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1. Neonatal jaundice

Neonatal jaundice Neonatal jaundice - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Neonatal jaundice Last reviewed: February 2019 Last updated: January 2019 Summary Usually noted clinically when serum bilirubin is >85.5 micromol/L (5 mg/dL). Occurs in 50% to 70% of term neonates. Most cases physiological. Jaundice in the first 24 hours of life is considered pathological. Treatment for severe hyperbilirubinaemia (...) includes phototherapy and/or exchange transfusion. The major complication of unconjugated hyperbilirubinaemia is kernicterus. Definition Neonatal jaundice is the yellowing discoloration of the skin and sclera of a neonate, which is caused by increased levels of bilirubin in the blood. A neonate refers to an infant in the first 28 days of life. This topic focuses on recognising and managing early neonatal jaundice, which is most commonly caused by unconjugated hyperbilirubinaemia. While prolonged

2019 BMJ Best Practice

2. Neonatal jaundice

Neonatal jaundice Neonatal jaundice - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Neonatal jaundice Last reviewed: February 2019 Last updated: January 2019 Summary Usually noted clinically when serum bilirubin is >85.5 micromol/L (5 mg/dL). Occurs in 50% to 70% of term neonates. Most cases physiological. Jaundice in the first 24 hours of life is considered pathological. Treatment for severe hyperbilirubinaemia (...) includes phototherapy and/or exchange transfusion. The major complication of unconjugated hyperbilirubinaemia is kernicterus. Definition Neonatal jaundice is the yellowing discoloration of the skin and sclera of a neonate, which is caused by increased levels of bilirubin in the blood. A neonate refers to an infant in the first 28 days of life. This topic focuses on recognising and managing early neonatal jaundice, which is most commonly caused by unconjugated hyperbilirubinaemia. While prolonged

2018 BMJ Best Practice

3. Assessment of jaundice

Assessment of jaundice Assessment of jaundice - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of jaundice Last reviewed: February 2019 Last updated: June 2018 Summary Jaundice (icterus) is the result of accumulation of bilirubin in the bloodstream and subsequent deposition in the skin, sclera, and mucous membranes. The normal range for total bilirubin is 3.4 to 20 micromol/L (0.2-1.2 mg/dL). Jaundice may (...) not be clinically evident until serum levels exceed 51 micromol/L (3 mg/dL). The underlying aetiology of jaundice may be quite difficult to discern. A pointed history and physical examination is of utmost importance. By using this approach, an accurate diagnosis is possible in approximately 85% of patients. Greenberger NJ. History taking and physical examination for the patient with liver disease. In: Schiff ER, Sorrell MF, Maddrey WC, eds. Schiff's diseases of the liver. 9th ed. Philadelphia, PA: Lippincott

2018 BMJ Best Practice

4. Phototherapy Devices for Neonatal Jaundice: Clinical-Effectiveness, Cost-Effectiveness, and Guidelines

Phototherapy Devices for Neonatal Jaundice: Clinical-Effectiveness, Cost-Effectiveness, and Guidelines Phototherapy Devices for Neonatal Jaundice: Clinical-Effectiveness, Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Phototherapy Devices for Neonatal Jaundice: Clinical-Effectiveness, Cost-Effectiveness, and Guidelines Phototherapy Devices for Neonatal Jaundice: Clinical-Effectiveness, Cost-Effectiveness, and Guidelines Last updated: May 10, 2018 Project Number (...) : RB1212-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report Question What is the comparative clinical effectiveness of different phototherapy devices used to treat jaundice in newborns? What is the comparative clinical effectiveness of phototherapy devices used with or without incubators to treat jaundice in newborns? What is the clinical effectiveness of double phototherapy treatment for the treatment of newborn jaundice? What is the comparative

