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Intrauterine Growth Retardation

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61. Delayed Myelination in an Intrauterine Growth Retardation Model Is Mediated by Oxidative Stress Upregulating Bone Morphogenetic Protein 4 (PubMed)

Delayed Myelination in an Intrauterine Growth Retardation Model Is Mediated by Oxidative Stress Upregulating Bone Morphogenetic Protein 4 Intrauterine growth retardation (IUGR) is associated with neurological deficits including cerebral palsy and cognitive and behavioral disabilities. The pathogenesis involves oxidative stress that leads to periventricular white matter injury with a paucity of mature oligodendrocytes and hypomyelination. The molecular mechanisms underlying this damage remain (...) poorly understood. We used a rat model of IUGR created by bilateral ligation of the uterine artery at embryonic Day 19 that results in fetal growth retardation and oxidative stress in the developing brain. The IUGR rat pups showed significant delays in oligodendrocyte differentiation and myelination that resolved by 8 weeks. Bone morphogenetic protein 4 (BMP4), which inhibits oligodendrocyte maturation, was elevated in IUGR brains at postnatal time points and returned to near normal by adulthood

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2012 Journal of neuropathology and experimental neurology

62. Effect of intrauterine growth retardation on liver and long-term metabolic risk. (PubMed)

Effect of intrauterine growth retardation on liver and long-term metabolic risk. Intrauterine growth retardation predisposes toward long-term morbidity from type 2 diabetes and cardiovascular disease. To explain this association, the concept of programming was introduced to indicate a process whereby a stimulus or insult at a critical period of development has lasting or lifelong consequences on key endocrine and metabolic pathways. Subtle changes in cell composition of tissues, induced (...) by suboptimal conditions in utero, can influence postnatal physiological functions. There is increasing evidence, suggesting that liver may represent one of the candidate organs targeted by programming, undergoing structural, functional and epigenetic changes following exposure to an unfavorable intrauterine environment. The aim of this review is to provide insights into the molecular mechanisms underlying liver programming that contribute to increase the cardiometabolic risk in subjects with intrauterine

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2012 International Journal of Obesity

63. Association between preterm birth and intrauterine growth retardation and child asthma. (PubMed)

Association between preterm birth and intrauterine growth retardation and child asthma. An association between preterm birth and an increased risk of childhood asthma has been demonstrated, but the importance of intrauterine growth retardation on asthma risk is unclear. Using data from Swedish health registers, infant characteristics and childhood asthma were studied. Analyses were made using Mantel-Haenszel methodology with adjustment for year of birth, maternal age, parity, smoking in early (...) pregnancy and maternal body mass index. Preterm birth, birth weight and birth weight for gestational week were analysed and childhood asthma was evaluated from prescriptions of anti-asthmatic drugs. Neonatal respiratory problems and treatment for them were studied as mediating factors. Both short gestational duration and intrauterine growth retardation appeared to be risk factors and seemed to act separately. The largest effect was seen from short gestational duration. Use of mechanical ventilation

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2012 European Respiratory Journal

64. Long Term Effect of Somatropin in Subjects With Intrauterine Growth Retardation

Long Term Effect of Somatropin in Subjects With Intrauterine Growth Retardation Long Term Effect of Somatropin in Subjects With Intrauterine Growth Retardation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Long Term Effect of Somatropin in Subjects With Intrauterine Growth Retardation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01734447 Recruitment Status : Completed First Posted : November 27, 2012 Last Update Posted : February 28, 2017 Sponsor: Novo Nordisk A/S Information provided

2012 Clinical Trials

65. Intrauterine Growth Retardation

Intrauterine Growth Retardation Intrauterine Growth Retardation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Intrauterine Growth (...) Retardation Intrauterine Growth Retardation Aka: Intrauterine Growth Retardation , Small for Gestational Age , IUGR From Related Chapters II. Definitions Intrauterine Growth Retardation (IUGR) Estimated fetal weight < 10% per Some suggest cutoff of 5% to reduce false positives Small for Gestational Age (SGA) Normal small infants without adverse risks III. Evaluation Indicators of IUGR Poor Maternal Weight gain Most sensitive indicator for IUGR Fundal Height less than expected for Consider environmental

