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Intrauterine Growth Retardation

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181. Low-Dose Aspirin Use During Pregnancy

, Nicolaides K, Giguere Y, Vainio M, Bakthi A, et al. Early administration of low-dose aspirin forthepreventionofpretermandtermpreeclampsia:asys- tematic review and meta-analysis. Fetal Diagn Ther 2012; 31:141–6. 45. Wallenburg HC, Rotmans N. Prevention of recurrent idi- opathic fetal growth retardation by low-dose aspirin and dipyridamole. Am J Obstet Gynecol 1987;157:1230–5. 46. Leitich H, Egarter C, Husslein P, Kaider A, Schemper M. A meta-analysis of low dose aspirin for the prevention of intrauterine (...) , and the World Institute of Pain. Reg Anesth Pain Med 2015;40:182–212. 37. Wallenburg HC, Dekker GA, Makovitz JW, Rotmans P. Low-dose aspirin prevents pregnancy-induced hyperten- sion and pre-eclampsia in angiotensin-sensitive primigra- vidae. Lancet 1986;1:1–3. 38. Low-dose aspirin in prevention and treatment of intrauter- ine growth retardation and pregnancy-induced hyperten- sion.Italianstudyofaspirininpregnancy.Lancet1993;341: 396–400. 39. RolnikDL,WrightD,PoonLC,O’GormanN,SyngelakiA, de Paco Matallana C

2018 American College of Obstetricians and Gynecologists

182. CRACKCast E177 – Acute Complications of Pregnancy

or intracranial bleeding, renal insufficiency, and death. Neonatal complications: placental infarcts, intrauterine growth retardation, premature delivery 13) Describe the management of eclampsia and severe pre-eclampsia. The patient who has severe preeclampsia should have an IV line and fetal monitoring initiated. Blood testing should include complete blood cell count, renal function studies, liver function tests, platelet count, and coagulation profile. A baseline magnesium level should also be determined (...) trimester bleeding. Thinking outside in: Other pelvic source – rectal vs. urinary External/internal labia Introitus source Vaginal wall / vault Cervix Intrauterine Miscarriage Implantation bleeding Molar pregnancy Or worst first: Ectopic Miscarriage Molar pregnancy Cervical lesion (cancer) Coagulopathy 2) List 5 RFs for miscarriage. What percentage of women who have bleeding miscarry? Increased maternal age (especially > 40 yrs) Increasing parental age Increased parity Hx of prior miscarriage Multiple

2018 CandiEM

183. Guidelines for the Investigation and Management of Transient Leukaemia of Down Syndrome

should also be taken in neonates with intrauterine growth restriction (IUGR) or other history of placental insufficiency (e.g. maternal hypertension, pre-eclampsia or diabetes mellitus) as these babies may have lower blast counts despite large mutant GATA1 clones. Clinical features of TL-DS From their origin in the fetal liver, megakaryoblastic TL-DS cells can spread locally, spill into the peripheral blood and infiltrate throughout the liver as well as distant tissues. This usually manifests (...) with the regional Paediatric Oncology Principal Treatment Centre and a peripheral blood sample sent for GATA1 mutation analysis (Grade 1A). • Any child who did not have a peripheral blood blast cell percentage performed in the first 3 days of life or in whom there was significant intra-uterine growth retardation (when blast counts may be suppressed) should be considered to be still at risk of clinical problems of TL-DS in the first 4-8 weeks of life and should be monitored accordingly. GATA1 mutation analysis

2018 British Association of Perinatal Medicine

184. Management of specific situations in polycythaemia vera and secondary erythrocytosis Full Text available with Trip Pro

of obstetric complications, such as fetal loss throughout all trimesters, intra‐uterine growth retardation, prematurity, maternal thromboembolism and haemorrhage. Previously significant fetal loss and maternal morbidity was seen, but a recent prospective study of pregnancy outcomes in MPNs showed better outcomes. There were no maternal deaths or thrombotic events (Alimam et al , ). This improvement in pregnancy outcomes is probably partly due to a more protocol‐based management and a multidisciplinary (...) pregnancies should be identified (Table ). These are patients with previous arterial or venous thrombosis or haemorrhage attributed to PV, previous pregnancy complications (>3 first trimester losses, >1 s or third trimester loss, birth weight <5th centile for gestation, intrauterine death or stillbirth, pre‐eclampsia), extreme thrombocytosis before or during pregnancy, diabetes mellitus or hypertension requiring pharmacological treatment. Table 1. Management of risk factors during pregnancy During

2018 British Committee for Standards in Haematology

185. Management of Hypertension (5th Edition)

creatinine = 90 micromol/l or oliguria. iii. Liver disease: raised transaminases and / or severe right upper quadrant or epigastric pain. iv . Neurological problems: convulsions (eclampsia), hyperreflexia with clonus or severe headaches, persistent visual disturbances (scotoma). v. Haematological disturbances: thrombocytopenia, coagulopathy, haemolysis. vi. Fetal growth restriction. This is followed by normalization of the BP by three months postpartum. Oedema is no longer part of the definition (...) been shown to lead to fetal growth restriction. The use of ARBs, ACEIs and thiazide diuretics are associated with fetal anomaly 243 and are therefore contraindicated in pregnancy. It should be noted that the treatment of hypertension in pregnancy is solely for maternal safety. It does not reduce the risk of development of preeclampsia or perinatal mortality, nor improve fetal growth. 243 Pregnant women with uncomplicated chronic hypertension should have their BP kept lower than 150/100 mmHg

