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Intrauterine Growth Retardation

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141. Down-regulating SOCS3 with siRNA ameliorates insulin signaling and glucose metabolism in hepatocytes of IUGR rats with catch-up growth. Full Text available with Trip Pro

Down-regulating SOCS3 with siRNA ameliorates insulin signaling and glucose metabolism in hepatocytes of IUGR rats with catch-up growth. Individuals with intrauterine growth retardation (IUGR) who demonstrate a catch-up in body weight are prone to insulin resistance. High expressions of suppressor of cytokine signaling 3 (SOCS3) are thought to aggravate insulin resistance. We hypothesized that downregulating SOCS3 expression via small interfering RNA (siRNA) might have beneficial effects (...) on insulin-resistant hepatocytes of catch-up growth IUGR rats (CG-IUGRs).An IUGR rat model was employed via maternal nutritional restriction. After evaluating metabolic states of CG-IUGR offspring, effective SOCS3-specific siRNA (siSOCS3) was transfected into cultured hepatocytes using liposomes. mRNA levels of SOCS3, insulin receptor substrates (IRSs), phosphatidylinositol 3-kinase (PI3K), and Akt2, key gluconeogenesis genes, were assessed via real-time PCR. Protein expression and phosphorylation

2012 Pediatric Research

142. Pre- and postoperative growth in persistent ductus arteriosus. Full Text available with Trip Pro

Pre- and postoperative growth in persistent ductus arteriosus. Children with a persistent ductus arteriosus requiring ligation under 6 months of age show evidence of intrauterine growth retardation. By the time of operation the weight centile of 17 (71%) of 24 such infants had fallen, but 20(84%) of the 24 gained weight postoperatively. Those who did not so were either large-for-dates infants growing towards the normal or small-for-dates infants who remained small postoperatively.

1976 Archives of Disease in Childhood

143. Growth Hormone Investigation in Patients with Mental Dysfunction Full Text available with Trip Pro

Growth Hormone Investigation in Patients with Mental Dysfunction Seventy-three children with disorders of physical growth and mental development were stimulated by insulin hypoglycemia and arginine infusion and their human growth hormone (HGH) responses were determined. Only four patients exhibited absent or impaired pituitary hormone secretion and one of them presented a unique syndrome of panhypopituitarism associated with intrauterine growth retardation, long eyelashes and eyebrows, sparse (...) hair and degeneration of the retina. Statistical analysis indicated no significant HGH peak concentrations in groups of either tall males or stunted females who possessed various sex chromosome abnormalities, nor did these groups differ in a variety of clinical parameters including age, physical growth, birth weight and intelligence.

1971 Canadian Medical Association Journal

144. Spirometric Lung Function in School Age Children: Effect of Intrauterine Growth Retardation and Catch-up Growth. Full Text available with Trip Pro

Spirometric Lung Function in School Age Children: Effect of Intrauterine Growth Retardation and Catch-up Growth. Few studies have investigated childhood respiratory outcomes of intrauterine growth retardation (IUGR), and it is unclear if catch-up growth in these children influences lung function.We determined if lung function differed in 8- to 9-year-old children born at term with or without growth retardation, and, in the growth-retarded group, if lung function differed between those who did (...) subjects. Growth-retarded asymmetric and symmetric children had similar lung function.IUGR is associated with poorer lung function at 8-9 years of age compared with control children. Although the differences were not statistically significant, spirometry was higher in children who showed weight catch-up growth, but remained significantly lower than the control children.

2010 American Journal of Respiratory and Critical Care Medicine

145. Heterozygous Mutation within a Kinase-Conserved Motif of the Insulin-Like Growth Factor I Receptor Causes Intrauterine and Postnatal Growth Retardation. Full Text available with Trip Pro

Heterozygous Mutation within a Kinase-Conserved Motif of the Insulin-Like Growth Factor I Receptor Causes Intrauterine and Postnatal Growth Retardation. IGF-I receptor (IGF1R) plays an essential role in human intrauterine and postnatal development. Few heterozygous mutations in IGF1R leading to IGF-I resistance and intrauterine and postnatal growth retardation have been described to date.The clinical and functional relevance of a novel heterozygous IGF1R mutation identified in a girl with short (...) in reduced autophosphorylation of 36 +/- 10% of wild-type levels, suggesting a partial dominant-negative effect.The identified G1125A mutation results in a kinase-deficient IGF1R, which is likely to cause the phenotype of intrauterine and postnatal growth retardation.