2015 FP Notebook

66. Growth Problems in Children: Intrauterine Growth Retardation (PubMed)

Growth Problems in Children: Intrauterine Growth Retardation 20468396 2010 06 28 2018 11 13 0008-350X 15 6 1969 Jun Canadian family physician Medecin de famille canadien Can Fam Physician Growth problems in children: intrauterine growth retardation. 31-4 Cochrane W A WA eng Journal Article Canada Can Fam Physician 0120300 0008-350X 2010 5 15 6 0 1969 6 1 0 0 1969 6 1 0 1 ppublish 20468396 PMC2281395 JAMA. 1965 Dec 20;194(12):1277-83 5898080 Am J Dis Child. 1961 Aug;102:249-79 13783175 Arch Dis

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1969 Canadian Family Physician

67. The Influence of Down-regulation of Suppressor of Cellular Signaling Proteins by RNAi on Glucose Transport of Intrauterine Growth Retardation Rats. (PubMed)

The Influence of Down-regulation of Suppressor of Cellular Signaling Proteins by RNAi on Glucose Transport of Intrauterine Growth Retardation Rats. Intrauterine growth retardation (IUGR) has been linked to metabolic syndrome including insulin resistance, and overexpression of suppressors of cytokine signaling (SOCSs) proteins is thought to be associated with increased whole-body insulin sensitivity. The insulin-resistant IUGR rat model was established by maternal food restriction (about 30

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2011 Pediatric Research

68. Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat. (PubMed)

Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat. The abnormal intrauterine milieu of intrauterine growth retardation (IUGR) permanently alters gene expression and function of pancreatic beta cells leading to the development of diabetes in adulthood. Expression of the pancreatic homeobox transcription factor Pdx1 is permanently reduced in IUGR islets suggesting an epigenetic mechanism. Exendin-4 (Ex-4

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2011 Diabetologia

69. Maternal health-related quality of life after induction of labor or expectant monitoring in pregnancy complicated by intrauterine growth retardation beyond 36 weeks. (PubMed)

Maternal health-related quality of life after induction of labor or expectant monitoring in pregnancy complicated by intrauterine growth retardation beyond 36 weeks. Pregnancies complicated by intrauterine growth retardation (IUGR) beyond 36 weeks of gestation are at increased risk of neonatal morbidity and mortality. Optimal treatment in IUGR at term is highly debated. Results from the multicenter DIGITAT (Disproportionate Intrauterine Growth Intervention Trial At Term) trial show

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2011 Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation Controlled trial quality: uncertain

70. Placental scanning with computer-linked gamma camera to detect impaired placental blood flow and intrauterine growth retardation. (PubMed)

Placental scanning with computer-linked gamma camera to detect impaired placental blood flow and intrauterine growth retardation. By retrospective analysis of 65 placental localization studies by a computer-linked gamma camera the isotope studies by a computer-linked gamma camera the isotope uptake patterns were correlated with the eventual outcome of the pregnancies. The uptakes by anterior and lateral placentae were reduced in pregnancies which resulted in growth-retarded babies

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1975 British medical journal

71. A prospective approach to the diagnosis of intrauterine growth retardation. (PubMed)

A prospective approach to the diagnosis of intrauterine growth retardation. 5453438 1970 10 13 2018 11 13 0035-9157 63 5 1970 May Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. A prospective approach to the diagnosis of intrauterine growth retardation. 501-2 Beard R W RW Roberts G M GM eng Journal Article England Proc R Soc Med 7505890 0035-9157 0 Estrogens 0 Radioisotopes AE28F7PNPL Methionine EC 3.1.3.1 Alkaline Phosphatase H6241UJ22B Selenium IM Acid-Base Equilibrium (...) Alkaline Phosphatase blood Birth Weight Embryonic and Fetal Development Estrogens urine Female Fetal Heart physiology Gestational Age Growth Disorders diagnosis Humans Maternal-Fetal Exchange Methionine Placenta physiology Pregnancy Pregnancy Complications Pregnancy, Multiple Radioisotopes Selenium 1970 5 1 1970 5 1 0 1 1970 5 1 0 0 ppublish 5453438 PMC1811808 Pediatrics. 1967 Feb;39(2):238-47 6017959 J Obstet Gynaecol Br Commonw. 1968 Sep;75(9):903-16 5685276

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1970 Proceedings of the Royal Society of Medicine

72. Some biochemical aspects of intrauterine growth retardation. (PubMed)

Some biochemical aspects of intrauterine growth retardation. 5812781 1969 04 08 2013 11 21 1468-2044 44 233 1969 Feb Archives of disease in childhood Arch. Dis. Child. Some biochemical aspects of intrauterine growth retardation. 136 Cockburn F F eng Journal Article England Arch Dis Child 0372434 0003-9888 FB33469R8E Estriol IM Birth Weight Embryonic and Fetal Development Estriol urine Female Humans Infant, Newborn Placenta physiology Pre-Eclampsia Pregnancy 1969 2 1 1969 2 1 0 1 1969 2 1 0 0

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1969 Archives of Disease in Childhood

73. CIRCUMVALLATE PLACENTA AND INTRAUTERINE GROWTH RETARDATION. (PubMed)

CIRCUMVALLATE PLACENTA AND INTRAUTERINE GROWTH RETARDATION. A study has been made of a prospectively selected material of circumvallate placentae; the latter being defined as an elevated edge of more than 50% of the circumference. The material consists of 447 placentae from liveborn singleton infants, where 287 were from exemplary pregnancies, and 160 from births with a gestational age (GA) of less than 266 days and/or a birth weight of less than 2 750 g. The material was prospectively

1978 Acta Obstetricia et Gynecologica Scandinavica Controlled trial quality: uncertain

74. THE RELATIONSHIP BETWEEN SOME DISORDERS OF THE UMBILICAL CORD AND INTRAUTERINE GROWTH RETARDATION. (PubMed)

THE RELATIONSHIP BETWEEN SOME DISORDERS OF THE UMBILICAL CORD AND INTRAUTERINE GROWTH RETARDATION. Some disorders of the umbilical cord-Single umbilical artery, oedema of the cord, battledore insertion and velamentous insertion-have been examined in a prospectively randomized material. The material consists of 447 placentae from liveborn, singleton infants, where 287 were from exemplary pregnancies, and 160 from births with a gestational age of less than 266 days and/or a birth weight of less

1978 Acta Obstetricia et Gynecologica Scandinavica Controlled trial quality: uncertain

75. Morphology of early intrauterine deaths with full trisomy 15. (PubMed)

miscarriages, and no case of full trisomy 15 was observed in 62 fetal miscarriages. Fifty-eight embryos with full trisomy 15 showed structural defects on embryoscopic examination. The most common defects were craniofacial anomalies (n = 73), retarded development of the limbs (n = 39), and abnormally short umbilical cords closely attaching the embryo to the chorionic plate (n = 27). Seven embryos were classified as growth disorganized. Limb reduction defects with a prevalence of 5.6/10 000 births, all (...) Morphology of early intrauterine deaths with full trisomy 15. The morphologic features of embryos with full trisomy 15 are described.A total of 1195 pregnancy losses were examined embryoscopically and cytogenetically.Of 1173 successfully karyotyped specimens, full trisomy 15 was diagnosed cytogenetically in 59 cases (5%). All 59 trisomy 15 embryos were diagnosed cytogenetically in the group of 962 embryonic miscarriages (6%). Trisomy 15 was not registered in 171 anembryonic or yolk sac

