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1. Oral Polysaccharide Iron Complex and Heme Iron Polypeptide for Those Requiring Iron Supplementation: Clinical Effectiveness, Cost-Effectiveness, Safety, and Guidelines

Oral Polysaccharide Iron Complex and Heme Iron Polypeptide for Those Requiring Iron Supplementation: Clinical Effectiveness, Cost-Effectiveness, Safety, and Guidelines Oral Polysaccharide Iron Complex and Heme Iron Polypeptide for Those Requiring Iron Supplementation: Clinical Effectiveness, Cost-Effectiveness, Safety, and Guidelines | CADTH.ca Find the information you need Oral Polysaccharide Iron Complex and Heme Iron Polypeptide for Those Requiring Iron Supplementation: Clinical (...) Effectiveness, Cost-Effectiveness, Safety, and Guidelines Oral Polysaccharide Iron Complex and Heme Iron Polypeptide for Those Requiring Iron Supplementation: Clinical Effectiveness, Cost-Effectiveness, Safety, and Guidelines Last updated: February 26, 2019 Project Number: RA1014-000 Product Line: Research Type: Drug Report Type: Reference List Result type: Report Question What is the comparative clinical effectiveness of oral polysaccharide iron complex or heme iron polypeptide versus oral iron salts

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

2. Iron (III) Isomaltoside 1000 (Monoferric) - iron deficiency anemia

Iron (III) Isomaltoside 1000 (Monoferric) - iron deficiency anemia Iron (III) Isomaltoside 1000 | CADTH.ca Find the information you need Iron (III) Isomaltoside 1000 Iron (III) Isomaltoside 1000 Last Updated: October 3, 2019 Result type: Reports Project Number: SR0622-000 Product Line: Generic Name: Iron (III) Isomaltoside 1000 Brand Name: Monoferric Manufacturer: Pharmacosmos A/S Indications: iron deficiency anemia Manufacturer Requested Reimbursement Criteria 1 : Reimbursed for the treatment (...) of iron deficiency anemia in adult patients who have intolerance or unresponsiveness to oral iron therapy. The diagnosis must be based on laboratory tests. Submission Type: New Project Status: Active Biosimilar: No Companion Diagnostics: No Fee Schedule: Schedule A The requested reimbursement criteria are provided by the applicant and do not necessarily reflect the views of CADTH. Reimbursement criteria from CADTH will be documented in the final recommendation, if applicable. Key Milestones 2 Call

2019 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

3. General medicine: Iron absorption from oral iron supplements given on consecutive versus alternate days in iron-depleted women

General medicine: Iron absorption from oral iron supplements given on consecutive versus alternate days in iron-depleted women Iron absorption from oral iron supplements given on consecutive versus alternate days in iron-depleted women | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Iron absorption from oral iron supplements given on consecutive versus alternate days in iron-depleted women Article Text Journal club General medicine

2018 Evidence-Based Medicine (Requires free registration)

4. Fortification of maize flour with iron for controlling anaemia and iron deficiency in populations. (PubMed)

Fortification of maize flour with iron for controlling anaemia and iron deficiency in populations. Approximately 800 million women and children have anaemia, a condition thought to cause almost 9% of the global burden of years lived with disability. Around half this burden could be amenable to interventions that involve the provision of iron. Maize (corn) is one of the world's most important cereal grains and is cultivated across most of the globe. Several programmes around the world have (...) fortified maize flour and other maize-derived foodstuffs with iron and other vitamins and minerals to combat anaemia and iron deficiency.To assess the effects of iron fortification of maize flour, corn meal and fortified maize flour products for anaemia and iron status in the general population.We searched the following international and regional sources in December 2017 and January 2018: Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE; MEDLINE (R) In Process; Embase; Web of Science

2018 Cochrane

5. How do I use CosmoFer (iron dextran) total dose infusion for correction of iron deficiency anaemia?

How do I use CosmoFer (iron dextran) total dose infusion for correction of iron deficiency anaemia? How do I use CosmoFer (iron dextran) total dose infusion for correction of iron deficiency anaemia? – SPS - Specialist Pharmacy Service – The first stop for professional medicines advice Menu · · 27th November 2019 · UKMi This updated Medicines Q&A provides guidance on the administration of Cosmofer (iron dextran) total dose infusion for the treatment of iron deficiency anaemia Attachments · Word