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

5. Beyond ?Asian?: Specific East and Southeast Asian Races or Ethnicities Associated With Jaundice Readmission

Beyond ?Asian?: Specific East and Southeast Asian Races or Ethnicities Associated With Jaundice Readmission Beyond “Asian”: Specific East and Southeast Asian Races or Ethnicities Associated With Jaundice Readmission | Brief Report | Hospital Pediatrics '); document.write(''); } function OAS_AD(pos) { if (OAS_version >= 11 && typeof(OAS_RICH)!='undefined') { OAS_RICH(pos); } else { OAS_NORMAL(pos); } } //--> Search for this keyword Source User menu Sections Sign up for highlighting editor-chosen (...) studies with the greatest impact on clinical care. Beyond “Asian”: Specific East and Southeast Asian Races or Ethnicities Associated With Jaundice Readmission Michael G. Bentz , Nancy Carmona , Manavi M. Bhagwat , Lindsay M. Thimmig , Jamal Saleh , Uchechukwu Eke , Jolene Kokroko , Rand Dadasovich , Brooke Rice , Michael D. Cabana Abstract OBJECTIVES: Clinical practice guidelines have recognized “Asian” and “East Asian” as risk factors for newborn jaundice and readmission. We sought to identify more

2018 American Academy of Pediatrics

6. Flowchart: Management of neonatal jaundice

Flowchart: Management of neonatal jaundice Queensland Health State of Queensland (Queensland Health) 2018 http://creativecommons.org/licenses/by-nc-nd/3.0/au/deed.en Queensland Clinical Guidelines, Guidelines@health.qld.gov.au Queensland Clinical Guidelines www.health.qld.gov.au/qcg Management of neonatal jaundice Queensland Clinical Guidelines Neonatal jaundice: F17.7-1-V6-R22 Phototherapy · Check spectral irradiance and output of light source · Repeat TSB as per nomogram · Plot TSB levels (...) on nomogram (gestation, weight and age appropriate) · If TSB rising consider intensive phototherapy · Nurse baby unclothed except for nappy · Protect eyes · Continuous observation of baby · Monitor baby’s temperature · Continue normal oral feeds · Assess hydration status · Discontinue depending on baby’s age, TSB and cause of hyperbilirubinaemia Risk factors Maternal · Blood group O · RhD negative · Red call antibodies · Genetic–family history, East Asian, Mediterranean · Diabetes · Previous jaundiced

2018 Queensland Health

7. Guideline Supplement: Neonatal jaundice

Guideline Supplement: Neonatal jaundice Refer to online version, destroy printed copies after use Page 1 of 19 Maternity and Neonatal C linical G uideline Queensland Health Guideline Supplement: Neonatal jaundice Queensland Clinical Guideline Supplement: Neonatal jaundice Refer to online version, destroy printed copies after use Page 2 of 19 Table of Contents List of Tables 2 1 Introduction 3 1.1 Funding 3 1.2 Conflict of interest 3 1.3 Guideline review 4 2 Methodology 6 2.1 Topic (...) of this licence contact: Intellectual Property Officer, Queensland Health, GPO Box 48, Brisbane Qld 4001, email ip_officer@health.qld.gov.au, phone (07) 3234 1479. Queensland Clinical Guideline Supplement: Neonatal jaundice Refer to online version, destroy printed copies after use Page 3 of 19 1 Introduction This document is a supplement to the Queensland Clinical Guideline (QCG) Neonatal jaundice. It provides supplementary information regarding guideline development, makes summary recommendations, suggests

2018 Queensland Health

8. Neonatal jaundice

Neonatal jaundice Maternity and Neonatal C linical G uideline Queensland Health Neonatal jaundice Queensland Clinical Guideline: Neonatal jaundice Document title: Neonatal jaundice Publication date: December 2017 Document number: MN17.7-V7-R22 Document supplement: The document supplement is integral to and should be read in conjunction with this guideline. Amendments: Full version history is supplied in the document supplement. Amendment date: Amended April 2018 Replaces document: MN17.7-V6-R17 (...) @health.qld.gov.au, phone (07) 3234 1479. Refer to online version, destroy printed copies after use Page 2 of 40 Queensland Clinical Guideline: Neonatal jaundice Flow Chart: Management of neonatal jaundice Queensland Clinical Guidelines Neonatal jaundice: F17.7-1-V6-R22 Phototherapy · Check spectral irradiance and output of light source · Repeat TSB as per nomogram · Plot TSB levels on nomogram (gestation, weight and age appropriate) · If TSB rising consider intensive phototherapy · Nurse baby unclothed except