2018 Prenatal diagnosis

76. Glucocorticoid mediates prenatal caffeine exposure-induced endochondral ossification retardation and its molecular mechanism in female fetal rats (PubMed)

Glucocorticoid mediates prenatal caffeine exposure-induced endochondral ossification retardation and its molecular mechanism in female fetal rats Our previous studies discovered that prenatal caffeine exposure (PCE) could induce intrauterine growth retardation (IUGR) and long-bone dysplasia in offspring rats, accompanied by maternal glucocorticoid over-exposure. This study is to explore whether intrauterine high glucocorticoid level can cause endochondral ossification retardation and clarify (...) its molecular mechanism in PCE fetal rats. Pregnant Wistar rats were intragastrically administered 30 and 120 mg/kg day of caffeine during gestational days (GDs) 9-20, then collected fetal serum and femurs at GD20. In vitro, primary chondrocytes were treated with corticosterone (0-1250 nM), caffeine (0-100 μM), mitogen-inducible gene 6 (Mig-6) siRNA and epidermal growth factor receptor (EGFR) siRNA, respectively, or together. Results showed that the hypertrophic chondrocytes zone (HZ) of PCE fetal

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2017 Cell death & disease

77. Unstressed antepartum cardiotocography in the management of the fetus suspected of growth retardation. (PubMed)

Unstressed antepartum cardiotocography in the management of the fetus suspected of growth retardation. A detailed analysis of the antenatal cardiotocographs (CTGs) in 57 patients with suspected fetal growth retardation is presented. Four traces were normal and 53 were 'non-reactive. 'Non-reactive' traces can be sub-divided into three categories, which, in order of severity are, 'suspect', 'flat' and 'ominous'. When compared with the 'suspect' group, perinatal mortality was significantly (...) increased and the Apgar scores at one and five minutes significantly decreased in the 'flat' and 'ominous' groups. The presence of fetal distress in labour was significantly higher in the 'flat' group as compared with the 'suspect' group. Intrauterine deaths occurred only in the 'ominous' group. With experience, ten patients later in the series with 'ominous' patterns were delivered within 24 hours of the detection of such and nine infants survived. At follow-up between 6 and 34 months after birth

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2014 BJOG

78. Trial on the Impact of Technical Anesthetic in Pregnancies With Intrauterine Growth Restriction

Trial on the Impact of Technical Anesthetic in Pregnancies With Intrauterine Growth Restriction Trial on the Impact of Technical Anesthetic in Pregnancies With Intrauterine Growth Restriction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Trial on the Impact of Technical Anesthetic in Pregnancies With Intrauterine Growth Restriction The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02666794 Recruitment Status : Recruiting

2015 Clinical Trials

79. Leukemia Inhibitory Factor Level in Intrauterine Growth Restriction Neonates

Leukemia Inhibitory Factor Level in Intrauterine Growth Restriction Neonates Leukemia Inhibitory Factor Level in Intrauterine Growth Restriction Neonates - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Leukemia Inhibitory Factor Level in Intrauterine Growth Restriction Neonates The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02518126 Recruitment Status : Unknown Verified August 2015 by Rambam Health Care Campus. Recruitment status was: Not yet recruiting First Posted : August 7, 2015 Last Update

2015 Clinical Trials

80. Sildenafil Therapy In Dismal Prognosis Early-Onset Intrauterine Growth Restriction

Sildenafil Therapy In Dismal Prognosis Early-Onset Intrauterine Growth Restriction Sildenafil Therapy In Dismal Prognosis Early-Onset Intrauterine Growth Restriction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Sildenafil Therapy In Dismal Prognosis Early-Onset Intrauterine Growth Restriction (STRIDER Canada) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02442492 Recruitment Status : Suspended (STRIDER-Canada trial suspended recruitment until further information can be obtained following

2015 Clinical Trials

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