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Intravenous Drug Abuse

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61. Effectiveness of alcohol and other drug interventions in at-risk Aboriginal youth

drug use OR cannabis smoking OR marijuana OR opioids OR opiates OR heroin OR methadone OR inhalant abuse OR gasoline OR petroleum OR petrol sniffing OR amphetamine OR methamphetamine OR stimulants OR psychoactive drugs OR hallucinogens OR designer drugs OR street drugs OR pharmaceutical drug misuse 4. intervention OR counselling OR prevention OR treatment OR support OR therapy OR health care access OR referral OR program* OR policy OR policies OR social services OR family health OR rehabilitation (...) Shakeshaft. 2 1. Centre for Indigenous Health Equity Research, School of Health, Medical & Applied Sciences, Central Queensland University 2. National Drug and Alcohol Research Centre, University of New South Wales June 2017 © Sax Institute 2017 This work is copyright. It may be reproduced in whole or in part for study training purposes subject to the inclusions of an acknowledgement of the source. It may not be reproduced for commercial usage or sale. Reproduction for purposes other than those indicated

2018 Sax Institute Evidence Check

62. Alcohol and other drugs prevention in vulnerable young people

* OR Lesbi* OR Queer OR Crime victims OR Drug users OR Drug abusers OR Drug addicts OR Risk factors OR Trauma and stressor related Disorders OR Trauma OR Substance-related disorders OR Disabled persons OR Rural Population OR Remote OR Offender OR crime OR Possession OR Delinquen* 3. 1 AND 2 4. Prevent* OR Interven* OR Primary prevention OR Secondary prevention OR “early intervention” OR “brief intervention” OR “Cognitive therapy” OR Cognitive Behavioral therapy OR Family OR emotional regulation impulse (...) OR "psycho stimulant" OR "illicit drug" OR "volatile drug" OR Polydrug OR Heroin OR Opioids OR Opiates OR Methadone OR Stimulants OR Hallucinogens OR Street drugs OR Designer drugs OR Pharmaceutical drug misuse OR polysubstance OR Cocaine OR Ice OR “new psychoactive substances” 9. Reduc* OR Dela OR Ceas* OR Disorder OR Abuse OR Misuse OR Stop* OR Recidiv* OR reoffend* 10. 8 AND 9 11. Canada OR Australia OR New Zealand OR United States OR United Kingdom 12. 3 AND 6 AND 7 AND 10 AND 11 11 ALCOHOL AND OTHER

2018 Sax Institute Evidence Check

63. The Patient Centred Medical Home: barriers and enablers to implementation

The Patient Centred Medical Home: barriers and enablers to implementation The Patient Centred Medical Home: barriers and enablers to implementation An Evidence Check rapid review brokered by the Sax Institute for COORDINARE. January 2018 An Evidence Check rapid review brokered by the Sax Institute for COORDINARE. January 2018. This report was prepared by: Jim Pearse and Deniza Mazevska – Health Policy Analysis Pty Ltd. January 2018 © Sax Institute 2018 This work is copyright. It may (...) : Pearse J, Mazevska D. The Patient Centered Medical Home: barriers and enablers: an Evidence Check rapid review brokered by the Sax Institute (www.saxinstitute.org.au) for COORDINARE, 2018. Disclaimer: This Evidence Check Review was produced using the Evidence Check methodology in response to specific questions from the commissioning agency. It is not necessarily a comprehensive review of all literature relating to the topic area. It was current at the time of production (but not necessarily

2018 Sax Institute Evidence Check

64. Depression as a moderator of STAIR Narrative Therapy for women with post-traumatic stress disorder related to childhood abuse (Full text)

Therapy, as compared to two control conditions where one component (STAIR or Narrative Therapy) was replaced with Supportive Counseling. Method: Participants were 104 women with PTSD related to childhood abuse. Participants were randomized into three conditions: (1) STAIR plus Narrative Therapy (SNT), (2) STAIR plus Supportive Counseling (SSC), and (3) Supportive Counseling plus Narrative Therapy (SCNT). Clinician-Administered PTSD Scale for DSM-IV (CAPS-IV) PTSD symptom severity was assessed at pre (...) Depression as a moderator of STAIR Narrative Therapy for women with post-traumatic stress disorder related to childhood abuse Background: Depression among those who have experienced childhood abuse is associated with earlier onset, more persistent and severe symptoms, more frequent relapse, and poorer treatment outcomes across a variety of psychiatric disorders. In addition, individuals with a history of childhood abuse are more likely to develop post-traumatic stress disorder (PTSD) co

