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Intravenous Drug Abuse

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161. A mechanistic investigation of thrombotic microangiopathy associated with intravenous abuse of Opana ER. Full Text available with Trip Pro

A mechanistic investigation of thrombotic microangiopathy associated with intravenous abuse of Opana ER. Since 2012, a number of case reports have described the occurrence of thrombotic microangiopathy (TMA) following IV abuse of extended-release oxymorphone hydrochloride (Opana ER), an oral opioid for long-term treatment of chronic pain. Here, we present unique clinical features of 3 patients and investigate IV exposure to the tablet's inert ingredients as a possible causal mechanism. Guinea (...) inquisitive of IV drug abuse when presented with cases of TMA.

2016 Blood

162. Intravenous melatonin abuse leading to recurrent aortic valve endocarditis: a case report and discussion. Full Text available with Trip Pro

Intravenous melatonin abuse leading to recurrent aortic valve endocarditis: a case report and discussion. Reports of inappropriate medication use are widespread. There is a growing literature detailing abuse of drugs not typically thought to have high abuse liability. Melatonin is considered to be generally safe and is categorized by the Food and Drug Administration as a nutritional supplement. There are no known reports of intravenous melatonin abuse in the medical literature.The authors (...) report a case of a patient injecting melatonin with euphoric and then sedative effects leading to two episodes of infective endocarditis culminating in aortic valve replacement.Infective endocarditis continues to be a major potential complication of intravenous drug abuse. The proliferation of novel street drugs, resurgence in the use of older drugs and ongoing abuse of medications warrant continued research and vigilance in treating substance use disorders and attendant medical complications.

2016 BMC Psychiatry

163. Intravenous abuse potential study of oxycodone alone or in combination with naltrexone in nondependent recreational opioid users. (Abstract)

participants experienced adverse events after intravenous oxycodone (n = 27 [90%]) versus intravenous simulated crushed ALO-02 (n = 4 [12.5%]) or placebo (n = 2 [6.5%]).Intravenous administration of simulated crushed ALO-02 resulted in significantly lower abuse potential, as assessed by subjective ratings of drug liking and high, than intravenous oxycodone in nondependent, recreational opioid users. This suggests that injection of ALO-02 may not be as desirable to recreational opioid users compared (...) Intravenous abuse potential study of oxycodone alone or in combination with naltrexone in nondependent recreational opioid users. ALO-02, comprising pellets of extended-release oxycodone surrounding sequestered naltrexone, is intended to deter abuse.Determine the abuse potential of intravenous oxycodone combined with naltrexone, which represents simulated crushed ALO-02 in solution, compared with intravenous oxycodone in nondependent, recreational opioid users.A randomized, double-blind

2016 The American journal of drug and alcohol abuse Controlled trial quality: predicted high

164. Cost-effectiveness of integrating methadone maintenance and antiretroviral treatment for HIV-positive drug users in Vietnam's injection-driven HIV epidemics

) for patients with HIV or AIDS, who were drug users, in Vietnam. The authors concluded that providing methadone with ART was cost-effective. The study was poorly reported and the paper was not well written, and so there can be little confidence in the results and in the authors' conclusions. Type of economic evaluation Cost-utility analysis Study objective This study evaluated the cost-effectiveness of two strategies for adding methadone maintenance therapy to antiretroviral therapy (ART) for patients (...) were discounted at a 5% annual rate. Cost data: The costs included the drugs, personnel, management, laboratory tests, and site operation and maintenance. Site operation and maintenance costs were assumed to be identical for same-site and for separate-site therapy. The costs were from published Vietnamese sources and they were discounted at a 5% annual rate. The costs were converted from Vietnamese dong to US $ and inflated to 2009 prices. Analysis of uncertainty: The authors conducted

