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Irritant Contact Dermatitis

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1. Interventions for preventing occupational irritant hand dermatitis. Full Text available with Trip Pro

and strategies (physical and behavioural) for preventing OIHD in healthy people (who have no hand dermatitis) who work in occupations where the skin is at risk of damage due to contact with water, detergents, chemicals or other irritants, or from wearing gloves.We updated our searches of the following databases to January 2018: the Cochrane Skin Specialised Register, CENTRAL, MEDLlNE, and Embase. We also searched five trials registers and checked the bibliographies of included studies for further references (...) Interventions for preventing occupational irritant hand dermatitis. Occupational irritant hand dermatitis (OIHD) causes significant functional impairment, disruption of work, and discomfort in the working population. Different preventive measures such as protective gloves, barrier creams and moisturisers can be used, but it is not clear how effective these are. This is an update of a Cochrane review which was previously published in 2010.To assess the effects of primary preventive interventions

2018 Cochrane

2. IL6Rα function in myeloid cells modulates the inflammatory response during Irritant Contact Dermatitis. (Abstract)

IL6Rα function in myeloid cells modulates the inflammatory response during Irritant Contact Dermatitis. Irritant contact dermatitis (ICD) is characterized by epidermal hyperplasia, infiltration of leucocytes into lesional skin and inflammatory cytokine release. The cellular infiltrate during ICD comprises primarily cells of the myeloid lineage. Our group has previously shown that the cytokine IL-6 confers a protective effect to lesional skin during ICD. How IL-6Rα function in myeloid cells (...) is involved in the inflammatory response during ICD is, however, unknown. In the present study, utilizing a chemical model of ICD, it is shown that mice with a myeloid-specific knockout of the IL-6Rα (IL-6RαΔmyeloid ) display an exaggerated inflammatory response to benzalkonium chloride (BKC) and Jet propellant-8 (JP8) fuel, two well-characterized irritants relative to littermate control. Results from immunohistochemical and flow cytometric analyses revealed that IL-6RαΔmyeloid mouse skin displayed

2019 Experimental Dermatology

3. Phospholipase Cγ1 is required for normal irritant contact dermatitis responses and sebaceous gland homeostasis. (Abstract)

Phospholipase Cγ1 is required for normal irritant contact dermatitis responses and sebaceous gland homeostasis. Differentiation and proliferation of keratinocyte are controlled by various signalling pathways. The epidermal growth factor receptor (EGFR) is known to be an important regulator of multiple epidermal functions. Inhibition of EGFR signalling disturbs keratinocyte proliferation, differentiation and migration. Previous studies have revealed that one of the EGFR downstream signalling (...) the role of PLCγ1 in irritant contact dermatitis (ICD), in which epidermal cells play a pivotal role. Upon irritant stimulation, PLCγ1 cKO mice showed exaggerated ICD responses. Further study revealed that epidermal loss of PLCγ1 induced sebaceous gland hyperplasia, indicating that PLCγ1 regulates homeostasis of one of the epidermal appendages. Taken together, our results indicate that, although PLCγ1 is dispensable in interfollicular keratinocyte for normal differentiation, proliferation and migration

2019 Experimental Dermatology

4. Bullous irritant contact dermatitis due to alcoholic extract from Juglans regia leaves. (Abstract)

Bullous irritant contact dermatitis due to alcoholic extract from Juglans regia leaves. 30740710 2019 03 13 1600-0536 2019 Feb 11 Contact dermatitis Contact Derm. Bullous irritant contact dermatitis caused by an alcoholic extract from Juglans regia leaves. 10.1111/cod.13240 Corazza Monica M https://orcid.org/0000-0003-2105-6217 Section of Dermatology, Department of Medical Sciences, University of Ferrara, Ferrara, Italy. Scuderi Valeria V https://orcid.org/0000-0001-7280-3118 Section (...) Contact Dermatitis 7604950 0105-1873 Juglans regia leaves case report irritant contact dermatitis 2019 02 06 2019 02 08 2019 2 12 6 0 2019 2 12 6 0 2019 2 12 6 0 aheadofprint 30740710 10.1111/cod.13240