2017 European Journal of Psychotraumatology Controlled trial quality: uncertain PubMed abstract

65. Trauma-related emotions and radical acceptance in dialectical behavior therapy for posttraumatic stress disorder after childhood sexual abuse (Full text)

Trauma-related emotions and radical acceptance in dialectical behavior therapy for posttraumatic stress disorder after childhood sexual abuse Posttraumatic Stress Disorder (PTSD) related to childhood sexual abuse (CSA) is often associated with a wide range of trauma-related aversive emotions such as fear, disgust, sadness, shame, guilt, and anger. Intense experience of aversive emotions in particular has been linked to higher psychopathology in trauma survivors. Most established psychosocial (...) to the Clinician Administered PTSD-Scale (CAPS) for the DSM-IV was associated with changes in trauma-related emotions and acceptance. The data was collected within a randomized controlled trial testing the efficacy of DBT-PTSD, and a subsample of 23 women was included in this secondary data analysis.In a multilevel model, shame, guilt, disgust, distress, and fear decreased significantly from the start to the end of the therapy whereas radical acceptance increased. Therapy response measured with the CAPS

2017 Borderline personality disorder and emotion dysregulation Controlled trial quality: uncertain PubMed abstract

66. Is There a Potential of Misuse for Quetiapine?: Literature Review and Analysis of the European Medicines Agency/European Medicines Agency Adverse Drug Reactions' Database. (Full text)

Is There a Potential of Misuse for Quetiapine?: Literature Review and Analysis of the European Medicines Agency/European Medicines Agency Adverse Drug Reactions' Database. A recent years' increase in both prescribing and availability of second-generation antipsychotics (SGAs) has been observed. According to the literature, typically made up by case studies/series, quetiapine seems to be the most commonly misused SGA, with both intranasal and intravenous intake modalities having been described (...) . Another SGA that has been anecdotally reported to be misused is olanzapine. For these molecules, both a previous history of drug misuse and being an inmate have been described as factors associated with misuse. Hence, while providing here an updated literature review of the topic, we aimed at assessing all cases of quetiapine misuse/abuse/dependence/withdrawal as reported to the European Medicines Agency's EudraVigilance (EV) database; this was carried out in comparison with the reference drug

2017 Journal of Clinical Psychopharmacology PubMed abstract

67. Putting risk compensation to rest: Reframing the relationship between risk behavior and antiretroviral therapy among injection drug users (Full text)

Canadian Institutes of Health Research Canada R01-DA021525 DA NIDA NIH HHS United States Editorial Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Comment England AIDS 8710219 0269-9370 IM X AIDS. 2012 Nov 28;26(18):2383-91 23079804 Antiretroviral Therapy, Highly Active Female HIV Infections drug therapy Humans Male Medication Adherence statistics & numerical data Needle Sharing statistics & numerical data Risk-Taking Substance Abuse, Intravenous epidemiology Unsafe Sex statistics (...) Putting risk compensation to rest: Reframing the relationship between risk behavior and antiretroviral therapy among injection drug users 23151496 2013 06 03 2018 12 02 1473-5571 26 18 2012 Nov 28 AIDS (London, England) AIDS Putting risk compensation to rest: reframing the relationship between risk behavior and antiretroviral therapy among injection drug users. 2405-7 10.1097/QAD.0b013e3283519b42 Marshall Brandon D L BD Wood Evan E eng R01 DA021525 DA NIDA NIH HHS United States MOP-79297

