of clinical bilirubin-induced neurologic dysfunction (BIND) when the bilirubin

2014 eMedicine Pediatrics

11. Kernicterus (Follow-up)

Kernicterus (Follow-up) Kernicterus Follow-up: Further Outpatient Care, Further Inpatient Care, Transfer Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTc1Mjc2LWZvbGxvd3Vw processing > Kernicterus Follow-up (...) Updated: Apr 02, 2014 Author: Shelley C Springer, JD, MD, MSc, MBA, FAAP; Chief Editor: Ted Rosenkrantz, MD Share Email Print Feedback Close Sections Sections Kernicterus Follow-up Further Outpatient Care To help ensure that infants may reach their maximum neurodevelopmental potential, referring babies with bilirubin-induced neurologic dysfunction (BIND) to a neurodevelopmental pediatrician skilled in caring for these patients is important. Early identification of and intervention

2014 eMedicine Pediatrics

12. Kernicterus (Diagnosis)

Kernicterus (Diagnosis) Kernicterus: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTc1Mjc2LW92ZXJ2aWV3 processing > Kernicterus Updated: Apr 02, 2014 Author: Shelley C (...) Springer, JD, MD, MSc, MBA, FAAP; Chief Editor: Ted Rosenkrantz, MD Share Email Print Feedback Close Sections Sections Kernicterus Overview Background The term kernicterus literally means "yellow kern," with kern indicating the most commonly afflicted region of the brain (ie, the nuclear region). Historically, the term refers to an anatomic diagnosis made at autopsy based on a characteristic pattern of staining found in babies who had marked hyperbilirubinemia before they died. Hervieux first described

2014 eMedicine Pediatrics

13. Neonatal Death Suspected To Be From Sepsis Was Found To Be Kernicterus With G6PD Deficiency. Full Text available with Trip Pro

Neonatal Death Suspected To Be From Sepsis Was Found To Be Kernicterus With G6PD Deficiency. We cared for a term male infant born to Burmese immigrants. At about 24 hours a total serum bilirubin (TSB) was 9.3 mg/dL, and phototherapy was begun. It was stopped 48 hours later, with a TSB of 10.9 mg/dL, and he was discharged from the hospital with an appointment for a repeat TSB check 48 hours later. A few hours before the appointment he became listless and apneic, and his parents took him (...) to the emergency department of the regional children's hospital, where sepsis was suspected. The TSB was 41 mg/dL. He died 4 hours later, despite intensive care efforts, with opisthotonus and refractory hypotension. Blood drawn before the exchange transfusion had low glucose-6-phosphate dehydrogenase (G6PD) enzymatic activity, and sequencing of the G6PD gene revealed the G6PD Mahidol mutation (c.487G>A). Cultures and postmortem examination did not demonstrate an infectious process, but kernicterus was present

2013 Pediatrics

14. Acute Kernicterus in a Neonate With O/B Blood Group Incompatibility and a Mutation in SLC4A1. Full Text available with Trip Pro

Acute Kernicterus in a Neonate With O/B Blood Group Incompatibility and a Mutation in SLC4A1. We cared for a term female newborn, who at 108 hours of age, with a total serum bilirubin of 15.4 mg/dL, was discharged from the hospital on home phototherapy. At a return appointment 44 hours later, her total serum bilirubin was 41.7 mg/dL and signs of acute kernicterus were present. Maternal/fetal blood group O/B incompatibility was identified, with a negative direct antiglobulin test, which (...) and 4 months showed developmental delays consistent with mild kernicterus.

2013 Pediatrics

15. Chronic Kernicterus: MRI

Chronic Kernicterus: MRI Chronic Kernicterus: MRI - Sumer's Radiology Blog Top Ad unit 728 × 90 Radiology News radiology Chronic Kernicterus: MRI Chronic Kernicterus: MRI Chronic Kernicterus: MRI Reviewed by Sumer Sethi on Saturday, October 22, 2016 Rating: 5 Tags : Sumer Sethi About Dr. Sumer Sethi Number of Entries : 35 Unique blend of academic excellence and entrepreneurship, heading leading firms in India- Teleradiology Providers, pioneering company providing teleradiology services and DAMS

2016 Sumer's Radiology Blog

16. Kernicterus

Kernicterus Kernicterus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Kernicterus Kernicterus Aka: Kernicterus , Bilirubin Toxicity (...) , Bilirubin Encephalopathy , Acute Bilirubin Encephalopathy , Chronic Bilirubin Encephalopathy From Related Chapters II. Epidemiology: Incidence Acute Bilirubin Encephalopathy: 1 infant in 10,000 Progresses to Kernicterus in 5% of infants Chronic Bilirubin Encephalopathy (Kernicterus): 1 infant in 100,000 III. Risk Factors See Severe (>20 mg/dl) alone does not predict Bilirubin Encephalopathy For healthy infants at term with >30 mg/dl, only 5% develop Bilirubin Encephalopathy Earlier IV. Pathophysiology

2015 FP Notebook

17. Cerebral Sequelæ, after Neonatal Jaundice, ascribed to Kernicterus Full Text available with Trip Pro

Cerebral Sequelæ, after Neonatal Jaundice, ascribed to Kernicterus 19991615 2010 06 24 2010 06 24 0035-9157 31 9 1938 Jul Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Cerebral Sequelae, after Neonatal Jaundice, ascribed to Kernicterus. 1121-2 Field C E CE eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1938 7 1 0 0 1938 7 1 0 1 ppublish 19991615 PMC2076952

1938 Proceedings of the Royal Society of Medicine

18. A Boy Exhibiting Nervous Symptoms ascribed to Kernicterus with Septic Neonatal Jaundice as Cause Full Text available with Trip Pro

A Boy Exhibiting Nervous Symptoms ascribed to Kernicterus with Septic Neonatal Jaundice as Cause 19991464 2010 06 24 2010 06 24 0035-9157 31 6 1938 Apr Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. A Boy Exhibiting Nervous Symptoms ascribed to Kernicterus with Septic Neonatal Jaundice as Cause. 559 Lightwood R R Colver T T eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1938 4 1 0 0 1938 4 1 0 1 ppublish 19991464 PMC2076866

1938 Proceedings of the Royal Society of Medicine

19. Case of Kernicterus Full Text available with Trip Pro

Case of Kernicterus 19992043 2010 06 24 2010 06 24 0035-9157 32 10 1939 Aug Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Case of Kernicterus. 1200 Illingworth R S RS eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1939 8 1 0 0 1939 8 1 0 1 ppublish 19992043 PMC1997960

1939 Proceedings of the Royal Society of Medicine

20. An Electron Microscopic and Radioautographic Study on Experimental Kernicterus: II. Bilirubin Movement Within Neurons and Release of Waste Products via Astroglia Full Text available with Trip Pro

An Electron Microscopic and Radioautographic Study on Experimental Kernicterus: II. Bilirubin Movement Within Neurons and Release of Waste Products via Astroglia Response of the neurons to bilirubin in asphyxiated newborn rabbits was studied in vivo with the use of the electron microscope and radioautographic technics. A morphologic basis for the mode of intraneuronal bilirubin movement in kernicterus has been established. The absorbed bilirubin had ready access to the Golgi complex from

1971 The American journal of pathology

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