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Iron Ingestion

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1. Acute carbohydrate ingestion does not influence the post-exercise iron-regulatory response in elite keto-adapted race walkers. (PubMed)

Acute carbohydrate ingestion does not influence the post-exercise iron-regulatory response in elite keto-adapted race walkers. Adhering to a low carbohydrate (CHO) high fat (LCHF) diet can alter markers of iron metabolism in endurance athletes. This investigation examined the re-introduction of CHO prior to, and during exercise on the iron-regulatory response to exercise in a homogenous (in regard to serum ferritin concentration) group of athletes adapted to a LCHF diet.Parallel groups (...) diet was not attenuated by an acute increase in exogenous CHO availability. Despite diet-induced differences in IL-6 response to exercise, post-exercise hepcidin levels were similar between diets and trials, indicating CHO availability has minimal influence on post-exercise iron metabolism.Copyright © 2018. Published by Elsevier Ltd.

2019 Journal of Science and Medicine in Sport

2. Chronic penetrating renal trauma due to iron wire ingestion: An unusual case report. (PubMed)

Chronic penetrating renal trauma due to iron wire ingestion: An unusual case report. Foreign body ingestion is a common presentation in the emergency room. However, the complication such as penetrating renal trauma due to sharp objects ingestion is relatively rare. We herein describe an unusual case of penetrating renal trauma in the absence of any other urinary symptoms. A 53-year-old man who had a history of iron wire ingestion went to our hospital, on examination, he only had slight (...) abdominal tenderness due to swallowing a ball pen and 1 cap nut 1 day before, radiological imaging showed penetrating renal trauma, the blood test showed his renal function is normal. Surgical strategies were recommended to remove the pen and the iron wire simultaneously, nonetheless the patient eventually agreed to only receive surgical removal of the swallowed ball pen and cap nut, meanwhile leave the kidney untreated. During 30 months follow-up by phone and regular outpatient examination, he

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2017 Medicine

3. Trends of Magnet Ingestion in Children, an Ironic Attraction. (PubMed)

Trends of Magnet Ingestion in Children, an Ironic Attraction. Ingestion of rare earth magnets is a serious ongoing hazard for pediatric patients. Our study aims to investigate whether 2012 Consumer Product Safety Commission (CPSC) policy action, in coordination with efforts from consumer and physician advocacy groups, decreased the incidence of magnet ingestions in children in the United States since 2012.Data from the National Electronic Injury Surveillance System (NEISS) was used to evaluate (...) trends in emergency department (ED) encounters with pediatric patients (<18 years) who presented with suspected magnet ingestions (SMI) from 2010 to 2015. National estimates of SMI were made using the NEISS-supplied weights and variance variables.An estimated 14,586 children (59% male, 50% age <5 years) presented to the ED for SMI from 2010 to 2015. A significant upward trend in magnet-related ED visits preceded the CPSC action, with the peak ingestions of 3167 (95% confidence interval, 1612-4723

2017 Journal of Pediatric Gastroenterology and Nutrition

4. Toxic ingestions in children

Toxic ingestions in children Toxic ingestions in children - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Toxic ingestions in children Last reviewed: February 2019 Last updated: March 2018 Summary Children may ingest a toxic substance accidentally while exploring their environment, or deliberately in response to stress or underlying mental problems, or in an attempt to get 'high'. A regional poison-control centre (...) or medical toxicologist should be contacted with any suspected overdose in a child. The range of possible ingestions is broad; diagnosis is based on a combination of thorough clinical assessment and comprehensive laboratory investigation to identify all ingested substances. Some asymptomatic patients require observation for 6 hours, or 24 hours for high-risk ingestions. The mainstay of management of symptomatic patients is management of airway, breathing, and circulation, with appropriate supportive care