2012 AIDS (London, England) PubMed abstract

68. Disease-Modifying Antirheumatic Drugs Cycle Combination Therapy Research

-Modifying Antirheumatic Drugs Cycle Combination Therapy Research (DCCT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01617590 Recruitment Status : Unknown Verified June 2012 by Li Xiaofeng, Shanxi Medical University. Recruitment status was: Recruiting First Posted : June 12, 2012 Last Update Posted (...) Disease-Modifying Antirheumatic Drugs Cycle Combination Therapy Research Disease-Modifying Antirheumatic Drugs Cycle Combination Therapy Research - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Disease

2012 Clinical Trials

69. Controlled drugs in peri-operative care

PILs and SPCs for different medicines. https://www.gov.uk/pil-spc 17. Association of Anaesthetists. Injectable drug labelling & packaging. (in press) 18. Association of Anaesthetists and Society of Intravenous Regional Anaesthesia. Safe practice of total intravenous anaesthesia (TIVA) 2018 https://onlinelibrary.wiley.com/doi/full/10.1111/anae.14428 19. DuPont RL, McLellan AT, White WL, Merlo LJ, Gold MS. Setting the standard for recovery: Physicians’ Health Programs. Journal of Substance Abuse (...) /competency/safe use of controlled drugs by theatre staff. • Medication Safety Officer/Medical Device Safety Officer o The CQC checks whether there is a medication safety officer appointed to link with the theatre team and the CDAO/pharmacy team around safe use of medicines and devices. • Implementation of relevant legislation and guidance o Whether the organisation’s controlled drugs policy takes account of relevant legislation, alerts and national guidance.7 Association of Anaesthetists | Controlled

2019 Association of Anaesthetists of GB and Ireland

70. American Gastroenterological Association Institute Guideline on the Medical Management of Opioid-Induced Constipation (Full text)

practices and monitoring during treatment is outlined in a recent guideline from the US Centers for Disease Control and Prevention. x 17 Dowell, D., Haegerich, T.M., and Chou, R. CDC guideline for prescribing opioids for chronic pain—United States, 2016. MMWR Recomm Rep . 2016 ; 65 : 1–49 | | | Patients on chronic opioid therapy must have a clear understanding of the risks of long-term opioid treatment, which include death due to drug misuse and abuse. x 18 Seth, P., Scholl, L., Rudd, R.A. et al (...) ., Dorn, S.D. et al. American Gastroenterological Association medical position statement on constipation. Gastroenterology . 2013 ; 144 : 211–217 | | | | | Once a diagnosis of OIC has been confirmed and other potential causes of constipation are excluded, the recommendations here can help guide appropriate evidence-based management. This guideline focuses on the medical management of OIC. Therefore, it does not address the role of psychological therapy, alternative medicine approaches, surgery

2019 American Gastroenterological Association Institute PubMed abstract

71. Pharmaceutical Treatment of Fatigue After Aneurysmal Subarachnoid Hemorrhage

of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Arm A OSU6162, drug given to half of the patients after randomization Drug: OSU 6162 All patients will receive a dose of OSU6162 15 mg BID x 2 per day. The expected duration of therapy is 12 weeks. After 1 week of treatment, patients who do not respond to treatment will have their dose increased to maximum 30 mg BID x 2 per day. Other Name: PNU-9639 Placebo Comparator: Arm B Placebo oral tablet, drug given (...) to halv of the patients after randomization Drug: Placebo Oral Tablet All patients will receive a dose of placebo 15 mg BID x 2 per day. The expected duration of therapy is 12 weeks. After 1 week of treatment, patients who do not respond to treatment will have their dose increased to maximum 30 mg BID x 2 per day. Outcome Measures Go to Primary Outcome Measures : Change in Fatigue Severity Scale over time [ Time Frame: Baseline, week 1, 4 12, and 20. ] FSS - change Secondary Outcome Measures : Beck

2017 Clinical Trials

72. 12?step programs for reducing illicit drug use (Full text)

the link below to share a full-text version of this article with your friends and colleagues. Copy URL Share a link Share on 1 The terms use, misuse, abuse and dependence will be used interchangeably throughout the review and refer to an addiction stage of drug usage. remains a severe problem worldwide (United Nations Office on Drugs and Crime, UNODC, 2010). A central issue in reducing the worldwide drug problem is the demand for illicit drugs, and hence the need to identify effective methods (...) and economic costs of illicit drug use motivate the strong political interest in treatment for illicit drug use and in identifying effective treatments. The main types of treatment are cognitive‐behavioural therapies, motivational enhancement, contingency management, psychoanalysis, network therapy and – the object of this review –12‐step programs (Galanter & Kleber, 2008). 1.2 DESCRIPTION OF THE INTERVENTION 12‐step approaches to the treatment of drug use are widespread in many countries. The oldest

