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Intravenous Dextrose

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1. A randomized, double-blinded, controlled trial of the effects of fluid rate and/or presence of dextrose in intravenous fluids on the labor course of nulliparas

A randomized, double-blinded, controlled trial of the effects of fluid rate and/or presence of dextrose in intravenous fluids on the labor course of nulliparas Prolonged labor has been demonstrated to increase adverse maternal and neonatal outcome. A practice that may decrease the risk of prolonged labor is the modification of fluid intake during labor.Several studies demonstrated that increased hydration in labor as well as addition of dextrose-containing fluids may be associated (...) with a decrease in length of labor. The purpose of our study was to characterize whether high-dose intravenous fluids, standard-dose fluids with dextrose, or high-dose fluids with dextrose show a difference in the duration of labor in nulliparas.Nulliparous subjects with singletons who presented in active labor were randomized to 1 of 3 groups of intravenous fluids: 250 mL/h of normal saline, 125 mL/h of 5% dextrose in normal saline, or 250 mL/h of 2.5% dextrose in normal saline. The primary outcome was total

2017 EvidenceUpdates

2. Oral Dextrose Gel Reduces the Need for Intravenous Dextrose Therapy in Neonatal Hypoglycemia (PubMed)

Oral Dextrose Gel Reduces the Need for Intravenous Dextrose Therapy in Neonatal Hypoglycemia Newborn infants with risk factors may require intravenous (IV) dextrose for asymptomatic hypoglycemia. Administration of IV dextrose and transfer to the neonatal intensive care unit (NICU) may interfere with parent-infant bonding.To study the effect of implementing dextrose gel supplement with feeds in late preterm/term infants affected by asymptomatic hypoglycemia on reducing IV dextrose therapy.A (...) retrospective study was conducted before and after dextrose gel use: 05/01/2014 to 10/31/2014 and 11/01/2014 to 04/30/2015, respectively. Asymptomatic hypoglycemic (blood glucose level <45 mg/dl) infants in the newborn nursery (NBN) were given a maximum of 3 doses of dextrose gel (200 mg/kg of 40% dextrose) along with feeds. Transfer to the NICU for IV dextrose was considered treatment failure.Dextrose gel with feeds increased the blood glucose level in 184/250 (74%) of asymptomatic hypoglycemic infants

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2016 Biomedicine hub

3. Effect of intravenous dextrose administration on postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomised controlled trial. (PubMed)

Effect of intravenous dextrose administration on postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomised controlled trial. 28872580 2018 10 04 2018 10 04 1365-2346 34 10 2017 10 European journal of anaesthesiology Eur J Anaesthesiol Effect of intravenous dextrose administration on postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomised controlled trial. 705-707 10.1097/EJA.0000000000000643 Rao Vikram V From (...) the Department of Anaesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, India (VR, IB, DJ, NB). Bala Indu I Jain Divya D Bharti Neerja N eng Letter Randomized Controlled Trial England Eur J Anaesthesiol 8411711 0265-0215 IY9XDZ35W2 Glucose IM Administration, Intravenous Adult Cholecystectomy, Laparoscopic adverse effects trends Double-Blind Method Female Glucose administration & dosage Humans Infusions, Intravenous Male Middle Aged Postoperative Care

2018 European Journal of Anaesthesiology

4. The effects of intravenous dextrose 5%, Ringer's solution, and oral intake on the duration of labor stages in nulliparous women: a double-blind, randomized, controlled trial. (PubMed)

The effects of intravenous dextrose 5%, Ringer's solution, and oral intake on the duration of labor stages in nulliparous women: a double-blind, randomized, controlled trial. Childbirth consists of a three-stage period beginning with uterine contractions and ending in the expulsion of the placenta. The present study was conducted to compare the effects of Ringer's solution, dextrose solution 5%, and oral intake on the duration of total labor and labor stages (primary outcome) and the frequency (...) of oxytocin administration and prolonged labor (secondary outcome) in nulliparous women with spontaneous vaginal delivery.The present randomized clinical trial was conducted on 201 nulliparous women in labor assigned with a randomized block design to three groups, each receiving either Ringer's solution plus oral fluids, dextrose solution 5% solution plus oral fluids or oral fluids alone. The solutions were intravenously administered at a rate of 125 ml/h in the groups receiving the solutions

2018 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

5. Does perioperative intravenous dextrose reduce postoperative nausea and vomiting? A systematic review and meta-analysis (PubMed)

Does perioperative intravenous dextrose reduce postoperative nausea and vomiting? A systematic review and meta-analysis Perioperative dextrose-containing fluid administration has been used as a non-pharmacologic preventive measure against postoperative nausea and vomiting (PONV), a common and distressing complication of anesthesia. However, its efficacy remains unclear as previous studies reported inconsistent results. Our objective was to compare dextrose-containing fluid with non-dextrose (...) was poor due to high risks of selection and performance biases and substantial statistical heterogeneity. After subgroup analysis, the risk for PONV was reduced in patients who had undergone laparoscopic cholecystectomy, but not other surgeries, and the effects of dextrose on the risk for PONV did not differ according to the fluid volume administered.Perioperative intravenous (i.v.) dextrose did not reduce the risk for PONV. However, it did reduce the need for anti-emetics after general anesthesia

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2018 Therapeutics and clinical risk management

6. Clinical Impact of Rapid Intravenous Rehydration With Dextrose Serum in Children With Acute Gastroenteritis. (PubMed)

Clinical Impact of Rapid Intravenous Rehydration With Dextrose Serum in Children With Acute Gastroenteritis. We designed a study to compare rapid intravenous rehydration based on 0.9% normal saline (NS) or on NS + glucose 2.5% serum (SGS 2.5%) in patients with dehydration secondary to acute gastroenteritis. Our hypothesis is that the addition of glucose 2.5% serum (SGS 2.5%) to 0.9% saline solution could reduce the proportion of hospital admissions and return emergency visits in these patients

2017 Pediatric Emergency Care

7. Effect of acetate Ringer(')ssolution with or without 5% dextrose administered intravenously to diarrheic calves. (PubMed)

Effect of acetate Ringer(')ssolution with or without 5% dextrose administered intravenously to diarrheic calves. The objectives of this study were to evaluate the effects of intravenous acetate Ringer's solution, with or without dextrose, on diarrheic calves with either experimentally induced or spontaneous diarrhea. In the experimental model, diarrhea was induced in nine healthy calves by administering cold milk (below 4°C) twice a day for 2 days. The calves were randomly assigned (...) to the isotonic saline (ISS), acetated Ringer's (AR) or acetated Ringer's with 5% dextrose (ARD) groups, with three calves assigned to each group. The calves received 80 ml/kg of their designated solution, at a flow rate of 20 ml/kg/hr. Infusion of ISS, AR and ARD were all found to be safe and effective in increasing plasma volume. Intravenous (IV) infusion of ISS resulted in the acidification secondary to dilution, while AR and ARD infusion inhibited acidification. In addition, prevention of catabolism

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2017 The Journal of Veterinary Medical Science

8. The effect of intravenous dextrose administration for prevention of post-operative nausea and vomiting after laparoscopic cholecystectomy: A double-blind, randomised controlled trial (PubMed)

The effect of intravenous dextrose administration for prevention of post-operative nausea and vomiting after laparoscopic cholecystectomy: A double-blind, randomised controlled trial Post-operative nausea and vomiting (PONV) is a common and distressing complication after laparoscopic cholecystectomy (LC). The aim of this study was to evaluate the effect of intravenous (IV) dextrose administration for the prophylaxis of PONV after LC.In a double-blind, randomised controlled trial, a total of 150 (...) female patients who were scheduled for elective LC were randomly assigned into two groups (A and B). Thirty minutes before induction of anaesthesia, patients received an infusion of 500 cc lactated Ringer's solution (Group A) and 5% dextrose in lactated Ringer's solution (Group B) and over a period of 30 min. All patients rated their nausea and vomiting intensity using the verbal rating scale immediately at post-anaesthesia care unit (PACU) arrival; 30, 60, 90 and 120 min after arriving at the PACU

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2017 Indian journal of anaesthesia

9. Oral dextrose gel for the treatment of hypoglycaemia in newborn infants. (PubMed)

Oral dextrose gel for the treatment of hypoglycaemia in newborn infants. Neonatal hypoglycaemia, a common condition, can be associated with brain injury. It is frequently managed by providing infants with an alternative source of glucose, given enterally with formula or intravenously with dextrose solution. This often requires that mother and baby are cared for in separate environments and may inhibit breast feeding. Dextrose gel is simple and inexpensive and can be administered directly (...) hypoglycaemic event. We found no evidence of a difference between dextrose gel and placebo gel for major neurosensory disability at two-year follow-up (risk ratio (RR) 6.27, 95% confidence interval (CI) 0.77 to 51.03; one trial, n = 184; quality of evidence very low). Dextrose gel compared with placebo gel or no gel did not alter the need for intravenous treatment for hypoglycaemia (typical RR 0.78, 95% CI 0.46 to 1.32; two trials, 312 infants; quality of evidence very low). Infants treated with dextrose

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2016 Cochrane

10. Double-blind, randomized crossover study of intravenous infusion of magnesium sulfate versus 5% dextrose on depressive symptoms in adults with treatment-resistant depression. (PubMed)

Double-blind, randomized crossover study of intravenous infusion of magnesium sulfate versus 5% dextrose on depressive symptoms in adults with treatment-resistant depression. Treatment-resistant depression patients are more likely to suffer from comorbid physical and mental disorders, experience marked and protracted functional impairment, and incur higher health-care costs than non-affected individuals. Magnesium sulfate is a treatment option that may offer great potential for patients (...) with treatment-resistant depression based on prior work in animals and humans.Twelve subjects with mild or moderate treatment-resistant depression were randomized into a double-blind crossover trial to receive an infusion of 4 g of magnesium sulfate in 5% dextrose or placebo infusion of 5% dextrose with a 5-day washout in between the 8-day intervention period. Subjects were assessed before and after the intervention for serum and urine magnesium, lipid panel, the Hamilton Rating Scale for Depression

2016 Psychiatry and clinical neurosciences

11. Intravenous Dextrose

Intravenous Dextrose Intravenous Dextrose Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Intravenous Dextrose Intravenous Dextrose (...) Aka: Intravenous Dextrose From Related Chapters II. Indications by rapid bedside Child who fails to respond to III. Physiology Ill children deplete glycogen stores rapidly depresses neonatal myocardial function Effects of on brain Ischemic Neonatal brain May benefit from Mature Child brain Poor neurologic outcome with IV. Dosing See dosing by the rule of 50 below Dextrose 12.5% (D12.5W): 1:3 dilution of D50W in water Newborn: 0.5-1.0 g/kg (4-8 ml/kg) D12.5W IV or IO Dextrose 25% (D25W): 1:1

2018 FP Notebook

12. Dextrose versus no dextrose intravenous fluids for reduction of length of labor: a systematic review and meta analysis of randomized trials

Dextrose versus no dextrose intravenous fluids for reduction of length of labor: a systematic review and meta analysis of randomized trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2017 PROSPERO

13. Is perioperative administration of 5% dextrose effective in reducing the incidence of PONV in laparoscopic cholecystectomy?: A randomized control trial. (PubMed)

I to II undergoing laparoscopic cholecystectomy were enrolled in this study.Patients were randomized into two groups [normal saline (NS) group and 5% dextrose (D) group]. Both the groups received Ringer acetate (Sterofundin ISO) intravenously as a maintenance fluid during intraoperative period. Besides this, patients of group NS received 250ml of 0.9% normal saline and patients of group D received 5% dextrose @ 100ml/h started at the time when gall bladder was taken out. It was continued (...) Is perioperative administration of 5% dextrose effective in reducing the incidence of PONV in laparoscopic cholecystectomy?: A randomized control trial. To compare the incidence of postoperative nausea and vomiting (PONV) during perioperative administration of 5% dextrose and normal saline in laparoscopic cholecystectomy.Prospective, randomized, double-blind trial.Operating rooms in a tertiary care hospital of Northern India.One hundred patients with American Society of Anesthesiologists status

2018 Journal of clinical anesthesia

14. Study of Early Enteral Dextrose in Sepsis

and in-hospital mortality. Condition or disease Intervention/treatment Phase Sepsis Other: Enteral Dextrose Infusion Other: Free Water Infusion Not Applicable Detailed Description: The central objective of this research project is to determine how early caloric support impacts inflammatory and metabolic outcomes in the acute phase of sepsis. Preliminary data from our mouse models suggest that provision of dextrose via an intravenous route, even at low levels early in the course of sepsis, markedly impairs (...) Study of Early Enteral Dextrose in Sepsis Study of Early Enteral Dextrose in Sepsis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study of Early Enteral Dextrose in Sepsis (SEEDS) The safety

2018 Clinical Trials

15. Impact of dextrose dose on hypoglycemia development following treatment of hyperkalemia (PubMed)

Impact of dextrose dose on hypoglycemia development following treatment of hyperkalemia Hyperkalemia is an electrolyte abnormality that may cause ventricular dysrhythmias and cardiac arrest. The presence of hyperkalemia may necessitate prompt treatment via intravenous insulin and dextrose. One notable complication of this therapy is the development of hypoglycemia. Previous trials have examined the impact of altering the insulin dose administered on hypoglycemia development; no trials to date (...) however, have examined the impact of altering the dextrose dose.This was a multicenter, retrospective, matched cohort study of patients who received intravenous insulin and dextrose for reversal of hyperkalemia. Patients received either 25 g or 50 g of dextrose in addition to 10 units of insulin. Study populations were matched based on preexisting rates of acute kidney injury, end-stage renal disease, and diabetes mellitus. Blood glucose levels were measured at 60 and 240 min following treatment.A

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2018 Therapeutic advances in drug safety

