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Intrauterine Growth Retardation

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81. Growth Hormone Treatment of Children Diagnosed of Intrauterine Growth Retardation

Growth Hormone Treatment of Children Diagnosed of Intrauterine Growth Retardation Growth Hormone Treatment of Children Diagnosed of Intrauterine Growth Retardation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Growth Hormone Treatment of Children Diagnosed of Intrauterine Growth Retardation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01697644 Recruitment Status : Completed First Posted : October 2, 2012 Last Update Posted : January 18, 2017 Sponsor: Novo Nordisk A/S Information provided

2012 Clinical Trials

82. Prenatal caffeine exposure-induced adrenal developmental abnormality in male offspring rats and its possible intrauterine programming mechanisms Full Text available with Trip Pro

unknown. In the present study, a rat model of intrauterine growth retardation (IUGR) was established by PCE, male fetuses and adult offspring were sacrificed at postnatal day (PD) 1, PD7, PD35, PD100 and PD168, respectively. Results showed that the PCE fetal weight decreased and the IUGR rate increased, while the serum corticosterone (CORT) level increased but the insulin-like growth factor 1 (IGF1) level decreased. Fetal adrenal exhibited an enhanced GC-activation system (11β-hydroxysteroid (...) Prenatal caffeine exposure-induced adrenal developmental abnormality in male offspring rats and its possible intrauterine programming mechanisms Glucocorticoid (GC) is a major factor for fetal tissue maturation and fate decision after birth. We previously demonstrated that prenatal caffeine exposure (PCE) suppressed fetal adrenal steroidogenesis and resulted in adrenal dysplasia. However, whether these changes play a role until adulthood and its intrauterine programming mechanisms remain

2016 Toxicology research

83. Loss of function of PCDH12 underlies recessive microcephaly mimicking intrauterine infection. Full Text available with Trip Pro

brain foci, microcephaly, and intrauterine growth retardation. Postnatally, patients had progressive severe microcephaly, neonatal seizures, and virtually no developmental milestones. Brain imaging revealed dysplastic elongated masses in the midbrain-hypothalamus-optic tract area. Whole exome sequencing of one affected child revealed only PCDH12 c.2515C>T, p.R839X, to be homozygous in the proband and to cosegregate with the condition in her family. The allele frequency of PCDH12 p.R839X is <0.00001 (...) Loss of function of PCDH12 underlies recessive microcephaly mimicking intrauterine infection. To identify the genetic basis of a recessive syndrome characterized by prenatal hyperechogenic brain foci, congenital microcephaly, hypothalamic midbrain dysplasia, epilepsy, and profound global developmental disability.Identification of the responsible gene by whole exome sequencing and homozygosity mapping.Ten patients from 4 consanguineous Palestinian families manifested in utero with hyperechogenic

2016 Neurology

84. Impairment of cellular immunity is associated with overexpression of heat shock protein 70 in neonatal pigs with intrauterine growth retardation Full Text available with Trip Pro

Impairment of cellular immunity is associated with overexpression of heat shock protein 70 in neonatal pigs with intrauterine growth retardation Neonates with intrauterine growth retardation (IUGR) are susceptible to decreases in cellular immunity. In recent years, a growing body of evidence indicates that Hsp70 may serve as a danger signal to the innate immune system and promote receptor-mediated apoptosis. Using neonatal pigs with IUGR, we investigated immune function of pigs and expression

2012 Cell stress & chaperones

85. Delayed Myelination in an Intrauterine Growth Retardation Model Is Mediated by Oxidative Stress Upregulating Bone Morphogenetic Protein 4 Full Text available with Trip Pro

Delayed Myelination in an Intrauterine Growth Retardation Model Is Mediated by Oxidative Stress Upregulating Bone Morphogenetic Protein 4 Intrauterine growth retardation (IUGR) is associated with neurological deficits including cerebral palsy and cognitive and behavioral disabilities. The pathogenesis involves oxidative stress that leads to periventricular white matter injury with a paucity of mature oligodendrocytes and hypomyelination. The molecular mechanisms underlying this damage remain (...) poorly understood. We used a rat model of IUGR created by bilateral ligation of the uterine artery at embryonic Day 19 that results in fetal growth retardation and oxidative stress in the developing brain. The IUGR rat pups showed significant delays in oligodendrocyte differentiation and myelination that resolved by 8 weeks. Bone morphogenetic protein 4 (BMP4), which inhibits oligodendrocyte maturation, was elevated in IUGR brains at postnatal time points and returned to near normal by adulthood

