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Intravenous Drug Abuse

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41. Hemolytic Disease of the Fetus and Newborn due to Intravenous Drug Use (PubMed)

Hemolytic Disease of the Fetus and Newborn due to Intravenous Drug Use Objectives The objective is to present a pregnancy complication associated with intravenous drug use, namely, that of red blood cell alloimmunization and hemolytic disease of the fetus and newborn. Methods An observational case series is presented including women with red blood cell alloimmunization most likely secondary to intravenous drug abuse Results Five pregnancies were identified that were complicated by red blood (...) cell alloimmunization and significant hemolytic disease of the fetus and newborn, necessitating intrauterine transfusion, an indicated preterm birth, or neonatal therapy. Conclusions As opioid abuse continues to increase in the United States, clinicians should be aware of the potential for alloimmunization to red blood cell antibodies as yet another negative outcome from intravenous drug abuse.

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2016 AJP Reports

42. Cardiac surgery for infective endocarditis in patients with intravenous drug use (PubMed)

Cardiac surgery for infective endocarditis in patients with intravenous drug use Intravenous drug users have a high risk of infective endocarditis and reduced survival. Cardiac surgery may be recommended for these patients, but redo surgery is controversial. This study describes the characteristics and outcomes of intravenous drug users accepted for surgery during a 12-year period.This retrospective study included 29 injecting drug users treated with valve surgery for endocarditis between (...) January 2001 and December 2013 at a tertiary academic centre. Survival was assessed by Kaplan-Meier analysis.The median patient age was 36 (24-63) years and 27 patients (93%) were male. Staphylococcus aureus (52%) and Enterococcus faecalis (17%) were the most common microorganisms. Common illicit drugs were opioids (69%), amphetamines (52%) and benzodiazepines (24%). Mixed abuse was reported in 66% of patients. Seven patients (24%) had prior intracardial implants or native valve pathology. Twenty-five

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2016 Interactive cardiovascular and thoracic surgery

43. Sexualized drug use (chemsex and methamphetamine) and men who have sex with men

to develop anhedonia, which is the inability to feel pleasure (42). A synthetic drug, methamphetamine can be manufactured using a variety of starting materials and methods (42), such as inexpensive over-the-counter medications (46). The final product can be purchased as tablets, rock-like chunks (48), or as a powder that can be easily dissolved in water or alcohol (46); hence, it can be administered through oral, nasal, or intravenous routes (47). After smoking or injecting the substance into a vein (...) ? 2018. Available from: Accessed April 12, 2019. The University of Queensland. What are neurotransmitters? 2017. Available from: Accessed on April 12, 2019. National Drug Institute on Drug Abuse for Teens. Mind over matter: The brain’s response to methamphetamine. 2019. Available from: Accessed April 11, 2019. National Institute on Drug Abuse. Research report series: Methamphetamine. 2013. Available from: Accessed April 11, 2019. Centre for Addiction and Mental Health. Methamphetamines. 2012

2019 Ontario HIV Treatment Network

44. Cotton Fever: An Evanescent Process Mimicking Sepsis in an Intravenous Drug Abuser. (PubMed)

Cotton Fever: An Evanescent Process Mimicking Sepsis in an Intravenous Drug Abuser. Although many complications of intravenous drug abuse are well described, "cotton fever" has had little mention in recent medical literature. Cotton fever is street terminology for the post-injection fever experienced by many drug users after "shooting up" with heroin reclaimed from a previously used cotton filter.We report on a 22-year-old man with a history of intravenous drug abuse with fever 30 min after

2013 Journal of Emergency Medicine

45. Intravenous Doxorubicin Nanoparticles for Advanced Hepatocellular Carcinoma

as these outputs are produced as required for our stakeholders. > > > Intravenous Doxorubicin Nanoparticles for Advanced Hepatocellular Carcinoma Intravenous Doxorubicin Nanoparticles for Advanced Hepatocellular Carcinoma July 2017 Doxorubicin Nanoparticles are an injectable drug made up of microscopic polymer based spheres containing the drug doxorubicin. Doxorubicin, a chemotherapy drug used to treat many types of cancer, slows or stops the growth of cancer cells by blocking an enzyme called topoisomerase (...) and Oral Health and Maxillo-facial Surgery Ear Nose and Throat Emergency Care Endocrine Nutritional and Metabolic Eye Disease Gastrointestinal Pancreatic and Liver Disease Gynaecology Womens Sexual Health and Benign Breast Disease Haematology and Blood Products Health Promotion and Protection including Screening Immunology and Allergy Infectious Disease and Immunisation Mens Health and Sexual Health Mental Health Drug Abuse and Learning Difficulties Musculoskeletal Neurology and Neurosurgery Other

