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Intrauterine Growth Retardation

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101. Timing of Delivery in Fetal Growth Restriction of Uncomplicated Women

: No Additional relevant MeSH terms: Layout table for MeSH terms Fetal Growth Retardation Fetal Diseases Pregnancy Complications Growth Disorders Pathologic Processes (...) Timing of Delivery in Fetal Growth Restriction of Uncomplicated Women Timing of Delivery in Fetal Growth Restriction of Uncomplicated Women - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Timing of Delivery

2017 Clinical Trials

102. De novo chromosome 7q36.1q36.2 triplication in a child with developmental delay, growth failure, distinctive facial features, and multiple congenital anomalies: a case report. (PubMed)

De novo chromosome 7q36.1q36.2 triplication in a child with developmental delay, growth failure, distinctive facial features, and multiple congenital anomalies: a case report. Studying human genome using chromosomal microarrays has significantly improved the accuracy and yield of diagnosing genomic disorders. Chromosome 7q36 deletions and duplications are rare genomic disorders that have been reported in a limited number of children with developmental delay, growth retardation, and congenital (...) malformation. Altered dosage of SHH and HLXB9, both located in 7q36.3, is believed to play roles in the phenotypes associated with these rearrangements. In this report we describe a child with 7q36.1q36.2 triplication that is proximal to the 7q36.3 region. In addition to the clinical description, we discuss the genes located in the triplicated region.We report a 22 month old male child with a de novo 1.35 Mb triplication at 7q36.1q36.2. His prenatal course was complicated by oligohydramnios, intrauterine

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2017 BMC Medical Genetics

103. Plasmodium falciparum infection early in pregnancy has profound consequences for foetal growth. (PubMed)

in pregnancy. Compared with uninfected controls, women with early Plasmodium falciparum exposure had retarded intrauterine growth between gestational ages of 212 and 253 days (difference between means, 107 g [95% confidence interval {CI}, 26-188]; P = .0099) and a shorter pregnancy duration (difference between means, 6.6 days [95% CI, 1.0-112.5]; P = .0087). The birth weight (difference between means, 221 g [95% CI, 6-436]; P = .044) and the placental weight (difference between means, 84 g [95% CI, 18-150 (...) Plasmodium falciparum infection early in pregnancy has profound consequences for foetal growth. Malaria during pregnancy constitutes a large health problem in areas of endemicity. The World Health Organization recommends that interventions are initiated at the first antenatal visit, and these improve pregnancy outcomes. This study evaluated fetal growth by ultrasonography and birth outcomes in women who were infected prior to the first antenatal visit (gestational age, <120 days) and not later

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2017 Journal of Infectious Diseases

104. Investigating the Structured Use of Ultrasound Scanning for Fetal Growth

/ reference ranges for ultrasound values. Condition or disease Stillbirth Fetal Death Fetal Growth Retardation Small for Gestational Age Fetal Growth Restriction Perinatal Death Intrauterine Growth Restriction Detailed Description: There is no requirement for patient participation in this study. All data collected and analysed is routinely collected clinical data. Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 56000 participants Observational Model (...) : September 7, 2018 Last Update Posted: September 7, 2018 Last Verified: September 2018 Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Death Fetal Growth Retardation Stillbirth Fetal Death Perinatal Death Pathologic Processes Fetal Diseases Pregnancy Complications Growth Disorders

2017 Clinical Trials

105. Effect of Maternal Obesity on Fetal Growth and Expression of Placental Fatty Acid Transporters (PubMed)

levels of CD36, FATP-1, and FATP-4 in DIO dams were decreased significantly (p<0.05).Maternal obesity induced by a HF diet led to intrauterine growth retardation and down-regulated the expression of placental fatty acid transporters. (...) Effect of Maternal Obesity on Fetal Growth and Expression of Placental Fatty Acid Transporters To explore the effects of maternal high-fat (HF) diet-induced obesity on fetal growth and the expression of placental nutrient transporters.Maternal obesity was established in rats by 8 weeks of pre-pregnancy fed HF diet, while rats in the control group were fed normal (CON) diet. Diet-induced obesity (DIO) rats and diet-induced obesity-resistant (DIR) rats were selected according to body weight gain

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2017 Journal of clinical research in pediatric endocrinology