2019 Specialist Pharmacy Services

6. Daily iron supplementation for improving anaemia, iron status and health in menstruating women. (PubMed)

Daily iron supplementation for improving anaemia, iron status and health in menstruating women. Iron-deficiency anaemia is highly prevalent among non-pregnant women of reproductive age (menstruating women) worldwide, although the prevalence is highest in lower-income settings. Iron-deficiency anaemia has been associated with a range of adverse health outcomes, which restitution of iron stores using iron supplementation has been considered likely to resolve. Although there have been many trials (...) reporting effects of iron in non-pregnant women, these trials have never been synthesised in a systematic review.To establish the evidence for effects of daily supplementation with iron on anaemia and iron status, as well as on physical, psychological and neurocognitive health, in menstruating women.In November 2015 we searched CENTRAL, Ovid MEDLINE, EMBASE, and nine other databases, as well as four digital thesis repositories. In addition, we searched the World Health Organization International

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2016 Cochrane

7. MONOVER (iron isomaltoside 1000), injectable iron

MONOVER (iron isomaltoside 1000), injectable iron Haute Autorité de Santé - MONOVER (fer isomaltoside 1000), fer par voie injectable Développer la qualité dans le champ sanitaire, social et médico-social Recherche Évaluation & Recommandation La HAS Accréditation & Certification Outils, Guides & Méthodes Agenda Avis sur les Médicaments MONOVER (fer isomaltoside 1000), fer par voie injectable Substance active (DCI) fer (III) isomaltoside 1000 HEMATOLOGIE - Nouveau médicament Nature de la demande

2017 Haute Autorite de sante

8. Other Estimation of Blood Losses in Hemodialysis and Formula for Translating Liver Iron Concentration From Iron Balance Calculation Based on Iron Removal by Phlebotomy (PubMed)

Other Estimation of Blood Losses in Hemodialysis and Formula for Translating Liver Iron Concentration From Iron Balance Calculation Based on Iron Removal by Phlebotomy 29340339 2018 11 13 2468-0249 3 1 2018 Jan Kidney international reports Kidney Int Rep Other Estimation of Blood Losses in Hemodialysis and Formula for Translating Liver Iron Concentration From Iron Balance Calculation Based on Iron Removal by Phlebotomy. 220 10.1016/j.ekir.2017.11.012 Rottembourg Jacques J Service de Néphrologie

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2017 Kidney international reports

9. Oral iron supplementation frequency and dose amount for optimisation of iron stores in otherwise healthy iron replete humans: a systematic review

Oral iron supplementation frequency and dose amount for optimisation of iron stores in otherwise healthy iron replete humans: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

10. Can double fortification of salt with iron and iodine reduce anaemia, iron deficiency anaemia, iron deficiency, and iodine deficiency? Evidence of efficacy, effectiveness, and safety

Can double fortification of salt with iron and iodine reduce anaemia, iron deficiency anaemia, iron deficiency, and iodine deficiency? Evidence of efficacy, effectiveness, and safety Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility

2019 PROSPERO

11. Use of a Probiotic to Enhance Iron Absorption in a Randomized Trial of Pediatric Patients Presenting with Iron Deficiency

Use of a Probiotic to Enhance Iron Absorption in a Randomized Trial of Pediatric Patients Presenting with Iron Deficiency To evaluate the efficacy of low dose ferrous sulfate for the treatment of iron deficiency and if the probiotic Lactobacillus plantarum 299v (LP299v) enhances treatment.This randomized, double-blinded, controlled trial of the treatment of iron deficiency in children compared the use of low-dose ferrous sulfate (1-3 mg/kg/day), with or without probiotic (LP299v).Serum ferritin (...) effects.Treatment with low-dose ferrous sulfate is well-tolerated and effective in correcting iron deficiency in children. However, the probiotic LP299v did not enhance treatment. Further attention should examine the dose-response effect in children, including an alternate day dosing schedule.ClinicalTrials.gov: NCT01617044.Copyright © 2019 Elsevier Inc. All rights reserved.