2017 NIHR Innovation Observatory

46. Effectiveness of alcohol and other drug interventions in at-risk Aboriginal youth

(and their corresponding subject headings in each database where specialised thesauri existed): 1. Indigenous OR Aborigin* OR “Torres Strait Island”* OR Inuit OR Maori OR “First Nation”* OR Metis OR “Native American”* OR “American Indian”* OR “Native Hawaiian” 2. adolescen* OR youth* OR young people OR young adult* OR child* OR teenage* OR juvenile* 3. alcohol or alcohol drinking OR tobacco OR tobacco smoking OR nicotine OR illicit drugs OR substance abuse OR substance misuse OR drug abuse OR polydrug use OR injecting (...) drug use OR cannabis smoking OR marijuana OR opioids OR opiates OR heroin OR methadone OR inhalant abuse OR gasoline OR petroleum OR petrol sniffing OR amphetamine OR methamphetamine OR stimulants OR psychoactive drugs OR hallucinogens OR designer drugs OR street drugs OR pharmaceutical drug misuse 4. intervention OR counselling OR prevention OR treatment OR support OR therapy OR health care access OR referral OR program* OR policy OR policies OR social services OR family health OR rehabilitation

2018 Sax Institute Evidence Check

47. Controlled drugs in peri-operative care

PILs and SPCs for different medicines. https://www.gov.uk/pil-spc 17. Association of Anaesthetists. Injectable drug labelling & packaging. (in press) 18. Association of Anaesthetists and Society of Intravenous Regional Anaesthesia. Safe practice of total intravenous anaesthesia (TIVA) 2018 https://onlinelibrary.wiley.com/doi/full/10.1111/anae.14428 19. DuPont RL, McLellan AT, White WL, Merlo LJ, Gold MS. Setting the standard for recovery: Physicians’ Health Programs. Journal of Substance Abuse (...) in anaesthesia by intravenous infusions [18]; both under review at the time of writing). For infusions that will not leave the theatre complex: • Medicine and base fluid; • Concentration. For infusions set up in the theatre complex and to be continued on a ward: • Medicine and base fluid; • Concentration; • Patient’s name; • Date and time of preparation; • Initials of person preparing the infusion. Disposal of part-used infusions Controlled drugs that are used in theatre only should be disposed of in theatre

2019 Association of Anaesthetists of GB and Ireland

48. Perinatal Drug Abuse and Neonatal Drug Withdrawal (Treatment)

Perinatal Drug Abuse and Neonatal Drug Withdrawal (Treatment) Perinatal Drug Abuse and Neonatal Drug Withdrawal Treatment & Management: Medical Care, Consultations, Diet Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTc4NDkyLXRyZWF0bWVudA== processing > Perinatal Drug Abuse and Neonatal Drug Withdrawal Treatment & Management Updated: Jan 29, 2014 Author: Marvin Wang, MD; Chief Editor: Ted Rosenkrantz, MD Share Email Print Feedback Close Sections Sections Perinatal Drug Abuse and Neonatal Drug Withdrawal Treatment Medical Care Perhaps the most important aspect of medical care for the potentially withdrawing infant should be that all nurseries caring for such infants develop a care protocol addressing screening and treatment

2014 eMedicine Pediatrics

49. First report of endocarditis by Gluconobacter spp. in a patient with a history of intravenous-drug abuse. (PubMed)

First report of endocarditis by Gluconobacter spp. in a patient with a history of intravenous-drug abuse. Gluconobacter belongs to the acetic acid bacteria (AAB), which are microorganisms commonly found in the environment and used in the food industry. These bacteria have increasingly been reported as organisms that can potentially infect humans. We report a case of Gluconobacter spp. bloodstream infection associated with endocardial lesions in a 25 year-old female intravenous drug abuser

2012 Journal of Infection

50. 12-step programs for reducing illicit drug use

| www.campbellcollaboration.org Plain language summary 12-step programs for reducing illicit drug use are neither better nor worse than other interventions Illicit drug abuse has serious and far-reaching implications for the abuser, their family members, friends, and society as a whole. Preferred intervention programs are those that effectively reduce illicit drug use and its negative consequences, and are cost-effective as well. Current evidence shows that overall, 12-step programs are just as effective as alternative (...) , psychosocial interventions. The costs of programs are, therefore, an important consideration. However, the strength of the studies is weak and further evidence regarding the effectiveness of 12-step programs is needed. What did the review study? Illicit drug abuse is a globally recognised problem leading to high human, social and economic costs. The 12-step program, modelled on the approach of Alcoholics Anonymous and adopted by Narcotics Anonymous and others, aims for complete abstinence. The 12-step

