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1. Fortification of maize flour with iron for controlling anaemia and iron deficiency in populations. (PubMed)

Fortification of maize flour with iron for controlling anaemia and iron deficiency in populations. Approximately 800 million women and children have anaemia, a condition thought to cause almost 9% of the global burden of years lived with disability. Around half this burden could be amenable to interventions that involve the provision of iron. Maize (corn) is one of the world's most important cereal grains and is cultivated across most of the globe. Several programmes around the world have (...) fortified maize flour and other maize-derived foodstuffs with iron and other vitamins and minerals to combat anaemia and iron deficiency.To assess the effects of iron fortification of maize flour, corn meal and fortified maize flour products for anaemia and iron status in the general population.We searched the following international and regional sources in December 2017 and January 2018: Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE; MEDLINE (R) In Process; Embase; Web of Science

2018 Cochrane

2. Daily iron supplementation for improving anaemia, iron status and health in menstruating women. (PubMed)

Daily iron supplementation for improving anaemia, iron status and health in menstruating women. Iron-deficiency anaemia is highly prevalent among non-pregnant women of reproductive age (menstruating women) worldwide, although the prevalence is highest in lower-income settings. Iron-deficiency anaemia has been associated with a range of adverse health outcomes, which restitution of iron stores using iron supplementation has been considered likely to resolve. Although there have been many trials (...) reporting effects of iron in non-pregnant women, these trials have never been synthesised in a systematic review.To establish the evidence for effects of daily supplementation with iron on anaemia and iron status, as well as on physical, psychological and neurocognitive health, in menstruating women.In November 2015 we searched CENTRAL, Ovid MEDLINE, EMBASE, and nine other databases, as well as four digital thesis repositories. In addition, we searched the World Health Organization International

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2016 Cochrane

3. MONOVER (iron isomaltoside 1000), injectable iron

MONOVER (iron isomaltoside 1000), injectable iron Haute Autorité de Santé - MONOVER (fer isomaltoside 1000), fer par voie injectable Développer la qualité dans le champ sanitaire, social et médico-social Recherche Évaluation & Recommandation La HAS Accréditation & Certification Outils, Guides & Méthodes Agenda Avis sur les Médicaments MONOVER (fer isomaltoside 1000), fer par voie injectable Substance active (DCI) fer (III) isomaltoside 1000 HEMATOLOGIE - Nouveau médicament Nature de la demande

2017 Haute Autorite de sante

4. Other Estimation of Blood Losses in Hemodialysis and Formula for Translating Liver Iron Concentration From Iron Balance Calculation Based on Iron Removal by Phlebotomy (PubMed)

Other Estimation of Blood Losses in Hemodialysis and Formula for Translating Liver Iron Concentration From Iron Balance Calculation Based on Iron Removal by Phlebotomy 29340339 2018 11 13 2468-0249 3 1 2018 Jan Kidney international reports Kidney Int Rep Other Estimation of Blood Losses in Hemodialysis and Formula for Translating Liver Iron Concentration From Iron Balance Calculation Based on Iron Removal by Phlebotomy. 220 10.1016/j.ekir.2017.11.012 Rottembourg Jacques J Service de Néphrologie

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2017 Kidney international reports

5. Can double fortification of salt with iron and iodine reduce anaemia, iron deficiency anaemia, iron deficiency, and iodine deficiency? Evidence of efficacy, effectiveness, and safety

Can double fortification of salt with iron and iodine reduce anaemia, iron deficiency anaemia, iron deficiency, and iodine deficiency? Evidence of efficacy, effectiveness, and safety Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility

2019 PROSPERO

6. Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult menstruating women. (PubMed)

Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult menstruating women. Anaemia is a condition in which the number of red blood cells is insufficient to meet physiologic needs; it is caused by many conditions, particularly iron deficiency. Traditionally, daily iron supplementation has been a standard practice for preventing and treating anaemia. However, its long-term use has been limited, as it has been associated with adverse side (...) effects such as nausea, constipation, and teeth staining. Intermittent iron supplementation has been suggested as an effective and safer alternative to daily iron supplementation for preventing and reducing anaemia at the population level, especially in areas where this condition is highly prevalent.To assess the effects of intermittent oral iron supplementation, alone or in combination with other nutrients, on anaemia and its associated impairments among menstruating women, compared

2019 Cochrane

7. Iron for the treatment of restless legs syndrome. (PubMed)

Iron for the treatment of restless legs syndrome. Restless legs syndrome (RLS) is a common neurologic disorder that is associated with peripheral iron deficiency in a subgroup of patients. It is unclear whether iron therapy is effective treatment for RLS.To evaluate the efficacy and safety of oral or parenteral iron for the treatment of restless legs syndrome (RLS) when compared with placebo or other therapies.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (...) , Embase, PsycNFO, and CINAHL for the time period January 1995 to September 2017. We searched reference lists for additional published studies. We searched Clinicaltrials.gov and other clinical trial registries (September 2017) for ongoing or unpublished studies.Controlled trials comparing any formulation of iron with placebo, other medications, or no treatment, in adults diagnosed with RLS according to expert clinical interview or explicit diagnostic criteria.Two review authors independently extracted

2019 Cochrane

8. Parenteral versus oral iron therapy for adults and children with chronic kidney disease. (PubMed)

Parenteral versus oral iron therapy for adults and children with chronic kidney disease. The anaemia seen in chronic kidney disease (CKD) may be exacerbated by iron deficiency. Iron can be provided through different routes, with advantages and drawbacks of each route. It remains unclear whether the potential harms and additional costs of intravenous (IV) compared with oral iron are justified. This is an update of a review first published in 2012.To determine the benefits and harms of IV iron (...) supplementation compared with oral iron for anaemia in adults and children with CKD, including participants on dialysis, with kidney transplants and CKD not requiring dialysis.We searched the Cochrane Kidney and Transplant Register of Studies up to 7 December 2018 through contact with the Information Specialist using search terms relevant to this review. Studies in the Register are identified through searches of CENTRAL, MEDLINE, and EMBASE, conference proceedings, the International Clinical Trials Register

2019 Cochrane

9. Canadian expert consensus: management of hypersensitivity reactions to intravenous iron in adults

Canadian expert consensus: management of hypersensitivity reactions to intravenous iron in adults Canadian expert consensus: management of hypersensitivity reactions to intravenous iron in adults - Lim - - Vox Sanguinis - Wiley Online Library The full text of this article hosted at iucr.org is unavailable due to technical difficulties.

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2019 CPG Infobase

10. Intravenous (IV) iron for severe iron deficiency

Intravenous (IV) iron for severe iron deficiency November - December 2015 97 © Tel.: 604 822•0700 Fax: 604 822•0701 E-mail: info@ti.ubc.ca www.ti.ubc.ca Mailing Address: Therapeutics Initiative The University of British Columbia Department of Anesthesiology, Pharmacology & Therapeutics 2176 Health Sciences Mall Vancouver, BC Canada V6T 1Z3 Intravenous (IV) iron for severe iron deficiency his Hb was 120 g/L and MCV 79 fL. Additional iron sucrose compensated for ongoing lower GI bleeding, and his (...) Hb peaked at 143 g/L with a ferritin of 89 mcg/L. Indications and Dosing Severe iron deficiency plus inability to tolerate or absorb oral iron is the main indication. In the face of ongoing blood loss or urgent surgery, IV iron corrects anemia much faster than oral iron. The bodies of well-nourished people contain about 4 - 5 grams of elemental iron, half circulating in red cells. The remainder is stored in the bone marrow, liver, and spleen. Adult patients with profound iron deficiency require

2016 Therapeutics Letter

11. Total dose iron dextran infusion versus oral iron for treating iron deficiency anemia in pregnant women: a randomized controlled trial. (PubMed)

Total dose iron dextran infusion versus oral iron for treating iron deficiency anemia in pregnant women: a randomized controlled trial. To test safety, efficacy, and cost-effectiveness of total dose infusion (TDI) of low molecular weight (LMW) iron dextran for treatment of iron deficiency anemia (IDA) during pregnancy in comparison to oral ferrous fumarate.Prospective interventional randomized controlled trial (RCT). Design classification. Canadian Task Force II3.Antenatal clinic and causality (...) unit of a tertiary care referral facility and University Hospital.A total 66 anemic pregnant women (hemoglobin level between 7-10 g/dl).Administration of a LMW iron dextran as a TDI (group A) or Oral iron ferrous fumarate 60 mg elemental iron three times daily (group B) followed by remeasurement of hemoglobin after 4 weeks.The main outcome measure was clinical and laboratory improvement of anemia after 4 weeks of starting the therapy. Both groups showed a significant clinical improvement of anemia

2019 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

12. Iron Bisglycinate Chelate and Polymaltose Iron for the Treatment of Iron Deficiency Anemia: A Pilot Randomized Trial. (PubMed)

Iron Bisglycinate Chelate and Polymaltose Iron for the Treatment of Iron Deficiency Anemia: A Pilot Randomized Trial. Iron Deficiency Anemia (IDA) is a major public health problem worldwide. Iron Bisglycinate Chelate (FeBC) and polymaltose iron (FeP) are used for the treatment of IDA and exhibit good tolerability with a low incidence of adverse effects. However, these compounds have important differences in their structures and bioavailability.To compare the efficacy of oral supplementation (...) with FeBC and FeP in anemic children.In this double-blind study, children aged 1 to 13 years who were diagnosed with IDA were randomly divided into two groups: i) FeBC, supplemented with iron bisglycinate chelate, and ii) FeP, supplemented with polymaltose iron (3.0 mg iron/kg body weight/day for 45 days for both groups).Both treatments resulted in significant increases in hemoglobin levels, Mean Corpuscular Volume (MCV) and Cell Distribution Width (RDW) and in a reduction of transferrin levels

