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Kaolin Mineral Dressing

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1. Kaolin Mineral Dressing

Kaolin Mineral Dressing Kaolin Mineral Dressing Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Kaolin Mineral Dressing Kaolin Mineral (...) Dressing Aka: Kaolin Mineral Dressing , Mineral Dressing with Impregnated Kaolin , Kaolin , Combat Gauze II. Mechanism Similar to Aluminum silicate activates Increases and platelet concentration at wound sites via water absorption III. Efficacy Slower control of bleeding Significantly increased survival in animal models May be less effective coagulopathic patients IV. Advantages Available as gauze rolls (3 inch wide, 4 yard long) Combat Gauze is now primary hemostatic agent used on battlefield Some

2018 FP Notebook

2. Kaolin Mineral Dressing

Kaolin Mineral Dressing Kaolin Mineral Dressing Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Kaolin Mineral Dressing Kaolin Mineral (...) Dressing Aka: Kaolin Mineral Dressing , Mineral Dressing with Impregnated Kaolin , Kaolin , Combat Gauze II. Mechanism Similar to Aluminum silicate activates Increases and platelet concentration at wound sites via water absorption III. Efficacy Slower control of bleeding Significantly increased survival in animal models May be less effective coagulopathic patients IV. Advantages Available as gauze rolls (3 inch wide, 4 yard long) Combat Gauze is now primary hemostatic agent used on battlefield Some

2015 FP Notebook

3. Toxicity of Aluminum Silicates Used in Hemostatic Dressings Toward Human Umbilical Veins Endothelial Cells, HeLa Cells, and RAW267.4 Mouse Macrophages. (PubMed)

be exposed to this mineral and compared the results with other minerals such as bentonite, kaolin, and QuikClot ACS+ (QC+).Human umbilical vein endothelial cells (HUVEC), HeLa cells, and RAW267.4 mouse macrophage-like cells (RAW) were incubated directly with different concentrations of each mineral for 24 hours. Cell viability was determined metabolically using the AlamarBlue fluorescent technique. In another experiment, minerals were exposed to HUVEC via Transwell inserts with a polycarbonate filter (...) (0.4-μm pore size) to prevent direct contact between cells and minerals for determining whether direct exposure or leaching compounds from minerals cause cytotoxicity.Incubation of HUVEC and RAW cells with 1 to 100 μg/mL of the minerals for 24 hours resulted in differential toxicities. The cytotoxicity of WS was equal to that of bentonite and higher than kaolin and QC+. Neither cell type survived for 24 hours in the presence of 100 μg/mL WS or bentonite. These minerals, however, had little effect

2011 Journal of Trauma

4. Clot-inducing minerals versus plasma protein dressing for topical treatment of external bleeding in the presence of coagulopathy. (PubMed)

Clot-inducing minerals versus plasma protein dressing for topical treatment of external bleeding in the presence of coagulopathy. Previous studies identified WoundStat (WS, smectite) and Combat Gauze (CG, kaolin-coated gauze) as the most effective available agents for controlling arterial bleeding with potential utility in casualty care. Tissue sealant properties of WS suggested its potential advantage over clot-promoting CG for treating coagulopathic bleeding. This study compared the efficacy (...) of CG and WS with a fibrinogen-based (FAST) dressing to control bleeding in coagulopathic animals.Coagulopathy was induced in pigs (n = 55, 35 kg) by ∼50% isovolemic hemodilution and hypothermia (core temperature, 33°C ± 0.5°C). A 6-mm arteriotomy was made in the femoral artery and free bleeding allowed for 30 seconds. A test agent (n = 13-15 per group) or control product (gauze, GZ, n = 12) was applied to the wounds and compressed with a Kerlix gauze for 2 minutes. Fluid resuscitation was given

2010 Journal of Trauma

5. Gastrointestinal Complications (PDQ®): Health Professional Version

, perform digital rectal examination to rule out low impaction. Continue above steps AND: If impacted, disimpact manually if stool is soft. If not, soften with mineral oil fleets enema before disimpaction. Follow up with milk of molasses enemas until clear with no formed stools. Consider use of rescue analgesics before disimpaction. If not impacted on rectal examination, patient may still have higher level impaction; if history is appropriate, consider abdominal imaging and/or administer milk (...) evening meal. - Calcium salts of sennosides: 12 to 24 mg at bedtime; senna: Senolax, Seneson, or Black-Draught (two tablets); Senokot (two tablets or 10–15 cc at bedtime). - Bisacodyl: 10 to 15 mg swallowed whole, not chewed, or a 10-mg suppository. Lubricant laxatives Lubricant laxatives lubricate intestinal mucosa and soften stool. Caution: Administer on empty stomach at bedtime. Mineral oil prevents absorption of oil-soluble vitamins and drugs. With older patients, aspiration potential suggests

2018 PDQ - NCI's Comprehensive Cancer Database

6. Prevention and Treatment of Thrombosis in Pediatric and Congenital Heart Disease

: individualized dosing titrated to INR. Target INR range, 2–3.Mechanical mitral valves, 2.5–3.5. INR daily until therapeutic, then decreased frequency when stable with minimum monthly testing.Test INR with illness, medication, or diet change. Hemorrhage, 0.5% per patient-y.Increases with INR >8.Prosthetic valves0.4% per patient-y. , Tracheal calcification, hair loss, decreased bone mineral density. , Antiplatelet therapy ( ) Aspirin , Inhibition of COX-1 and COX-2 activity Oralt½ is dose dependent. 15–20 min