2017 Campbell Collaboration

51. Substance Abuse in Canada: The Effects of Cannabis Use during Adolescence (Report)

Table of Contents The Effects of Cannabis Use during Adolescence1 Canadian Centre on Substance Abuse SUBSTANCE ABUSE IN CANADA—The Effects of Cannabis Use during Adolescence For over 25 years, the Canadian Centre on Substance Abuse (CCSA) has provided national leadership to advance solutions that will reduce the harms of alcohol and drugs on individuals and their families. Part of our unique role involves bringing people and knowledge together to effect changes in policy, practice and programs (...) developmental years can lead to or protect against later-life substance use disorders and concurrent mental and physical health problems. The 2014 SAIC report highlighted important questions about the connection of mental health issues, environmental factors and substance abuse in younger children and adolescents. As we are all aware, adolescence is a time of significant development and change. It is also the period when substance use most commonly begins. In Canada, the drug of choice for young people

2015 Canadian Centre on Substance Abuse

52. Thrombotic Microangiopathy and Acute Kidney Injury Associated With Intravenous Abuse of an Oral Extended-Release Formulation of Oxymorphone Hydrochloride: Kidney Biopsy Findings and Report of 3 Cases. (PubMed)

-resistant reformulation. However, instances of melting and dissolving tablets with subsequent injection continue to occur. We report 3 cases of hemolytic anemia and acute kidney injury associated with intravenous abuse of this reformulated drug. All 3 patients underwent native kidney biopsy that showed thrombotic microangiopathy characterized by severe arterial and arteriolar mucoid intimal edema with resultant glomerular and tubular ischemia. All 3 patients required hemodialysis and 2 also underwent (...) Thrombotic Microangiopathy and Acute Kidney Injury Associated With Intravenous Abuse of an Oral Extended-Release Formulation of Oxymorphone Hydrochloride: Kidney Biopsy Findings and Report of 3 Cases. There have been recent reports and warnings of a thrombotic thrombocytopenic purpura-like illness associated with intravenous abuse of a prescription narcotic intended for oral use. Oral extended-release oxymorphone hydrochloride (Opana ER) is an opioid agonist that has undergone a tamper

2014 American Journal of Kidney Diseases

53. Abusive Head Trauma and the Eye in Infancy

Abusive Head Trauma and the Eye in Infancy 1 The Royal College of Paediatrics and Child Health and The Royal College of Ophthalmologists Abusive Head Trauma and the Eye in Infancy June 2013 Scientific Department The Royal College of Ophthalmologists 17 Cornwall Terrace Regent’s Park London NW1 4QW Telephone: 020 7935 0702 Facsimile: 020 7487 4674 www.rcophth.ac.uk © The Royal College of Ophthalmologists 2013 All rights reserved For permission to reproduce any of the content contained herein (...) please contact events@rcophth.ac.uk 2 Executive Summary A child suspected of abusive head injury is referred by paediatricians to an ophthalmologist for evaluation. The incidence of abusive head injury in children is highest in infancy and less frequently seen in children over 3 years of age. Retinal haemorrhages have a high positive predictive rate for abusive head injury. In the presence of head injury without any plausible medical explanation the description of the retinal findings help

2013 Royal College of Ophthalmologists

54. Using Clinical Laboratory Tests to Monitor Drug Therapy in Pain Management Patients

of Pathology and Laboratory Medicine University of North Carolina School of Medicine Chapel Hill, NC Marilyn A. Huestis National Institute on Drug Abuse Baltimore, MD Cheryl A. Kassed American Association for Clinical Chemistry Washington, DC Tim J. Lamer Department of Anesthesiology Mayo Clinic Rochester, MN Gwendolyn A. McMillin Department of Pathology University of Utah Salt Lake City, UT Stacy E. Melanson Department of Pathology Brigham and Women’s Hospital Boston, MA The AACC Academy Presents (...) prominently at the front of the document: Reproduced (translated) with permission of AACC, Washington, DC. This document (PID 11774) was approved by the AACC Board of Directors in November 2017.LABORATORY MEDICINE PRACTICE GUIDELINES Executive Summary 5 Preamble 34 Introduction 38 Chapter 1: Testing for common classes of relevant over-the-counter, prescribed, and non-prescribed drugs and illicit substances abused by pain management patients 47 Chapter 2: Specimen types and detection times 52 Chapter 3

2018 American Academy of Pain Medicine

55. A Prenatal Mentalization-focused 4D Ultrasound and a Pregnancy Diary Intervention for Substance-abusing Women

abuse documented in the hospital medical records (intoxications, urine screening results, marks indicating intravenous substance abuse): The more findings, the worse the outcome. Prenatal anxiety symptoms post-intervention at 35 gestational weeks [ Time Frame: Post-intervention at 35 gestational weeks ] Assessment of prenatal anxiety symptoms with The State Section of The State-Trait Anxiety Inventory (STAI): theoretical range of total scale is 20-80points (minimum and maximum scores), and lower (...) : No Criteria Inclusion Criteria: Pregnant women referred to the hospital maternity outpatient clinic from primary health care due to substance abuse were recruited to participate in a randomized and controlled study. The subjects were referred from primary health care due to: documented or self-reported illicit drug use, misuse of prescription medication or alcohol within three years prior to or during this pregnancy, and/or sum score ≥ 3 points on TWEAK alcohol screening (Russell, 1994). The inclusion

