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Iron Deficiency Anemia

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1. Iron (III) Isomaltoside 1000 (Monoferric) - iron deficiency anemia

Iron (III) Isomaltoside 1000 (Monoferric) - iron deficiency anemia Iron (III) Isomaltoside 1000 | CADTH.ca Find the information you need Iron (III) Isomaltoside 1000 Iron (III) Isomaltoside 1000 Last Updated: October 3, 2019 Result type: Reports Project Number: SR0622-000 Product Line: Generic Name: Iron (III) Isomaltoside 1000 Brand Name: Monoferric Manufacturer: Pharmacosmos A/S Indications: iron deficiency anemia Manufacturer Requested Reimbursement Criteria 1 : Reimbursed for the treatment (...) of iron deficiency anemia in adult patients who have intolerance or unresponsiveness to oral iron therapy. The diagnosis must be based on laboratory tests. Submission Type: New Project Status: Active Biosimilar: No Companion Diagnostics: No Fee Schedule: Schedule A The requested reimbursement criteria are provided by the applicant and do not necessarily reflect the views of CADTH. Reimbursement criteria from CADTH will be documented in the final recommendation, if applicable. Key Milestones 2 Call

2019 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

2. Ferric maltol (Accrufer) - To treat iron deficiency anemia in adults

Ferric maltol (Accrufer) - To treat iron deficiency anemia in adults Drug Approval Package: ACCRUFER U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: ACCRUFER Company: Shield Therapeutics (UK) Ltd. Application Number: 212320 Approval Date: 07/25/2019 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. FDA Approval Letter and Labeling (PDF) (PDF) FDA Application Review Files (PDF) (PDF) (PDF

2019 FDA - Drug Approval Package

5. Iron Deficiency Anemia (IDA)

Iron Deficiency Anemia (IDA) IRON DEFICIENCY ANEMIA (IDA) Clinical Practice Guideline | March 2018 These recommendations are systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances. They should be used as an adjunct to sound clinical decision making. OBJECTIVE Alberta clinicians (specifically primary care and emergency department physicians) will be able to diagnose iron deficiency anemia (IDA), treat (...) are administered and underlying cause of iron deficiency is addressed. Iron Deficiency Anemia (IDA) | March 2018 Clinical Practice Guideline Page 6 of 21 Recommendations Table 5: Monitoring Algorithm IF PATIENT IS RESPONDING TO THERAPY IF PATIENT IS NOT RESPONDING TO THERAPY: ? Continue to monitor hemoglobin and Ferritin monthly/bimonthly to ensure levels remain within the normal range. ? For school-aged children, treat for 3-4 months then stop as long as all parameters have normalized (CBC, ferritin and iron

2018 Toward Optimized Practice

6. How can we diagnose iron deficiency in the setting of anemia of chronic disease?

How can we diagnose iron deficiency in the setting of anemia of chronic disease? Chiefs’ Inquiry Corner – 11/11/19 – Clinical Correlations Search Chiefs’ Inquiry Corner – 11/11/19 November 11, 2019 2 min read Many patients with anemia of chronic disease will also be iron deficient. However, diagnosing underlying iron deficiency is challenging in the setting of inflammation because cytokines and inflammatory mediators reduce duodenal iron absorption and sequester iron in macrophages and ferritin (...) . Thus ferritin does not accurately reflect iron stores in patients with chronic disease. A newer blood test called a “soluble transferrin receptor” (sTfR) is an indirect measure of erythropoiesis that is less affected by an inflammatory state. There is growing evidence that this test, alone or divided by log ferritin values (ferritin index) can help detect underlying iron deficiency in patients with anemia of chronic disease. References: It is critical to determine if patients with NAFLD have

2019 Clinical Correlations

7. Total dose iron dextran infusion versus oral iron for treating iron deficiency anemia in pregnant women: a randomized controlled trial. (PubMed)

Total dose iron dextran infusion versus oral iron for treating iron deficiency anemia in pregnant women: a randomized controlled trial. To test safety, efficacy, and cost-effectiveness of total dose infusion (TDI) of low molecular weight (LMW) iron dextran for treatment of iron deficiency anemia (IDA) during pregnancy in comparison to oral ferrous fumarate.Prospective interventional randomized controlled trial (RCT). Design classification. Canadian Task Force II3.Antenatal clinic and causality (...) unit of a tertiary care referral facility and University Hospital.A total 66 anemic pregnant women (hemoglobin level between 7-10 g/dl).Administration of a LMW iron dextran as a TDI (group A) or Oral iron ferrous fumarate 60 mg elemental iron three times daily (group B) followed by remeasurement of hemoglobin after 4 weeks.The main outcome measure was clinical and laboratory improvement of anemia after 4 weeks of starting the therapy. Both groups showed a significant clinical improvement of anemia

2019 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

8. Iron Bisglycinate Chelate and Polymaltose Iron for the Treatment of Iron Deficiency Anemia: A Pilot Randomized Trial. (PubMed)

Iron Bisglycinate Chelate and Polymaltose Iron for the Treatment of Iron Deficiency Anemia: A Pilot Randomized Trial. Iron Deficiency Anemia (IDA) is a major public health problem worldwide. Iron Bisglycinate Chelate (FeBC) and polymaltose iron (FeP) are used for the treatment of IDA and exhibit good tolerability with a low incidence of adverse effects. However, these compounds have important differences in their structures and bioavailability.To compare the efficacy of oral supplementation (...) with FeBC and FeP in anemic children.In this double-blind study, children aged 1 to 13 years who were diagnosed with IDA were randomly divided into two groups: i) FeBC, supplemented with iron bisglycinate chelate, and ii) FeP, supplemented with polymaltose iron (3.0 mg iron/kg body weight/day for 45 days for both groups).Both treatments resulted in significant increases in hemoglobin levels, Mean Corpuscular Volume (MCV) and Cell Distribution Width (RDW) and in a reduction of transferrin levels

2019 Current pediatric reviews

9. A prospective, multicenter, randomized comparison of iron isomaltoside 1000 versus iron sucrose in patients with iron deficiency anemia (the FERWON-IDA trial). (PubMed)

A prospective, multicenter, randomized comparison of iron isomaltoside 1000 versus iron sucrose in patients with iron deficiency anemia (the FERWON-IDA trial). Iron deficiency anemia (IDA) is prevalent, and intravenous iron, especially if given in a single dose, may result in better adherence compared with oral iron. The present trial (FERWON-IDA) is part of the FERWON program with iron isomaltoside 1000/ferric derisomaltose (IIM), evaluating safety and efficacy of high dose IIM in IDA patients (...) of mixed etiologies. This was a randomized, open-label, comparative, multi-center trial conducted in the USA. The IDA patients were randomized 2:1 to a single dose of 1000 mg IIM, or iron sucrose (IS) administered as 200 mg intravenous injections, up to five times. The co-primary endpoints were adjudicated serious or severe hypersensitivity reactions, and change in hemoglobin from baseline to week eight. A total of 1512 patients were enrolled. The frequency of patients with serious or severe

2019 American journal of hematology

10. Increased Iron Deficiency and Iron Deficiency Anemia in Children with Zinc Deficiency (PubMed)

Increased Iron Deficiency and Iron Deficiency Anemia in Children with Zinc Deficiency The aim of the present study is to determine the presence of iron (Fe) deficiency and Fe deficiency anemia in children with zinc (Zn) deficiency.This retrospective study comprised 560 patients aged 6 months to 16 years in whom Zn levels in hair samples were measured concurrently with serum levels of ferritin, Fe, Fe-binding capacity, and blood count analysis. For all patients, we retrospectively assessed serum (...) difference between any of these parameters and the presence of Fe deficiency and Fe deficiency anemia between patients with and without Zn deficiency.A total of 238 patients had Zn levels <100 µg/g, and 322 patients had Zn levels >100 µg/g. The median ferritin level was 16.2 (9.8-24.9) ng/mL in the Zn-deficient group and 18.7 (12-29.3) ng/mL in those without Zn deficiency group. The presence of Fe deficiency was higher in the Zn deficiency group (60.1%) than in the without Zn deficiency group (50%; p

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2018 The Eurasian journal of medicine

11. The opposing effects of acute inflammation and iron deficiency anemia on serum hepcidin and iron absorption in young women. (PubMed)