2017 Campbell Collaboration PubMed abstract

73. QTc Prolongation and Psychotropic Medications

-related QTc interval prolongation is an important consideration, so medications administered intravenously that achieve higher plasma concentrations more rapidly, may increase this risk compared with oral administration. Presence of hepatic cirrhosis and/or renal insufficiency will add to the QTc interval prolonging effect of the drug by impairing its metabolism and/or excretion, resulting in higher than usual (or toxic) drug plasma concentrations. In states of mild insufficiency, the effect may (...) General Hospital, Boston, MA; 3 Harvard Medical School, Boston, MA; 4 Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI; 5 Mount Pearl, Newfoundland, Canada; 6 Department of Psychiatry, Virginia Commonwealth University, Richmond, VA; 7 Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, IL; 8 Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI; 9 Krannert Institute of Cardiology

2018 American Psychiatric Association

74. Association of Cohort and Individual Substance Use With Risk of Transitioning to Drug Use, Drug Use Disorder, and Remission From Disorder: Findings From the World Mental Health Surveys. (Full text)

with onset and transitions across stages of drug use, abuse, dependence, and remission.The World Health Organization World Mental Health Surveys carried out cross-sectional general population surveys in 25 countries using a consistent research protocol and assessment instrument. Adults from representative household samples were interviewed face-to-face in the community in relation to drug use disorders. The surveys were conducted between 2001 and 2015. Data analysis was performed from July 2017 to July (...) 2018.Data on timing of onset of lifetime drug use, DSM-IV drug use disorders, and remission from these disorders was assessed using the Composite International Diagnostic Interview. Associations of cohort-level alcohol prevalence and drug use prevalence were examined as factors associated with these transitions.Among the 90 027 respondents (48.1% [SE, 0.2%] men; mean [SE] age, 42.1 [0.1] years), 1 in 4 (24.8% [SE, 0.2%]) reported either illicit drug use or extramedical use of prescription drugs

2019 JAMA psychiatry (Chicago, Ill.) PubMed abstract

75. Thrombotic Microangiopathy Secondary to Intravenous Abuse of Opana® ER (Full text)

Thrombotic Microangiopathy Secondary to Intravenous Abuse of Opana® ER Opana ER (oxymorphone) is an opioid drug available throughout the United States, and intravenous abuse of the crushed oral formulation has been associated with drug-induced thrombotic microangiopathy. In this abstract, we describe two young patients who lived together and used Opana ER intravenously. Both presented with microangiopathic hemolytic anemia that mimicked thrombotic thrombocytopenic purpura (TTP). Treating (...) this condition poses a clinical challenge, as it is difficult to distinguish it from TTP. The role for plasma exchange is not clear but can be used while awaiting the results of the ADAMTS-13 activity, but ultimately supportive care with drug discontinuation is the recommended therapy of choice. Patients should be counseled against Opana ER's intravenous use, and users should be offered drug rehabilitation therapy.

2017 Case reports in hematology PubMed abstract

76. Cognitive behavioural therapy for men who physically abuse their female partner (Full text)

Cognitive behavioural therapy for men who physically abuse their female partner Cognitive behavioural therapy for men who physically abuse their female partner - Smedslund - 2011 - Campbell Systematic Reviews - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term UPDATED SYSTEMATIC REVIEW Open Access Cognitive behavioural therapy for men who physically abuse their female partner Corresponding Author E (...) interventions: a 12‐week substance abuse and domestic violence group (grounded in CBT) (N = 32) or a 12‐week twelve‐step facilitation group (N = 32). Data were collected using the SCID (Structured Clinical Interview for DSM‐IV‐TR), Addiction Severity Index, Substance Abuse Calendar, Conflict Tactics Scale Revised, breath samples, urine toxicology screens, and collateral reports from female partners at baseline, monthly, and post‐treatment periods. Risk of bias in included studies San Diego Navy 2000