2019 Contact Dermatitis

5. Does Adherence to World Health Organization Hand Hygiene Protocols in the Operating Room Have the Potential to Produce Irritant Contact Dermatitis in Anesthesia Providers? (Abstract)

Does Adherence to World Health Organization Hand Hygiene Protocols in the Operating Room Have the Potential to Produce Irritant Contact Dermatitis in Anesthesia Providers? Anesthesia providers have the burden of constant hand hygiene during task dense periods. The requirement for hand hygiene often demands frequent application of alcohol-based hand rub. To assess whether frequent alcohol-based hand rub use leads to skin changes or irritant contact dermatitis, volunteers cleaned their hands (...) with alcohol-based hand rub every 15 minutes for 8 hours for 5 sequential days. They were examined by a dermatologist before and after and asked about subjective skin changes. Results suggest an increase in irritant contact dermatitis scores and subjective complaints.

2019 Anesthesia and Analgesia

6. Irritant contact dermatitis caused by a shower cream used as a leave-on product. (Abstract)

Irritant contact dermatitis caused by a shower cream used as a leave-on product. 31265145 2019 07 18 1600-0536 2019 Jul 02 Contact dermatitis Contact Derm. Irritant contact dermatitis caused by a shower cream used as a leave-on product. 10.1111/cod.13347 Opstrup Morten S MS https://orcid.org/0000-0002-3510-477X Department of Dermatology, Zealand University Hospital, Roskilde, Denmark. Yazdanyar Shiva S Department of Dermatology, Zealand University Hospital, Roskilde, Denmark. eng Journal (...) Article 2019 07 02 England Contact Dermatitis 7604950 0105-1873 case report irritant contact dermatitis shower cream 2019 06 26 2019 07 01 2019 7 3 6 0 2019 7 3 6 0 2019 7 3 6 0 aheadofprint 31265145 10.1111/cod.13347

2019 Contact Dermatitis

7. Skin Biophysical Parameters and Patch Test Results in People Predisposing to Xiaotong Tiegao Induced Irritant Contact Dermatitis. Full Text available with Trip Pro

Skin Biophysical Parameters and Patch Test Results in People Predisposing to Xiaotong Tiegao Induced Irritant Contact Dermatitis. Xiaotong Tiegao (XTT) is an ancient topical Tibetan medicine plaster which is widely used in China. Irritant contact dermatitis (ICD) caused by XTT is very common. It is still unclear why some people are more prone to develop ICD. The aim of this study is to study the baseline skin biophysical parameters and patch test results in individuals predisposing to XTT (...) induced ICD.During a four-month period, 149 healthy volunteers with ICD and 50 volunteers without ICD after applying XTT were recruited. The skin biophysical parameters were measured, and contact allergy to 20 common allergens was patch tested, at two weeks after the ICD was recovered.There were no significant differences in age and sex between ICD and control groups. It was found that skin median melanin value (176.50 vs 189.50, P < 0.05, Mann-Whitney U-test) and erythema value (319.90 ± 70.49 vs

2019 Evidence-based Complementary and Alternative Medicine (eCAM)

8. Comparative Study between Talcum and Zinc Oxide Cream for the Prevention of Irritant Contact Diaper Dermatitis in Infants. (Abstract)

Comparative Study between Talcum and Zinc Oxide Cream for the Prevention of Irritant Contact Diaper Dermatitis in Infants. Baby powder which consists of talcum powder (magnesium silicate) as an active ingredient has been popularly used for prevention of irritant contact diaper dermatitis for a long time because it has water absorbent and friction-decreased properties. There are some case reports of its side effects of pulmonary complication from massive inhalation and the risk of ovarian tumors (...) to evaluate an occurrence of diaper dermatitis and to collect the median time-to-event data (the duration of disease occurrence). The clinical severity was assessed by using diaper dermatitis severity scoring scale and the side effects were recorded.The average age of the infants was 8.8 months old. The incidence of irritant contact diaper dermatitis from the talcum group was 4 per 1,000 persons-day (95% confidence interval, 95% CI: 2-7) while the incidence of diaper dermatitis from the zinc oxide group

