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Keratoacanthoma

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1. The detection rate of Human Papillomavirus (HPV) in well differentiated squamous cell carcinoma and keratoacanthoma: is there new evidence for a viral pathogenesis of keratoacanthoma? (PubMed)

The detection rate of Human Papillomavirus (HPV) in well differentiated squamous cell carcinoma and keratoacanthoma: is there new evidence for a viral pathogenesis of keratoacanthoma? The "keratinocyte skin cancer" term stands as a sort of umbrella covering different stages within the progression of cutaneous squamous cell carcinoma (cSCC). The invasive forms of are further classified on the basis of histopathologic differentiation grade as well differentiated, moderate and poorly (...) differentiated cSCC. Whether or not keratoacanthoma (KA) represents a form of well differentiated tumor remains currently a matter of debate. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

2019 British Journal of Dermatology

2. Comment on 'The detection rate of Human Papillomavirus (HPV) in well differentiated squamous cell carcinoma and keratoacanthoma: is there new evidence for a viral pathogenesis of keratoacanthoma?' - Reply from authors. (PubMed)

Comment on 'The detection rate of Human Papillomavirus (HPV) in well differentiated squamous cell carcinoma and keratoacanthoma: is there new evidence for a viral pathogenesis of keratoacanthoma?' - Reply from authors. We fully agree with the authors that there is lack of validated histopathological criteria that allow to accurately differentiate well-differentiated SCC from KA. For this reason, we believe that both terms should be best avoided in the future. Therefore, we recently proposed

2019 British Journal of Dermatology

3. Management of Keratoacanthoma: 157 Tumors Managed With Surgery or Intralesional Methotrexate. (PubMed)

Management of Keratoacanthoma: 157 Tumors Managed With Surgery or Intralesional Methotrexate. Keratoacanthomas (KAs) are common tumors of squamous cell origin that grow rapidly and may regress; however, differentiation from an aggressive squamous cell carcinoma is problematic.To report the authors' experience in managing KA with intralesional methotrexate (MTX) or surgical excision.The authors collected data on 157 tumors (136 patients) over 6 months from a single institution.There were 73

2019 Dermatologic Surgery

4. Eruptive squamous atypia (also known as eruptive keratoacanthoma): Definition of the disease entity and successful management via intralesional 5-fluorouracil. (PubMed)

Eruptive squamous atypia (also known as eruptive keratoacanthoma): Definition of the disease entity and successful management via intralesional 5-fluorouracil. Eruptive squamous atypia (ESA), which is an idiopathic, sometimes koebnerizing, proliferation of atypical but well-differentiated keratinocytes (also termed eruptive keratoacanthoma), is often misdiagnosed as cancer and managed by excisional surgery, provoking further koebnerization. A clear definition of this phenomenon and treatment

2019 Journal of American Academy of Dermatology

5. Multiple disseminated keratoacanthoma-like nodules: a rare form of distant metastases to the skin (PubMed)

Multiple disseminated keratoacanthoma-like nodules: a rare form of distant metastases to the skin 30429717 2018 12 07 1642-395X 35 5 2018 Oct Postepy dermatologii i alergologii Postepy Dermatol Alergol Multiple disseminated keratoacanthoma-like nodules: a rare form of distant metastases to the skin. 535-537 10.5114/ada.2018.77245 Jankowska-Konsur Alina A Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland. Kopeć-Pytlarz Karolina K Department

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2018 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

6. Digital dermatoscopy as a useful tool for evaluating therapeutic efficacy in a patient with eruptive keratoacanthomas (PubMed)

