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Intrauterine Growth Retardation

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81. Evaluation of Infants With Intrauterine Growth Restriction

Study ID Numbers: 142 /181/ 20.05.2014 First Posted: August 4, 2015 Last Update Posted: August 6, 2015 Last Verified: August 2015 Keywords provided by Hășmășanu Monica Gabriela, Iuliu Hatieganu University of Medicine and Pharmacy: IUGR (intrauterine growth restriction) IGF2 (insulin-like growth factor 2) morbidity Additional relevant MeSH terms: Layout table for MeSH terms Fetal Growth Retardation Fetal Diseases Pregnancy Complications Growth Disorders Pathologic Processes (...) Evaluation of Infants With Intrauterine Growth Restriction Evaluation of Infants With Intrauterine Growth Restriction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluation of Infants With Intrauterine

2015 Clinical Trials

82. Re: Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review. (PubMed)

Re: Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review. 26589866 2016 02 24 2018 12 02 1471-0528 122 13 2015 Dec BJOG : an international journal of obstetrics and gynaecology BJOG Re: Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review. 1850 10.1111/1471-0528.13705 Khalil Asma A Fetal Medicine Unit, St George's, University of London, London, UK. Morales-Roselló Jose J Fetal Medicine Unit (...) , St George's, University of London, London, UK. Thilaganathan Basky B Fetal Medicine Unit, St George's, University of London, London, UK. eng Letter Comment England BJOG 100935741 1470-0328 AIM IM BJOG. 2015 Jul;122(8):1062-72 25990812 Developmental Disabilities epidemiology Female Fetal Growth Retardation epidemiology Humans Pregnancy 2015 07 28 2015 11 22 6 0 2015 11 22 6 0 2016 2 26 6 0 ppublish 26589866 10.1111/1471-0528.13705

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2015 BJOG : an international journal of obstetrics and gynaecology

83. LOSS OF METHYLATION AT GNAS EXON A/B IS ASSOCIATED WITH INCREASED INTRAUTERINE GROWTH. (PubMed)

of methylation (LOM) at exon A/B alone or sporadic PHP1B (sporPHP1B) associated with broad GNAS methylation changes. Similar to effects other imprinted genes have on early development, we recently observed severe intrauterine growth retardation in newborns, later diagnosed with pseudopseudohypoparathyroidism (PPHP) because of paternal GNAS loss-of-function mutations.This study aimed to determine whether GNAS methylation abnormalities affect intrauterine growth.Birth parameters were collected of patients who (...) LOSS OF METHYLATION AT GNAS EXON A/B IS ASSOCIATED WITH INCREASED INTRAUTERINE GROWTH. GNAS is one of few genetic loci that undergo allelic-specific methylation resulting in the parent-specific expression of at least four different transcripts. Due to monoallelic expression, heterozygous GNAS mutations affecting either paternally or maternally derived transcripts cause different forms of pseudohypoparathyroidism (PHP), including autosomal-dominant PHP type Ib (AD-PHP1B) associated with loss

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2015 Journal of Clinical Endocrinology and Metabolism

84. Gender-Specific Relationship Between Prenatal Exposure to Phthalates and Intrauterine Growth Restriction. (PubMed)

Gender-Specific Relationship Between Prenatal Exposure to Phthalates and Intrauterine Growth Restriction. No study has examined the association between prenatal phthalate exposure and intrauterine growth retardation (IUGR). This study aimed to investigate whether prenatal exposure to phthalates was associated with increased risk of IUGR.A total of 126 mother-newborn pairs, including 42 IUGR cases and 84 control newborns and their mothers, were enrolled in this case-control study. Spot urine (...) significantly inversely associated with fetal growth indicators (birth weight and Quetelet's index). When mothers were stratified by infant sex, MEHHP and MEOHP concentrations were still negatively associated with fetal growth indicators, while no significant association was observed in females. In addition, exposure-response relationships were observed between MEHHP/SumDEHP concentrations in maternal urine and IUGR.Prenatal exposure to phthalates was associated with increased risk of IUGR, and male