16. Clinical Practice Guideline: Maintenance Intravenous Fluids in Children

days to 18 years of age requiring maintenance IVFs should receive isotonic solutions with appropriate potassium chloride and dextrose because they significantly decrease the risk of developing hyponatremia (evidence quality: A; recommendation strength: strong) Abbreviations: AAP — American Academy of Pediatrics ADH — antidiuretic hormone AVP — arginine vasopressin CHF — congestive heart failure CI — confidence interval CNS — central nervous system IV — intravenous IVF — intravenous fluid kcal (...) solutions have a sodium concentration similar to PlasmaLyte, or 0.9% NaCl. Recommendations are not made regarding the safety of lactated Ringer solution. Researchers in the majority of studies added dextrose (2.5%–5%) to the intravenous (IV) solution. The search revealed 17 randomized clinical trials , , , , – that met the search criteria, including a total 2455 patients (2313 patients had primary outcome data for analysis in ), to help evaluate the question of whether isotonic or hypotonic fluids

2019 American Academy of Pediatrics

17. Reduction of total labour length through the addition of parenteral dextrose solution in induction of labor in nulliparous: results of DEXTRONS prospective randomized controlled trial. (PubMed)

during delivery. Therefore, it seemed imperative to evaluate the impact of adding carbohydrate supplements on the course of labor.We sought to provide evidence as to whether intravenous glucose supplementation during labor induction in nulliparous women can reduce total duration of active labor.We performed a single-center prospective double-blind randomized controlled trial comparing the use of parental intravenous dextrose 5% with normal saline to normal saline in induced nulliparous women (...) . The study was conducted in a tertiary-level university hospital setting. Participants, caregivers, and those assessing the outcomes were blinded to group assignment. Inclusion criteria were singleton pregnancy at term with cephalic presentation and favorable cervix. Based on blocked randomization, patients were assigned to receive either 250 mL/h of intravenous dextrose 5% with normal saline or 250 mL/h of normal saline for the whole duration of induction, labor, and delivery. The primary outcome

2017 American Journal of Obstetrics and Gynecology

18. Dextrose Containing Fluid and the Postoperative Nausea and Vomiting in the Gynecologic Laparoscopic Surgery

Posted : May 8, 2017 Sponsor: Chiang Mai University Information provided by (Responsible Party): Pathomporn Pin on, M.D., Chiang Mai University Study Details Study Description Go to Brief Summary: The investigators tested the hypothesis that administration of intravenous dextrose as a maintenance fluid in gynecologic laparoscopic surgery would reduce the incidence and severity of postoperative nausea and vomiting (PONV) compared with normal saline solution in the same dose. A prospective randomized (...) intravenous fluid administration, such as 30 ml/ kg of sodium lactate solution, reduced the incidence of PONV after gynecologic laparoscopy compared to another group receiving 10 ml/kg of sodium lactate solution, this strategy did not reduce the PONV in other surgical procedures such as thyroidectomy. Among crystalloid solutions, results from previous studies were conflicting regarding the benefit of intravenous dextrose administration to reducing the PONV. Hypovolemia with and without hypoglycemia after

2017 Clinical Trials

19. Ureteric Visualization: Vitamin B Vs 5% Dextrose in Water

% dextrose in water) 5% Dextrose in Water: Patients in this arm will receive a placebo in the pre-operative area (for the purpose of blinding the surgical team) 60 to 120 minutes prior to surgery. Intraoperative cystoscopy will then be performed using D5W to see if this helps with detection of ureteric jets. Other: 5% Dextrose in Water (D5W) 5% Dextrose in Water is an irrigation/instillation fluid, commonly used in intravenous lines. Outcome Measures Go to Primary Outcome Measures : Detection rates (...) Ureteric Visualization: Vitamin B Vs 5% Dextrose in Water Ureteric Visualization: Vitamin B Vs 5% Dextrose in Water - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Ureteric Visualization: Vitamin B Vs 5

2017 Clinical Trials

20. Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit. (PubMed)

Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit. Proper sedation for neonates undergoing uncomfortable procedures may reduce stress and avoid complications. Midazolam is a short-acting benzodiazepine that is used increasingly in neonatal intensive care units (NICUs). However, its effectiveness as a sedative in neonates has not been systematically evaluated.Primary objeciveTo assess the effectiveness of intravenous midazolam infusion for sedation (...) , as evaluated by behavioural and/or physiological measurements of sedation levels, in critically ill neonates in the NICU. Secondary objectivesTo assess effects of intravenous midazolam infusion for sedation on complications including the following.1. Incidence of intraventricular haemorrhage (IVH)/periventricular leukomalacia (PVL).2. Mortality.3. Occurrence of adverse effects associated with the use of midazolam (hypotension, neurological abnormalities).4. Days of ventilation.5. Days of supplemental

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2017 Cochrane

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