Digital dermatoscopy as a useful tool for evaluating therapeutic efficacy in a patient with eruptive keratoacanthomas 30116665 2018 11 14 2160-9381 8 3 2018 Jul Dermatology practical & conceptual Dermatol Pract Concept Digital dermatoscopy as a useful tool for evaluating therapeutic efficacy in a patient with eruptive keratoacanthomas. 204-207 10.5826/dpc.0803a11 Toncic Ruzica Jurakic RJ Department of Dermatology and Venereology, University Hospital Centre Zagreb, Zagreb School of Medicine (...) , University Hospital Centre Zagreb, Zagreb School of Medicine, Zagreb, Croatia. Argenziano Giuseppe G Dermatology Unit, University of Campania, Naples, Italy. eng Journal Article 2018 07 31 United States Dermatol Pract Concept 101585990 2160-9381 digital dermoscopy follow-up eruptive keratoacanthomas keratoacanthoma treatment response to acitretin Competing interests: The authors have no conflicts of interest to disclose. 2017 09 25 2018 03 07 2018 8 18 6 0 2018 8 18 6 0 2018 8 18 6 1 epublish 30116665

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2018 Dermatology practical & conceptual

7. Successful Treatment of a Keratoacanthoma with Electrochemotherapy: A Case Report (PubMed)

Successful Treatment of a Keratoacanthoma with Electrochemotherapy: A Case Report Few studies have evaluated the efficacy of intralesional bleomycin injection combined with electroporation for the treatment of cutaneous tumors. However, the phenomenon that electroporation can enhance the cytotoxicity of bleomycin in vivo by 300-700 fold has been intensely investigated.Keratoacanthoma in an 86-year-old patient was treated with intralesional bleomycin combined with electroporation. Treatment (...) consisted of local application of shorty and intense electric pulses followed by local injection of bleomycin. Electroporation was always well tolerated by the patient, with no significant complaints, and the tumor had completely regressed by day 71 of the follow-up.The results suggest that intralesional bleomycin injection combined with electroporation could represent a valid alternative therapeutic approach for the treatment of keratoacanthomas.

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2018 Dermatology and therapy

8. Sporotrichoid Keratoacanthomas: Case Report and Review of Neoplasms Presenting in a Sporotrichoid Pattern (PubMed)

Sporotrichoid Keratoacanthomas: Case Report and Review of Neoplasms Presenting in a Sporotrichoid Pattern Sporotrichosis is a fungal infection known for its distinct pattern of infectious skin nodules. Several conditions can present with lesions that appear in a sporotrichoid pattern. An 82-year-old man that presented with three cutaneous nodules on his right leg in a sporotrichoid manner is described; biopsy of each lesion revealed a keratoacanthoma. In addition to keratoacanthomas, other (...) ) or the lower extremity (five patients). Treatments included systemic chemotherapy, surgical intervention, and radiation. Three of the patients died secondary to their tumors. In conclusion, various infections and some miscellaneous disorders can present in a sporotrichoid pattern. Keratoacanthomas can be added to the list of cancers (which include squamous cell carcinoma, lymphoma, epithelioid sarcoma, Langerhans cell histiocytosis, melanoma, and peripheral nerve sheath tumor) whose skin lesions have

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2018 Cureus

9. Multiple reactive keratoacanthomas treated with zinc oxide wraps and intralesional corticosteroids (PubMed)

Multiple reactive keratoacanthomas treated with zinc oxide wraps and intralesional corticosteroids 30128342 2019 02 26 2352-5126 4 7 2018 Aug JAAD case reports JAAD Case Rep Multiple reactive keratoacanthomas treated with zinc oxide wraps and intralesional corticosteroids. 701-704 10.1016/j.jdcr.2018.06.005 West Lindsey L Department of Dermatology, UT Southwestern Medical Center, Dallas, Texas. Ayoade Katherine K Department of Dermatology, UT Southwestern Medical Center, Dallas, Texas (...) . Vandergriff Travis T Department of Dermatology, UT Southwestern Medical Center, Dallas, Texas. Nijhawan Rajiv I RI Department of Dermatology, UT Southwestern Medical Center, Dallas, Texas. eng Case Reports 2018 08 15 United States JAAD Case Rep 101665210 2352-5126 KA, keratoacanthoma Keratoacanthoma 2018 8 22 6 0 2018 8 22 6 0 2018 8 22 6 1 epublish 30128342 10.1016/j.jdcr.2018.06.005 S2352-5126(18)30152-8 PMC6098212 J Dtsch Dermatol Ges. 2013 Aug;11(8):756 23621430 Dermatol Surg. 2004 Feb;30(2 Pt 2):326