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2014 Pediatric Research

85. The insulin-like growth factors and feto-placental growth. (PubMed)

circulations with 3-10 fold higher levels of IGF-II than IGF-1 during late gestation. Expression of the Igfgenes is developmentally regulated in a tissue specific manner and can be affected by nutritional and endocrine conditions in utero. Deletion of either Igfgene of the Igf1rgene retards fetal growth while over-expression of IGF-II leads to fetal overgrowth. In mice, placental growth is affected only by manipulation of the Igf2gene. The IGF's also effect the growth of individual fetal tissues (...) regulated by nutritional and endocrine signals. The Igf2gene appears to provide the constitutive drive for intrauterine growth via its placental effects and direct paracrine actions on fetal tissue while the Igf1gene regulates fetal growth in relation to the nutrient supply.

2017 Placenta

86. Loss of function of PCDH12 underlies recessive microcephaly mimicking intrauterine infection. (PubMed)

brain foci, microcephaly, and intrauterine growth retardation. Postnatally, patients had progressive severe microcephaly, neonatal seizures, and virtually no developmental milestones. Brain imaging revealed dysplastic elongated masses in the midbrain-hypothalamus-optic tract area. Whole exome sequencing of one affected child revealed only PCDH12 c.2515C>T, p.R839X, to be homozygous in the proband and to cosegregate with the condition in her family. The allele frequency of PCDH12 p.R839X is <0.00001 (...) Loss of function of PCDH12 underlies recessive microcephaly mimicking intrauterine infection. To identify the genetic basis of a recessive syndrome characterized by prenatal hyperechogenic brain foci, congenital microcephaly, hypothalamic midbrain dysplasia, epilepsy, and profound global developmental disability.Identification of the responsible gene by whole exome sequencing and homozygosity mapping.Ten patients from 4 consanguineous Palestinian families manifested in utero with hyperechogenic

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2016 Neurology

87. Prenatal caffeine exposure-induced adrenal developmental abnormality in male offspring rats and its possible intrauterine programming mechanisms (PubMed)

unknown. In the present study, a rat model of intrauterine growth retardation (IUGR) was established by PCE, male fetuses and adult offspring were sacrificed at postnatal day (PD) 1, PD7, PD35, PD100 and PD168, respectively. Results showed that the PCE fetal weight decreased and the IUGR rate increased, while the serum corticosterone (CORT) level increased but the insulin-like growth factor 1 (IGF1) level decreased. Fetal adrenal exhibited an enhanced GC-activation system (11β-hydroxysteroid (...) Prenatal caffeine exposure-induced adrenal developmental abnormality in male offspring rats and its possible intrauterine programming mechanisms Glucocorticoid (GC) is a major factor for fetal tissue maturation and fate decision after birth. We previously demonstrated that prenatal caffeine exposure (PCE) suppressed fetal adrenal steroidogenesis and resulted in adrenal dysplasia. However, whether these changes play a role until adulthood and its intrauterine programming mechanisms remain

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2016 Toxicology research

88. Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis

Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis Cnossen JS, Morris RK, ter (...) Riet G, Mol BW, van der Post JA, Coomarasamy A, Zwinderman AH, Robson SC, Bindels PJ, Kleijnen J, Khan KS CRD summary This review found that Doppler ultrasonography was a better predictor of pre-eclampsia than of intrauterine growth restriction; pulsatility index, alone or combined with notching, in the second trimester was the most predictive Doppler index. In addition to other limitations, most of the authors’ conclusions were based on results from single studies so cannot be considered reliable

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2008 DARE.

89. Intrauterine and postnatal growth failure with normal growth hormone/insulin-like growth factor-1 axis and insulin resistant diabetes in a consanguineous kinship. (PubMed)

Intrauterine and postnatal growth failure with normal growth hormone/insulin-like growth factor-1 axis and insulin resistant diabetes in a consanguineous kinship. To describe the clinical and biochemical features, and perform molecular analysis for candidate abnormalities in a novel familial syndrome of intrauterine growth retardation (IUGR), failure of an adolescent growth spurt with proportional adult short stature, minimal subluxation of the 5th metacarpal-phalangeal joint, and adult-onset (...) the association of IUGR and adult MS, including diabetes, has been well documented, these subjects did not have typical manifestations of MS. Abnormalities in common components that could result in a combination of IUGR, severe postnatal growth, and insulin resistance have been ruled out. A mutation in an unidentified gene may affect intrauterine and postnatal growth, with insulin resistance directly affected or as a result of this growth phenomenon.

