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1. Chemical and in vitro Toxicity Analysis of a Supercritical Fluid Extraction of Kava kava (Piper methysticum). Full Text available with Trip Pro

Chemical and in vitro Toxicity Analysis of a Supercritical Fluid Extraction of Kava kava (Piper methysticum). Kava and kava extracts have shown great potential as a way to minimize anxiety-associated symptoms and to help alleviate pain. Hepatoxicity has been associated with the consumption of kava products. The chemical compounds, kavalactones (KL) and flavokavains (FK) have been implicated in kava's psychotropic and possible hepatotoxic properties.To investigate the kavalactone and flavokavain (...) content and in vitro toxicity of KAVOA™, a supercritical carbon dioxide extraction (SFE) of kava.Kavalactone and flavokavain content of SFE kava and noble kava root were determined following extraction in acetone, cell culture media, and water using ultra high-performance liquid chromatography (UHPLC). Using water extractions of the kava products, the cell viability and toxicity on the human hepatocellular carcinoma cell line (HepG2) were determined using luminescent and fluorescent assays

2019 Journal of Ethnopharmacology

2. Inflammatory sebotropic reaction associated with kava kava ingestion Full Text available with Trip Pro

Inflammatory sebotropic reaction associated with kava kava ingestion 29984274 2019 02 26 2352-5126 4 5 2018 Jun JAAD case reports JAAD Case Rep Inflammatory sebotropic reaction associated with kava kava ingestion. 437-439 10.1016/j.jdcr.2017.12.011 Brown-Joel Zoe O ZO University of Iowa Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa. Colleran Erica S ES private practice, University of Iowa Hospitals and Clinics, Iowa City, Iowa. Stone Mary Seabury MS (...) Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa. Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa. eng Case Reports 2018 04 30 United States JAAD Case Rep 101665210 2352-5126 histopathology kava kava natural medicine nutritional supplements sebotropic 2018 7 10 6 0 2018 7 10 6 0 2018 7 10 6 1 epublish 29984274 10.1016/j.jdcr.2017.12.011 S2352-5126(17)30330-2 PMC6031569 Int J Dermatol. 2014 Dec;53(12):1490-4 25069767 J Am Acad Dermatol

2018 JAAD Case Reports

3. The effectiveness and safety of Kava Kava for treating anxiety symptoms: A systematic review and analysis of randomized clinical trials. (Abstract)

The effectiveness and safety of Kava Kava for treating anxiety symptoms: A systematic review and analysis of randomized clinical trials. To determine if Kava Kava is an effective treatment for combating symptoms of anxiety despite warnings of hepatotoxicity from the Centers for Disease Control and Prevention (CDC).Databases PubMed, CINAHL, and PsycINFO were utilized to obtain clinical trials on Kava Kava and its effects on anxiety. A total of 11 articles met inclusion/exclusion criteria: 2 (...) for Kava Kava vs. another anti-anxiety medication, 2 detailing additional adverse events, and 7 for Kava Kava vs. placebo. Mantel-Haenszel fixed-effects model was used to analyze the data, with responder rates being pooled to compute weighted risk ratios.Kava Kava was shown to be more effective than placebo in 3 of the 7 trials. A final risk ratio of 1.50 (95% CI: 1.12, 2.01) from responder rates was calculated in favor of the intervention from 5 clinical trials (n = 330). Adverse events were shown

2018 Complementary Therapies in Clinical Practice

4. Epidemiological and clinical features of Kawasaki disease in Spain over 5 years and risk factors for aneurysm development. (2011-2016): KAWA-RACE study group. Full Text available with Trip Pro

Epidemiological and clinical features of Kawasaki disease in Spain over 5 years and risk factors for aneurysm development. (2011-2016): KAWA-RACE study group. Kawasaki disease (KD) is an acute self-limited systemic vasculitis of unknown etiology affecting mainly children less than 5 years of age. Risk factors for cardiac involvement and resistance to treatment are insufficiently studied in non-Japanese children.This study aimed to investigate the epidemiology, clinical features and risk factors (...) for resistance to treatment and coronary artery lesions (CAL) in KD in Spain.Retrospective study (May 2011-June 2016) of all patients less than 16 years of age diagnosed with KD included in KAWA-RACE network (84 Spanish hospitals).A total of 625 cases were analyzed, 63% were males, 79% under 5 year-olds and 16.8% younger than 12 months. On echocardiographic examination CAL were the most frequent findings (23%) being ectasia the most common (12%). Coronary aneurysms were diagnosed in 9.6%, reaching 20

