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Japanese Encephalitis

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141. Japanese encephalitis vaccine-facilitated dengue virus infection-enhancement antibody in adults. Full Text available with Trip Pro

Japanese encephalitis vaccine-facilitated dengue virus infection-enhancement antibody in adults. Dengue virus (DENV) and Japanese encephalitis virus (JEV) belong to the genus Flavivirus, and infection with a virus within this genus induces antibodies that are cross-reactive to other flaviviruses. Particularly in DENV infection, antibodies to DENV possess two competing activities: neutralizing activity and infection-enhancing activity. These antibody activities are considered central (...) in modulating clinical outcomes of DENV infection. Here, we determined the neutralizing and infection-enhancing activity of DENV cross-reactive antibodies in adults before and after JE vaccination.Participants were 77 Japanese adults who had received a single dose of inactivated Vero cell-derived JE vaccine. A total of 154 serum samples were obtained either before or approximately a month after a single dose of JE vaccination. The antibody-dependent enhancement (ADE) activity to each of four DENV serotypes

2016 BMC Infectious Diseases

142. Emergence or improved detection of Japanese encephalitis virus in the Himalayan highlands? Full Text available with Trip Pro

Emergence or improved detection of Japanese encephalitis virus in the Himalayan highlands? The emergence of Japanese encephalitis virus (JEV) in the Himalayan highlands is of significant veterinary and public health concern and may be related to climate warming and anthropogenic landscape change, or simply improved surveillance. To investigate this phenomenon, a One Health approach focusing on the phylogeography of JEV, the distribution and abundance of the mosquito vectors, and seroprevalence (...) in humans and animal reservoirs would be useful to understand the epidemiology of Japanese encephalitis in highland areas. © The Author 2016. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.

2016 Transactions of the Royal Society of Tropical Medicine & Hygiene

143. One-year immunogenicity kinetics and safety of a purified chick embryo cell rabies vaccine and an inactivated Vero cell-derived Japanese encephalitis vaccine administered concomitantly according to a new, 1-week, accelerated primary series. Full Text available with Trip Pro

One-year immunogenicity kinetics and safety of a purified chick embryo cell rabies vaccine and an inactivated Vero cell-derived Japanese encephalitis vaccine administered concomitantly according to a new, 1-week, accelerated primary series. Conventional rabies pre-exposure prophylaxis (PrEP) and Japanese encephalitis (JE) primary series vaccination regimens each require up to 4 weeks to complete and, thus, may not be feasible for individuals who need these immunizations on short notice

2016 Journal of Travel Medicine Controlled trial quality: uncertain

144. Differential Diagnosis of Japanese Encephalitis Virus Infections with the Inbios JE Detect™ and DEN Detect™ MAC-ELISA Kits. Full Text available with Trip Pro

Differential Diagnosis of Japanese Encephalitis Virus Infections with the Inbios JE Detect™ and DEN Detect™ MAC-ELISA Kits. Japanese encephalitis virus (JEV) is the leading cause of pediatric viral neurological disease in Asia. The JEV-specific IgM antibody-capture enzyme-linked immunosorbent assay (MAC-ELISA) in cerebrospinal fluid (CSF) and serum is the recommended method of laboratory diagnosis, but specificity of JEV MAC-ELISA can be low due to cross-reactivity. To increase the specificity (...) of the commercially available JEDetect™ MAC-ELISA (JEDetect), a differential testing algorithm was developed in which samples tested by JEDetect with positive results were subsequently tested by the DENDetect™ MAC-ELISA (DENDetect) kit, and results of both tests were used to make the final interpretation. The testing algorithm was evaluated with a reference panel of serum and CSF samples submitted for confirmatory testing. In serum, the false Japanese encephalitis (JE) positive rate was reduced, but sequential

2016 American Journal of Tropical Medicine & Hygiene

145. Sampling Design Influences the Observed Dominance of Culex tritaeniorhynchus: Considerations for Future Studies of Japanese Encephalitis Virus Transmission Full Text available with Trip Pro

Sampling Design Influences the Observed Dominance of Culex tritaeniorhynchus: Considerations for Future Studies of Japanese Encephalitis Virus Transmission Mosquito sampling during Japanese encephalitis virus (JEV)-associated studies, particularly in India, has usually been conducted via aspirators or light traps to catch mosquitoes around cattle, which are dead-end hosts for JEV. High numbers of Culex tritaeniorhynchus, relative to other species, have often been caught during these studies (...) . Less frequently, studies have involved sampling outdoor resting mosquitoes. We aimed to compare the relative abundance of mosquito species between these two previously used mosquito sampling methods. From September to December 2013 entomological surveys were undertaken in eight villages in a Japanese encephalitis (JE) endemic area of Bangladesh. Light traps were used to collect active mosquitoes in households, and resting boxes and a Bina Pani Das hop cage were used near oviposition sites