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2011 European Journal of Endocrinology

90. Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants

Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01942525 Recruitment Status : Unknown Verified September 2013 by Katrin Klebermass-Schrehof, Medical University of Vienna. Recruitment

2013 Clinical Trials

91. Association of hereditary thrombophilia with intrauterine growth restriction (PubMed)

Association of hereditary thrombophilia with intrauterine growth restriction Intrauterine growth retardation (IUGR) contributes significantly to fetal morbidity and mortality, but its etiology is unknown in most cases.The aim of this study was to examine the association between inherited thrombophilia and IUGR.A case-control study was performed in a tertiary referral center (Afzalipour Hospital) over 2-years period (2010-2011). Cases (n=25) were women who had pregnancies complicated by IUDR (...) and control subjects (n=25) were women who had normal growth fetuses. All women were tested for inherited thrombophilia at least 4 weeks after delivery. Main outcome measure was prevalence of maternal thrombophlia. Genotyping for factor V Leiden, prothrombin gene (nucleotide G20210A), and MTHFR (C677T) mutation was performed by PCR technique. Protein C, S and antithrombin III activity were determined with a clotting assay (STA-Staclot, France).The prevalence of hereditary thrombophilia was 68% (n=17

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2013 Iranian Journal of Reproductive Medicine

92. Optimal Growth of Preterm Infants With Growth Restriction

- University of Munich University Hospital Tuebingen University of Erlangen-Nürnberg Medical School University of Milan Poznan University of Medical Sciences Lund University Information provided by (Responsible Party): Nadja Haiden,MD, Medical University of Vienna Study Details Study Description Go to Brief Summary: In this prospective randomized controlled multi center trial the investigators stratify "Very Low Birthweight " (VLBW)-infants with growth retardation in small for gestational age (SGA (...) ) or intrauterine growth restricted (IUGR) - infants and aim to investigate the impact of a nutritional management with enhanced nutrients from discharge up to the 52nd week of postconceptional age on growth, body composition, metabolic programming, metabolomics, microbiome and long term neurodevelopmental outcome. In this study, the investigators will evaluate the difference in metabolic profiles of SGA and IUGR preterm infants. The investigators will further longitudinally assess, how different nutritional

2016 Clinical Trials

93. Growth and Asymmetric diMethylArginine

): University Hospital, Lille Study Details Study Description Go to Brief Summary: Principal objective : Validation of a handy biochemical parameter, plasma concentration of Asymmetric DimethylArginine (ADMA), based on a recognize biochemical parameter, the dilation of the brachial artery, at ultrasound examination, after the deflation of a cushion to evaluate artery dysfunction (vascular suffering) in growth diseases, growth hormone deficiency (GHD) and intrauterine growth retardation (IUGR) Secondary (...) Perspective: Prospective Official Title: Validation of the Dosage of Asymmetric Dimethylarginine (ADMA) Plasma in the Assessment of Endothelial Dysfunction During Growth Hormone Deficiency and Intrauterine Growth Retardation Study Start Date : June 2014 Estimated Primary Completion Date : December 2020 Estimated Study Completion Date : December 2020 Resource links provided by the National Library of Medicine related topics: related topics: resources: Groups and Cohorts Go to Group/Cohort Intervention

2018 Clinical Trials

94. Indicators of Growth, Nutritional Status and Comorbide Disorders of Newborns With Down Syndrome

to 2015) were included. The data were obtained from the medical histories of mothers, infants and the delivery protocol. The objective was to access predictive values of the auxological parameters and indexes for risk of comorbid malformations in newborns with Down syndrome (DS) Conclusion Higher CI were found in hyportrophic (SGA) newborns with DS and indicated their intrauterine growth restriction with brain sparing and increased further risk of severe psychomotor retardation. The SGA newborns have (...) lower parameters and indexes of nutritive status and significantly differed from eutrophic and hypertrophic newborns. These SGA newborns with DS have increased developmental risks and that requires further diagnostic attention. Condition or disease Down Syndrome,Auxological Indexes, Auxological Parametars, Intrauterine Growth Restriction Detailed Description: Use of anthropometric charts developed specifically for children with DS have a better expression of real growth restriction (small