2019 Current pediatric reviews

13. Serum ferritin, soluble transferrin receptor, and total body iron for the detection of iron deficiency in early pregnancy: a multiethnic population-based study with low use of iron supplements. (PubMed)

Serum ferritin, soluble transferrin receptor, and total body iron for the detection of iron deficiency in early pregnancy: a multiethnic population-based study with low use of iron supplements. Which blood-based indicator best reflects the iron status in pregnant women is unclear. Better assessments of iron status in today's multiethnic populations are needed to optimize treatment and clinical recommendations.We aimed to determine the prevalence of anemia (hemoglobin <11.0 g/dL in first (...) and <10.5 g/dL in second trimester) and iron deficiency (ID) by the iron indicators serum ferritin <15 µg/L, serum soluble transferrin receptor (sTfR) >4.4 mg/L, and calculated total body iron <0 mg/kg, and their associations with ethnicity.This was a population-based cross-sectional study from primary antenatal care of 792 healthy women in early pregnancy in Oslo, Norway. We categorized the women into 6 ethnic groups: Western European, South Asian, Middle Eastern, Sub-Saharan African, East Asian

2019 American Journal of Clinical Nutrition

14. Consumption of Galacto-Oligosaccharides Increases Iron Absorption from Ferrous Fumarate: A Stable Iron Isotope Study in Iron-Depleted Young Women. (PubMed)

Consumption of Galacto-Oligosaccharides Increases Iron Absorption from Ferrous Fumarate: A Stable Iron Isotope Study in Iron-Depleted Young Women. Animal studies suggest prebiotics can increase iron absorption, but results from human studies are equivocal.In iron-depleted women, before (baseline) and after daily consumption of galacto-oligosaccharides (GOS) for 4 wk, we sought to assess fractional iron absorption (FIA) from an iron supplement given with and without single doses of GOS in test (...) meals or water.In all women (n = 34; median serum ferritin concentration = 16.4 µg/L), FIA from doses of 14 mg iron labeled with stable isotopes was measured in the following conditions at baseline: 1) FIA from ferrous fumarate (FeFum) in water given with and without 15 g GOS; 2) FIA from FeFum in a test meal given with and without 15 g GOS; 3) FIA from ferrous sulfate (FeSO4) in a test meal given without 15 g GOS. All subjects then consumed ∼15 g GOS daily for 4 wk. Then the following conditions

2019 Journal of Nutrition

15. Iron Deficiency – Diagnosis and Management

Iron Deficiency – Diagnosis and Management Iron Deficiency – Diagnosis and Management - Province of British Columbia theme_3_collection theme_3_frontend theme_3_collection theme_3_frontend Birth, Adoption, Death, Marriage & Divorce theme_1_collection theme_1_frontend theme_1_collection theme_1_frontend British Columbians & Our Governments theme_data_collection data_frontend theme_data_collection data_frontend Data theme_5_collection theme_5_frontend theme_5_collection theme_5_frontend Driving (...) , Recreation, Arts & Culture theme_8_collection theme_8_frontend theme_8_collection theme_8_frontend Taxes & Tax Credits theme_14_collection theme_14_frontend theme_14_collection theme_14_frontend Tourism & Immigration Search default_collection default_frontend Section Navigation Iron Deficiency – Diagnosis and Management Effective Date: April 17, 2019 Recommendations and Topics Scope This guideline provides recommendations for the diagnosis, investigation and management of iron deficiency in patients

2019 Clinical Practice Guidelines and Protocols in British Columbia

16. Iron deficiency anaemia in adults

Iron deficiency anaemia in adults Iron deficiency and anaemia in adults RCN guidance for nursing staff This publication is supported by industry. Full information inside.This publication is due for review in June 2018. To provide feedback on its contents or on your experience of using the publication, please email publications.feedback@rcn.org.uk RCN Legal Disclaimer This publication contains information, advice and guidance to help members of the RCN. It is intended for use within the UK (...) and Transplant Sheila Johnston RGN, BSc, MSc, Lead Nurse, Chronic Kidney Disease, Royal Free London NHS Foundation Trust Isobel Mason RGN, MSc, MCGI, Nurse Consultant, Gastroenterology, Royal Free London NHS Foundation Trust Emma Whitmore RGN, Patient Blood Management Practitioner, NHS Blood and Transplant This guidance contains scientific material produced by the RCN with financial support from Vifor Pharma UK Ltd. Vifor Pharma have provided some iron deficiency anaemia information and advice on the IV iron

2019 Royal College of Nursing

17. Iron levels, genes involved in iron metabolism and antioxidative processes and lung cancer incidence. (PubMed)

Iron levels, genes involved in iron metabolism and antioxidative processes and lung cancer incidence. Lung cancer is the most common adult malignancy accounting for the largest proportion of cancer related deaths. Iron (Fe) is an essential trace element and is a component of several major metabolic pathways playing an important role in many physiological processes. In this study we evaluated the association between Fe concentration in serum, iron metabolism parameters and genetic variaton in 7 (...) genes involved in iron metabolism and anti-oxidative processes with the incidence of lung cancer in Poland.The study included 200 lung cancer patients and 200 matched healthy control subjects. We analyzed serum iron concentration and iron metabolism parameters (TIBC, UIBC, serum ferritin and transferrin saturation), and genotyped seven variants in seven genes: HFE, TFR1, HAMP, TF, SOD2, CAT and GPX1.Lung cancer patients compared to their matched controls had significantly higher mean serum iron

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2019 PLoS ONE

18. Effect of stimulated erythropoiesis on liver SMAD signaling pathway in iron-overloaded and iron-deficient mice. (PubMed)

Effect of stimulated erythropoiesis on liver SMAD signaling pathway in iron-overloaded and iron-deficient mice. Expression of hepcidin, the hormone regulating iron homeostasis, is increased by iron overload and decreased by accelerated erythropoiesis or iron deficiency. The purpose of the study was to examine the effect of these stimuli, either alone or in combination, on the main signaling pathway controlling hepcidin biosynthesis in the liver, and on the expression of splenic modulators (...) of hepcidin biosynthesis. Liver phosphorylated SMAD 1 and 5 proteins were determined by immunoblotting in male mice treated with iron dextran, kept on an iron deficient diet, or administered recombinant erythropoietin for four consecutive days. Administration of iron increased liver phosphorylated SMAD protein content and hepcidin mRNA content; subsequent administration of erythropoietin significantly decreased both the iron-induced phosphorylated SMAD proteins and hepcidin mRNA. These results

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2019 PLoS ONE

19. Determination of Non-Transferrin Bound Iron, Transferrin Bound Iron, Drug Bound Iron and Total Iron in Serum in a Rats after IV Administration of Sodium Ferric Gluconate Complex by Simple Ultrafiltration Inductively Coupled Plasma Mass Spectrometric Detec (PubMed)

Determination of Non-Transferrin Bound Iron, Transferrin Bound Iron, Drug Bound Iron and Total Iron in Serum in a Rats after IV Administration of Sodium Ferric Gluconate Complex by Simple Ultrafiltration Inductively Coupled Plasma Mass Spectrometric Detec A rapid, sensitive and specific ultrafiltration inductively-coupled plasma mass spectrometry (UF-ICP-MSICP-MS) method was developed and validated for the quantification of non-transferrin bound iron (NTBI), transferrin bound iron (TBI), drug (...) bound iron (DI) and total iron (TI) in the same rat serum sample after intravenous (IV) administration of iron gluconate nanoparticles in sucrose solution (Ferrlecit®). Ultrafiltration with a 30 kDa molecular cut-off filter was used for sample cleanup. Different elution solvents were used to separate each form of iron from sample serum. Isolated fractions were subjected to inductively-coupled mass spectrometric analysis after microwave digestion in 4% nitric acid. The reproducibility of the method

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2018 Nanomaterials

20. Daily Maternal Lipid-Based Nutrient Supplementation with 20 mg Iron, Compared with Iron and Folic Acid with 60 mg Iron, Resulted in Lower Iron Status in Late Pregnancy but Not at 6 Months Postpartum in Either the Mothers or Their Infants in Bangladesh. (PubMed)

Daily Maternal Lipid-Based Nutrient Supplementation with 20 mg Iron, Compared with Iron and Folic Acid with 60 mg Iron, Resulted in Lower Iron Status in Late Pregnancy but Not at 6 Months Postpartum in Either the Mothers or Their Infants in Bangladesh. Maternal anemia and iron deficiency are prevalent in low- and middle-income countries.We aimed to determine the effects of lipid-based nutrient supplements for pregnant and lactating women (LNS-PL) on hemoglobin (Hb), anemia, and iron status (...) (nonprimary outcomes) at 36 weeks of gestation (women) and 6 mo postpartum (women and infants).The Rang-Din Nutrition Study, a cluster-randomized effectiveness trial, enrolled 4011 Bangladeshi pregnant women at ≤20 weeks of gestation to receive either daily LNS-PL (20 mg Fe) during pregnancy and the first 6 mo postpartum, or iron and folic acid (IFA, 60 mg Fe + 400 µg folic acid) daily during pregnancy and every other day during the first 3 mo postpartum. Biochemical measurements from a subsample of women

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2018 Journal of Nutrition

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