2012 Journal of neuropathology and experimental neurology

86. Heat Shock Protein 70 Expression is Increased in the Liver of Neonatal Intrauterine Growth Retardation Piglets Full Text available with Trip Pro

Heat Shock Protein 70 Expression is Increased in the Liver of Neonatal Intrauterine Growth Retardation Piglets Intrauterine growth retardation (IUGR) leads to the dysfunction in digestive system, as well as the alteration in the expression of some functional proteins. Heat shock protein 70 (Hsp70) could be induced by various stress factors, but whether Hsp70 expression is changed in neonatal IUGR infants has not been demonstrated. This study was conducted to explore the expression of Hsp70

2012 Asian-Australasian journal of animal sciences

87. Long Term Effect of Somatropin in Subjects With Intrauterine Growth Retardation

Long Term Effect of Somatropin in Subjects With Intrauterine Growth Retardation Long Term Effect of Somatropin in Subjects With Intrauterine Growth Retardation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Long Term Effect of Somatropin in Subjects With Intrauterine Growth Retardation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01734447 Recruitment Status : Completed First Posted : November 27, 2012 Last Update Posted : February 28, 2017 Sponsor: Novo Nordisk A/S Information provided

2012 Clinical Trials

88. Effect of intrauterine growth retardation on liver and long-term metabolic risk. Full Text available with Trip Pro

Effect of intrauterine growth retardation on liver and long-term metabolic risk. Intrauterine growth retardation predisposes toward long-term morbidity from type 2 diabetes and cardiovascular disease. To explain this association, the concept of programming was introduced to indicate a process whereby a stimulus or insult at a critical period of development has lasting or lifelong consequences on key endocrine and metabolic pathways. Subtle changes in cell composition of tissues, induced (...) by suboptimal conditions in utero, can influence postnatal physiological functions. There is increasing evidence, suggesting that liver may represent one of the candidate organs targeted by programming, undergoing structural, functional and epigenetic changes following exposure to an unfavorable intrauterine environment. The aim of this review is to provide insights into the molecular mechanisms underlying liver programming that contribute to increase the cardiometabolic risk in subjects with intrauterine

2012 International Journal of Obesity

89. Association between preterm birth and intrauterine growth retardation and child asthma. Full Text available with Trip Pro

Association between preterm birth and intrauterine growth retardation and child asthma. An association between preterm birth and an increased risk of childhood asthma has been demonstrated, but the importance of intrauterine growth retardation on asthma risk is unclear. Using data from Swedish health registers, infant characteristics and childhood asthma were studied. Analyses were made using Mantel-Haenszel methodology with adjustment for year of birth, maternal age, parity, smoking in early (...) pregnancy and maternal body mass index. Preterm birth, birth weight and birth weight for gestational week were analysed and childhood asthma was evaluated from prescriptions of anti-asthmatic drugs. Neonatal respiratory problems and treatment for them were studied as mediating factors. Both short gestational duration and intrauterine growth retardation appeared to be risk factors and seemed to act separately. The largest effect was seen from short gestational duration. Use of mechanical ventilation

2012 European Respiratory Journal

90. IGF1R Variants in Patients With Growth Impairment: Four Novel Variants and Genotype-Phenotype Correlations. Full Text available with Trip Pro

IGF1R Variants in Patients With Growth Impairment: Four Novel Variants and Genotype-Phenotype Correlations. IGF1R gene mutations have been associated with varying degrees of intrauterine and postnatal growth retardation, as well as microcephaly. Both autosomal-dominant and autosomal-recessive inheritance patterns have been reported. This study aimed to analyze the IGF1R gene in children with growth impairment using whole-exome sequencing (WES) and assess the clinical features with the autosomal (...) gene, which expanded the known mutation spectrum. Through a comparison among patients with reported IGF1R pathogenic variations, this study determined that an autosomal-recessive inheritance model of the IGF1R gene may result in a more severe phenotype with developmental and speech delays, as well as mental retardation.