2018 Clinical Trials

95. IGF1R variants in patients with growth impairment: Four novel variants and genotype-phenotype correlations. (PubMed)

IGF1R variants in patients with growth impairment: Four novel variants and genotype-phenotype correlations. IGF1R gene mutations have been associated with varying degrees of intrauterine and postnatal growth retardation, as well as microcephaly. Both autosomal-dominant and autosomal-recessive inheritance patterns have been reported. This study aimed to analyze the IGF1R gene in children with growth impairment using whole-exome sequencing (WES) and assess the clinical features with the autosomal (...) gene, which expanded the known mutation spectrum. Through a comparison among patients with reported IGF1R pathogenic variations, this study determined that an autosomal-recessive inheritance model of the IGF1R gene may result in a more severe phenotype with developmental and speech delays, as well as mental retardation.

2018 Journal of Clinical Endocrinology and Metabolism

96. An approach to solving problems of growth retardation in the child and teenager. (PubMed)

An approach to solving problems of growth retardation in the child and teenager. The physician who looks after children and teenagers is often confronted with the problem of short stature or growth failure. Common causes of growth failure include genetic background, intrauterine disease, malnutrition, chronic illness and hormonal disorders; some cases are attributed to mental retardation or primary central nervous system disease. A major concern in the evaluation of these patients is when

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1977 Canadian Medical Association Journal

97. Intrauterine growth restriction affects hippocampal dual specificity phosphatase 5 gene expression and epigenetic characteristics (PubMed)

Intrauterine growth restriction affects hippocampal dual specificity phosphatase 5 gene expression and epigenetic characteristics Intrauterine growth retardation (IUGR) predisposes humans toward hippocampal morbidities, such as impaired learning and memory. Hippocampal dual specificity phosphatase 5 (DUSP5) may be involved in these morbidities because DUSP5 regulates extracellular signal-regulated kinase phosphorylation (Erk). In the rat, IUGR causes postnatal changes in hippocampal gene

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2011 Physiological genomics

98. Early screening for pre-eclampsia and intrauterine growth restriction. (PubMed)

Early screening for pre-eclampsia and intrauterine growth restriction. 21520318 2011 06 29 2016 11 25 1469-0705 37 5 2011 May Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Ultrasound Obstet Gynecol Early screening for pre-eclampsia and intrauterine growth restriction. 623-4 10.1002/uog.9018 Harrington Kevin K eng Journal Article England Ultrasound Obstet Gynecol 9108340 0960-7692 IM Early Diagnosis Female (...) Fetal Growth Retardation diagnostic imaging Humans Mass Screening Placental Circulation Pre-Eclampsia diagnostic imaging Pregnancy Ultrasonography 2011 4 27 6 0 2011 4 27 6 0 2011 6 30 6 0 ppublish 21520318 10.1002/uog.9018

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2011 Ultrasound in Obstetrics and Gynecology

99. Can Low Molecular Weight Heparin During Pregnancy With Intrauterine Growth Restriction Increase Birth Weight?

Can Low Molecular Weight Heparin During Pregnancy With Intrauterine Growth Restriction Increase Birth Weight? Can Low Molecular Weight Heparin During Pregnancy With Intrauterine Growth Restriction Increase Birth Weight? - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Can Low Molecular Weight Heparin During Pregnancy With Intrauterine Growth Restriction Increase Birth Weight? (IUGR) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01390051 Recruitment Status : Completed First Posted : July 8, 2011 Last

2011 Clinical Trials

100. EG-VEGF : Potential Marker of Pre-eclampsia and / or Intrauterine Growth Restriction

EG-VEGF : Potential Marker of Pre-eclampsia and / or Intrauterine Growth Restriction EG-VEGF : Potential Marker of Pre-eclampsia and / or Intrauterine Growth Restriction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. EG-VEGF : Potential Marker of Pre-eclampsia and / or Intrauterine Growth Restriction (EGEVE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01490489 Recruitment Status : Unknown Verified February 2015 by Institut National de la Santé Et de la Recherche Médicale, France. Recruitment

2011 Clinical Trials

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