2018 Queensland Health

9. Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non-Jaundiced Rat Brain Full Text available with Trip Pro

Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non-Jaundiced Rat Brain Neonatal hyperbilirubinemia targets specific brain regions and can lead to kernicterus. One of the most debilitating symptoms of kernicterus is dystonia, which results from bilirubin toxicity to the globus pallidus (GP). Stem cell transplantation into the GP to replace lost neurons and restore basal ganglia circuits function is a potential therapeutic strategy to treat dystonia (...) in kernicterus. In this study we transplanted human medial ganglionic eminence (MGE)-like neural progenitor cells (NPCs) that we differentiated into a primarily gamma-aminobutyric acid (GABA)ergic phenotype, into the GP of non-immunosuppressed jaundiced (jj) and non-jaundiced (Nj) rats. We assessed the survival and development of graft cells at three time-points post-transplantation. While grafted MGE-like NPCs survived and generated abundant fibers in both jj and Nj brains, NPC survival was greater

2018 Cell transplantation

10. Guidelines for Management of Jaundice in the Breastfeeding Infant 35 Weeks or More of Gestation

Guidelines for Management of Jaundice in the Breastfeeding Infant 35 Weeks or More of Gestation ABM Protocol ABM Clinical Protocol #22: Guidelines for Management of Jaundice in the Breastfeeding Infant 35 Weeks or More of Gestation—Revised 2017 Valerie J. Flaherman, 1 M. Jeffrey Maisels, 2 and the Academy of Breastfeeding Medicine A central goal of The Academy of Breastfeeding Medicine is the development of clinical protocols free from commercial interest or in?uence for managing common medical (...) problems that may impact breastfeeding success. These protocols serve only as guidelines for the care of breastfeeding mothers and infants and do not delineate an exclusive course of treatment or serve as standards of medical care. Variations in treatment may be appropriate according to the needs of an individual patient. Purpose 1. To provide guidance in determining whether and how breastfeeding may or may not be contributing to infant jaundice. 2. To review evidence-based strategies for ameliorating

2017 Academy of Breastfeeding Medicine

11. Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of NASPGHAN and ESPGHAN

Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of NASPGHAN and ESPGHAN Copyright © ESPGHAL and NASPGHAN. All rights reserved. Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Rima Fawaz, y Ulrich Baumann, z Udeme Ekong, § Bjo ¨rn Fischler, jj Nedim (...) Hadzic, Cara L. Mack, # Vale ´rie A. McLin, Jean P. Molleston, yy Ezequiel Neimark, zz Vicky L. Ng, and §§ Saul J. Karpen ABSTRACT Cholestatic jaundice in infancy affects approximately 1 in every 2500 term infants and is infrequently recognized by primary providers in the setting of physiologic jaundice. Cholestatic jaundice is always pathologic and indicates hepatobiliary dysfunction. Early detection by the primary care physician and timely referrals to the pediatric gastroenterologist

2017 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

12. A simple rat model of in situ reversible obstructive jaundice in situ reversible obstructive jaundice model Full Text available with Trip Pro

A simple rat model of in situ reversible obstructive jaundice in situ reversible obstructive jaundice model To develop a simple and reliable rat model of in situ reversible obstructive jaundice with low morbidity and mortality rates.Rats were divided into 4 groups with 8 rats each: the sham-operated (SH) group only underwent laparotomy, the control internal drainage (ID-C) group underwent choledochoduodenostomy, the new internal drainage (ID-N) group and the long-term internal drainage (ID-L (...) study provided an efficient, simple, and reliable rat model that is especially suitable for long-term or consecutive studies of reversible obstructive jaundice.