2011 Campbell Collaboration PubMed abstract

77. A Phase IV Study in Drug-Naive Patients With T2DM in China

Controlled Phase IV Study to Assess the Efficacy and Safety of Dapagliflozin as Monotherapy Compared With Acarbose in Drug-Naive Patients With Type 2 Diabetes Mellitus (T2DM) in China Actual Study Start Date : December 15, 2017 Estimated Primary Completion Date : August 31, 2020 Estimated Study Completion Date : August 31, 2020 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Dapagliflozin (...) A Phase IV Study in Drug-Naive Patients With T2DM in China A Phase IV Study in Drug-Naive Patients With T2DM in China - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Phase IV Study in Drug-Naive Patients

2017 Clinical Trials

78. A Study to Evaluate the Safety and Efficacy of Ex Vivo Expanded Autologous Immune Killer Cells (IKC) in Stage IV Non-small Cell Lung Cancer (NSCLC) in Patients Who Failed Chemotherapy or Target Therapy

A Study to Evaluate the Safety and Efficacy of Ex Vivo Expanded Autologous Immune Killer Cells (IKC) in Stage IV Non-small Cell Lung Cancer (NSCLC) in Patients Who Failed Chemotherapy or Target Therapy A Study to Evaluate the Safety and Efficacy of Ex Vivo Expanded Autologous Immune Killer Cells (IKC) in Stage IV Non-small Cell Lung Cancer (NSCLC) in Patients Who Failed Chemotherapy or Target Therapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer (...) to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study to Evaluate the Safety and Efficacy of Ex Vivo Expanded Autologous Immune Killer Cells (IKC) in Stage IV Non-small Cell Lung Cancer (NSCLC) in Patients Who Failed Chemotherapy or Target Therapy (IVY03) The safety and scientific validity of this study

2018 Clinical Trials

79. A Study of Intraperitoneal and Intravenous Paclitaxel Plus Apatinib and S-1 Conversion Therapy for Gastric Cancer With Positive Exfoliative Cancer Cells

of intraperitoneal and intravenous paclitaxel plus apatinib and S-1 in the conversion therapy of gastric cancer with positive exfoliative cancer cells Condition or disease Intervention/treatment Phase Gastric Cancer With Positive Exfoliative Cancer Cells Drug: apatinib Drug: paclitaxel Drug: S-1 Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 36 participants Intervention Model: Single Group Assignment Masking: None (Open Label (...) ) Primary Purpose: Treatment Official Title: A Study of Intraperitoneal and Intravenous Paclitaxel Plus Apatinib and S-1 Conversion Therapy for Gastric Cancer With Positive Exfoliative Cancer Cells Estimated Study Start Date : October 30, 2018 Estimated Primary Completion Date : October 30, 2019 Estimated Study Completion Date : October 30, 2020 Resource links provided by the National Library of Medicine related topics: available for: resources: Arms and Interventions Go to Arm Intervention/treatment

2018 Clinical Trials

80. Rucaparib and Pembrolizumab for Maintenance Therapy in Stage IV Non-Squamous Non-Small Cell Lung Cancer

pembrolizumab as maintenance therapy in patients with stage IV non-squamous non-small cell lung cancer (NSCLC) without progressive disease (PD), as confirmed on CT scans, after induction therapy with carboplatin/pemetrexed/pembrolizumab (CPP) triplet therapy. Condition or disease Intervention/treatment Phase Stage IV Non-small Cell Lung Cancer Drug: Pembrolizumab Drug: Pemetrexed Drug: Carboplatin Drug: Rucaparib Phase 1 Phase 2 Study Design Go to Layout table for study information Study Type (...) : July 2027 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Rucaparib and Pembrolizumab Maintenance All patients will receive induction therapy with Pembrolizumab (200mg IV on day 1 of every 21 days), Pemetrexed (500mg/m^2 IV on day 1 of every 21 days), and Carboplatin (AUC5 IV on day 1 of every 21 days). This will be followed by maintenance therapy with Pembrolizumab

2018 Clinical Trials

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