2018 BMJ Best Practice

5. Iron Ingestion

Iron Ingestion Iron Ingestion Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Iron Ingestion Iron Ingestion Aka: Iron Ingestion , Iron (...) Poisoning , Acute Iron Toxicity , Acute Iron Poisoning From Related Chapters II. Precautions toxicity after acute ingestion is difficult to gauge supplements in overdosage may be lethal in children (FDA black box warning) III. Pathophysiology: Iron Toxicity Stage 1: Gastrointestinal Stage 2: Stability (duration of hours) may be present Stage 3: Hypovolemia and Stage 4: Hepatotoxicity (onset within 48 hours) IV. Labs See levels predict severity of ingestion V. Management Initial emergent supportive care

2018 FP Notebook

6. Intravenous (IV) iron for severe iron deficiency

by hemoglobin (Hb), but also for energy metabolism, including the mitochondr- ial electron transport chain. Deficiency without anemia may cause non-specific symptoms (e.g. fatigue, impaired concentration, weakness) and signs (e.g. hair loss, nail and mucosal changes), but there is surprisingly little evidence about whether treatment is beneficial. 3,4,5 Identifying the cause is always important. Treatment with oral iron and/or diet is usually simple, although only a tiny fraction of ingested elemental iron (...) Intravenous (IV) iron for severe iron deficiency November - December 2015 97 © Tel.: 604 822•0700 Fax: 604 822•0701 E-mail: info@ti.ubc.ca www.ti.ubc.ca Mailing Address: Therapeutics Initiative The University of British Columbia Department of Anesthesiology, Pharmacology & Therapeutics 2176 Health Sciences Mall Vancouver, BC Canada V6T 1Z3 Intravenous (IV) iron for severe iron deficiency his Hb was 120 g/L and MCV 79 fL. Additional iron sucrose compensated for ongoing lower GI bleeding, and his

2016 Therapeutics Letter

7. Iron Ingestion

Iron Ingestion Iron Ingestion Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Iron Ingestion Iron Ingestion Aka: Iron Ingestion , Iron (...) Poisoning , Acute Iron Toxicity , Acute Iron Poisoning From Related Chapters II. Precautions toxicity after acute ingestion is difficult to gauge supplements in overdosage may be lethal in children (FDA black box warning) III. Pathophysiology: Iron Toxicity Stage 1: Gastrointestinal Stage 2: Stability (duration of hours) may be present Stage 3: Hypovolemia and Stage 4: Hepatotoxicity (onset within 48 hours) IV. Labs See levels predict severity of ingestion V. Management Initial emergent supportive care

2017 FP Notebook

8. CRACKCast E157 – Iron and Heavy Metals

Asymptomatic patients seeking ED care for an abnormal metal test need follow-up evaluation arranged with a medical toxicologist. Metal testing in the ED should only be ordered in consultation with a medical toxicologist or regional poison center. Acute ingestion of the salts of most metals causes rapid severe gastrointestinal pain and emesis. Any abnormal neurologic signs in a patient with any metal exposure warrants admission for further evaluation and chelation therapy. Acute iron poisoning can result (...) in gastrointestinal symptoms, metabolic acidosis, and hepatotoxicity. Serum iron levels at 3 and 6 hours after ingestion determine toxicity and need for therapy. The chelation agent of choice for severe iron poisoning is deferoxamine and is indicated for peak serum iron concentrations greater than 500 μg/dL (90 mmol/L) and patients with severe signs and symptoms regardless of the iron level. The most important intervention for lead poisoning is removal from the source of exposure. The gastrointestinal

2018 CandiEM

9. Iron bioavailability from fresh cheese fortified with iron-enriched yeast. (PubMed)

ferrous sulfate (2.5 mg 57Fe) when ingested with fresh cheese alone or with fresh cheese consumed with bread and butter. Iron absorption was determined based on erythrocyte incorporation of isotopic labels 14 days after consumption of the last test meal.Geometric mean fractional iron absorption from fresh cheese fortified with iron-enriched yeast consumed alone was significantly lower than from the cheese fortified with FeSO4 (20.5 vs. 28.7 %; p = 0.0007). When the fresh cheese was consumed with bread (...) Iron bioavailability from fresh cheese fortified with iron-enriched yeast. An iron-enriched yeast able to lyse at body temperature was developed for iron fortification of chilled dairy products. The aim was to evaluate iron (Fe) absorption from iron-enriched yeast or ferrous sulfate added to fresh cheese.Two stable isotope studies with a crossover design were conducted in 32 young women. Fe absorption from fresh cheese fortified with iron-enriched yeast (2.5 mg 58Fe) was compared to that from