2017 Annals of surgical treatment and research

13. Home- versus hospital-based phototherapy for the treatment of non-haemolytic jaundice in infants at more than 37 weeks' gestation. (Abstract)

Home- versus hospital-based phototherapy for the treatment of non-haemolytic jaundice in infants at more than 37 weeks' gestation. Phototherapy is commonly used for the treatment of neonatal jaundice, and home-based phototherapy is now being used in certain centres. Home-based phototherapy offers possible advantages by avoiding prolonged hospital admissions, promoting mother-infant bonding and reducing hospitalisation costs. Potential problems include increased duration of phototherapy (...) , increased readmission to hospital and increased risk of bilirubin encephalopathy.To compare exclusively home-based versus exclusively hospital-based phototherapy or a combination of home- and hospital-based phototherapy for the management of non-haemolytic jaundice in term infants up to 28 days of age. We planned to include specific subgroups for duration in hospital, method of phototherapy and criteria for readiness for discharge.We searched the Cochrane Neonatal Review Group Specialised Register

2014 Cochrane

14. Aetiology of viral hepatitis among jaundiced patients presenting to a tertiary hospital in Ghana. Full Text available with Trip Pro

Aetiology of viral hepatitis among jaundiced patients presenting to a tertiary hospital in Ghana. Viral hepatitis continues to play significant role in causing morbidity and mortality in sub-Saharan Africa. Apart from the few population based studies available, not many have investigated the burden of these viruses in jaundiced patients. Among the few studies, hepatitis E is the least studied among jaundiced patients. This study was aimed at describing the frequency, distribution and risk (...) of the different hepatitis viruses among jaundiced patients reporting to the second largest teaching hospital in Ghana.From November, 2015 to April, 2016, a cross-sectional study was conducted among jaundiced patients attending the Komfo Anokye Teaching Hospital. Between 3-5 ml of blood was collected from each patient and screened for viral hepatitis agents using both serologic and molecular-based assays.In the 155 patients recruited, hepatitis B was the most prevalent [54.2% (95% CI = 46.0%-62.2%)] followed

2018 PLoS ONE

15. A comparison of the effectiveness of three LED phototherapy machines, single- and double-sided, for treating neonatal jaundice in a low resource setting. Full Text available with Trip Pro

A comparison of the effectiveness of three LED phototherapy machines, single- and double-sided, for treating neonatal jaundice in a low resource setting. Neonatal jaundice is one of the most common reasons for hospital admission in low resource settings. Treatment is frequently inadequate as conventional phototherapy requires frequent bulb changes. LED phototherapy has comparable efficacy to conventional phototherapy, and the bulbs last over 40,000 hours. This observational study compares (...) the effectiveness of three LED machines, two single-sided and one double-sided in routine use in Vietnam.We included all infants weighting ≥1500g and with jaundice diagnosed visually or by Total Serum Bilirubin (TSB) measurement at The Da Nang Hospital for Women and Children (Da Nang, Vietnam). The primary endpoint was the average hourly change in TSB over the first six hours of treatment. The secondary endpoints were duration of treatment; average hourly change in TSB over treatment, and length of stay

2018 PLoS ONE

16. The Turkish Neonatal Jaundice Online Registry: A national root cause analysis. Full Text available with Trip Pro

The Turkish Neonatal Jaundice Online Registry: A national root cause analysis. Neonatal jaundice (NNJ) is common, but few root cause analyses based on national quality registries have been performed. An online registry was established to estimate the incidence of NNJ in Turkey and to facilitate a root cause analysis of NNJ and its complications.A multicenter prospective study was conducted on otherwise healthy newborns born at ≥35 weeks of gestation and hospitalized for only NNJ in 50 (...) collaborator neonatal intensive care units across Turkey over a 1-year period. Patients were analyzed for their demographic and clinical characteristics, treatment options, and complications.Of the 5,620 patients enrolled, 361 (6.4%) had a bilirubin level ≥25 mg/dL on admission and 13 (0.23%) developed acute bilirubin encephalopathy. The leading cause of hospital admission was hemolytic jaundice, followed by dehydration related to a lack of proper feeding. Although all infants received phototherapy, 302