2018 Ministry of Health, Malaysia

186. Preterm labour and birth

, because of extreme growth retardation in the baby or maternal conditions such as pre-eclampsia). This guideline reviews the evidence for the best way to provide treatment for women who present with symptoms and signs of preterm labour and women who are scheduled to have a preterm birth. It also reviews how preterm birth can be optimally diagnosed in symptomatic women, given that many women thought to be in preterm labour on a clinical assessment will not deliver preterm. The guideline does not cover (...) care of preterm babies, including location of care explaining about the immediate problems that can arise when a baby is born preterm Preterm labour and birth (NG25) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 6 of 27explaining about the possible long-term consequences of prematurity for the baby (how premature babies grow and develop) ongoing opportunities to talk about and state their wishes about

2015 National Institute for Health and Clinical Excellence - Clinical Guidelines

187. Sonographic Differences in Brain Measurements Between Normal and Intrauterine Growth Restriction (IUGR) Fetuses

Sonographic Differences in Brain Measurements Between Normal and Intrauterine Growth Restriction (IUGR) Fetuses Sonographic Differences in Brain Measurements Between Normal and Intrauterine Growth Restriction (IUGR) Fetuses - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Sonographic Differences in Brain Measurements Between Normal and Intrauterine Growth Restriction (IUGR) Fetuses The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01178619 Recruitment Status : Withdrawn First Posted : August 10, 2010

2010 Clinical Trials

188. Safety and Efficacy of Somatropin in Children With Growth Hormone Deficiency

transplantation or any syndrome known to give short stature (examples are: Prader-Willi Syndrome, Russell-Silver Syndrome, Turner Syndrome, Noonan Syndrome) Intrauterine growth retardation: birth weight below 3rd percentile, adjusted for gestational age Pregnancy or the intention to become pregnant Breast-feeding Administration of other growth-altering medication Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact (...) for age and gender) or inadequate growth deemed secondary to growth hormone deficiency (GHD) Naïve to growth hormone therapy Exclusion Criteria: Known or suspected allergy to the trial product or related products Growth retardation attributable to causes other than GHD. Growth retardation attributable to diabetes mellitus, inborn errors of metabolism, primary bone disease, chromosomal disorders or disease of the genitourinary, cardiopulmonary, gastrointestinal or central nervous system; bone marrow

2011 Clinical Trials

189. Maternal Progesterone Level in Fetal Growth Restriction and Its Relationship with Doppler Velocimetry Indices Full Text available with Trip Pro

Maternal Progesterone Level in Fetal Growth Restriction and Its Relationship with Doppler Velocimetry Indices To verify whether progesterone concentration is changed in the maternal serum of intra-uterine growth retardation (IUGR) pregnancies and to assess if there is a relationship between maternal progesterone and fetal Doppler velocimetry.Thirty-five patients with intrauterine growth retardation infants and thirty-seven pregnant women with appropriate for gestational age (AGA) fetuses were

2011 Iranian Journal of Radiology

190. Severe Short Stature Caused by Novel Compound Heterozygous Mutations of the Insulin-Like Growth Factor 1 Receptor (IGF1R). Full Text available with Trip Pro

the patient.Only the second compound heterozygous IGF1R mutations to be identified, the p.E121K/E234K variant is the cause of intrauterine growth retardation and the most severe postnatal growth failure described to date in a patient with IGF1R defects. Whether the mutant IGF1R also contributes to the diabetic phenotype, however, remains to be determined. (...) Severe Short Stature Caused by Novel Compound Heterozygous Mutations of the Insulin-Like Growth Factor 1 Receptor (IGF1R). IGF-I, essential for normal human growth in utero and postnatally, mediates its effects through the IGF-I receptor (IGF1R). More than nine heterozygous mutations, including one compound heterozygous mutation, of the IGF1R gene have been reported in patients with varying degrees of intrauterine and postnatal growth retardation.The objective of the study was the analysis

2011 Journal of Clinical Endocrinology and Metabolism

191. Intrapartum fetal surveillance – Indications

) er beskrevet i Dansk Føtalmedicinsk Selskabs guideline om IUGR. For at undgå begrebsforvirring har vi i denne guideline valgt at anvende betegnelsen ultralyds (UL)- vægtestimat på -15 til -22%. Søgestrategi: Mesh terms: IUGR, Intrauterine growth restriction, SGA, Small for gestational age, FGR, Fetal growth retardation, low EFW, Estimated fetal weight. Der er søgt på ovenstående i kombination med de outcomes der er beskrevet i indledningen (PICO spørgsmål) Evidens I litteraturgennemgangen er der (...) komplikationer under graviditeten og med normal fostertilvækst, kan overvåges med intermitterende auskultation. Konsensus 35 Fødende med hypo- eller hyperthyreose med påviste maternelle og/eller føtale komplikationer (f.eks. i form af føtal væksthæmning) overvåges i henhold til gældende standard for disse komplikationer. