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Intrauterine Growth Retardation

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21. Intrauterine Growth Restriction: Screening, Diagnosis, and Management

Intrauterine Growth Restriction: Screening, Diagnosis, and Management Intrauterine Growth Restriction: Screening, Diagnosis, and Management - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 35, Issue 8, Pages 741–748 Intrauterine Growth Restriction: Screening, Diagnosis, and Management PRINCIPAL AUTHORS, x Andrea Lausman , MD Toronto ON x John Kingdom , MD Toronto ON x MATERNAL FETAL MEDICINE COMMITTEE x Robert Gagnon (...) Anne Roggensack , x Frank Sanderson , MD x Frank Sanderson DOI: To view the full text, please login as a subscribed user or . Click to view the full text on ScienceDirect. Abstract Background Intrauterine growth restriction (IUGR) is an obstetrical complication, which by definition would screen in 10% of fetuses in the general population. The challenge is to identify the subset of pregnancies affected with pathological growth restriction in order to allow intervention that would decrease morbidity

2013 Society of Obstetricians and Gynaecologists of Canada

22. Disturbances in Maternal Steroidogenesis and Appearance of Intrauterine Growth Retardation at High-Altitude Environments Are Established from Early Pregnancy. Effects of Treatment with Antioxidant Vitamins Full Text available with Trip Pro

Disturbances in Maternal Steroidogenesis and Appearance of Intrauterine Growth Retardation at High-Altitude Environments Are Established from Early Pregnancy. Effects of Treatment with Antioxidant Vitamins Pregnancies at high-altitudes are influenced by hypoxia and oxidative stress and frequently affected by IUGR. However, a common thought is that early pregnant women visiting altitude have no major complications for gestation development, since IUGR is developed during the second half (...) of pregnancy. Thus, using a well-characterized sheep-model, we aimed to determine whether long- and/or short-term exposure to high-altitude may affect maternal steroidogenesis and therefore embryo-fetal growth from conception. The second aim was to differentiate the relative role of hypoxia and oxidative stress by assessing the effects of supplementation with antioxidant agents during this early-pregnancy stage, which were previously found to be useful to prevent IUGR. The results indicate that both long

2015 PloS one

23. Data Mining of Determinants of Intrauterine Growth Retardation Revisited Using Novel Algorithms Generating Semantic Maps and Prototypical Discriminating Variable Profiles Full Text available with Trip Pro

Data Mining of Determinants of Intrauterine Growth Retardation Revisited Using Novel Algorithms Generating Semantic Maps and Prototypical Discriminating Variable Profiles Intra-uterine growth retardation is often of unknown origin, and is of great interest as a "Fetal Origin of Adult Disease" has been now well recognized. We built a benchmark based upon a previously analysed data set related to Intrauterine Growth Retardation with 46 subjects described by 14 variables, related with the insulin (...) and Competition System algorithm instead works as a dynamic non linear associative memory on the weight matrices of other algorithms, and is able to produce a prototypical variable profile of a given target.Classical statistical analysis, proved to be unable to distinguish intrauterine growth retardation from appropriate-for-gestational age (AGA) subjects due to the high non-linearity of underlying functions. Auto-contractive map succeeded in clustering and differentiating completely the conditions under

2015 PloS one

24. Regulatory T Cells Ameliorate Intrauterine Growth Retardation in a Transgenic Rat Model For Preeclampsia. Full Text available with Trip Pro

Regulatory T Cells Ameliorate Intrauterine Growth Retardation in a Transgenic Rat Model For Preeclampsia. Preeclampsia is a multisystemic syndrome during pregnancy that is often associated with intrauterine growth retardation. Immunologic dysregulation, involving T cells, is implicated in the pathogenesis. The aim of this study was to evaluate the effect of upregulating regulatory T cells in an established transgenic rat model for preeclampsia. Application of superagonistic monoclonal antibody (...) pressure and albuminuria (30.6±15.1 versus 14.6±5.5 mg/d) were similar in the superagonist or control antibody-treated preeclamptic group for both protocols. Rats treated with CD28 superagonist showed increased pup weights in the prevention protocol (2.66±0.03 versus 2.37±0.05 g) and in the treatment protocol (3.04±0.04 versus 2.54±0.1 g). Intrauterine growth retardation, calculated by brain:liver weight ratio, was also decreased by the superagonist in both protocols. Further analysis of brain