2013 American Heart Association

7. Topical Hemostatic Agent

. Preparations: Zeolite Mineral Dressing (QuickClot) Mechanism Factor Concentrator Increases and platelet concentration at wound sites via water absorption Efficacy Stops bleeding in 92% of wounds not stopped with direct pressure Effective for low pressure, venous bleeding Adverse effects Prior formulation caused severe local burns (no longer an issue with newer bead formulations) XV. Preparations: Mineral Dressing with Impregnated Kaolin Mechanism (similar to s) Factor Concentrator Increases and platelet (...) Hemostatic Agent Aka: Topical Hemostatic Agent , Hemostatic Agents II. Mechanism Topical Hemostatic Agents III. Indications Significant Bleeding Indicated for rapid non-extremity bleeding not controlled with direct manual pressure IV. Precautions Newer agents (Chitosan, and mineral dressings) are not widely available Primarily found in military and large s as of 2013 Risk of wound contamination with hemostatic agent (may require later debridement) V. Preparations: Agent Types Factor Concentrators (drying

2018 FP Notebook

8. Gastrointestinal Complications (PDQ®): Health Professional Version

, perform digital rectal examination to rule out low impaction. Continue above steps AND: If impacted, disimpact manually if stool is soft. If not, soften with mineral oil fleets enema before disimpaction. Follow up with milk of molasses enemas until clear with no formed stools. Consider use of rescue analgesics before disimpaction. If not impacted on rectal examination, patient may still have higher level impaction; if history is appropriate, consider abdominal imaging and/or administer milk (...) evening meal. - Calcium salts of sennosides: 12 to 24 mg at bedtime; senna: Senolax, Seneson, or Black-Draught (two tablets); Senokot (two tablets or 10–15 cc at bedtime). - Bisacodyl: 10 to 15 mg swallowed whole, not chewed, or a 10-mg suppository. Lubricant laxatives Lubricant laxatives lubricate intestinal mucosa and soften stool. Caution: Administer on empty stomach at bedtime. Mineral oil prevents absorption of oil-soluble vitamins and drugs. With older patients, aspiration potential suggests

2015 PDQ - NCI's Comprehensive Cancer Database

9. Gastrointestinal Complications

tablets, if using separately), and add one or both of the following: Milk of magnesia oral concentrate (1170/5 mL), 10 mL by mouth 2 to 4 times per day. Polyethylene glycol (MiraLAX), 17 g in 8-oz beverage daily. If no response to above, perform digital rectal examination to rule out low impaction. Continue above steps AND: If impacted, disimpact manually if stool is soft. If not, soften with mineral oil fleets enema before disimpaction. Follow up with milk of molasses enemas until clear (...) intestinal mucosa and soften stool. Caution: Administer on empty stomach at bedtime. Mineral oil prevents absorption of oil-soluble vitamins and drugs. With older patients, aspiration potential suggests that mineral oil be avoided because it can cause lipid pneumonitis. It can interfere with postoperative healing of anorectal surgery. Avoid giving with docusate sodium. Docusate sodium causes increased systemic absorption of mineral oil. Use: Prophylactically to prevent straining in patients for whom

2012 PDQ - NCI's Comprehensive Cancer Database

10. Safety Study of Quickclot for Bleeding Control After Adenotonsillectomy

provided by (Responsible Party): Eastern Virginia Medical School Study Details Study Description Go to Brief Summary: Hemostasis will be achieved during Pediatric Tonsillectomy/Adenoidectomy with the use of QuickClot. Condition or disease Intervention/treatment Phase Sleep Apnea, Obstructive Device: QuickClot Not Applicable Detailed Description: The Quickclot dressing contains Kaolin, a natural mineral that promotes the body's clotting process. This dressing will be applied for one minute to the area

2013 Clinical Trials

11. Topical Hemostatic Agent

. Preparations: Zeolite Mineral Dressing (QuickClot) Mechanism Factor Concentrator Increases and platelet concentration at wound sites via water absorption Efficacy Stops bleeding in 92% of wounds not stopped with direct pressure Effective for low pressure, venous bleeding Adverse effects Prior formulation caused severe local burns (no longer an issue with newer bead formulations) XV. Preparations: Mineral Dressing with Impregnated Kaolin Mechanism (similar to s) Factor Concentrator Increases and platelet (...) Hemostatic Agent Aka: Topical Hemostatic Agent , Hemostatic Agents II. Mechanism Topical Hemostatic Agents III. Indications Significant Bleeding Indicated for rapid non-extremity bleeding not controlled with direct manual pressure IV. Precautions Newer agents (Chitosan, and mineral dressings) are not widely available Primarily found in military and large s as of 2013 Risk of wound contamination with hemostatic agent (may require later debridement) V. Preparations: Agent Types Factor Concentrators (drying

2015 FP Notebook

12. Radiation Exposure and Contamination

of radioactive elements with half-lives comparable to the age of the earth (~4.5 billion years). In particular, uranium ( 238 U) and thorium ( 232 Th) along with several dozen of their radioactive progeny and a radioactive isotope of potassium ( 40 K) are present in many rocks and minerals. Small quantities of these radionuclides are in the food, water, and air and thus contribute to internal exposure as these radionuclides are invariably incorporated into the body. The majority of the dose from internally (...) . Inducing sweating (eg, placing a rubber glove over a contaminated hand) may help remove residual skin contamination. Burns are rinsed gently because scrubbing may increase injury severity. Subsequent dressing changes help remove residual contamination. Decontamination is not necessary for patients who have been irradiated by an external source and are not contaminated. Internal decontamination Ingested radioactive material should be removed promptly by induced vomiting or lavage if exposure is recent

2013 Merck Manual (19th Edition)

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