2018 PLoS ONE

17. The pharmacokinetics of dexmedetomidine in patients with obstructive jaundice: A clinical trial. Full Text available with Trip Pro

The pharmacokinetics of dexmedetomidine in patients with obstructive jaundice: A clinical trial. Dexmedetomidine, a highly selective central α2-agonist, undergoes mainly biotransformation in the liver. The pharmacokinetics of dexmedetomidine were significantly affected by hepatic insufficiency. The clearance of dexmedetomidine in patients with severe hepatic failure decreased by 50% compared with controls. We tested the hypothesis that the pharmacokinetics of dexmedetomidine would be affected (...) by obstructive jaundice. The prospective registration number of clinical trial is ChiCTR-IPR-15007572.18 patients with obstructive jaundice and 12 non-jaundiced patient controls received dexmedetomidine, 1 μg/kg, over 10 min. Arterial blood samples were drawn before, during, and up to 5 h after the infusion. Plasma dexmedetomidine concentrations were determined by 1290 infinity high performance liquid chromatography coupled with 6470 tandem mass spectrometry. The relevant pharmacokinetic parameters were

2018 PLoS ONE Controlled trial quality: uncertain

18. Adenosquamous Carcinoma of the Ampulla of Vater: A Rare Cause of Obstructive Jaundice Full Text available with Trip Pro

Adenosquamous Carcinoma of the Ampulla of Vater: A Rare Cause of Obstructive Jaundice 29998166 2018 11 14 2341-4545 25 4 2018 Jun GE Portuguese journal of gastroenterology GE Port J Gastroenterol Adenosquamous Carcinoma of the Ampulla of Vater: A Rare Cause of Obstructive Jaundice. 195-197 10.1159/000481457 Carvalho Liliana L Gastroenterology Department, Hospital Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal. Túlio Maria Ana MA Gastroenterology Department, Hospital Egas (...) 101685861 2387-1954 Adenosquamous carcinoma Ampullary tumor Endoscopic ultrasonography Jaundice 2017 07 17 2017 08 15 2018 7 13 6 0 2018 7 13 6 0 2018 7 13 6 1 ppublish 29998166 10.1159/000481457 pjg-0025-0195 PMC6029213 World J Surg Oncol. 2013 May 31;11:124 23721111 World J Surg Oncol. 2015 Sep 29;13:287 26420726 Surg Case Rep. 2016 Dec;2(1):2 26943678

2017 GE Portuguese journal of gastroenterology

20. Randomised controlled trial: Filtered sunlight reduces serum bilirubin levels as effectively as conventional phototherapy in late preterm and term neonates with mild jaundice

Randomised controlled trial: Filtered sunlight reduces serum bilirubin levels as effectively as conventional phototherapy in late preterm and term neonates with mild jaundice Filtered sunlight reduces serum bilirubin levels as effectively as conventional phototherapy in late preterm and term neonates with mild jaundice | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any (...) as conventional phototherapy in late preterm and term neonates with mild jaundice Article Text Therapeutics/Prevention Randomised controlled trial Filtered sunlight reduces serum bilirubin levels as effectively as conventional phototherapy in late preterm and term neonates with mild jaundice Praveen Kumar Statistics from Altmetric.com Commentary on: Slusher TM , Olusanya BO , Vreman HJ , et al . A randomized trial of phototherapy with filtered sunlight in African neonates . Context Phototherapy (PT

2016 Evidence-Based Medicine

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