The opposing effects of acute inflammation and iron deficiency anemia on serum hepcidin and iron absorption in young women. Hepatic hepcidin synthesis is stimulated by inflammation but inhibited during iron deficiency anemia. In humans, the relative strength of these opposing signals on serum hepcidin and the net effect on iron absorption and systemic iron recycling is uncertain. In this prospective, 45-day study, in young women (n=46; age 18-49 y) with or without iron deficiency anemia, we (...) compared iron and inflammation markers, serum hepcidin and erythrocyte iron incorporation from 57Fe-labeled test meals, before and 8, 24 and 36 hours after influenza/DPT vaccination as an acute inflammatory stimulus. Compared to baseline, at 24-36 hours after vaccination: 1) interleukin-6 increased 2-3-fold in both groups (p<001); 2) serum hepcidin increased >2-fold in the non-anemic group (p<001), but did not significantly change in the iron-deficiency anemia group; 3) serum iron decreased in the non

2019 Haematologica

12. Effect of Low-Dose Ferrous Sulfate vs Iron Polysaccharide Complex on Hemoglobin Concentration in Young Children With Nutritional Iron-Deficiency Anemia: A Randomized Clinical Trial. (PubMed)

Effect of Low-Dose Ferrous Sulfate vs Iron Polysaccharide Complex on Hemoglobin Concentration in Young Children With Nutritional Iron-Deficiency Anemia: A Randomized Clinical Trial. Iron-deficiency anemia (IDA) affects millions of persons worldwide, and is associated with impaired neurodevelopment in infants and children. Ferrous sulfate is the most commonly prescribed oral iron despite iron polysaccharide complex possibly being better tolerated.To compare the effect of ferrous sulfate (...) of diarrhea in the iron complex group than in the ferrous sulfate group (58% vs 35%, respectively; P = .04).Among infants and children aged 9 to 48 months with nutritional iron-deficiency anemia, ferrous sulfate compared with iron polysaccharide complex resulted in a greater increase in hemoglobin concentration at 12 weeks. Once daily, low-dose ferrous sulfate should be considered for children with nutritional iron-deficiency anemia.clinicaltrials.gov Identifier: NCT01904864.

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2017 JAMA

13. Comparison of ferric Carboxymaltose and iron sucrose complex for treatment of iron deficiency anemia in pregnancy- randomised controlled trial. (PubMed)

Comparison of ferric Carboxymaltose and iron sucrose complex for treatment of iron deficiency anemia in pregnancy- randomised controlled trial. To evaluate the efficacy and safety of intravenous Ferric Carboxymaltose. (FCM) in comparison with intravenous Iron sucrose complex (ISC) for treatment of iron deficiency anemia in pregnancy.A randomized clinical trial was conducted from (January 2016-August 2017). at a tertiary hospital. Pregnant women diagnosed with moderate to severe iron deficiency (...) anaemia were screened for the study. One hundred patients were randomized to receive either intravenous FCM or ISC. Primary outcome was rise in hemoglobin (Hb) from baseline after 12 weeks. Secondary outcomes were change in RBC indices, serum iron studies, improvement in fatigue scores, number of visits and perinatal outcome.Mean rise in Hb at 12 weeks was significantly higher in FCM group (29 g/L vs 22 g/L; p value < 0.01). FCM was associated with greater improvement in fatigue scores. Number

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2019 BMC Pregnancy and Childbirth

14. Anemia, Iron Deficiency, and Iron Supplementation in Relation to Mortality among HIV-Infected Patients Receiving Highly Active Antiretroviral Therapy in Tanzania. (PubMed)

Anemia, Iron Deficiency, and Iron Supplementation in Relation to Mortality among HIV-Infected Patients Receiving Highly Active Antiretroviral Therapy in Tanzania. Anemia in HIV-infected patients improves with highly active antiretroviral therapy (HAART); however, it may still be associated with mortality among patients receiving treatment. We examined the associations of anemia severity and iron deficiency anemia (IDA) at HAART initiation and during monthly prospective follow-up with mortality (...) follow-up versus no anemia or iron deficiency (both P < 0.001). These associations differed significantly by gender, body mass index, and iron supplement use (all interaction test P < 0.001). The magnitude of association was stronger among men. Mortality risk with severe anemia was 13 times greater versus no anemia among obese patients, whereas it was only two times greater among underweight patients. Higher mortality risk was observed among iron supplement users, irrespective of anemia severity