2010 Journal of Clinical Endocrinology and Metabolism

146. A Heterozygous Mutation of the Insulin-Like Growth Factor-I Receptor Causes Retention of the Nascent Protein in the Endoplasmic Reticulum and Results in Intrauterine and Postnatal Growth Retardation. Full Text available with Trip Pro

A Heterozygous Mutation of the Insulin-Like Growth Factor-I Receptor Causes Retention of the Nascent Protein in the Endoplasmic Reticulum and Results in Intrauterine and Postnatal Growth Retardation. Mutations in the IGF-I receptor (IGF1R) gene can be responsible for intrauterine and postnatal growth disorders.Here we report on a novel mutation in the IGF1R gene in a female patient. The aim of our study was to analyze the functional impact of this mutation.At birth, the girl's length was 47 cm (...) the patient's wild-type allele is supposed to lead to insufficient IGF-I signaling. We hypothesize that this mechanism results in intrauterine and postnatal growth retardation of the affected patient. The reported retention of the nascent IGF1R in the endoplasmic reticulum presents a novel mechanism of IGF-I resistance.

2010 Journal of Clinical Endocrinology and Metabolism

147. Clinical and Functional Characteristics of a Novel Heterozygous Mutation of the IGF1R Gene and IGF1R Haploinsufficiency due to Terminal 15q26.2->qter Deletion in Patients with Intrauterine Growth Retardation and Postnatal Catch-Up Growth Failure. Full Text available with Trip Pro

Clinical and Functional Characteristics of a Novel Heterozygous Mutation of the IGF1R Gene and IGF1R Haploinsufficiency due to Terminal 15q26.2->qter Deletion in Patients with Intrauterine Growth Retardation and Postnatal Catch-Up Growth Failure. Mutations in the IGF1R gene result in intrauterine growth retardation and postnatal growth failure.The objective of this study was to describe the clinical features of subjects with a mutation in the IGF1R gene and to evaluate the molecular (...) and functional characteristics of a novel IGF1R mutation.Three children with unexplained intrauterine growth retardation (birth weight <-1.5 SD score) and persistent short stature (<-2.0 SD score) were included in the study.Auxological and endocrinological profiles were measured. All coding regions, including the intron-exon boundaries of the IGF1R gene, were amplified via PCR and directly sequenced. To study the functional effect of the IGF1R gene mutation on IGF-I signaling, total IGF1R protein expression

2010 Journal of Clinical Endocrinology and Metabolism

148. Randomized Clinical Trial: Expectant Management vs Laser Treatment of Monochorionic Twins With Severe Selective Intrauterine Growth Retardation and Absent or Reverse Diastolic Flow in the Umbilical Artery

Randomized Clinical Trial: Expectant Management vs Laser Treatment of Monochorionic Twins With Severe Selective Intrauterine Growth Retardation and Absent or Reverse Diastolic Flow in the Umbilical Artery Randomized Clinical Trial: Expectant Management vs Laser Treatment of Monochorionic Twins With Severe Selective Intrauterine Growth Retardation and Absent or Reverse Diastolic Flow in the Umbilical Artery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer (...) to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Randomized Clinical Trial: Expectant Management vs Laser Treatment of Monochorionic Twins With Severe Selective Intrauterine Growth Retardation and Absent or Reverse Diastolic Flow in the Umbilical Artery The safety and scientific validity of this study

2010 Clinical Trials

149. The effect of intrauterine growth retardation on the expression of developmental factors in porcine placenta subsequent to the initiation of placentation. (Abstract)

The effect of intrauterine growth retardation on the expression of developmental factors in porcine placenta subsequent to the initiation of placentation. Intrauterine growth retardation (IUGR) hinders fetal growth and postnatal development in swine; however the etiology of IUGR is essentially unknown. Expression of fourteen candidate genes associated with placental development or IUGR was examined in gestational day 50 (gd50) control and IUGR fetus whole placental tissue or areolae by real

2010 Placenta

151. The Combined Use of Ultrasound and Fetal Magnetic Resonance Imaging for a Comprehensive Fetal Neurological Assessment in Fetal Congenital Cardiac Defects

of the semicircular canals in CHARGE syndrome (a condition composed of the following features: coloboma of the eye, heart defects, atresia choanae, growth retardation, genital and/or urinary abnormalities, and ear abnormalities and hearing impairment). Larger, long‐term studies are needed to appreciate the importance of obtaining antenatal information about not only overt abnormalities but quantifiable deviations in brain development alongside diagnostic accuracy in CHD, with respect to counselling, birth (...) . , , Furthermore, studies on fetuses incorporating magnetic resonance imaging (MRI), magnetic resonance spectroscopy and diffusion tension imaging (DTI) have revealed abnormalities of brain microstructure and metabolism before birth, as well as shortly after birth and before surgery. The origin of these changes is almost certainly multifactorial, with congenital brain abnormalities, intrauterine haemodynamic alterations and acquired brain injury all implicated. At present, the correlation of fetal neurological