2019 EvidenceUpdates

12. Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult menstruating women. (PubMed)

Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult menstruating women. Anaemia is a condition in which the number of red blood cells is insufficient to meet physiologic needs; it is caused by many conditions, particularly iron deficiency. Traditionally, daily iron supplementation has been a standard practice for preventing and treating anaemia. However, its long-term use has been limited, as it has been associated with adverse side (...) effects such as nausea, constipation, and teeth staining. Intermittent iron supplementation has been suggested as an effective and safer alternative to daily iron supplementation for preventing and reducing anaemia at the population level, especially in areas where this condition is highly prevalent.To assess the effects of intermittent oral iron supplementation, alone or in combination with other nutrients, on anaemia and its associated impairments among menstruating women, compared

2019 Cochrane

13. Iron for the treatment of restless legs syndrome. (PubMed)

Iron for the treatment of restless legs syndrome. Restless legs syndrome (RLS) is a common neurologic disorder that is associated with peripheral iron deficiency in a subgroup of patients. It is unclear whether iron therapy is effective treatment for RLS.To evaluate the efficacy and safety of oral or parenteral iron for the treatment of restless legs syndrome (RLS) when compared with placebo or other therapies.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (...) , Embase, PsycNFO, and CINAHL for the time period January 1995 to September 2017. We searched reference lists for additional published studies. We searched Clinicaltrials.gov and other clinical trial registries (September 2017) for ongoing or unpublished studies.Controlled trials comparing any formulation of iron with placebo, other medications, or no treatment, in adults diagnosed with RLS according to expert clinical interview or explicit diagnostic criteria.Two review authors independently extracted

2019 Cochrane

14. Parenteral versus oral iron therapy for adults and children with chronic kidney disease. (PubMed)

Parenteral versus oral iron therapy for adults and children with chronic kidney disease. The anaemia seen in chronic kidney disease (CKD) may be exacerbated by iron deficiency. Iron can be provided through different routes, with advantages and drawbacks of each route. It remains unclear whether the potential harms and additional costs of intravenous (IV) compared with oral iron are justified. This is an update of a review first published in 2012.To determine the benefits and harms of IV iron (...) supplementation compared with oral iron for anaemia in adults and children with CKD, including participants on dialysis, with kidney transplants and CKD not requiring dialysis.We searched the Cochrane Kidney and Transplant Register of Studies up to 7 December 2018 through contact with the Information Specialist using search terms relevant to this review. Studies in the Register are identified through searches of CENTRAL, MEDLINE, and EMBASE, conference proceedings, the International Clinical Trials Register

2019 Cochrane

15. Canadian expert consensus: management of hypersensitivity reactions to intravenous iron in adults

Canadian expert consensus: management of hypersensitivity reactions to intravenous iron in adults Canadian expert consensus: management of hypersensitivity reactions to intravenous iron in adults - Lim - - Vox Sanguinis - Wiley Online Library The full text of this article hosted at iucr.org is unavailable due to technical difficulties.

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2019 CPG Infobase

16. Intravenous (IV) iron for severe iron deficiency

Intravenous (IV) iron for severe iron deficiency November - December 2015 97 © Tel.: 604 822•0700 Fax: 604 822•0701 E-mail: info@ti.ubc.ca www.ti.ubc.ca Mailing Address: Therapeutics Initiative The University of British Columbia Department of Anesthesiology, Pharmacology & Therapeutics 2176 Health Sciences Mall Vancouver, BC Canada V6T 1Z3 Intravenous (IV) iron for severe iron deficiency his Hb was 120 g/L and MCV 79 fL. Additional iron sucrose compensated for ongoing lower GI bleeding, and his (...) Hb peaked at 143 g/L with a ferritin of 89 mcg/L. Indications and Dosing Severe iron deficiency plus inability to tolerate or absorb oral iron is the main indication. In the face of ongoing blood loss or urgent surgery, IV iron corrects anemia much faster than oral iron. The bodies of well-nourished people contain about 4 - 5 grams of elemental iron, half circulating in red cells. The remainder is stored in the bone marrow, liver, and spleen. Adult patients with profound iron deficiency require

2016 Therapeutics Letter

17. Serum ferritin, soluble transferrin receptor, and total body iron for the detection of iron deficiency in early pregnancy: a multiethnic population-based study with low use of iron supplements. (PubMed)