2013 NHS Economic Evaluation Database.

165. Prevention of Acute Nausea and Vomiting due to Antineoplastic Medication in Pediatric Cancer Patients

: Additional Literature Search: Dronabinol and Levomepromazine 142 Appendix E: Quality of Evidence and Strength of Recommendation 148 Appendix F: Tables of Included Studies 149 F.1 Summary of studies used to inform recommendation #2a 149 F.1a Highly emetogenic antineoplastic therapy as ranked by POGO Guideline for Classification of the Acute Emetogenic Potential of antineoplastic Medication in Pediatric Cancer Patients 5 Version date: February 28, 2013 F.1b Highly emetogenic antineoplastic therapy (...) as ranked by study investigators where insufficient information available to assign emetogenic risk using the POGO Guideline for Classification of the Acute Emetogenic Potential of antineoplastic Medication in Pediatric Cancer Patients F.2 Summary of studies used to inform recommendation #2b 154 F.2a Moderately emetogenic antineoplastic therapy as ranked by POGO Guideline for Classification of the Acute Emetogenic Potential of antineoplastic Medication in Pediatric Cancer Patients F.2b Moderately

2013 SickKids Supportive Care Guidelines

166. Polyvinylpyrrolidone induced artefactual prolongation of activated partial thromboplastin times in intravenous drug users with renal failure. Full Text available with Trip Pro

as underlying cause in patients with renal failure.Unexpectedly prolonged activated partial thromboplastin times (APTTs) were noted in several patients with chronic renal insufficiency and a history of intravenous drug abuse. Deposits of polyvinylpyrrolidone (PVP), an excipient in one oral methadone solution used in opioid maintenance programs, were found in renal biopsies. One case is described in detail, and this is followed by a summary of findings in 11 other patients and the results of an in vitro (...) in patients with chronic renal failure and a history of intravenous drug abuse.© 2016 International Society on Thrombosis and Haemostasis.

2016 Journal of Thrombosis and Haemostasis

167. Intravenous drug use is associated with alloimmunization in pregnancy. (Abstract)

Intravenous drug use is associated with alloimmunization in pregnancy. Anecdotal evidence has suggested an association of intravenous drug abuse with alloimmunization; however, published data are limited to case reports.The purpose of this study was to determine whether women with a history of intravenous drug abuse have an increased risk of alloimmunization.A retrospective cohort study was performed with the use of data from a single-center blood bank and perinatal database from 2008-2014 (...) . Blood bank data were used to identify women with alloimmunization, which was defined as a positive antibody screen in pregnancy not due to naturally occurring antibodies, agglutinins, autoantibodies, or Rh immunoglobulin administration. Intravenous drug abuse was ascertained from a comprehensive database that has captured all drug abuse in pregnancy since 2008. For women who contributed >1 pregnancy to the database, only the most recent pregnancy was included. The rates of alloimmunization among

2016 American Journal of Obstetrics and Gynecology

168. Cardiac surgery for infective endocarditis in patients with intravenous drug use Full Text available with Trip Pro

Cardiac surgery for infective endocarditis in patients with intravenous drug use Intravenous drug users have a high risk of infective endocarditis and reduced survival. Cardiac surgery may be recommended for these patients, but redo surgery is controversial. This study describes the characteristics and outcomes of intravenous drug users accepted for surgery during a 12-year period.This retrospective study included 29 injecting drug users treated with valve surgery for endocarditis between (...) January 2001 and December 2013 at a tertiary academic centre. Survival was assessed by Kaplan-Meier analysis.The median patient age was 36 (24-63) years and 27 patients (93%) were male. Staphylococcus aureus (52%) and Enterococcus faecalis (17%) were the most common microorganisms. Common illicit drugs were opioids (69%), amphetamines (52%) and benzodiazepines (24%). Mixed abuse was reported in 66% of patients. Seven patients (24%) had prior intracardial implants or native valve pathology. Twenty-five