2018 Journal of the Medical Association of Thailand = Chotmaihet thangphaet Controlled trial quality: uncertain

9. Irritant Contact Dermatitis. (Abstract)

Irritant Contact Dermatitis. Contact dermatitis accounts for 95% of occupational skin disorders. Irritant contact dermatitis (ICD) is often caused by cumulative exposure to weak irritants, accounting for 80% of all cases of contact dermatitis. ICD can co-exist with atopic dermatitis (AD) and allergic contact dermatitis (ACD). Patients with AD and ACD may have a lower inflammatory threshold for developing ICD. Therefore, it needs to be distinguished from lesions of AD and ACD. ICD Patients (...) report stinging and burning in excess of pruritus. Pruritus is classically reported by patients with AD and ACD. ICD lesions are typically well-demarcated unlike AD and ACD. ICD is diagnosed by exclusion. Patients undergo testing to rule out type I and type IV hypersensitivity. Negative results suggest a diagnosis of ICD. Management consists of irritant identification and avoidance with regular emollient use. Although ICD is more common in certain occupations, genetics and environment play

2018 Clinical Reviews in Allergy & Immunology

10. Diaper Dermatitis, Irritant and Candidal - Guidelines for Prescribing Topical Antifungals and Hydrocortisone

Diaper Dermatitis, Irritant and Candidal - Guidelines for Prescribing Topical Antifungals and Hydrocortisone Diaper Dermatitis, Irritant and Candidal - Guidelines for Prescribing Topical Antifungals and Hydrocortisone - medSask Home - College of Pharmacy and Nutrition - University of Saskatchewan Toggle Menu Search the U of S Search Diaper Dermatitis, Irritant and Candidal - Guidelines for Prescribing Topical Antifungals and Hydrocortisone A rash occurring under the covered area of a diaper (...) Caused by factors leading to compromised skin barrier: Over-hydration Friction Prolonged contact with urine and feces, leading to increased skin pH, disruption of the stratum corneum, and maceration of the skin Use of irritants Rash may become secondarily infected with microorganisms such as Candida albicans . Risk or aggravating factors: Diarrhea or frequent bowel movements Infrequent diaper changes Formula feeding Recent antibiotic use Prevalent in ~30% of the infant population Peak incidence at 9

2017 medSask

11. Contact dermatitis

Contact dermatitis Contact dermatitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Contact dermatitis Last reviewed: February 2019 Last updated: June 2018 Summary Irritant contact dermatitis is caused by direct toxicity without prior sensitisation, and allergic contact dermatitis is a delayed hypersensitivity reaction. Results in localised burning, stinging, itching, blistering, redness, and swelling at the area (...) of contact with the allergen or irritant. Patch testing may aid identification of the causative agent. Skin biopsy may also be helpful, but may not be able to distinguish between other causes of dermatitis. Treatment involves removal of the causative agent, future avoidance of the causative agent, topical corticosteroids, and/or a short course of oral corticosteroids. Rarely, contact dermatitis can become generalised, leading to areas of dermatitis in locations distant from the site of contact

2018 BMJ Best Practice

12. Irritant Contact Dermatitis

Irritant Contact Dermatitis Irritant Contact Dermatitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Irritant Contact Dermatitis (...) Irritant Contact Dermatitis Aka: Irritant Contact Dermatitis , Contact Dermatitis From Irritants From Related Chapters II. Pathophysiology Occurs in all members of population Elderly and very young more susceptible Great variations in individual susceptibility exists III. Risk Factors s are more susceptible Filaggrin Mutation Results in keratinization disorder Nickel hypersensitivity IV. Causes Very potent irritants Wet cement Strong acids (e.g. Hydrofluoric acid) Ethylene oxide Heavy metals Common