2019 Royal College of Obstetricians and Gynaecologists

152. Covid-19: ASRM Recommendations For Reducing The Risk Of Viral Transmission During Fertility Treatment With The Use Of Autologous Gametes

transmission of their infections. Adoption and, in circum- stances involving an infected man and uninfected woman, donor inseminationshould bepresented as the safest options. Couples who decide to proceed with partner-intrauterine insemination(IUI)orotherfertilitytreatmentmustagreetorea- sonableinterventionsaimedatreducingthetransmissionrisk. Counseling and education concerning safe sex practices should be provided and emphasized. In cases where the male,butnotthefemale,partnerisinfected,thecoupleshould (...) restricted host cell speci?city. Gamma herpes viruses, which include EBV and HHV-8, are slow-growing lymphotropic viruses. Human herpes virus infections are endemic and cause wide- ranging pathology. Certain herpes viruses encode proteins thatoverridenormalcontrolsoncelldivision,leadingtoma- lignant transformation. EBV has been implicated as a causal factor in a number of malignancies, including Burkitt's lymphoma,Hodgkin'slymphoma,andnasopharyngealcarci- noma. HHV-8 has been associated with Kaposi's

2020 Society for Assisted Reproductive Technology

153. Management of Women With Phenylalanine Hydroxylase Deficiency (Phenylketonuria)

weeks of gestation, metabolic control achieved later may not decrease the risk of cardiac malformations . Reduction of the maternal blood phenylalanine level to 10 mg/dL or less decreases the incidence of microcephaly from 73% to 8% . In addition to complications with excessive phenylalanine, there are data to suggest that markedly low maternal phenylalanine levels, especially during the second and third trimesters, may be associated with intrauterine growth restriction . Therefore, a detailed (...) phenylalaninemia might increase the risk of intra uterine growth retardation. AFDPHE (Association Française pour le Dépistage et la Prévention des Handicaps de l’Enfant). J Inherit Metab Dis 2012;35:993–9. Article Locations: Camp KM, Parisi MA, Acosta PB, Berry GT, Bilder DA, Blau N, et al. Phenylketonuria Scientific Review Conference: state of the science and future research needs. Mol Genet Metab 2014;112:87–122. Article Locations: Regier DS, Greene CL. Phenylalanine hydroxylase deficiency. In: Adam MP

2020 American College of Obstetricians and Gynecologists

154. Diagnostic testing for uniparental disomy

]: clinical features are rather caused by (hidden) trisomy 16 mosaicism than by upd(16)mat itself. Clin Genet. 2017;92:45–51. 9. Hansen WF, Bernard LE, Langlois S, et al. Maternal uniparental disomy of chromosome 2 and confined placental mosaicism for trisomy 2 in a fetus with intrauterine growth restriction, hypospadias, and oligohydramnios. Prenat Diagn. 1997;17:443–450. 10. Trisomy 15 CPM: probable origins, pregnancy outcome and risk of fetal UPD: European Collaborative Research on Mosaicism in CVS (...) of interstitial maternal uniparental disomy (UPD) (14) and complete maternal UPD(20) in a cohort of growth retarded patients. J Med Genet. 2001;38:86–89. 25. McGowan-Jordan J, Simons A, Schmid M. ISCN 2016: an international system for human cytogenetic nomenclature. Basel, Switzerland: Karger; 2016. 26. Kearney HM, Kearney JB, Conlin LK. Diagnostic implications of excessive homozygosity detected by SNP-based microarrays: consanguinity, uniparental disomy, and recessive single-gene mutations. Clin Lab Med

2020 American College of Medical Genetics and Genomics

155. Overview of pregnancy complications

=bestpractice.com and illicit drug use. Sequelae include intrauterine growth restriction and premature delivery. Hydatidiform moles are chromosomally abnormal pregnancies that have the potential to become malignant (gestational trophoblastic neoplasia). Gestational trophoblastic disease (GTD) includes tumours of fetal tissues, including hydatidiform moles, arising from placental trophoblasts. The most common presenting symptom is vaginal bleeding and patients typically present in the first trimester (...) ) progress to actual labour and delivery. The remainder of pre-term birth is due to reasons for early delivery, most commonly because of pre-eclampsia and intrauterine growth restriction. Breech presentation in pregnancy occurs when a baby presents with the buttocks or feet rather than the head first (cephalic presentation) and is associated with increased morbidity and mortality for both the mother and the baby. It is common in early pregnancy and decreases with advancing gestational age, as most babies