2016 Interactive cardiovascular and thoracic surgery

169. Hemolytic Disease of the Fetus and Newborn due to Intravenous Drug Use Full Text available with Trip Pro

cell alloimmunization and significant hemolytic disease of the fetus and newborn, necessitating intrauterine transfusion, an indicated preterm birth, or neonatal therapy. Conclusions As opioid abuse continues to increase in the United States, clinicians should be aware of the potential for alloimmunization to red blood cell antibodies as yet another negative outcome from intravenous drug abuse. (...) Hemolytic Disease of the Fetus and Newborn due to Intravenous Drug Use Objectives The objective is to present a pregnancy complication associated with intravenous drug use, namely, that of red blood cell alloimmunization and hemolytic disease of the fetus and newborn. Methods An observational case series is presented including women with red blood cell alloimmunization most likely secondary to intravenous drug abuse Results Five pregnancies were identified that were complicated by red blood

2016 AJP Reports

170. Occupational therapy in neonatal services and early intervention

Therapists to produce its practice guidelines. Accreditation is valid for five years from January 2013 and is applicable to guidance produced using the processes described in the Practice guideline development manual 3rd edition (2017). More information on NICE accreditation can be viewed at www.nice.org.uk/accreditation. Contents iv Occupational therapy in neonatal services and early intervention 7.2 Organisational and fi nancial barriers 76 7.3 Implementation reso urces 78 8 Recommendations for future (...) of other children removed from home; criminal record; involvement with child protection; maternal isolation; homelessness; refugee status; substance abuse. 113 Royal College of Occupational Therapists 2017 Appendix 4: Examples of occupational therapy services in neonatal settings Table A3: Decision-making framework PSYCHOSOCIAL ENVIRONMENT AXIS 1. Adequate Environment 2. Moderate Risk Environment 3. High-Risk Environment INFANT BIOMEDICAL AXIS A Low Risk Advocates for and promotes appropriate

2017 Publication 1554

171. Cognitive?Behavioural Interventions for Children Who Have Been Sexually Abused: A Systematic Review Full Text available with Trip Pro

those of definition, mean that estimates of the incidence and prevalence of child sexual abuse vary considerably. Girls are more likely to be victims than boys, with estimates of prevalence rates ranging between 20% and 32% for females and between 4% and 8% for males ( ; ; ). Child sexual abuse refers not to a disease or medical condition but to an event, or series of events, in a child's life. Some children are victimised on a single occasion, but more often sexual abuse occurs over a period (...) sexual abuse is strongly associated with a wide range of psychiatric disorders. In an analysis of the UK Adult Psychiatric Morbidity Survey 2007, examined the association between sexual abuse in childhood (defined as younger than 16 years) and adulthood (16 or over) and six types of common mental disorder (depression, mixed anxiety/depression, generalised anxiety disorder, panic, phobia and obsessive compulsive disorder), dependence disorders (alcohol and drug misuse) and disorders established from

2012 Campbell Collaboration

172. Abuse and Misuse Potential of Pregabalin: A Review of the Clinical Evidence

effects were limited and did not continue with time or continued drug use in some clinical trials, and that withdrawal effects of pregabalin were less severe than those with substances currently controlled in Schedule IV, pregabalin was not categorized in Schedule IV in the USA. 7 Although Schedule V drugs are defined as having a low potential for abuse relative to the drugs in Schedule IV, abuse of Schedule V drugs may lead to limited physical dependence or psychological dependence. 3 The Swedish (...) activity in susceptible populations.” (p5) Schwan, 8 2010 Sweden 16 reports concerned PGB of 198 reports indicative of abuse or addiction to any drug IC = 3.99 (3.21-4.59) on the basis of the 16 reports Feelings of becoming “high”, “a nice benzodiazepine effect, an “amphetamine trip” with euphoria and hospitalization for detoxification reported 13 patients with history of past or current substance abuse and 2 patients selling their prescribed medication No case indicative of abuse or addiction