2018 European journal of nutrition

10. Commentary: Iron deficiency of pregnancy - a new approach involving intravenous iron (PubMed)

abnormalities which persist after iron repletion. Oral iron is the frontline standard but is associated with an unacceptably high incidence of gastrointestinal adverse events leading to poor adherence. Prospective evidence reports an incidence of neonatal iron deficiency up to 45% even with oral iron supplementation. New evidence reports oral iron ingestion increases serum hepcidin leading to decreased absorption suggesting further decreasing efficacy. Published evidence reports that intravenous iron (...) Commentary: Iron deficiency of pregnancy - a new approach involving intravenous iron Iron deficiency anemia of pregnancy is common, especially in South Asia, and is associated with adverse maternal and fetal outcomes including increased incidences of maternal mortality, preterm labor and low birth weight. Screening for anemia alone is not sufficient to diagnose iron deficiency. Iron deficiency in neonates is associated with a statistically significant increment in cognitive and behavioral

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2018 Reproductive health

11. Iron Aid IPS on Performance, Fatigue and Iron Levels During 12 Weeks of Supplementation and Aerobic Training

Iron Aid IPS on Performance, Fatigue and Iron Levels During 12 Weeks of Supplementation and Aerobic Training Iron Aid IPS on Performance, Fatigue and Iron Levels During 12 Weeks of Supplementation and Aerobic Training - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Iron Aid IPS on Performance, Fatigue and Iron Levels During 12 Weeks of Supplementation and Aerobic Training The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03523455 Recruitment Status : Terminated (Unable to recruit qualified participants

2018 Clinical Trials

12. Iron Sucrose Versus Ferrous Bis-glycinate for Treatment of Iron Deficiency Anemia

by (Responsible Party): Ahmed Mohamed Abbas, Assiut University Study Details Study Description Go to Brief Summary: Iron deficiency may result from inadequate dietary intake, achlorhydria or excessive ingestion of proton pump inhibitors, parasitic infestations, chronic infections and repeated pregnancies. Iron supplementation of antenatal patients is a basic tenet of antenatal care programmes in numerous developing and underdeveloped nations. Postpartum anemia is defined as hemoglobin of less than 11.5 gm (...) Iron Sucrose Versus Ferrous Bis-glycinate for Treatment of Iron Deficiency Anemia Iron Sucrose Versus Ferrous Bis-glycinate for Treatment of Iron Deficiency Anemia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2017 Clinical Trials

13. A Young Adult with Unintended Acute Intravenous Iron Intoxication Treated with Oral Chelation: The Use of Liver Ferriscan for Diagnosing and Monitoring Tissue Iron Load (PubMed)

A Young Adult with Unintended Acute Intravenous Iron Intoxication Treated with Oral Chelation: The Use of Liver Ferriscan for Diagnosing and Monitoring Tissue Iron Load Acute iron intoxication (FeI) in humans has not been adequately studied. The manifestation of FeI, defined as a serum iron concentration >300 μg/dL (55 μmol/L) within 12 hours of ingestion, include various symptoms appearing in progressive stages. Systemic toxicity is expected with an intake of 60 mg/kg. A 27-year-old female (...) nurse presented with unintended acute intravenous iron intoxication (FeI) a week after self-injecting herself with 20 ampoules of IV iron (4,000 mg elemental iron, 60 mg/kg). She had stable vital signs and mild hepatic tenderness. Hepatic MRI (Ferriscan®) showed a moderate/severe liver iron content (LIC: 9 mg/g dry tissue). Her hemogram, electrolytes, hepatic and renal functions were normal. Based on the high dose of iron received and her elevated LIC, chelation therapy was advised. She accepted