2019 PLoS ONE

5. Kava for Generalized Anxiety Disorder: A Review of Current Evidence. (Abstract)

Kava for Generalized Anxiety Disorder: A Review of Current Evidence. Generalized anxiety disorder (GAD) is a chronic and debilitating condition characterized by persistent and overpowering anxiety. Treatment of GAD with antidepressants and benzodiazepines is only moderately effective and not free from side effects. Kava (Piper methysticum) has been explored as a potential phytotherapeutic option for GAD.To perform a systematic review and meta-analysis of the available evidence on Kava (...) as a treatment for GAD.Systematic search of English-language publications from major databases for clinical trials reporting the effects of Kava for the treatment of GAD.Twelve articles were included in this review. Evidence supporting Kava as an effective treatment for GAD was found in two placebo-controlled trials and a reference-controlled trial. One negative trial demonstrated that Kava was not more effective than placebo. Meta-analyses of the results of three placebo-controlled trials (n = 130) favored

2018 Journal of Alternative and Complementary Medicine

6. Exploring the Impact of Two-week Kava on the Metabolism of Nicotine and NNK

Exploring the Impact of Two-week Kava on the Metabolism of Nicotine and NNK Exploring the Impact of Two-week Kava on the Metabolism of Nicotine and NNK - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Exploring the Impact of Two-week Kava on the Metabolism of Nicotine and NNK The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03606655 Recruitment Status : Not yet recruiting First Posted : July 31, 2018 Last Update Posted

2018 Clinical Trials

7. Kava-induced acute cutaneous toxicity: An increasingly recognized characteristic clinicohistologic pattern Full Text available with Trip Pro

Kava-induced acute cutaneous toxicity: An increasingly recognized characteristic clinicohistologic pattern 30456280 2018 12 07 2352-5126 4 10 2018 Nov JAAD case reports JAAD Case Rep Kava-induced acute cutaneous toxicity: An increasingly recognized characteristic clinicohistologic pattern. 1037-1038 10.1016/j.jdcr.2018.08.011 Rzepecki Alexandra K AK Department of Dermatology, University of Michigan Medical School, Ann Arbor. Department of Medicine, Division of Dermatology, Montefiore Medical (...) , Bronx. eng Journal Article 2018 11 10 United States JAAD Case Rep 101665210 2352-5126 dermatitis kava neutrophilic infiltrate seborrheic distribution sebotrophic eruption 2018 11 21 6 0 2018 11 21 6 0 2018 11 21 6 1 epublish 30456280 10.1016/j.jdcr.2018.08.011 S2352-5126(18)30215-7 PMC6232697 J Am Acad Dermatol. 2005 Nov;53(5):906 16243159 JAAD Case Rep. 2018 Apr 30;4(5):437-439 29984274 J Am Acad Dermatol. 1998 Jan;38(1):104-6 9448214 J Am Acad Dermatol. 1994 Jul;31(1):89-97 8021378 J Clin

2018 JAAD Case Reports

8. Kava-241 Reduced Periodontal Destruction in a Collagen Antibody Primed Porphyromonas gingivalis Model of Periodontitis. Full Text available with Trip Pro

Kava-241 Reduced Periodontal Destruction in a Collagen Antibody Primed Porphyromonas gingivalis Model of Periodontitis. The aim of this study was to evaluate the effect of Kava-241, an optimized Piper methysticum Kava compound, on periodontal destruction in a collagen antibody primed oral gavage model of periodontitis.Experimental periodontitis was induced by oral gavage of Porphyromonas gingivalis (P. gingivalis) + type II collagen antibody (AB) in mice during 15 days. Mice were treated (...) with Kava-241 concomitantly or prior to P. gingivalis gavage and compared to untreated mice. Comprehensive histomorphometric analyses were performed.Oral gavage with P. gingivalis induced mild epithelial down-growth and alveolar bone loss, while oral gavage with additional AB priming had greater tissular destruction in comparison with gavage alone (p < .05). Kava-241 treatment significantly (p < .05) reduced epithelial down-growth (72%) and alveolar bone loss (36%) in P. gingivalis+AB group. This Kava