Serum ferritin, soluble transferrin receptor, and total body iron for the detection of iron deficiency in early pregnancy: a multiethnic population-based study with low use of iron supplements. Which blood-based indicator best reflects the iron status in pregnant women is unclear. Better assessments of iron status in today's multiethnic populations are needed to optimize treatment and clinical recommendations.We aimed to determine the prevalence of anemia (hemoglobin <11.0 g/dL in first (...) and <10.5 g/dL in second trimester) and iron deficiency (ID) by the iron indicators serum ferritin <15 µg/L, serum soluble transferrin receptor (sTfR) >4.4 mg/L, and calculated total body iron <0 mg/kg, and their associations with ethnicity.This was a population-based cross-sectional study from primary antenatal care of 792 healthy women in early pregnancy in Oslo, Norway. We categorized the women into 6 ethnic groups: Western European, South Asian, Middle Eastern, Sub-Saharan African, East Asian

2019 American Journal of Clinical Nutrition

18. Consumption of Galacto-Oligosaccharides Increases Iron Absorption from Ferrous Fumarate: A Stable Iron Isotope Study in Iron-Depleted Young Women. (PubMed)

Consumption of Galacto-Oligosaccharides Increases Iron Absorption from Ferrous Fumarate: A Stable Iron Isotope Study in Iron-Depleted Young Women. Animal studies suggest prebiotics can increase iron absorption, but results from human studies are equivocal.In iron-depleted women, before (baseline) and after daily consumption of galacto-oligosaccharides (GOS) for 4 wk, we sought to assess fractional iron absorption (FIA) from an iron supplement given with and without single doses of GOS in test (...) meals or water.In all women (n = 34; median serum ferritin concentration = 16.4 µg/L), FIA from doses of 14 mg iron labeled with stable isotopes was measured in the following conditions at baseline: 1) FIA from ferrous fumarate (FeFum) in water given with and without 15 g GOS; 2) FIA from FeFum in a test meal given with and without 15 g GOS; 3) FIA from ferrous sulfate (FeSO4) in a test meal given without 15 g GOS. All subjects then consumed ∼15 g GOS daily for 4 wk. Then the following conditions

2019 Journal of Nutrition

19. Renal Iron Accelerates the Progression of Diabetic Nephropathy in HFE (High Fe-iron) Gene Knockout Mouse Model of Iron Overload. (PubMed)

Renal Iron Accelerates the Progression of Diabetic Nephropathy in HFE (High Fe-iron) Gene Knockout Mouse Model of Iron Overload. Diabetic Nephropathy (DN) is the most common cause of end-stage renal disease associated with high mortality worldwide. Increase in iron levels have been reported in the diabetic rat kidneys as well as in the human urine of diabetic patients. In addition, low iron diet or iron chelators delay DN progression in diabetic patients and in animal models of diabetes (...) . Possible maladaptive mechanisms of organ damage by tissue iron accumulation have not been well studied. We recently reported that iron induced retinal renin angiotensin system (RAS) and accelerated the progression of diabetic retinopathy. However, whether iron regulates systemic RAS is unknown. To explore if iron alters the expression of intra renal RAS and its role in the progression of DN, we used HFE (High Fe-iron) knockout mouse, a genetic model of systemic iron overload. We found that diabetes

2019 American Journal of Physiology. Renal physiology

20. A prospective, multicenter, randomized comparison of iron isomaltoside 1000 versus iron sucrose in patients with iron deficiency anemia (the FERWON-IDA trial). (PubMed)

A prospective, multicenter, randomized comparison of iron isomaltoside 1000 versus iron sucrose in patients with iron deficiency anemia (the FERWON-IDA trial). Iron deficiency anemia (IDA) is prevalent, and intravenous iron, especially if given in a single dose, may result in better adherence compared with oral iron. The present trial (FERWON-IDA) is part of the FERWON program with iron isomaltoside 1000/ferric derisomaltose (IIM), evaluating safety and efficacy of high dose IIM in IDA patients (...) of mixed etiologies. This was a randomized, open-label, comparative, multi-center trial conducted in the USA. The IDA patients were randomized 2:1 to a single dose of 1000 mg IIM, or iron sucrose (IS) administered as 200 mg intravenous injections, up to five times. The co-primary endpoints were adjudicated serious or severe hypersensitivity reactions, and change in hemoglobin from baseline to week eight. A total of 1512 patients were enrolled. The frequency of patients with serious or severe

2019 American journal of hematology Controlled trial quality: uncertain

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