2019 American Journal of Tropical Medicine & Hygiene

15. Treatment of iron deficiency and iron deficiency anemia with intravenous ferric carboxymaltose in pregnancy (PubMed)

Treatment of iron deficiency and iron deficiency anemia with intravenous ferric carboxymaltose in pregnancy To evaluate the efficacy and safety of intravenous ferric carboxymaltose administration to pregnant women with varying severities of iron deficiency anemia and iron deficiency without anemia.In this prospective observational study of local obstetric practice, we analyzed data from 863 pregnant women with iron deficiency according to anemia status and severity. All women were treated (...) with intravenous ferric carboxymaltose in pregnancy. Treatment efficacy was assessed by repeat hemoglobin measurements at 3 and 6 week post-infusion and ferritin levels, where available. Safety was assessed by analysis of adverse events, fetal heart rate monitoring, and newborn health outcome data.Ferric carboxymaltose significantly increased hemoglobin in women with mild, moderate, and severe iron deficiency anemia and women with iron deficiency alone at 3 and 6 week post-infusion (p < 0.01 for all

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2018 Archives of gynecology and obstetrics

16. Routine iron supplementation and screening for iron deficiency anemia in pregnant women

Routine iron supplementation and screening for iron deficiency anemia in pregnant women Routine iron supplementation and screening for iron deficiency anemia in pregnant women Routine iron supplementation and screening for iron deficiency anemia in pregnant women McDonagh M, Cantor A, Bougatsos C, Dana T, Blazina I Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made (...) for the HTA database. Citation McDonagh M, Cantor A, Bougatsos C, Dana T, Blazina I. Routine iron supplementation and screening for iron deficiency anemia in pregnant women. Rockville: Agency for Healthcare Research and Quality (AHRQ). Evidence Synthesis No. 123. 2015 Authors' objectives To systematically update the prior USPSTF reviews on screening and supplementation for iron deficiency anemia in pregnancy. Authors' conclusions Evidence supports the effectiveness of routine iron supplementation during

2015 Health Technology Assessment (HTA) Database.

17. Routine iron supplementation and screening for iron deficiency anemia in children ages 6 to 24 months: a systematic review to update the U.S. Preventive Services Task Force Recommendation

Routine iron supplementation and screening for iron deficiency anemia in children ages 6 to 24 months: a systematic review to update the U.S. Preventive Services Task Force Recommendation Routine iron supplementation and screening for iron deficiency anemia in children ages 6 to 24 months: a systematic review to update the U.S. Preventive Services Task Force Recommendation Routine iron supplementation and screening for iron deficiency anemia in children ages 6 to 24 months: a systematic review (...) to update the U.S. Preventive Services Task Force Recommendation McDonagh M, Blazina I, Dana T, Cantor A, Bougatsos C Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation McDonagh M, Blazina I, Dana T, Cantor A, Bougatsos C. Routine iron supplementation and screening for iron deficiency anemia in children ages 6 to 24 months: a systematic review

2015 Health Technology Assessment (HTA) Database.

18. Correction: Iron deficiency anemia, population health and frailty in a modern Portuguese skeletal sample. (PubMed)

Correction: Iron deficiency anemia, population health and frailty in a modern Portuguese skeletal sample. [This corrects the article DOI: 10.1371/journal.pone.0213369.].

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2019 PLoS ONE

19. Iron deficiency anemia, population health and frailty in a modern Portuguese skeletal sample. (PubMed)

Iron deficiency anemia, population health and frailty in a modern Portuguese skeletal sample. Portugal underwent significant political, demographic and epidemiological transitions during the 20th century resulting in migration to urban areas with subsequent overcrowding and issues with water sanitation. This study investigates population health during these transitions and interprets results within a framework of recent history and present-day public health information. We investigate skeletal (...) in urban Lisbon during the 1800s and 1900s and the possibility of water-borne parasites as the contributing factor for iron deficiency anemia.

2019 PLoS ONE

20. Intravenous iron for the treatment of iron deficiency with or without anemia in patients with chronic heart failure

Intravenous iron for the treatment of iron deficiency with or without anemia in patients with chronic heart failure Intravenous iron for the treatment of iron deficiency with or without anemia in patients with chronic heart failure Intravenous iron for the treatment of iron deficiency with or without anemia in patients with chronic heart failure Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made (...) for the HTA database. Citation Intravenous iron for the treatment of iron deficiency with or without anemia in patients with chronic heart failure. Lansdale: HAYES, Inc.. Directory Publication. 2014 Authors' objectives Intravenous (IV) iron supplementation is used in patients with chronic heart failure and iron deficiency with or without anemia, to increase iron and hemoglobin levels. The goal of IV iron therapy is to improve quality of life, functional status, cardiac function, and exercise tolerance

2014 Health Technology Assessment (HTA) Database.

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