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2017 Mediterranean journal of hematology and infectious diseases

14. Titanium Dioxide Nanoparticle Ingestion Alters Nutrient Absorption in an In Vitro Model of the Small Intestine (PubMed)

Titanium Dioxide Nanoparticle Ingestion Alters Nutrient Absorption in an In Vitro Model of the Small Intestine Ingestion of titanium dioxide (TiO2) nanoparticles from products such as agricultural chemicals, processed food, and nutritional supplements is nearly unavoidable. The gastrointestinal tract serves as a critical interface between the body and the external environment, and is the site of essential nutrient absorption. The goal of this study was to examine the effects of ingesting the 30 (...) nm TiO2 nanoparticles with an in vitro cell culture model of the small intestinal epithelium, and to determine how acute or chronic exposure to nano-TiO2 influences intestinal barrier function, reactive oxygen species generation, proinflammatory signaling, nutrient absorption (iron, zinc, fatty acids), and brush border membrane enzyme function (intestinal alkaline phosphatase). A Caco-2/HT29-MTX cell culture model was exposed to physiologically relevant doses of TiO2 nanoparticles for acute (four

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2017 NanoImpact

15. An integrated methodology for assessing the impact of food matrix and gastrointestinal effects on the biokinetics and cellular toxicity of ingested engineered nanomaterials (PubMed)

An integrated methodology for assessing the impact of food matrix and gastrointestinal effects on the biokinetics and cellular toxicity of ingested engineered nanomaterials Engineered nanomaterials (ENMs) are increasingly added to foods to improve their quality, sensory appeal, safety and shelf-life. Human exposure to these ingested ENMs (iENMS) is inevitable, yet little is known of their hazards. To assess potential hazards, efficient in vitro methodologies are needed to evaluate particle (...) using a three-stage GIT simulator; 3) assessment of iENMs biokinetics and cellular toxicity after exposure to simulated GIT conditions using a triculture cell model. As a case study, a model food (corn oil-in-water emulsion) was infused with Fe2O3 (Iron(III) oxide or ferric oxide) ENMs and processed using this three-stage integrated platform to study the impact of food matrix and GIT effects on nanoparticle biokinetics and cytotoxicity .A corn oil in phosphate buffer emulsion was prepared using

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2017 Particle and fibre toxicology

16. Response to effect of deferasirox on iron absorption in a randomized, placebo-controlled, crossover study in a human model of acute supratherapeutic iron ingestion. (PubMed)

Response to effect of deferasirox on iron absorption in a randomized, placebo-controlled, crossover study in a human model of acute supratherapeutic iron ingestion. 21782558 2011 09 20 2018 12 01 1097-6760 58 2 2011 Aug Annals of emergency medicine Ann Emerg Med Response to effect of deferasirox on iron absorption in a randomized, placebo-controlled, crossover study in a human model of acute supratherapeutic iron ingestion. 219-20; author reply 220 10.1016/j.annemergmed.2011.03.056 Parikh Amay (...) A Jang David H DH Hoffman Robert S RS Howland Mary Ann MA eng Letter Comment United States Ann Emerg Med 8002646 0196-0644 0 Antidotes 0 Benzoates 0 Iron Chelating Agents 0 Triazoles E1UOL152H7 Iron V8G4MOF2V9 Deferasirox AIM IM Ann Emerg Med. 2011 Jul;58(1):69-73 21288598 Antidotes therapeutic use Benzoates therapeutic use Deferasirox Humans Iron blood metabolism poisoning Iron Chelating Agents therapeutic use Triazoles therapeutic use 2011 03 05 2011 03 05 2011 03 09 2011 7 26 6 0 2011 7 26 6 0