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

173. Steady State Bioequivalence Study of Torrent Pharmaceuticals Ltd's Bioequivalence Study of Torrent Pharmaceuticals Ltd's Quetiapine Tablets

of epilepsy or risk for seizures positive urine drug of abuse test at enrollment. A history of alcohol or drug dependence by Diagnostic and statistical manual of Mental disorders IV(DSM-IV) criteria during the 6 month period immediately prior to study entry. A total white blood cell count below 4000/ml, or absolute neutrophil count below 2000/ml Female patients with pregnancy or Breast feeding or intend to become pregnant during the study and not able to follow contraception methods. History of multiple (...) Intervention/treatment Phase Schizophrenia Drug: Torrent's Quetiapine Fumarate Tablets Phase 1 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Official Title: An Open-Label, Randomised, 2-Period, 2-Treatment, 2-sequence, Crossover, Steady State Bioequivalence Study of Quetiapine Fumarate 300 mg Tablets [Test Formulation; Torrent Pharmaceuticals Ltd., India] Versus Seroquel® 300 mg Tablet [Reference Formulation; AstraZeneca, USA] in Schizophrenic Patients

2012 Clinical Trials

174. Lifetime history of heroin use is associated with greater drug severity among prescription opioid abusers. Full Text available with Trip Pro

Lifetime history of heroin use is associated with greater drug severity among prescription opioid abusers. While research suggests primary prescription opioid (PO) abusers may exhibit less severe demographic and drug use characteristics than primary heroin abusers, less is known about whether a lifetime history of heroin use confers greater severity among PO abusers.In this secondary analysis, we examined demographic and drug use characteristics as a function of lifetime heroin use among 89 PO (...) ) was examined in the subset of H(+) and H(-) participants randomized to receive the 4-week taper condition (N=22).H(+) participants were significantly older and more likely to be male. They reported longer durations of illicit opioid use, greater alcohol-related problems, more past-month cocaine use, greater lifetime IV drug use, and greater lifetime use of cigarettes, amphetamines and hallucinogens. H(+) participants also had lower scores on the Positive Symptom Distress and Depression subscales

2014 Addictive behaviors Controlled trial quality: uncertain

175. Ruptured Mycotic Common Femoral Artery Pseudoaneurysm: Fatal Pulmonary Embolism after Emergency Stent-Grafting in a Drug Abuser Full Text available with Trip Pro

Ruptured Mycotic Common Femoral Artery Pseudoaneurysm: Fatal Pulmonary Embolism after Emergency Stent-Grafting in a Drug Abuser The rupture of a mycotic femoral artery pseudoaneurysm in an intravenous drug abuser is a limb- and life-threatening condition that necessitates emergency intervention. Emergency stent-grafting appears to be a viable, minimally invasive alternative, or a bridge, to subsequent open surgery. Caution is required in cases of suspected concomitant deep vein thrombosis (...) in order to minimize the possibility of massive pulmonary embolism during stent-grafting, perhaps by omitting stent-graft postdilation or by inserting an inferior vena cava filter first. We describe the emergency endovascular management, in a 60-year-old male intravenous drug abuser, of a ruptured mycotic femoral artery pseudoaneurysm, which was complicated by a fatal pulmonary embolism.

2014 Texas Heart Institute Journal

176. The Efficacy of Brief Motivational Interviewing for Trauma Patients Related to Alcohol or Other Abuse Drugs.

: No Criteria Inclusion Criteria: Trauma patients who have had: 1) A road crash, 2) A sport injury, 3) Occupational accident. Tested positive on alcohol and/or other abuse drugs tests. Exclusion Criteria: Cognitive or brain-damage that prevent assessment and Brief Motivational Interview Psychopathological disorders Residence status that prevents follow-up (residence outside of Spain, homeless). Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you (...) The Efficacy of Brief Motivational Interviewing for Trauma Patients Related to Alcohol or Other Abuse Drugs. The Efficacy of Brief Motivational Interviewing for Trauma Patients Related to Alcohol or Other Abuse Drugs. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2014 Clinical Trials

