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Intrauterine Growth Retardation

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141. Growth Hormone Deficiency (Diagnosis)

> Pediatric Growth Hormone Deficiency Updated: Aug 22, 2018 Author: Vaneeta Bamba, MD; Chief Editor: Robert P Hoffman, MD Share Email Print Feedback Close Sections Sections Pediatric Growth Hormone Deficiency Overview Practice Essentials Presentation History The history in patients with suspected growth hormone deficiency (GHD) should focus on the following issues: Birth weight and length: Intrauterine growth retardation is an issue in the differential diagnosis and should be apparent from the birth (...) treated for growth hormone deficiency. South Med J . 1980. 83:653-5. Rosenfeld RG, Albertsson-Wikland K, Cassorla F. Diagnostic controversy: the diagnosis of childhood growth hormone deficiency revisited. J Clin Endocrinol Metab . 1995 May. 80(5):1532-40. . Rosenfeld RG, Wilson DM, Lee PD. Insulin-like growth factors I and II in evaluation of growth retardation. J Pediatr . 1986 Sep. 109(3):428-33. . Siklar Z, Tuna C, Dallar Y, Tanyer G. Zinc deficiency: a contributing factor of short stature

2014 eMedicine Pediatrics

142. Fetal Growth Restriction (Diagnosis)

is necessary. The ability to diagnose the disorder and understand its pathophysiology still outpaces the ability to prevent or treat its complications. The current therapeutic goals are to optimize the timing of delivery to minimize hypoxemia and maximize gestational age and maternal outcome. Further study may elucidate preventive or treatment strategies to assist the growth-restricted fetus. Previous References Severi FM, Rizzo G, Bocchi C, et al. Intrauterine growth retardation and fetal cardiac function (...) retardation and perinatal death? An overview. BJOG . 2000 Feb. 107(2):196-208. . Mandruzzato GP, Bogatti P, Fischer L, Gigli C. The clinical significance of absent or reverse end-diastolic flow in the fetal aorta and umbilical artery. Ultrasound Obstet Gynecol . 1991 May 1. 1(3):192-6. . Fong KW, Ohlsson A, Hannah ME, et al. Prediction of perinatal outcome in fetuses suspected to have intrauterine growth restriction: Doppler US study of fetal cerebral, renal, and umbilical arteries. Radiology . 1999 Dec

2014 eMedicine.com

143. Fetal Growth Restriction (Treatment)

is necessary. The ability to diagnose the disorder and understand its pathophysiology still outpaces the ability to prevent or treat its complications. The current therapeutic goals are to optimize the timing of delivery to minimize hypoxemia and maximize gestational age and maternal outcome. Further study may elucidate preventive or treatment strategies to assist the growth-restricted fetus. Previous References Severi FM, Rizzo G, Bocchi C, et al. Intrauterine growth retardation and fetal cardiac function (...) retardation and perinatal death? An overview. BJOG . 2000 Feb. 107(2):196-208. . Mandruzzato GP, Bogatti P, Fischer L, Gigli C. The clinical significance of absent or reverse end-diastolic flow in the fetal aorta and umbilical artery. Ultrasound Obstet Gynecol . 1991 May 1. 1(3):192-6. . Fong KW, Ohlsson A, Hannah ME, et al. Prediction of perinatal outcome in fetuses suspected to have intrauterine growth restriction: Doppler US study of fetal cerebral, renal, and umbilical arteries. Radiology . 1999 Dec

2014 eMedicine.com

144. Fetal Growth Restriction (Follow-up)

is necessary. The ability to diagnose the disorder and understand its pathophysiology still outpaces the ability to prevent or treat its complications. The current therapeutic goals are to optimize the timing of delivery to minimize hypoxemia and maximize gestational age and maternal outcome. Further study may elucidate preventive or treatment strategies to assist the growth-restricted fetus. Previous References Severi FM, Rizzo G, Bocchi C, et al. Intrauterine growth retardation and fetal cardiac function (...) retardation and perinatal death? An overview. BJOG . 2000 Feb. 107(2):196-208. . Mandruzzato GP, Bogatti P, Fischer L, Gigli C. The clinical significance of absent or reverse end-diastolic flow in the fetal aorta and umbilical artery. Ultrasound Obstet Gynecol . 1991 May 1. 1(3):192-6. . Fong KW, Ohlsson A, Hannah ME, et al. Prediction of perinatal outcome in fetuses suspected to have intrauterine growth restriction: Doppler US study of fetal cerebral, renal, and umbilical arteries. Radiology . 1999 Dec