2018 FP Notebook

13. British Association of Dermatologists? guidelines for the management of contact dermatitis

by erythema and vesiculation and, in the chronic phase, by dryness, licheni?ca- tion and ?ssuring. Contact dermatitis describes these patterns of reaction in response to external agents (exogenous); these agents can act either as irritants, where a cell-mediated immune response is not involved, or as allergens, where cell- mediated immunity is involved. Contact dermatitis may be classi?ed into the following reac- tion types. (i) Subjective irritancy: idiosyncratic stinging and smarting reactions occur (...) within minutes of contact, usually on the face, in the absence of visible changes. Cosmetic or sun- screen constituents are common precipitants. (ii) Acute irritant contact dermatitis: often the result of a single overwhelming exposure or a few brief exposures to strong irritants or caustic agents. (iii) Chronic (cumulative) irritant contact dermatitis: occurs following repetitive exposure to weaker irritants that may be either ‘wet’, such as detergents, organic solvents, soaps, weak acids

2017 British Association of Dermatologists

14. Botulinum neurotoxin A is an effective treatment for irritant dermatitis caused by ostomy leaks in patients with retractile stomas. (Abstract)

Botulinum neurotoxin A is an effective treatment for irritant dermatitis caused by ostomy leaks in patients with retractile stomas. Inflammatory or infectious conditions affecting the skin around a stoma occur in up to 73% of ostomates and can be associated with significant morbidity. Peristomal skin complications include dermatitis resulting from mechanical trauma, ICD, allergic contact dermatitis, infections and pyoderma gangrenosum. Peristomal dermatitis is most often caused by leakage (...) of stool or urine that is irritant to the skin. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

2019 British Journal of Dermatology

15. Variable impact of dupilumab on patch testing results and allergic contact dermatitis in adults with atopic dermatitis. (Abstract)

Variable impact of dupilumab on patch testing results and allergic contact dermatitis in adults with atopic dermatitis. Previous case reports and series suggested that dupilumab may be an effective treatment for allergic contact dermatitis (ACD). Little is known about the impact of dupilumab on patch test results and comorbid ACD in patients with atopic dermatitis (AD).Determine the impact of dupilumab on patch testing results and improvement of ACD in patients with AD.A retrospective study (...) of patients with AD treated with dupilumab who underwent patch testing (n = 7) or had concomitant ACD (n = 6).In all, 7 patients with AD were patch tested while taking dupilumab; in all of these patients, at least 1 positive patch test reaction was observed, with a total of 25 different allergens having a reaction graded as 1+ or stronger and few irritant reactions. In 1 patient, multiple previously positive relevant patch test results were not duplicated upon repeat patch testing. In the 6 patients

2019 Journal of American Academy of Dermatology

16. Allergic Contact Dermatitis To Personal Care Products And Topical Medications In Adults With Atopic Dermatitis. (Abstract)

Allergic Contact Dermatitis To Personal Care Products And Topical Medications In Adults With Atopic Dermatitis. Atopic dermatitis (AD) is associated with skin-barrier disruption, immune dysregulation, and application of emollients and topical medications that might predispose a person toward developing allergic contact dermatitis.To determine the predictors of allergic contact dermatitis and relevant allergens in AD.A retrospective chart review was performed for 502 adults (age ≥18 years) who (...) were patch tested to an expanded allergen series during 2014-2017.Overall, 108 (21.5%) had current AD and 109 (21.7%) had past AD. Patients with and without current AD had similar proportions of any positive (+, ++, or +++ 80 [74.1%] vs 254 [64.5%], respectively, chi-squared P = .06); strong-positive (++ and +++ 34 [31.5%] vs 102 [25.9%], respectively, P = .25); and irritant (56 [51.9%] vs 188 [47.7%], respectively, P = .45) patch-test reactions. AD patients had significantly higher rates