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2018 JAAD Case Reports

10. A prospective diagnostic study on povidone-iodine retention in lesions suspected to be squamous cell carcinoma or keratoacanthoma. (PubMed)

A prospective diagnostic study on povidone-iodine retention in lesions suspected to be squamous cell carcinoma or keratoacanthoma. While dermatoscopy improves diagnostic accuracy for raised nonpigmented lesions, those with white surface keratin can be problematical. We investigated whether retention of povidone-iodine by surface keratin provides a clue to benignity.We performed a retrospective pilot study (n = 57) followed by a prospective study (n = 117) on raised nonpigmented lesions

2018 Australasian Journal of Dermatology

11. Keratoacanthoma Centrifugum Marginatum with Spontaneous Regression and Its Possible Differential Diagnosis (PubMed)

Keratoacanthoma Centrifugum Marginatum with Spontaneous Regression and Its Possible Differential Diagnosis Keratoacanthoma centrifugum marignatum (KCM) is a rare variant of keratoacanthoma, which is characterized by the dense infiltration of inflammatory cells throughout the dermis, especially around the keratinocytic islands. Therefore, it is sometimes difficult to differentiate between KCM and cutaneous T-cell lymphomas. In this report, we describe a case of KCM with spontaneous regression

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2018 Case reports in oncology

12. Solitary Palmar Keratoacanthoma: Case Report (PubMed)

Solitary Palmar Keratoacanthoma: Case Report Keratoacanthoma (KA) is a squamous neoplasm exhibiting a triphasic growth pattern involving rapid growth, stabilization, and eventual spontaneous resolution. Historically, keratoacanthomas were thought to originate on hair-bearing skin or sun-exposed surfaces. However, recent reports demonstrate that they can occur on the mucous membranes, subungual regions, and palms and soles. We report a 74-year-old man who developed a KA on the left palmar (...) surface after minor trauma, for which he underwent Mohs' micrographic surgery. A literature review for the terms: keratoacanthoma, palm, palmar, volar, plantar, and sole resulted in only four reported cases of solitary or giant KA of the palms and soles; excluding our patient, all of the cases occurred on the plantar foot. A number of reports describe palmar KA in the context of multiple lesions occurring simultaneously. However, to our knowledge, our patient represents the first reported case

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2018 Cureus

13. Response to 'Eruptive keratoacanthomas arising in the setting of lichenoid toxicity after PD1 inhibition with nivolumab'. (PubMed)

Response to 'Eruptive keratoacanthomas arising in the setting of lichenoid toxicity after PD1 inhibition with nivolumab'. 28779501 2018 02 21 1468-3083 32 2 2018 Feb Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Response to 'Eruptive keratoacanthomas arising in the setting of lichenoid toxicity after patients on antiprogrammed cell death-1 inhibition with nivolumab'. e61-e62 10.1111/jdv.14510 Bandino J P JP Medical University of South

2017 Journal of the European Academy of Dermatology and Venereology

14. Keratoacanthoma management: results of a survey of UK dermatologists and surgeons. (PubMed)

Keratoacanthoma management: results of a survey of UK dermatologists and surgeons. 28758190 2018 12 20 1365-2133 178 1 2018 01 The British journal of dermatology Br. J. Dermatol. Keratoacanthoma management: results of a survey of U.K. dermatologists and surgeons. e49-e50 10.1111/bjd.15858 Watchorn R E RE 0000-0001-8337-2501 Department of Dermatology, Royal Devon & Exeter Hospital, Exeter, U.K. Thomas S S Clinical Research Unit, Faculty of Health and Social Sciences, Bournemouth University