2018 Journal of Clinical Endocrinology and Metabolism

91. Growth and Asymmetric diMethylArginine

): University Hospital, Lille Study Details Study Description Go to Brief Summary: Principal objective : Validation of a handy biochemical parameter, plasma concentration of Asymmetric DimethylArginine (ADMA), based on a recognize biochemical parameter, the dilation of the brachial artery, at ultrasound examination, after the deflation of a cushion to evaluate artery dysfunction (vascular suffering) in growth diseases, growth hormone deficiency (GHD) and intrauterine growth retardation (IUGR) Secondary (...) Perspective: Prospective Official Title: Validation of the Dosage of Asymmetric Dimethylarginine (ADMA) Plasma in the Assessment of Endothelial Dysfunction During Growth Hormone Deficiency and Intrauterine Growth Retardation Study Start Date : June 2014 Estimated Primary Completion Date : December 2020 Estimated Study Completion Date : December 2020 Resource links provided by the National Library of Medicine related topics: related topics: resources: Groups and Cohorts Go to Group/Cohort Intervention

2018 Clinical Trials

92. Indicators of Growth, Nutritional Status and Comorbide Disorders of Newborns With Down Syndrome

to 2015) were included. The data were obtained from the medical histories of mothers, infants and the delivery protocol. The objective was to access predictive values of the auxological parameters and indexes for risk of comorbid malformations in newborns with Down syndrome (DS) Conclusion Higher CI were found in hyportrophic (SGA) newborns with DS and indicated their intrauterine growth restriction with brain sparing and increased further risk of severe psychomotor retardation. The SGA newborns have (...) lower parameters and indexes of nutritive status and significantly differed from eutrophic and hypertrophic newborns. These SGA newborns with DS have increased developmental risks and that requires further diagnostic attention. Condition or disease Down Syndrome,Auxological Indexes, Auxological Parametars, Intrauterine Growth Restriction Detailed Description: Use of anthropometric charts developed specifically for children with DS have a better expression of real growth restriction (small

2018 Clinical Trials

93. Optimal Growth of Preterm Infants With Growth Restriction

- University of Munich University Hospital Tuebingen University of Erlangen-Nürnberg Medical School University of Milan Poznan University of Medical Sciences Lund University Information provided by (Responsible Party): Nadja Haiden,MD, Medical University of Vienna Study Details Study Description Go to Brief Summary: In this prospective randomized controlled multi center trial the investigators stratify "Very Low Birthweight " (VLBW)-infants with growth retardation in small for gestational age (SGA (...) ) or intrauterine growth restricted (IUGR) - infants and aim to investigate the impact of a nutritional management with enhanced nutrients from discharge up to the 52nd week of postconceptional age on growth, body composition, metabolic programming, metabolomics, microbiome and long term neurodevelopmental outcome. In this study, the investigators will evaluate the difference in metabolic profiles of SGA and IUGR preterm infants. The investigators will further longitudinally assess, how different nutritional

2016 Clinical Trials

94. Mental Retardation (Overview)

among children with seizure disorders, microcephaly, macrocephaly, history of intrauterine or postnatal growth retardation, prematurity, and congenital anomalies Evaluation of patients for ID can include the following examinations: Head circumference: Microcephaly correlates highly with cognitive deficits; macrocephaly may indicate hydrocephalus, is associated with some inborn errors of metabolism, and may be seen early on in some children later diagnosed with autism [ , ] Height: Short stature may (...) Mental Retardation (Overview) Intellectual Disability: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4MDcwOS1vdmVydmlldw== processing > Intellectual Disability

2014 eMedicine.com

95. Mental Retardation (Overview)

to the amount of alcohol ingested. Toxemia of pregnancy and placental insufficiency Intrauterine growth retardation has many causes, the most important being maternal toxemia with its consequences, ending in insult to the CNS. Prematurity may be of maternal or fetal origin. When it is connected with fetal developmental deviations, the prognosis depends on the infant's general condition. Prematurity and especially intrauterine growth retardation predispose to many perinatal complications, which may result (...) deficits. Neonatal bacterial infections might result in sepsis and meningitis, which, in turn, may cause hydrocephalus. Delivery problems During delivery, asphyxia is the most important factor causing an insult to the CNS. It leads to cell death, which might be demonstrated with neuroimaging techniques as leukomalacia. Premature infants and those with intrauterine growth retardation are at special risk for damage to the cortex or thalamus, which, in addition to affecting intelligence, causes various