2016 PLoS neglected tropical diseases

146. Antiviral Activity of a Novel Compound CW-33 against Japanese Encephalitis Virus through Inhibiting Intracellular Calcium Overload Full Text available with Trip Pro

Antiviral Activity of a Novel Compound CW-33 against Japanese Encephalitis Virus through Inhibiting Intracellular Calcium Overload Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, has five genotypes (I, II, III, IV, and V). JEV genotype I circulates widely in some Asian countries. However, current JEV vaccines based on genotype III strains show low neutralizing capacities against genotype I variants. In addition, JE has no specific treatment, except a few supportive treatments

2016 International journal of molecular sciences

147. Role of Anopheles subpictus Grassi in Japanese encephalitis virus transmission in Tirunelveli, South India Full Text available with Trip Pro

Role of Anopheles subpictus Grassi in Japanese encephalitis virus transmission in Tirunelveli, South India 28139547 2017 07 13 2018 11 13 0971-5916 144 3 2016 Sep The Indian journal of medical research Indian J. Med. Res. Role of Anopheles subpictus Grassi in Japanese encephalitis virus transmission in Tirunelveli, South India. 477-481 10.4103/0971-5916.198684 Thenmozhi Velayutham V Centre for Research in Medical Entomology (Indian Council of Medical Research), Madurai 625 002, Tamil Nadu (...) Entomology (Indian Council of Medical Research), Madurai 625 002, Tamil Nadu, India. Rajamannar Veeramanoharan V Centre for Research in Medical Entomology (Indian Council of Medical Research), Madurai 625 002, Tamil Nadu, India. Tyagi Brij Kishore BK Centre for Research in Medical Entomology (Indian Council of Medical Research), Madurai 625 002, Tamil Nadu, India. eng Letter India Indian J Med Res 0374701 0971-5916 IM Animals Anopheles virology Encephalitis Virus, Japanese pathogenicity Encephalitis

2016 The Indian journal of medical research

148. Sero-Molecular Epidemiology of Japanese Encephalitis in Zhejiang, an Eastern Province of China Full Text available with Trip Pro

Sero-Molecular Epidemiology of Japanese Encephalitis in Zhejiang, an Eastern Province of China Sporadic Japanese encephalitis (JE) cases still have been reported in Zhejiang Province in recent years, and concerns about vaccine cross-protection and population-level immunity have been raised off and on within the public health sphere. Genotype I (GI) has replaced GIII as the dominant genotype in Asian countries during the past few decades, which caused considerable concerns about the potential (...) change of epidemiology characteristics and the vaccine effectiveness. The aim of this study was to investigate the prevalence of JE neutralizing antibody and its waning antibody trend after live attenuated JE vaccine immunization. Additionally, this study analyzed the molecular characteristics of the E gene of Zhejiang Japanese encephalitis virus (JEV) strains, and established genetic relationships with other JEV strains.A total of 570 serum specimens were sampled from community population aged from

2016 PLoS neglected tropical diseases

149. Transmembrane Domains of NS2B Contribute to both Viral RNA Replication and Particle Formation in Japanese Encephalitis Virus Full Text available with Trip Pro

Transmembrane Domains of NS2B Contribute to both Viral RNA Replication and Particle Formation in Japanese Encephalitis Virus Flavivirus nonstructural protein 2B (NS2B) is a transmembrane protein that functions as a cofactor for viral NS3 protease. The cytoplasmic region (amino acids 51 to 95) alone of NS2B is sufficient for NS3 protease activity, whereas the role of transmembrane domains (TMDs) remains obscure. Here, we demonstrate for the first time that flavivirus NS2B plays a critical role (...) in virion assembly. Using Japanese encephalitis virus (JEV) as a model, we performed a systematic mutagenesis at the flavivirus conserved residues within the TMDs of NS2B. As expected, some mutations severely attenuated (L38A and R101A) or completely destroyed (G12L) viral RNA synthesis. Interestingly, two mutations (G37L and P112A) reduced viral RNA synthesis and blocked virion assembly. None of the mutations affected NS2B-NS3 protease activity. Because mutations G37L and P112A affected virion assembly