177. Nephropathy in Illicit Drug Abusers: A Postmortem Analysis. Full Text available with Trip Pro

and patterns of drug abuse.Histopathologic alterations of the kidney.Hematoxylin and eosin, periodic acid-Schiff, Sirius, and Congo Red stainings and immunoglobulin A immunohistochemistry of all cases; additional histochemical stainings or immunohistochemistry and electron microscopy in selected cases.Individuals were mostly white (99.2%), were male (82.2%), and had intravenous drug use (IVDU) (81.4%). Median age at death was 39 years and duration of drug abuse was 17 years. The majority (79.1%) took (...) Nephropathy in Illicit Drug Abusers: A Postmortem Analysis. Illicit drug abuse is an independent risk factor for chronic kidney disease, but the pathogenic consequences of long-term exposure to illicit drugs and contaminants under unsterile conditions remains unclear.Case series.All deceased persons (n 5 129) who underwent forensic autopsy because of suspected connection with illicit drug abuse between January 1, 2009, and April 30, 2011, in Frankfurt/Main, Germany.Clinical characteristics

2014 American Journal of Kidney Diseases

178. Effectiveness of a Brief Cognitive and Behavioral Skills Program on Stage Transitions for Chronic Ketamine Abusers

for cognitive behavioral skills training (CBST) or a time slot for education as usual (EAU), without being informed which was which. Primary Purpose: Treatment Official Title: Effectiveness of a Brief Cognitive and Behavioral Skills Program on Stage Transitions for Chronic Ketamine Abusers Actual Study Start Date : August 19, 2014 Actual Primary Completion Date : March 19, 2017 Actual Study Completion Date : March 19, 2017 Resource links provided by the National Library of Medicine available for: Arms (...) is to review what has been learned and reminds participants about the association of drug use with HIV/HCV. Behavioral: Cognitive behavioral skills training A brief cognitive behavioral skills training was applied to teach ketamine abusers about stimulus control, refusal skills, communication skills, decisional balance, and infectious diseases prevention. No Intervention: Education as usual The EAU group received six hours of informational lectures about ketamine, its effects on the brain, relevant

2018 Clinical Trials

179. The abuse-related effects of pyrrolidine-containing cathinones are related to their potency and selectivity to inhibit the dopamine transporter. Full Text available with Trip Pro

and α-PVP) are more effective reinforcers than prototypical stimulant drugs of abuse, such as cocaine or methamphetamine. Although the reinforcing potency of these cathinones is related to their potency to inhibit DAT, less is known about the pharmacological determinants of their unusually high reinforcing effectiveness. To this end, we tested the hypothesis that reinforcing effectiveness of cathinone stimulants is positively correlated with their selectivity for DAT relative to SERT. Uptake (...) inhibition assays in rat brain synaptosomes were used to directly compare the potency of MDPV, MDPBP, MDPPP, α-PVP, α-PPP, and cocaine at DAT, NET, and SERT, whereas intravenous self-administration in rats was used to quantify relative reinforcing effectiveness of the drugs using progressive ratio (PR) and behavioral economic procedures. All cathinones were more potent at DAT than NET or SERT, with a rank order for selectivity at DAT over SERT of α-PVP > α-PPP > MDPV > MDPBP > MDPPP > cocaine

2018 Neuropsychopharmacology

180. Macrophage-derived extracellular vesicles mediate smooth muscle hyperplasia: role of altered miRNA cargo in response to HIV infection and substance abuse Full Text available with Trip Pro

Macrophage-derived extracellular vesicles mediate smooth muscle hyperplasia: role of altered miRNA cargo in response to HIV infection and substance abuse Our previous studies consistently demonstrate enhanced pulmonary vascular remodeling in HIV-infected intravenous drug users, and in simian immunodeficiency virus-infected macaques or HIV-transgenic rats exposed to opioids or cocaine. Although we reported an associated increase in perivascular inflammation, the exact role of inflammatory cells (...) by delivery of its prosurvival miRNA cargo, which may play a crucial role in the development of PAH.-Sharma, H., Chinnappan, M., Agarwal, S., Dalvi, P., Gunewardena, S., O'Brien-Ladner, A., Dhillon, N. K. Macrophage-derived extracellular vesicles mediate smooth muscle hyperplasia: role of altered miRNA cargo in response to HIV infection and substance abuse.

2018 The FASEB Journal

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