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2017 British Journal of Dermatology

15. Eruptive keratoacanthomas arising in the setting of lichenoid toxicity after PD1 inhibition with nivolumab. (PubMed)

Eruptive keratoacanthomas arising in the setting of lichenoid toxicity after PD1 inhibition with nivolumab. 28776778 2018 02 21 1468-3083 32 2 2018 Feb Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Eruptive keratoacanthomas arising in the setting of lichenoid toxicity after programmed cell death 1 inhibition with nivolumab. e58-e59 10.1111/jdv.14503 Feldstein S I SI Department of Dermatology, University of California-Davis, Sacramento, CA

2017 Journal of the European Academy of Dermatology and Venereology

16. Eruptive Keratoacanthomas Associated With Pembrolizumab Therapy. (PubMed)

Eruptive Keratoacanthomas Associated With Pembrolizumab Therapy. To our knowledge, there have been no previous reports of eruptive keratoacanthomas (KAs) in patients receiving pembrolizumab.To report the cases of 3 consecutive patients with pembrolizumab-induced eruptive KAs and their management.Case report study of 3 patients from 2 centers with pembrolizumab-treated cancer who all developed eruptive KAs.All 3 patients had AK treatment with clobetasol ointment and intralesional triamcinolone

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2017 JAMA dermatology (Chicago, Ill.)

17. Aberrant DNA Methylation in Keratoacanthoma. (PubMed)

Aberrant DNA Methylation in Keratoacanthoma. Keratoacanthoma (KA) is a self-limiting epidermal tumor for which histopathological examination sometimes suggests malignancy. Based on inconsistent clinical views, KA can be regarded as both a benign tumor and a variant of squamous cell carcinoma (SCC). Aberrant DNA methylation frequently occurs in malignant tumors but it scarcely occurs in benign tumors. Whether aberrant methylation occurs in KA has not been previously examined.The aim

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2016 PLoS ONE

18. Solitary Large Keratoacanthomas of the Head and Neck: An Observational Study. (PubMed)

Solitary Large Keratoacanthomas of the Head and Neck: An Observational Study. Solitary large keratoacanthomas (KAs) of the head and neck present a management dilemma, as no reliable means to predict the clinical course is available. Although typically considered a low-grade tumor, KAs are reported to invade/metastasize, prompting more aggressive treatment. There is little published regarding factors that predict when a KA behaves more like an aggressive squamous cell carcinoma (SCC).To study

2017 Dermatologic Surgery

19. Cytokeratin 17 and Ki-67: Immunohistochemical markers for the differential diagnosis of keratoacanthoma and squamous cell carcinoma (PubMed)

Cytokeratin 17 and Ki-67: Immunohistochemical markers for the differential diagnosis of keratoacanthoma and squamous cell carcinoma The clinical and histopathological distinction between keratoacanthoma (KA) and squamous cell carcinoma (SCC) is essential, but frequently difficult to make. The utility of CK17 and Ki-67 expression in distinguishing between KA and SCC was investigated. Immunohistochemical staining patterns for CK17 and Ki-67 were evaluated in 24 KA and 27 SCC cases. The pattern

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2017 Oncology letters

20. A Case of Exophytic Pilomatricoma Clinically Resembling Keratoacanthoma (PubMed)

A Case of Exophytic Pilomatricoma Clinically Resembling Keratoacanthoma 28392667 2018 11 13 1013-9087 29 2 2017 Apr Annals of dermatology Ann Dermatol A Case of Exophytic Pilomatricoma Clinically Resembling Keratoacanthoma. 258-260 10.5021/ad.2017.29.2.258 Chun Seung Hyun SH Department of Dermatology, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan, Korea. Kim Chang Min CM Department of Dermatology, Korea University Ansan Hospital, College of Medicine, Korea

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2017 Annals of dermatology

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