2015 Hypertension

25. Frizzled-4 Variations Associated with Retinopathy and Intrauterine Growth Retardation: A Potential Marker for Prematurity and Retinopathy. (Abstract)

Frizzled-4 Variations Associated with Retinopathy and Intrauterine Growth Retardation: A Potential Marker for Prematurity and Retinopathy. To present the association between mutations affecting the Wnt-signaling receptor protein (FZD4), inherited vitreoretinopathies, and retinopathy of prematurity (ROP).Retrospective analysis of prospective samples at a tertiary referral center.Patients referred to our practice for management of a variety of pediatric vitreoretinopathies were offered (...) and intrauterine growth restriction suggests that it also may be a marker for increased risk of developing ROP and preterm birth.Copyright © 2015 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

2015 Ophthalmology

26. Effects of Choline on Meat Quality and Intramuscular Fat in Intrauterine Growth Retardation Pigs Full Text available with Trip Pro

Effects of Choline on Meat Quality and Intramuscular Fat in Intrauterine Growth Retardation Pigs The aim of this study was to investigate the effects of choline supplementation on intramuscular fat (IMF) and lipid oxidation in IUGR pigs. Twelve normal body weight (NBW) and twelve intrauterine growth retardation (IUGR) newborn piglets were collected and distributed into 4 treatments (Normal: N, Normal+Choline: N+C, IUGR: I, and IUGR+Choline: I+C) with 6 piglets in each treatment. At 23 d of age (...) ) while the muscle-carnitine palmityl transferase (M-CPT) and peroxisome proliferators-activated receptorγ (PPARγ) mRNA (P<0.05) gene expressions were decreased in the muscles of the IUGR pigs by choline supplementation. Furthermore, choline supplementation significantly increased (P<0.05) the MDA content as well as the O2•¯ scavenging activity in meat of IUGR pigs. The results suggested that IUGR pigs showed a permanent stunting effect on the growth performance, increased fat deposition and oxidative

2015 PloS one

27. Growth Disturbances ? Risk of Intrauterine Growth Restriction

Growth Disturbances ? Risk of Intrauterine Growth Restriction Revised 2018 ACR Appropriateness Criteria ® 1 Growth Disturbances–Risk of Fetal Growth Restriction American College of Radiology ACR Appropriateness Criteria ® Growth Disturbances–Risk of Fetal Growth Restriction Variant 1: Growth disturbance. Low risk for fetal growth restriction. Initial evaluation. Procedure Appropriateness Category Relative Radiation Level US pregnant uterus transabdominal Usually Appropriate O US duplex Doppler (...) that is used). The RRLs for these examinations are designated as “Varies”. References 1. Copel JA, Bahtiyar MO. A practical approach to fetal growth restriction. Obstet Gynecol 2014;123:1057-69. ACR Appropriateness Criteria ® 9 Growth Disturbances–Risk of Fetal Growth Restriction 2. Figueras F, Gratacos E. An integrated approach to fetal growth restriction. Best Pract Res Clin Obstet Gynaecol 2017;38:48-58. 3. Ott WJ. Intrauterine growth restriction and Doppler ultrasonography. J Ultrasound Med 2000;19:661

2012 American College of Radiology

28. Pentaerithrityl Tetranitrate (PETN) for Secondary Prevention of Intrauterine Growth Restriction

) to patients recognized at risk for FGR by impaired uterine artery Doppler at mid gestation (Schleussner, 2014). To confirm these results this prospective randomized placebo controlled double-blinded multicentre trial, was initiated. Condition or disease Intervention/treatment Phase Fetal Growth Retardation Pregnancy Related Intrauterine Growth Restriction Drug: Pentalong Drug: Placebos Phase 3 Detailed Description: Affecting approximately 10% of pregnancies, fetal growth restriction (FGR), is the most (...) Pentaerithrityl Tetranitrate (PETN) for Secondary Prevention of Intrauterine Growth Restriction Pentaerithrityl Tetranitrate (PETN) for Secondary Prevention of Intrauterine Growth Restriction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2018 Clinical Trials