106. Sildenafil Versus Low Molecular Weight Heparin in Fetal Growth Restriction Treatment

: One hundred pregnant women with documented intrauterine growth restriction due to placental insufficiency at 28-35 weeks of gestation will be distributed into two groups: Group S: 50 women will receive Sildenafil citrate 25 mg tab 3 times daily. Group H: 50 women will receive single dose of LMWH subcutaneous daily. Both groups will undergo strict fetal surveillance in the form of: Umbilical artery Doppler (UAD) is the primary surveillance tool in the FGR fetus: middle cerebral artery (MCA) Doppler (...) ClinicalTrials.gov Identifier: Other Study ID Numbers: Ain shams university maternity First Posted: July 26, 2017 Last Update Posted: July 26, 2017 Last Verified: July 2017 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: Undecided Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Fetal Growth Retardation Fetal Diseases Pregnancy Complications

2017 Clinical Trials

107. Octreotide therapy and restricted fetal growth: pregnancy in familial hyperinsulinemic hypoglycemia (PubMed)

restriction. During pregnancy, management of blood glucose levels in familial hyperinsulinemic hypoglycemia thus forms a medical dilemma. We report on pregnancy outcomes in a woman with symptomatic familial hyperinsulinemic hypoglycemia, type 3. During the patient's first pregnancy with a viable fetus octreotide treatment was instituted in gestational age 23 weeks to prevent severe hypoglycemic incidences. Fetal growth velocity declined, and at 37 weeks of gestation, intrauterine growth retardation (...) Octreotide therapy and restricted fetal growth: pregnancy in familial hyperinsulinemic hypoglycemia Hypoglycemia during pregnancy can have serious health implications for both mother and fetus. Although not generally recommended in pregnancy, synthetic somatostatin analogues are used for the management of blood glucose levels in expectant hyperinsulinemic mothers. Recent reports suggest that octreotide treatment in pregnancy, as well as hypoglycemia in itself, may pose a risk of fetal growth

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2017 Endocrinology, diabetes & metabolism case reports

108. Air pollution and in utero programming of poor fetal growth (PubMed)

Development Fetal Growth Retardation etiology Humans Maternal Exposure adverse effects Pregnancy Smoking adverse effects AHRR DNA methylation PM2.5 air pollution aryl hydrocarbon receptor repressor cigarette smoke fetal growth fetal programming intrauterine growth restriction tobacco 2017 2 25 6 0 2017 2 25 6 0 2018 9 27 6 0 ppublish 28234022 10.2217/epi-2017-0008 PMC5985501 JAMA. 2002 Mar 6;287(9):1132-41 11879110 Obstet Gynecol. 2002 Mar;99(3):490-6 11864679 BMC Genomics. 2014 Feb 22;15:151 24559495 Am (...) Air pollution and in utero programming of poor fetal growth 28234022 2018 09 26 2018 11 13 1750-192X 9 3 2017 03 Epigenomics Epigenomics Air pollution and in utero programming of poor fetal growth. 213-216 10.2217/epi-2017-0008 Burris Heather H HH Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Departments of Pediatrics & Obstetrics, Gynecology & Reproductive Biology, Harvard Medical School, Boston, MA 02215, USA. Department of Environmental Health

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2017 Epigenomics

109. Growth hormone reverses dyslipidemia in adult offspring after maternal undernutrition (PubMed)

Growth hormone reverses dyslipidemia in adult offspring after maternal undernutrition The abnormal intrauterine milieu of fetal growth retardation could lead to dyslipidemia in adulthood. Studies have shown that growth hormone (GH) therapy in small for gestational age (SGA) children would be beneficial for metabolic parameters. Here we investigated whether GH treatment introduced at adolescent period in SGA could reverse dyslipidemia during later life. SGA rat model was established by using

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2017 Scientific reports

110. A Heterozygous Mutation of the Insulin-Like Growth Factor-I Receptor Causes Retention of the Nascent Protein in the Endoplasmic Reticulum and Results in Intrauterine and Postnatal Growth Retardation. (PubMed)

A Heterozygous Mutation of the Insulin-Like Growth Factor-I Receptor Causes Retention of the Nascent Protein in the Endoplasmic Reticulum and Results in Intrauterine and Postnatal Growth Retardation. Mutations in the IGF-I receptor (IGF1R) gene can be responsible for intrauterine and postnatal growth disorders.Here we report on a novel mutation in the IGF1R gene in a female patient. The aim of our study was to analyze the functional impact of this mutation.At birth, the girl's length was 47 cm (...) the patient's wild-type allele is supposed to lead to insufficient IGF-I signaling. We hypothesize that this mechanism results in intrauterine and postnatal growth retardation of the affected patient. The reported retention of the nascent IGF1R in the endoplasmic reticulum presents a novel mechanism of IGF-I resistance.