2017 Journal of Clinical Periodontology

9. Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin Full Text available with Trip Pro

Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin HER2/neu positive breast tumors predict a high mortality and comprise 25%-30% of breast cancer. We have shown that Flavokawain A (FKA) preferentially reduces the viabilities of HER2-overexpressing breast cancer cell lines (i.e., SKBR3 and MCF7/HER2) versus those with less HER2 expression (i.e., MCF7 and MDA-MB-468). FKA at cytotoxic concentrations

2017 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

10. Kava

Kava Kava Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Kava Kava Aka: Kava , Kava Kava From Related Chapters II. Indications III (...) . Mechanism Potentiates GABA neurotransmitters IV. Adverse Effects Serious s Excessive sedation when used with other CNS depressants May exacerbate Dermopathy or Photosensitivity Pruritic s and s May be related to after kava ingestion Hepatotoxicity Unclear mechanism and incomplete data Some cases progressed to liver failure V. Drug Interactions Multiple cytochrome P450 interactions CYP2E1 inhibitor inhibitor inhibitor Additive effects with CNS Depressants s Barbiturates s VI. Precautions Routine use

2018 FP Notebook

11. Sebotropic eruption associated with use of oral kava kava supplement. (Abstract)

Sebotropic eruption associated with use of oral kava kava supplement. Supplement use is prevalent, and its use is increasing among older adults. Dermatologists need to be aware of the adverse cutaneous effects that can result from herbal supplement use. A 55-year-old man presented with an eruption in a sebotropic distribution after consuming kava kava for 3 weeks, which resolved after discontinuation of the supplement. This case highlights the need for clinicians to consider kava kava (...) in the differential of sebotropic eruptions. The biology, mechanism of action, and potential systemic and cutaneous effects of kava kava are reviewed. © 2014 British Association of Dermatologists.

2014 Clinical & Experimental Dermatology

12. Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes Full Text available with Trip Pro

Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes Context Flavokawains are secondary metabolites from the kava plant (Piper methysticum Forst. f., Piperaceae) that have anticancer properties and demonstrated oral efficacy in murine cancer models. However, flavokawains also have suspected roles in rare cases of kava-induced hepatotoxicity. Objective To compare the toxicity

2016 Pharmaceutical biology

13. Driving following Kava Use and Road Traffic Injuries: A Population-Based Case-Control Study in Fiji (TRIP 14) Full Text available with Trip Pro

Driving following Kava Use and Road Traffic Injuries: A Population-Based Case-Control Study in Fiji (TRIP 14) To investigate the association between kava use and the risk of four-wheeled motor vehicle crashes in Fiji. Kava is a traditional beverage commonly consumed in many Pacific Island Countries. Herbal anxiolytics containing smaller doses of kava are more widely available.Data for this population-based case-control study were collected from drivers of 'case' vehicles involved in serious (...) injury-involved crashes (where at least one road user was killed or admitted to hospital for 12 hours or more) and 'control' vehicles representative of 'driving time' in the study base. Structured interviewer administered questionnaires collected self-reported participant data on demographic characteristics and a range of risk factors including kava use and potential confounders. Unconditional logistic regression models estimated odds ratios relating to the association between kava use and injury

2016 PloS one

14. Hepatotoxicity Induced by “the 3Ks”: Kava, Kratom and Khat Full Text available with Trip Pro

Hepatotoxicity Induced by “the 3Ks”: Kava, Kratom and Khat The 3Ks (kava, kratom and khat) are herbals that can potentially induce liver injuries. On the one hand, growing controversial data have been reported about the hepatotoxicity of kratom, while, on the other hand, even though kava and khat hepatotoxicity has been investigated, the hepatotoxic effects are still not clear. Chronic recreational use of kratom has been associated with rare instances of acute liver injury. Several studies (...) and case reports have suggested that khat is hepatotoxic, leading to deranged liver enzymes and also histopathological evidence of acute hepatocellular degeneration. Numerous reports of severe hepatotoxicity potentially induced by kava have also been highlighted, both in the USA and Europe. The aim of this review is to focus on the different patterns and the mechanisms of hepatotoxicity induced by "the 3Ks", while trying to clarify the numerous aspects that still need to be addressed.