2018 BMJ Best Practice

156. Disorders of infant feeding

pulmonary infections and wheeze coughing or retching at meal times posture changes during feeds atopic features apparent life-threatening event (ALTEs) drooling ankyloglossia (tongue-tie) features of genetic conditions abnormal cardiorespiratory signs age <1 year prematurity intrauterine growth retardation developmental delay anatomical abnormalities of the oropharynx post-surgical correction of oropharyngeal or GI abnormalities Diagnostic investigations trial of hypoallergenic feed oesophageal 24-hour (...) the requirements for healthy growth in the long term. Failure to thrive may be a consequence of unresolved feeding problems of any aetiology. Aetiologies are often complex and multifactorial, and are best managed by a multidisciplinary team. Causes include anatomical, neuromuscular/neurodevelopmental, immunological, physiological, and behavioural factors. Diagnosis is usually clinical, with a consistent history supported by dietetic assessment. Complementary diagnostic tests and subsequent management

2018 BMJ Best Practice

157. Overview of pregnancy complications

=bestpractice.com and illicit drug use. Sequelae include intrauterine growth restriction and premature delivery. Hydatidiform moles are chromosomally abnormal pregnancies that have the potential to become malignant (gestational trophoblastic neoplasia). Gestational trophoblastic disease (GTD) includes tumours of fetal tissues, including hydatidiform moles, arising from placental trophoblasts. The most common presenting symptom is vaginal bleeding and patients typically present in the first trimester (...) ) progress to actual labour and delivery. The remainder of pre-term birth is due to reasons for early delivery, most commonly because of pre-eclampsia and intrauterine growth restriction. Breech presentation in pregnancy occurs when a baby presents with the buttocks or feet rather than the head first (cephalic presentation) and is associated with increased morbidity and mortality for both the mother and the baby. It is common in early pregnancy and decreases with advancing gestational age, as most babies

2018 BMJ Best Practice

158. Toxoplasmosis

have spread through the placenta to a fetus, T gondii rapidly travels to tissues and organs where it encysts and remains permanently. Infection in humans is life-long and often asymptomatic, unless a patient becomes immunosuppressed. History and exam presence of risk factors chorioretinitis focal neurological deficit blurry vision slurred speech headache unsteady gait confusion fever lymphadenopathy fetal microcephaly fetal intracranial calcification fetal hydrocephalus fetal intrauterine growth (...) retardation seizure malaise hepatitis pneumonitis myocarditis immunosuppression exposure during pregnancy residence in a high-risk area ingestion of undercooked or raw meat exposure to cat faeces heavy exposure to soil ingestion of unwashed unpeeled raw fruits and vegetables occupational exposure Diagnostic investigations anti-Toxoplasma IgG (serum) anti-Toxoplasma IgM (serum) CT (with IV contrast) or MR imaging of brain anti-Toxoplasma IgA (serum) anti-Toxoplasma IgE (serum) Toxoplasma-specific IgG

2018 BMJ Best Practice

159. Syphilis infection

or stillbirth (congenital syphilis) premature labour and intrauterine growth retardation (congenital syphilis) neonatal skin rash (congenital syphilis) tibial bowing (congenital syphilis) craniofacial malformation (congenital syphilis) tooth abnormalities (congenital syphilis) necrotising funisitis (congenital syphilis) mouth ulcer asymptomatic (latent syphilis) tremor headache meningismus eye pain hearing loss seizures peripheral oedema jaundice peripheral neuropathy areflexia angina dyspnoea organomegaly

2018 BMJ Best Practice

160. Practice guideline: joint CCMG-SOGC recommendations for the use of chromosomal microarray analysis for prenatal diagnosis and assessment of fetal loss in Canada

a single structural defect is seen in association with other non-structural ultrasound findings, the frequency of pathogenic CMA results is higher, especially with intrauterine growth retardation or overgrowth (13.6%) or abnormal amni- otic fluid volume (9.1%). 11 Increased nuchal translucency (NT) =3.5 mm, or >99 percen- tile, is associated with increased risk of fetal aneuploidy as well as increased risk of certain syndromes and other structural defects. 13 A recent meta-analysis of the use of CMA (...) of chromosomal microarray analysis (in addition to any other relevant diagnostic testing) is recommended in cases with multiple fetal anomalies identified by a comprehensive obstetric ultrasound (II-1A). Other diagnostic testing may include specific single gene, multigene panels or other genetic tests if the pattern of anomalies suggests a specific genetic condition not identified by array (II-2 A). B. Single structural defects in association with other abnormal ultrasound findings (eg, intrauterine growth

2018 CPG Infobase

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