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2010 Journal of Clinical Endocrinology and Metabolism

111. Clinical and Functional Characteristics of a Novel Heterozygous Mutation of the IGF1R Gene and IGF1R Haploinsufficiency due to Terminal 15q26.2->qter Deletion in Patients with Intrauterine Growth Retardation and Postnatal Catch-Up Growth Failure. (PubMed)

Clinical and Functional Characteristics of a Novel Heterozygous Mutation of the IGF1R Gene and IGF1R Haploinsufficiency due to Terminal 15q26.2->qter Deletion in Patients with Intrauterine Growth Retardation and Postnatal Catch-Up Growth Failure. Mutations in the IGF1R gene result in intrauterine growth retardation and postnatal growth failure.The objective of this study was to describe the clinical features of subjects with a mutation in the IGF1R gene and to evaluate the molecular (...) and functional characteristics of a novel IGF1R mutation.Three children with unexplained intrauterine growth retardation (birth weight <-1.5 SD score) and persistent short stature (<-2.0 SD score) were included in the study.Auxological and endocrinological profiles were measured. All coding regions, including the intron-exon boundaries of the IGF1R gene, were amplified via PCR and directly sequenced. To study the functional effect of the IGF1R gene mutation on IGF-I signaling, total IGF1R protein expression

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2010 Journal of Clinical Endocrinology and Metabolism

112. Heterozygous Mutation within a Kinase-Conserved Motif of the Insulin-Like Growth Factor I Receptor Causes Intrauterine and Postnatal Growth Retardation. (PubMed)

Heterozygous Mutation within a Kinase-Conserved Motif of the Insulin-Like Growth Factor I Receptor Causes Intrauterine and Postnatal Growth Retardation. IGF-I receptor (IGF1R) plays an essential role in human intrauterine and postnatal development. Few heterozygous mutations in IGF1R leading to IGF-I resistance and intrauterine and postnatal growth retardation have been described to date.The clinical and functional relevance of a novel heterozygous IGF1R mutation identified in a girl with short (...) in reduced autophosphorylation of 36 +/- 10% of wild-type levels, suggesting a partial dominant-negative effect.The identified G1125A mutation results in a kinase-deficient IGF1R, which is likely to cause the phenotype of intrauterine and postnatal growth retardation.

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2010 Journal of Clinical Endocrinology and Metabolism

113. Spirometric Lung Function in School Age Children: Effect of Intrauterine Growth Retardation and Catch-up Growth. (PubMed)

Spirometric Lung Function in School Age Children: Effect of Intrauterine Growth Retardation and Catch-up Growth. Few studies have investigated childhood respiratory outcomes of intrauterine growth retardation (IUGR), and it is unclear if catch-up growth in these children influences lung function.We determined if lung function differed in 8- to 9-year-old children born at term with or without growth retardation, and, in the growth-retarded group, if lung function differed between those who did (...) subjects. Growth-retarded asymmetric and symmetric children had similar lung function.IUGR is associated with poorer lung function at 8-9 years of age compared with control children. Although the differences were not statistically significant, spirometry was higher in children who showed weight catch-up growth, but remained significantly lower than the control children.