2018 Clinical Trials

56. Evaluation of Doxazosin to Alter the Abuse of Oxycodone

Date : December 30, 2019 Estimated Study Completion Date : March 30, 2020 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment Placebo Comparator: Doxazosin 0 mg (Placebo) Maintenance on a daily dose of oral doxazosin (0 mg) for 4 weeks. During this time subjects complete testing sessions (Self-administration, Cue session) assessing the abuse potential of intranasal oxycodone. Drug: Intranasal Oxycodone Under each (...) doxazosin maintenance condition the effects of intranasal oxycodone will be assessed in order to determine if doxazosin reduces dependent measures assessing its abuse potential. Other Name: Oxycodone HCl Behavioral: Cue Session During the cue exposure session participants are presented with neutral cues followed by drug-related cues. This procedure will allow the investigators to determine whether the study medication affects reactivity to drug-related cues. Active Comparator: Doxazosin 16 mg

2018 Clinical Trials

57. Macrophage-derived extracellular vesicles mediate smooth muscle hyperplasia: role of altered miRNA cargo in response to HIV infection and substance abuse (PubMed)

Macrophage-derived extracellular vesicles mediate smooth muscle hyperplasia: role of altered miRNA cargo in response to HIV infection and substance abuse Our previous studies consistently demonstrate enhanced pulmonary vascular remodeling in HIV-infected intravenous drug users, and in simian immunodeficiency virus-infected macaques or HIV-transgenic rats exposed to opioids or cocaine. Although we reported an associated increase in perivascular inflammation, the exact role of inflammatory cells (...) by delivery of its prosurvival miRNA cargo, which may play a crucial role in the development of PAH.-Sharma, H., Chinnappan, M., Agarwal, S., Dalvi, P., Gunewardena, S., O'Brien-Ladner, A., Dhillon, N. K. Macrophage-derived extracellular vesicles mediate smooth muscle hyperplasia: role of altered miRNA cargo in response to HIV infection and substance abuse.

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2018 The FASEB Journal

58. Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse

during a mood episode in Major Depressive Disorder (MDD) or Bipolar Disorder (BD) with or without comorbid recent abuse of alcohol. Condition or disease Intervention/treatment Phase Suicidal Ideation Depression Alcohol Abuse Drug: Intranasal ketamine Drug: Placebo Phase 3 Detailed Description: Clinicians have a limited ability to predict imminent suicidal behavior and efficacious treatments are not available to treat suicidal patients. Thus, Rapid-acting treatments for suicidal individuals are truly (...) Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse Actual Study Start Date : May 1, 2018 Estimated Primary Completion Date : January 1, 2019 Estimated Study Completion Date : March 1, 2019 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Intranasal ketamine Intranasal ketamine Drug: Intranasal ketamine Intranasal ketamine will be prepared as 100mg/ml

2018 Clinical Trials

59. Effectiveness of a Brief Cognitive and Behavioral Skills Program on Stage Transitions for Chronic Ketamine Abusers

is to review what has been learned and reminds participants about the association of drug use with HIV/HCV. Behavioral: Cognitive behavioral skills training A brief cognitive behavioral skills training was applied to teach ketamine abusers about stimulus control, refusal skills, communication skills, decisional balance, and infectious diseases prevention. No Intervention: Education as usual The EAU group received six hours of informational lectures about ketamine, its effects on the brain, relevant (...) , 2018 Last Verified: August 2018 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by Tony Szu-Hsien Lee, National Taiwan University: Substance Abuse Cognitive behavioral treatment Ketamine Stage of Change Additional relevant MeSH terms: Layout table for MeSH terms Substance-Related Disorders Chemically-Induced Disorders

2018 Clinical Trials

60. 48-year-old Man with Fevers, Chest Pain, and a History of Substance Abuse (PubMed)

48-year-old Man with Fevers, Chest Pain, and a History of Substance Abuse A 48-year-old male with a history of intravenous (IV) drug use presented to the emergency department (ED) for an area of mild pain and erythema on his chest. He was then triaged to the urgent care, or fast track, area of the ED. He was well appearing with normal lab findings and vital signs, but his workup revealed mediastinitis with osteomyelitis of the manubrium and clavicles, a surgical emergency. His treatment course

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2018 Clinical Practice and Cases in Emergency Medicine

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