2014 eMedicine.com

145. Growth Hormone Deficiency (Overview)

Growth Hormone Deficiency Updated: Aug 22, 2018 Author: Vaneeta Bamba, MD; Chief Editor: Robert P Hoffman, MD Share Email Print Feedback Close Sections Sections Pediatric Growth Hormone Deficiency Overview Practice Essentials Presentation History The history in patients with suspected growth hormone deficiency (GHD) should focus on the following issues: Birth weight and length: Intrauterine growth retardation is an issue in the differential diagnosis and should be apparent from the birth history (...) treated for growth hormone deficiency. South Med J . 1980. 83:653-5. Rosenfeld RG, Albertsson-Wikland K, Cassorla F. Diagnostic controversy: the diagnosis of childhood growth hormone deficiency revisited. J Clin Endocrinol Metab . 1995 May. 80(5):1532-40. . Rosenfeld RG, Wilson DM, Lee PD. Insulin-like growth factors I and II in evaluation of growth retardation. J Pediatr . 1986 Sep. 109(3):428-33. . Siklar Z, Tuna C, Dallar Y, Tanyer G. Zinc deficiency: a contributing factor of short stature

2014 eMedicine Pediatrics

146. Genotropin Treatment in Short Prepubertal Children With Intra-Uterine Growth Retardation

, 2010 Sponsor: Pfizer Information provided by: Pfizer Study Details Study Description Go to Brief Summary: To evaluate the effect of continuous and intermittent administration of Genotonorm on stature in short prepubertal children with intra-uterine growth retardation Condition or disease Intervention/treatment Phase Growth Disorders Intrauterine Growth Retardation Drug: Genotonorm Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual (...) Genotropin Treatment in Short Prepubertal Children With Intra-Uterine Growth Retardation Genotropin Treatment in Short Prepubertal Children With Intra-Uterine Growth Retardation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2010 Clinical Trials

147. Sonographic Differences in Brain Measurements Between Normal and Intrauterine Growth Restriction (IUGR) Fetuses

Sonographic Differences in Brain Measurements Between Normal and Intrauterine Growth Restriction (IUGR) Fetuses Sonographic Differences in Brain Measurements Between Normal and Intrauterine Growth Restriction (IUGR) Fetuses - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Sonographic Differences in Brain Measurements Between Normal and Intrauterine Growth Restriction (IUGR) Fetuses The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01178619 Recruitment Status : Withdrawn First Posted : August 10, 2010

2010 Clinical Trials

148. Prediction of Growth Restricted Fetuses Using Femur Length to Mid-thigh Circumference Ratio: A Case-control Study

, Ain Shams Maternity Hospital ClinicalTrials.gov Identifier: Other Study ID Numbers: 11110000 First Posted: November 13, 2013 Last Update Posted: November 13, 2013 Last Verified: October 2013 Keywords provided by Alaa Sayed Abdul-hafeez, Ain Shams Maternity Hospital: prediction IUGR FL/MTC Additional relevant MeSH terms: Layout table for MeSH terms Fetal Growth Retardation Fetal Diseases Pregnancy Complications Growth Disorders Pathologic Processes (...) Prediction of Growth Restricted Fetuses Using Femur Length to Mid-thigh Circumference Ratio: A Case-control Study Prediction of Growth Restricted Fetuses Using Femur Length to Mid-thigh Circumference Ratio: A Case-control Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2013 Clinical Trials

149. Antenatal Detection of Fetal Growth Restriction and Stillbirths Rate.

are SGA by customised birthweight curves and non-SGA by population birthweight curves, are not detected antenatally, despite the current strategy including the use of umbilical Doppler. to analyse prenatal care of a subsample of SGA stillbirths with and without detection of FGR by a confidential enquiry. Condition or disease Intervention/treatment Stillbirth Intrauterine Growth Retardation Infant, Small for Gestational Age Other: Antenatal identification of fetal growth restriction Detailed (...) Identifier: Other Study ID Numbers: DCIC12 08 First Posted: November 27, 2013 Last Update Posted: August 4, 2015 Last Verified: December 2014 Keywords provided by University Hospital, Grenoble: Stillbirth Fetal growth restriction Small for gestational age Antenatal detection Prenatal Care Mass Screening Additional relevant MeSH terms: Layout table for MeSH terms Stillbirth Fetal Growth Retardation Fetal Death Pregnancy Complications Death Pathologic Processes Fetal Diseases Growth Disorders