2016 Journal of virology

150. miR-370 mimic inhibits replication of Japanese encephalitis virus in glioblastoma cells Full Text available with Trip Pro

miR-370 mimic inhibits replication of Japanese encephalitis virus in glioblastoma cells Japanese encephalitis (JE) is one of the most severe viral infections of the central nervous system. No effective treatment for JE currently exists, because its pathogenesis remains largely unknown. The present study was designed to screen the potential microRNAs (miRNAs) involved in JE. Glioblastoma cells were collected, after being infected with the Japanese encephalitis virus (JEV). Total miRNAs were

2016 Neuropsychiatric disease and treatment

151. CCL2, but not its receptor, is essential to restrict immune privileged central nervous system‐invasion of Japanese encephalitis virus via regulating accumulation of CD11b+ Ly‐6Chi monocytes Full Text available with Trip Pro

CCL2, but not its receptor, is essential to restrict immune privileged central nervous system‐invasion of Japanese encephalitis virus via regulating accumulation of CD11b+ Ly‐6Chi monocytes Japanese encephalitis virus (JEV) is a re-emerging zoonotic flavivirus that poses an increasing threat to global health and welfare due to rapid changes in climate and demography. Although the CCR2-CCL2 axis plays an important role in trafficking CD11b(+) Ly-6C(hi) monocytes to regulate (...) immunopathological diseases, little is known about their role in monocyte trafficking during viral encephalitis caused by JEV infection. Here, we explored the role of CCR2 and its ligand CCL2 in JE caused by JEV infection using CCR2- and CCL2-ablated murine models. Somewhat surprisingly, the ablation of CCR2 and CCL2 resulted in starkly contrasting susceptibility to JE. CCR2 ablation induced enhanced resistance to JE, whereas CCL2 ablation highly increased susceptibility to JE. This contrasting regulation of JE

2016 Immunology

152. Neutralizing activities of human immunoglobulin derived from donors in Japan against mosquito-borne flaviviruses, Japanese encephalitis virus, West Nile virus, and dengue virus Full Text available with Trip Pro

Neutralizing activities of human immunoglobulin derived from donors in Japan against mosquito-borne flaviviruses, Japanese encephalitis virus, West Nile virus, and dengue virus Japanese encephalitis virus (JEV), West Nile virus (WNV), and dengue virus (DenV) are causal agents of Japanese encephalitis, West Nile fever, and dengue fever, respectively. JEV is considered to be indigenized and widespread in Japan, whereas WNV and DenV are not indigenized in Japan. Globulin products seem to reflect (...) the status of the donor population according to antivirus neutralization activity. However, the anti-JEV, -WNV, and -DenV neutralization activities of globulin products derived from donors in Japan have not been clarified. Furthermore, potential candidates for the development of an effective immunotherapeutic drug for encephalitis caused by JEV, WNV, or DenV have also not been identified. Therefore, the aim of this study was to determine the overall status of the donor population in Japan based

2016 Biologics : targets & therapy

153. Structure-based discovery of two antiviral inhibitors targeting the NS3 helicase of Japanese encephalitis virus Full Text available with Trip Pro

Structure-based discovery of two antiviral inhibitors targeting the NS3 helicase of Japanese encephalitis virus Japanese encephalitis virus (JEV) is a flavivirus that threatens more than half of the world's population. Vaccination can prevent the disease, but no specific antiviral drug is yet available for clinical therapy, and the death rate caused by JEV can reach as high as 60%. The C-terminus of non-structural protein 3 (NS3) of flavivirus encodes helicase and has been identified

2016 Scientific reports

154. TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A Full Text available with Trip Pro

TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A The members of tripartite-motif containing (TRIM) protein participate in various cellular processes and play an important role in host antiviral function. TRIM proteins exert their antiviral activity either directly by degrading viral proteins through their E3 ligase activity, or indirectly by promoting host innate immunity. This study demonstrated for the first time that TRIM52 is a novel antiviral TRIM protein (...) against Japanese encephalitis virus (JEV) infection. Overexpression of TRIM52 restricted JEV replication in BHK-21 and 293T cells. In addition, JEV nonstructural protein 2A (NS2A) is a protein that interacts with TRIM52. Their interaction degraded NS2A in a proteasome-dependent manner via the E3 ligase activity of TRIM52. Thus, TRIM52 is a novel antiviral TRIM protein, and it exerted antiviral activity against JEV infection by targeting and degrading viral NS2A.