29. Transcriptome Analyses Reveal Adult Metabolic Syndrome With Intrauterine Growth Restriction in Pig Models Full Text available with Trip Pro

Transcriptome Analyses Reveal Adult Metabolic Syndrome With Intrauterine Growth Restriction in Pig Models Epidemiological data have indicated that intrauterine growth retardation (IUGR) is a risk factor for the adult metabolic syndrome in pigs. However, the causative genetic mechanism leading to the phenotype in adulthood has not been well characterized. In the present study, both normal and IUGR adult pigs were used as models to survey the differences in global gene expression in livers

2018 Frontiers in genetics

30. Intrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner Full Text available with Trip Pro

development. We used a mouse model recapitulating clinical findings of prenatally exposed children, where pregnant mice were exposed to smoke until c-section or spontaneous delivery, and offspring weight development and lung function was monitored. Additionally, we investigated pulmonary transcriptome changes in fetal lungs (GD18.5) by mRNA/miRNA arrays, network analyses and qPCR. The results demonstrated that prenatally exposed mice showed intrauterine and postnatal growth retardation, and impaired lung (...) Intrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner Prenatal exposure to tobacco smoke is a significant risk-factor for airway disease development. Furthermore, the high prevalence of pregnant smoking women requires the establishment of strategies for offspring lung protection. Therefore, we here aimed to understand the molecular mechanism of how prenatal smoke exposure affects fetal lung

2018 Scientific reports

31. Early Childhood Obesity Programming by Intrauterine Growth Restriction

Early Childhood Obesity Programming by Intrauterine Growth Restriction Early Childhood Obesity Programming by Intrauterine Growth Restriction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Early Childhood (...) Obesity Programming by Intrauterine Growth Restriction The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03402139 Recruitment Status : Not yet recruiting First Posted : January 18, 2018 Last Update Posted : January 18, 2018

2018 Clinical Trials

32. Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency Full Text available with Trip Pro

Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency Inborn errors of DNA repair or replication underlie a variety of clinical phenotypes. We studied 5 patients from 4 kindreds, all of whom displayed intrauterine growth retardation, chronic neutropenia, and NK cell deficiency. Four of the 5 patients also had postnatal growth retardation. The association of neutropenia and NK cell deficiency, which is unusual among primary immunodeficiencies (...) signaling, defective cell cycle control, and genomic instability, which was rescued by WT GINS1. The residual levels of GINS1 activity reached 3% to 16% in patients' cells, depending on their GINS1 genotype, and correlated with the severity of growth retardation and the in vitro cellular phenotype. The levels of GINS1 activity did not influence the immunological phenotype, which was uniform. Autosomal recessive, partial GINS1 deficiency impairs DNA replication and underlies intra-uterine (and postnatal

2017 The Journal of clinical investigation

33. First Trimester Screening for Preeclampsia and Intrauterine Growth RestrIction Using Three Dimensional Doppler Angiography

First Trimester Screening for Preeclampsia and Intrauterine Growth RestrIction Using Three Dimensional Doppler Angiography First Trimester Screening for Preeclampsia and Intrauterine Growth RestrIction Using Three Dimensional Doppler Angiography - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. First Trimester Screening for Preeclampsia and Intrauterine Growth RestrIction Using Three Dimensional Doppler Angiography (SPIRIT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read

2017 Clinical Trials

34. L-arginine in Treatment of Intrauterine Growth Restriction

L-arginine in Treatment of Intrauterine Growth Restriction L-arginine in Treatment of Intrauterine Growth Restriction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. L-arginine in Treatment of Intrauterine (...) provided by (Responsible Party): Hayam Fathy Mohammad, Ain Shams University Study Details Study Description Go to Brief Summary: Intrauterine growth restriction is an important problem in neonatal care. Intrauterine growth restriction (IUGR) is defined as a fetal weight below the 10th percentile for gestational age. One of the main causes of IUGR is placental insufficiency. Nitric oxide(NO) increases placental blood flow. So,it might be useful to improve IUGR pregnancy outcome . Condition or disease