2013 Clinical Trials

150. Sildenafil citrate and uteroplacental perfusion in fetal growth restriction. (PubMed)

Sildenafil citrate and uteroplacental perfusion in fetal growth restriction. To determine whether the phosphodiesterase type 5 inhibitor, Sildenafil citrate, affects uteroplacental perfusion.Based on a randomized double-blinded and placebo-controlled trial, forty one pregnant women with documented intrauterine growth retardation at 24-37 weeks of gestation were evaluated for the effect of a single dose of Sildenafil citrate on uteroplacental circulation as determined by Doppler ultrasound study (...) [SD 0.60] [95% Cl 0.16-0.85], P=0.008).Doppler velocimetry index values reflect decreased placental bed vascular resistance after Sildenafil. Sildenafil citrate can improve fetoplacental perfusion in pregnancies complicated by intrauterine growth restriction. It could be a potential therapeutic strategy to improve uteroplacental blood flow in pregnancies with fetal growth restriction (FGR).

2013 Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences Controlled trial quality: predicted high

151. Down-regulating SOCS3 with siRNA ameliorates insulin signaling and glucose metabolism in hepatocytes of IUGR rats with catch-up growth. (PubMed)

Down-regulating SOCS3 with siRNA ameliorates insulin signaling and glucose metabolism in hepatocytes of IUGR rats with catch-up growth. Individuals with intrauterine growth retardation (IUGR) who demonstrate a catch-up in body weight are prone to insulin resistance. High expressions of suppressor of cytokine signaling 3 (SOCS3) are thought to aggravate insulin resistance. We hypothesized that downregulating SOCS3 expression via small interfering RNA (siRNA) might have beneficial effects (...) on insulin-resistant hepatocytes of catch-up growth IUGR rats (CG-IUGRs).An IUGR rat model was employed via maternal nutritional restriction. After evaluating metabolic states of CG-IUGR offspring, effective SOCS3-specific siRNA (siSOCS3) was transfected into cultured hepatocytes using liposomes. mRNA levels of SOCS3, insulin receptor substrates (IRSs), phosphatidylinositol 3-kinase (PI3K), and Akt2, key gluconeogenesis genes, were assessed via real-time PCR. Protein expression and phosphorylation

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2012 Pediatric Research

152. Metabolomic analysis reveals differences in umbilical vein plasma metabolites between normal and growth-restricted fetal pigs during late gestation. (PubMed)

Metabolomic analysis reveals differences in umbilical vein plasma metabolites between normal and growth-restricted fetal pigs during late gestation. Intrauterine growth restriction (IUGR) remains a major problem for both human health and animal production due to its association with high rates of neonatal morbidity and mortality, low efficiency of food utilization, permanent adverse effects on postnatal growth and development, and long-term health and productivity of the offspring. However (...) ) in umbilical vein plasma exhibited a cluster of differences between IUGR and NBW fetuses on d 90 and 110 of gestation. These changes in the IUGR group are associated with disorders of nutrient and energy metabolism as well as endocrine imbalances, which may contribute to the retardation of fetal growth and development. The findings help provide information regarding potential mechanisms responsible for IUGR in swine and also have important implications for the design of effective strategies to prevent

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2012 Journal of Nutrition

153. A Randomized Air Filter Intervention Study of Air Pollution and Fetal Growth in a Highly Polluted Community

, Simon Fraser University: Air pollution Particulate matter Mongolia Pregnancy Intrauterine growth restriction (IUGR) Fetal growth Birth weight Gestational age Additional relevant MeSH terms: Layout table for MeSH terms Fetal Growth Retardation Fetal Diseases Pregnancy Complications Growth Disorders Pathologic Processes (...) A Randomized Air Filter Intervention Study of Air Pollution and Fetal Growth in a Highly Polluted Community A Randomized Air Filter Intervention Study of Air Pollution and Fetal Growth in a Highly Polluted Community - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2012 Clinical Trials

154. Melatonin to Prevent Brain Injury in Unborn Growth Restricted Babies

University Study Details Study Description Go to Brief Summary: Intrauterine growth restriction is the term used to describe a condition where an unborn baby does not reach its optimum size. In the short and long term, intrauterine growth restricted babies have a higher risk of serious disease and even death. It is well established that very low levels of oxygen in the baby's blood can harm the baby's health through a state known as oxidative stress. Currently, there is no established treatment available (...) to treat intrauterine growth restriction or its complications. In experimental animal studies however, the naturally occuring hormone, melatonin, has been shown to significantly reduce oxidative stress and improve health of the unborn babies that have suffered from intrauterine growth restriction. This study aims to find out if the use melatonin twice per day throughout pregnancies affected by intrauterine growth restriction will lower the level of oxidative stress experienced by the unborn baby