2016 Scientific reports

155. Reemergence of Japanese Encephalitis in South Korea, 2010–2015 Full Text available with Trip Pro

Reemergence of Japanese Encephalitis in South Korea, 2010–2015 27648677 2018 02 01 2018 11 13 1080-6059 22 10 2016 10 Emerging infectious diseases Emerging Infect. Dis. Reemergence of Japanese Encephalitis in South Korea, 2010-2015. 1841-3 10.3201/eid2210.160288 Sunwoo Jun-Sang JS Jung Keun-Hwa KH Lee Soon-Tae ST Lee Sang Kun SK Chu Kon K eng Historical Article Letter Research Support, Non-U.S. Gov't United States Emerg Infect Dis 9508155 1080-6040 IM Communicable Diseases, Emerging (...) epidemiology history virology Encephalitis Virus, Japanese Encephalitis, Japanese epidemiology history virology History, 21st Century Incidence Population Surveillance Republic of Korea epidemiology Culex tritaeniorhynchus Japanese encephalitis South Korea arbovirus mosquitoes reemerging infectious diseases vaccination vector-borne infections viruses 2016 9 21 6 0 2016 9 21 6 0 2018 2 2 6 0 ppublish 27648677 PMC5038436 10.3201/eid2210.160288 Emerg Infect Dis. 2000 Jan-Feb;6(1):17-24 10653564 J Neurol Sci

2016 Emerging Infectious Diseases

156. Human T cell responses to Japanese encephalitis virus in health and disease Full Text available with Trip Pro

Human T cell responses to Japanese encephalitis virus in health and disease Japanese encephalitis (JE) virus (JEV) is an important cause of encephalitis in children of South and Southeast Asia. However, the majority of individuals exposed to JEV only develop mild symptoms associated with long-lasting adaptive immunity. The related flavivirus dengue virus (DENV) cocirculates in many JEV-endemic areas, and clinical data suggest cross-protection between DENV and JEV. To address the role of T cell

2016 The Journal of experimental medicine

157. Bivalent vaccine platform based on Japanese encephalitis virus (JEV) elicits neutralizing antibodies against JEV and hepatitis C virus Full Text available with Trip Pro

Bivalent vaccine platform based on Japanese encephalitis virus (JEV) elicits neutralizing antibodies against JEV and hepatitis C virus Directly acting antivirals recently have become available for the treatment of hepatitis C virus (HCV) infection, but there is no prophylactic vaccine for HCV. In the present study, we took advantage of the properties of Japanese encephalitis virus (JEV) to develop antigens for use in a HCV vaccine. Notably, the surface-exposed JEV envelope protein is tolerant

2016 Scientific reports

158. Differential Infectivities among Different Japanese Encephalitis Virus Genotypes in Culex quinquefasciatus Mosquitoes Full Text available with Trip Pro

Differential Infectivities among Different Japanese Encephalitis Virus Genotypes in Culex quinquefasciatus Mosquitoes During the last 20 years, the epidemiology of Japanese encephalitis virus (JEV) has changed significantly in its endemic regions due to the gradual displacement of the previously dominant genotype III (GIII) with clade b of GI (GI-b). Whilst there is only limited genetic difference distinguishing the two GI clades (GI-a and GI-b), GI-b has shown a significantly wider and more

2016 PLoS neglected tropical diseases

159. Intensive Circulation of Japanese Encephalitis Virus in Peri-urban Sentinel Pigs near Phnom Penh, Cambodia Full Text available with Trip Pro

Intensive Circulation of Japanese Encephalitis Virus in Peri-urban Sentinel Pigs near Phnom Penh, Cambodia Despite the increased use of vaccination in several Asian countries, Japanese Encephalitis (JE) remains the most important cause of viral encephalitis in Asia in humans with an estimated 68,000 cases annually. Considered a rural disease occurring mainly in paddy-field dominated landscapes where pigs are amplifying hosts, JE may nevertheless circulate in a wider range of environment given

2016 PLoS neglected tropical diseases

160. Cysticercosis and Japanese Encephalitis Full Text available with Trip Pro

Cysticercosis and Japanese Encephalitis 28208920 2019 01 09 2249-782X 10 12 2016 Dec Journal of clinical and diagnostic research : JCDR J Clin Diagn Res Cysticercosis and Japanese Encephalitis. OL01-OL02 10.7860/JCDR/2016/23098.9030 Joob Beuy B Sanitation 1 Medical Academic Center , Bangkok, Thailand . Wiwanitkit Viroj V Hainan Medical University , Haikou, China . eng Journal Article 2016 12 01 India J Clin Diagn Res 101488993 0973-709X 2016 07 26 2016 08 22 2017 2 18 6 0 2017 2 18 6 0 2017 2

2016 Journal of clinical and diagnostic research : JCDR

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