2017 Clinical Trials

35. Treatment of Intrauterine Growth Restriction With Low Molecular Heparin.

and ischemic placental lesions [ Time Frame: 13 weeks maximum ] Measured as the presence of one or more of the following: Intrauterine growth retardation (Neonatal weight below the 10th percentile of our population + umbilical artery pulsatility index during the third trimester (on two separate occasions> 48h) above the 95th percentile), Preeclampsia, Gestational age (weeks) at birth, Premature delivery before 34 weeks of gestation, Urgent cesarean section due to loss of fetal well-being, Neonatal weight (...) Treatment of Intrauterine Growth Restriction With Low Molecular Heparin. Treatment of Intrauterine Growth Restriction With Low Molecular Heparin. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment

2017 Clinical Trials

36. Predictors of Intrauterine Growth Restriction

Predictors of Intrauterine Growth Restriction Predictors of Intrauterine Growth Restriction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Predictors of Intrauterine Growth Restriction The safety (...) : Second Trimester Doppler Indices and Placental Vascularity as Predictors of Intrauterine Growth Restriction Estimated Study Start Date : October 2018 Estimated Primary Completion Date : October 2019 Estimated Study Completion Date : December 2019 Resource links provided by the National Library of Medicine related topics: resources: Groups and Cohorts Go to Intervention Details: Procedure: ultrasound A 3D volume of the uterus will be acquired by transabdominal sonography. The sweep angle was set

2017 Clinical Trials

37. Diagnosis and Management of Intrauterine Growth Restriction and Congenital Anomalies

Diagnosis and Management of Intrauterine Growth Restriction and Congenital Anomalies Diagnosis and Management of Intrauterine Growth Restriction and Congenital Anomalies - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Diagnosis and Management of Intrauterine Growth Restriction and Congenital Anomalies The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03398629 Recruitment Status : Not yet recruiting First Posted : January 12

2017 Clinical Trials

38. Aspirin in Asymmetrically Intrauterine Growth

Aspirin in Asymmetrically Intrauterine Growth Aspirin in Asymmetrically Intrauterine Growth - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Aspirin in Asymmetrically Intrauterine Growth The safety (...) : Intrauterine growth restriction refers to a fetus that has failed to get a specific measures by a gestational age. Asymmetric type of Intrauterine growth restriction is known by normal sized head with smaller abdomen.It is important to recognize the growth restricted fetuses, because these fetuses may have fetal or neonatal complications. When blood flow is increased, the oxygen and nutrients will deliver good to the fetus. The role of low-dose aspirin therapy in management of intrauterine growth

2017 Clinical Trials

39. Evaluation of Fetal Cardiac Function and Vascular Hemodynamics in Intrauterine Growth Restriction

Evaluation of Fetal Cardiac Function and Vascular Hemodynamics in Intrauterine Growth Restriction Evaluation of Fetal Cardiac Function and Vascular Hemodynamics in Intrauterine Growth Restriction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Evaluation of Fetal Cardiac Function and Vascular Hemodynamics in Intrauterine Growth Restriction The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03108040 Recruitment Status

2017 Clinical Trials

40. Epigenetics of hyper-responsiveness to allergen challenge following intrauterine growth retardation rat. Full Text available with Trip Pro

Epigenetics of hyper-responsiveness to allergen challenge following intrauterine growth retardation rat. Epidemiological studies have revealed that intrauterine growth retardation (IUGR) or low birth weight is linked to the later development of asthma. Epigenetic regulatory mechanisms play an important role in the fetal origins of adult disease. However, little is known regarding the correlation between epigenetic regulation and the development of asthma following IUGR.An IUGR and ovalbumin

2014 Respiratory research

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