2011 Annals of Emergency Medicine

17. Effect of deferasirox on iron absorption in a randomized, placebo-controlled, crossover study in a human model of acute supratherapeutic iron ingestion. (PubMed)

Effect of deferasirox on iron absorption in a randomized, placebo-controlled, crossover study in a human model of acute supratherapeutic iron ingestion. In 2005, the Food and Drug Administration approved deferasirox as an oral iron chelating agent for chronic iron overload. To determine usefulness in management of acute iron ingestion, we study the effect of orally administered deferasirox in healthy human adults.A double-blinded, placebo-controlled, randomized, crossover study of 8 healthy (...) human volunteers was conducted. Subjects ingested 5 mg/kg of elemental iron in the form of ferrous sulfate. One hour after iron ingestion, subjects were randomized to receive 20 mg/kg of deferasirox or placebo. Serial iron levels were then obtained. A 2-week washout was used between study arms. The paired t test was used to compare area under time-concentration curves from baseline to both 12- and 24-hour iron levels between groups.Baseline serum iron levels were similar in the 2 groups. Deferasirox

2011 Annals of Emergency Medicine

18. Changes in Iron Absorption After Roux-en-Y Gastric Bypass. (PubMed)

after RYGB. Twelve patients were tested with a single dose of 600 mg ferrous fumarate in tablet form (195 mg of elementary iron, group 1), and 12 patients received a single dose of 1390 mg ferrous gluconate as a solution (160 mg of elementary iron, group 2). Serum iron levels were measured before (T0) and every hour after ingestion of the supplement (T1-T9).Before surgery, iron absorption was similar for the two supplements (P = 0.71). However, RYGB was associated with a decrease in fumarate iron (...) Changes in Iron Absorption After Roux-en-Y Gastric Bypass. Iron deficiency is one of the most common deficiencies that may occur after Roux-en-Y gastric bypass (RYGB). Little is known about the optimal treatment of post-RYGB iron deficiency.The aim of this study is to evaluate the changes in iron absorption characteristics after RYGB for two oral iron formulations, one presented in tablet form and one as in the form of a solution.Iron absorption in 24 obese women was studied before and 1 month

2018 Obesity Surgery

19. Characterization of Divalent Metal Transporter 1 (DMT1) in Brugia malayi suggests an intestinal-associated pathway for iron absorption (PubMed)

. malayi functions as an iron transporter. The presence of this transporter in the intestine supports the hypothesis that iron acquisition by adult females requires oral ingestion and suggests that the intestine plays a functional role in at least some aspects of nutrient uptake.Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved. (...) Characterization of Divalent Metal Transporter 1 (DMT1) in Brugia malayi suggests an intestinal-associated pathway for iron absorption Lymphatic filariasis and onchocerciasis are neglected parasitic diseases which pose a threat to public health in tropical and sub-tropical regions. Strategies for control and elimination of these diseases by mass drug administration (MDA) campaigns are designed to reduce symptoms of onchocerciasis and transmission of both parasites to eventually eliminate

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2018 International Journal for Parasitology: Drugs and Drug Resistance

20. Ferrous Acetyl-Aspartate Casein Formulation Evaluation Over Ferrous Sulfate in Iron Deficiency Anemia

are less often. In parallel, animal studies have shown that casein itself primes the expression of enzymes that facilitate the absorption of iron across the duodenal mucosa. This formulation is anticipated to be better tolerated for oral ingestion since iron is readily absorbed in the duodenum. The aim is to compare the efficacy of the new oral formulation of Fe-ASP to oral ferrous sulfate in patients with IDA for the restoration of decreased circulating Hb. Study Design Go to Layout table for study (...) Ferrous Acetyl-Aspartate Casein Formulation Evaluation Over Ferrous Sulfate in Iron Deficiency Anemia Ferrous Acetyl-Aspartate Casein Formulation Evaluation Over Ferrous Sulfate in Iron Deficiency Anemia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2018 Clinical Trials

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