2014 eMedicine.com

96. Epilepsy in Children with Mental Retardation (Overview)

: Prevalence of ID is increased among children with seizure disorders, microcephaly, macrocephaly, history of intrauterine or postnatal growth retardation, prematurity, and congenital anomalies Evaluation of patients for ID can include the following examinations: Head circumference: Microcephaly correlates highly with cognitive deficits; macrocephaly may indicate hydrocephalus, is associated with some inborn errors of metabolism, and may be seen early on in some children later diagnosed with autism (...) Epilepsy in Children with Mental Retardation (Overview) Intellectual Disability: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4MDcwOS1vdmVydmlldw== processing

2014 eMedicine.com

97. Epilepsy in Adults with Mental Retardation (Overview)

: Prevalence of ID is increased among children with seizure disorders, microcephaly, macrocephaly, history of intrauterine or postnatal growth retardation, prematurity, and congenital anomalies Evaluation of patients for ID can include the following examinations: Head circumference: Microcephaly correlates highly with cognitive deficits; macrocephaly may indicate hydrocephalus, is associated with some inborn errors of metabolism, and may be seen early on in some children later diagnosed with autism (...) Epilepsy in Adults with Mental Retardation (Overview) Intellectual Disability: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4MDcwOS1vdmVydmlldw== processing

2014 eMedicine.com

98. Mental Retardation (Treatment)

. The severity of the symptoms is related to the amount of alcohol ingested. Toxemia of pregnancy and placental insufficiency Intrauterine growth retardation has many causes, the most important being maternal toxemia with its consequences, ending in insult to the CNS. Prematurity may be of maternal or fetal origin. When it is connected with fetal developmental deviations, the prognosis depends on the infant's general condition. Prematurity and especially intrauterine growth retardation predispose to many (...) , profound mental retardation, and neurological deficits. Neonatal bacterial infections might result in sepsis and meningitis, which, in turn, may cause hydrocephalus. Delivery problems During delivery, asphyxia is the most important factor causing an insult to the CNS. It leads to cell death, which might be demonstrated with neuroimaging techniques as leukomalacia. Premature infants and those with intrauterine growth retardation are at special risk for damage to the cortex or thalamus, which

2014 eMedicine.com

99. Mental Retardation (Follow-up)

. The severity of the symptoms is related to the amount of alcohol ingested. Toxemia of pregnancy and placental insufficiency Intrauterine growth retardation has many causes, the most important being maternal toxemia with its consequences, ending in insult to the CNS. Prematurity may be of maternal or fetal origin. When it is connected with fetal developmental deviations, the prognosis depends on the infant's general condition. Prematurity and especially intrauterine growth retardation predispose to many (...) , profound mental retardation, and neurological deficits. Neonatal bacterial infections might result in sepsis and meningitis, which, in turn, may cause hydrocephalus. Delivery problems During delivery, asphyxia is the most important factor causing an insult to the CNS. It leads to cell death, which might be demonstrated with neuroimaging techniques as leukomalacia. Premature infants and those with intrauterine growth retardation are at special risk for damage to the cortex or thalamus, which

2014 eMedicine.com

100. Mental Retardation (Diagnosis)

among children with seizure disorders, microcephaly, macrocephaly, history of intrauterine or postnatal growth retardation, prematurity, and congenital anomalies Evaluation of patients for ID can include the following examinations: Head circumference: Microcephaly correlates highly with cognitive deficits; macrocephaly may indicate hydrocephalus, is associated with some inborn errors of metabolism, and may be seen early on in some children later diagnosed with autism [ , ] Height: Short stature may (...) Mental Retardation (Diagnosis) Intellectual Disability: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE4MDcwOS1vdmVydmlldw== processing > Intellectual Disability

2014 eMedicine.com

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