2012 Clinical Trials

155. Growth Delay Onset Determination

Determination Growth Delay Onset Determination Aka: Growth Delay Onset Determination From Related Chapters II. Causes: Intrauterine Growth Retardation tic or chromosomal abnormality Transplacental infectious disease ( ) Toxins Nicotine Medications III. Causes: Birth Prolonged Panhypopituitarism IV. Causes: Childhood See Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Growth Delay Onset Determination." Click on the image (or right click (...) Growth Delay Onset Determination Growth Delay Onset Determination Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Growth Delay Onset

2015 FP Notebook

156. Severe Short Stature Caused by Novel Compound Heterozygous Mutations of the Insulin-Like Growth Factor 1 Receptor (IGF1R). (PubMed)

the patient.Only the second compound heterozygous IGF1R mutations to be identified, the p.E121K/E234K variant is the cause of intrauterine growth retardation and the most severe postnatal growth failure described to date in a patient with IGF1R defects. Whether the mutant IGF1R also contributes to the diabetic phenotype, however, remains to be determined. (...) Severe Short Stature Caused by Novel Compound Heterozygous Mutations of the Insulin-Like Growth Factor 1 Receptor (IGF1R). IGF-I, essential for normal human growth in utero and postnatally, mediates its effects through the IGF-I receptor (IGF1R). More than nine heterozygous mutations, including one compound heterozygous mutation, of the IGF1R gene have been reported in patients with varying degrees of intrauterine and postnatal growth retardation.The objective of the study was the analysis

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2011 Journal of Clinical Endocrinology and Metabolism

157. Safety and Efficacy of Somatropin in Children With Growth Hormone Deficiency

transplantation or any syndrome known to give short stature (examples are: Prader-Willi Syndrome, Russell-Silver Syndrome, Turner Syndrome, Noonan Syndrome) Intrauterine growth retardation: birth weight below 3rd percentile, adjusted for gestational age Pregnancy or the intention to become pregnant Breast-feeding Administration of other growth-altering medication Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact (...) for age and gender) or inadequate growth deemed secondary to growth hormone deficiency (GHD) Naïve to growth hormone therapy Exclusion Criteria: Known or suspected allergy to the trial product or related products Growth retardation attributable to causes other than GHD. Growth retardation attributable to diabetes mellitus, inborn errors of metabolism, primary bone disease, chromosomal disorders or disease of the genitourinary, cardiopulmonary, gastrointestinal or central nervous system; bone marrow

2011 Clinical Trials

158. Maternal Progesterone Level in Fetal Growth Restriction and Its Relationship with Doppler Velocimetry Indices (PubMed)

Maternal Progesterone Level in Fetal Growth Restriction and Its Relationship with Doppler Velocimetry Indices To verify whether progesterone concentration is changed in the maternal serum of intra-uterine growth retardation (IUGR) pregnancies and to assess if there is a relationship between maternal progesterone and fetal Doppler velocimetry.Thirty-five patients with intrauterine growth retardation infants and thirty-seven pregnant women with appropriate for gestational age (AGA) fetuses were

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2011 Iranian Journal of Radiology

159. Pre- and postoperative growth in persistent ductus arteriosus. (PubMed)

Pre- and postoperative growth in persistent ductus arteriosus. Children with a persistent ductus arteriosus requiring ligation under 6 months of age show evidence of intrauterine growth retardation. By the time of operation the weight centile of 17 (71%) of 24 such infants had fallen, but 20(84%) of the 24 gained weight postoperatively. Those who did not so were either large-for-dates infants growing towards the normal or small-for-dates infants who remained small postoperatively.

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1976 Archives of Disease in Childhood

160. Growth Hormone Investigation in Patients with Mental Dysfunction (PubMed)

Growth Hormone Investigation in Patients with Mental Dysfunction Seventy-three children with disorders of physical growth and mental development were stimulated by insulin hypoglycemia and arginine infusion and their human growth hormone (HGH) responses were determined. Only four patients exhibited absent or impaired pituitary hormone secretion and one of them presented a unique syndrome of panhypopituitarism associated with intrauterine growth retardation, long eyelashes and eyebrows, sparse (...) hair and degeneration of the retina. Statistical analysis indicated no significant HGH peak concentrations in groups of either tall males or stunted females who possessed various sex chromosome abnormalities, nor did these groups differ in a variety of clinical parameters including age, physical growth, birth weight and intelligence.

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1971 Canadian Medical Association Journal

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