2018 Journal of American Academy of Dermatology

17. Both children and adult patients with difficult-to-treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized. Full Text available with Trip Pro

Both children and adult patients with difficult-to-treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized. Concomitant allergic contact dermatitis (ACD) has been described as a possible cause of atopic dermatitis (AD) becoming difficult-to-treat. However, contact sensitization in this patient group has barely been studied.To study the occurrence of ACD in a population of difficult-to-treat AD children and adults.Clinical (...) and adults. The most frequent and relevant reactions were seen against wool alcohols, surfactants cocamidopropyl betaine and dimethylaminopropylamine, bichromate and fragrance mix I. Dynamic pattern analysis showed these reactions to be mostly allergic and not irritative of nature.Difficult-to-treat AD patients frequently suffer from concomitant (multiple) contact allergies, and this may be a reason why the AD turns into a difficult-to-treat disease. Awareness of this phenomenon is necessary

2018 Journal of the European Academy of Dermatology and Venereology

18. Short contact with nickel causes allergic contact dermatitis: an experimental study. Full Text available with Trip Pro

on the earlobe. On the SLS-pretreated arms of nickel-allergic participants, blood flow increased significantly more on the nickel-exposed skin than on the aluminium-exposed skin on days 2 and 4. No change in clinical reactivity or blood flow was found on normal forearm skin in nickel-allergic participants or on any skin in controls.This experimental study showed that relatively short repeated skin contact (3 × 10 min) with metallic nickel elicits allergic nickel dermatitis in irritated skin and at sites (...) Short contact with nickel causes allergic contact dermatitis: an experimental study. Knowledge about the required duration of exposure for elicitation of allergic nickel dermatitis in nickel-allergic individuals is limited. However, it often has been proposed that short skin contact is safe.To examine whether repeated skin contact with nickel over short time periods (3 × 10 min) can elicit allergic nickel dermatitis.Sixteen nickel-allergic adults and 10 controls were exposed to, respectively

2018 British Journal of Dermatology

19. Dermatitis - contact

Dermatitis - contact Dermatitis - contact - NICE CKS Share Dermatitis - contact: Summary Contact dermatitis is an inflammatory skin condition which occurs as a result of exposure to an external irritant or allergen. Allergic contact dermatitis is a type IV (delayed) hypersensitivity reaction that occurs after sensitization and subsequent re-exposure to a specific allergen or allergens. Common allergens include personal care products (such as cosmetics, skin care products, nail varnish (...) , fragrances, and hair dye), metals (such as nickel), topical medications (including antibiotics and corticosteroids) and certain plants (such as sunflower and primula). Irritant contact dermatitis is a non-immunological inflammatory reaction caused by the direct physical or toxic effects of an irritating substance on the skin — prior sensitisation is not required. Common irritants include repeated exposure to water (‘wet work’), detergents, cleaning agents, acids and alkalis and certain plants

2018 NICE Clinical Knowledge Summaries

20. The three moments of skin cream application: an evidence-based proposal for use of skin creams in the prevention of irritant contact dermatitis in the workplace. Full Text available with Trip Pro

The three moments of skin cream application: an evidence-based proposal for use of skin creams in the prevention of irritant contact dermatitis in the workplace. Contact dermatitis is one of the most common occupational diseases, with serious impact on quality of life, lost days at work and a condition that may be chronically relapsing. Regular prophylactic skin cream application is widely acknowledged to be an effective prevention strategy against occupational contact dermatitis; however (...) , compliance rates remain low. To present a simple programme for skin cream application in the workplace with focus on implementation to drive down the rate of occupational irritant contact dermatitis, an expert panel of eight international dermatologists combined personal experience with extensive literature review. The recommendations are based on clinical experience as supported by evidence-based data from interventional studies. The authors identified three moments for skin cream application

2016 Journal of the European Academy of Dermatology and Venereology

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