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2010 American Journal of Respiratory and Critical Care Medicine

114. Epilepsy in Children with Mental Retardation (Overview)

: Prevalence of ID is increased among children with seizure disorders, microcephaly, macrocephaly, history of intrauterine or postnatal growth retardation, prematurity, and congenital anomalies Evaluation of patients for ID can include the following examinations: Head circumference: Microcephaly correlates highly with cognitive deficits; macrocephaly may indicate hydrocephalus, is associated with some inborn errors of metabolism, and may be seen early on in some children later diagnosed with autism (...) Epilepsy in Children with Mental Retardation (Overview) Intellectual Disability: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4MDcwOS1vdmVydmlldw== processing

2014 eMedicine.com

115. Epilepsy in Adults with Mental Retardation (Overview)

: Prevalence of ID is increased among children with seizure disorders, microcephaly, macrocephaly, history of intrauterine or postnatal growth retardation, prematurity, and congenital anomalies Evaluation of patients for ID can include the following examinations: Head circumference: Microcephaly correlates highly with cognitive deficits; macrocephaly may indicate hydrocephalus, is associated with some inborn errors of metabolism, and may be seen early on in some children later diagnosed with autism (...) Epilepsy in Adults with Mental Retardation (Overview) Intellectual Disability: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4MDcwOS1vdmVydmlldw== processing

2014 eMedicine.com

116. Mental Retardation (Diagnosis)

among children with seizure disorders, microcephaly, macrocephaly, history of intrauterine or postnatal growth retardation, prematurity, and congenital anomalies Evaluation of patients for ID can include the following examinations: Head circumference: Microcephaly correlates highly with cognitive deficits; macrocephaly may indicate hydrocephalus, is associated with some inborn errors of metabolism, and may be seen early on in some children later diagnosed with autism [ , ] Height: Short stature may (...) Mental Retardation (Diagnosis) Intellectual Disability: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4MDcwOS1vdmVydmlldw== processing > Intellectual Disability

2014 eMedicine.com

117. Mental Retardation (Diagnosis)

. The severity of the symptoms is related to the amount of alcohol ingested. Toxemia of pregnancy and placental insufficiency Intrauterine growth retardation has many causes, the most important being maternal toxemia with its consequences, ending in insult to the CNS. Prematurity may be of maternal or fetal origin. When it is connected with fetal developmental deviations, the prognosis depends on the infant's general condition. Prematurity and especially intrauterine growth retardation predispose to many (...) , profound mental retardation, and neurological deficits. Neonatal bacterial infections might result in sepsis and meningitis, which, in turn, may cause hydrocephalus. Delivery problems During delivery, asphyxia is the most important factor causing an insult to the CNS. It leads to cell death, which might be demonstrated with neuroimaging techniques as leukomalacia. Premature infants and those with intrauterine growth retardation are at special risk for damage to the cortex or thalamus, which

2014 eMedicine.com

118. Epilepsy in Children with Mental Retardation (Diagnosis)

: Prevalence of ID is increased among children with seizure disorders, microcephaly, macrocephaly, history of intrauterine or postnatal growth retardation, prematurity, and congenital anomalies Evaluation of patients for ID can include the following examinations: Head circumference: Microcephaly correlates highly with cognitive deficits; macrocephaly may indicate hydrocephalus, is associated with some inborn errors of metabolism, and may be seen early on in some children later diagnosed with autism (...) Epilepsy in Children with Mental Retardation (Diagnosis) Intellectual Disability: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4MDcwOS1vdmVydmlldw== processing

2014 eMedicine.com

119. Epilepsy in Adults with Mental Retardation (Diagnosis)

: Prevalence of ID is increased among children with seizure disorders, microcephaly, macrocephaly, history of intrauterine or postnatal growth retardation, prematurity, and congenital anomalies Evaluation of patients for ID can include the following examinations: Head circumference: Microcephaly correlates highly with cognitive deficits; macrocephaly may indicate hydrocephalus, is associated with some inborn errors of metabolism, and may be seen early on in some children later diagnosed with autism (...) Epilepsy in Adults with Mental Retardation (Diagnosis) Intellectual Disability: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4MDcwOS1vdmVydmlldw== processing

2014 eMedicine.com

120. Mental Retardation (Overview)

among children with seizure disorders, microcephaly, macrocephaly, history of intrauterine or postnatal growth retardation, prematurity, and congenital anomalies Evaluation of patients for ID can include the following examinations: Head circumference: Microcephaly correlates highly with cognitive deficits; macrocephaly may indicate hydrocephalus, is associated with some inborn errors of metabolism, and may be seen early on in some children later diagnosed with autism [ , ] Height: Short stature may (...) Mental Retardation (Overview) Intellectual Disability: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4MDcwOS1vdmVydmlldw== processing > Intellectual Disability

2014 eMedicine.com

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