2016 International journal of molecular sciences

15. Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism Full Text available with Trip Pro

Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism Extracts of the pepper plant kava (Piper methysticum) are effective in alleviating anxiety in clinical trials. Despite the long-standing therapeutic interest in kava, the molecular target(s) of the pharmacologically active constituents, kavalactones have not been established. γ-Aminobutyric acid type A receptors (GABAARs) are assumed to be the in vivo

2016 PloS one

16. Kava for the treatment of generalised anxiety disorder (K-GAD): study protocol for a randomised controlled trial. Full Text available with Trip Pro

Kava for the treatment of generalised anxiety disorder (K-GAD): study protocol for a randomised controlled trial. Generalised anxiety disorder (GAD) is a chronic and pervasive condition that generates high levels of psychological stress, and it is difficult to treat in the long term. Current pharmacotherapeutic options for GAD are in some cases only modestly effective, and may elicit undesirable side effects. Through targeted actions on the gamma-aminobutyric acid (GABA) pathway, the South (...) Pacific medicinal plant kava (Piper methysticum) is a non-addictive, non-hypnotic anxiolytic with the potential to treat GAD. The evidence for the efficacy of kava for treating anxiety has been affirmed through clinical trials and meta-analyses. Recent research has also served to lessen safety concerns regarding the use of kava due to hepatotoxic risk, which is reflected in a recent German court overturning the previous kava ban in that country (which may in turn influence a reinstatement

2015 Trials Controlled trial quality: predicted high

17. Is driving under the influence of kava associated with motor vehicle crashes? A systematic review of the epidemiological literature. Full Text available with Trip Pro

Is driving under the influence of kava associated with motor vehicle crashes? A systematic review of the epidemiological literature. Kava is marketed as a herbal anxiolytic in several countries and is consumed recreationally in high doses in many indigenous Pacific and Australian Aboriginal communities. We reviewed the published literature examining the association (if any) between kava use and motor vehicle crashes (MVCs), MVC-related injuries or driving performance.Search of MEDLINE, EMBASE (...) , PsycINFO, CINAHL, Scopus, AMED, Australian Medical Index, Australian Transport Index and trials registries and injury journals up to August 2014.No studies quantifying the effects of kava on MVCs or related injury were located. Four experimental studies using computer-based driving simulation examined the effects of pharmacological doses of kavalactones on cognitive and visuomotor performance. While no statistically significant adverse changes attributable to kava were found, there was weak evidence

2015 Australian and New Zealand journal of public health

18. Investigation of Kava Effects on NNK Metabolism

Investigation of Kava Effects on NNK Metabolism Investigation of Kava Effects on NNK Metabolism - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Investigation of Kava Effects on NNK Metabolism The safety (...) Description Go to Brief Summary: This is a non-therapeutic, single-arm pilot clinical trial in adult healthy smokers to assess whether kava can alter NNK metabolism in humans. Condition or disease Intervention/treatment Phase Tobacco Smoking Dietary Supplement: Kava Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 24 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Basic

2015 Clinical Trials

19. Kava for the Treatment of Generalised Anxiety Disorder: A Double-Blind Randomised Placebo-Controlled Trial

Kava for the Treatment of Generalised Anxiety Disorder: A Double-Blind Randomised Placebo-Controlled Trial Kava for the Treatment of Generalised Anxiety Disorder: A Double-Blind Randomised Placebo-Controlled Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Kava for the Treatment of Generalised Anxiety Disorder: A Double-Blind Randomised Placebo-Controlled Trial (KGAD) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02219880 Recruitment Status : Completed First Posted : August 19, 2014 Last Update

2014 Clinical Trials

20. Kava dermopathy in Fiji: an acquired ichthyosis? (Abstract)

Kava dermopathy in Fiji: an acquired ichthyosis? Kava dermopathy is a common cutaneous effect of regular or heavy use of Kava, a psychoactive beverage consumed widely throughout the Pacific. In Fiji in 2012, over 1000 study participants underwent full skin examination, and kava dermopathy was a common cutaneous finding. The clinical manifestations of kava dermopathy share similarities with the spectrum of autosomal recessive congenital ichthyoses, predominantly lamellar ichthyosis (...) . The pathogenesis of Kava dermopathy may be associated with a functional defect in one or more cytochrome P450 enzymes implicated in epidermal integrity, thus mimicking the genetic defect as seen in lamellar ichthyosis type 3. © 2014 The International Society of Dermatology.

2014 International Journal of Dermatology

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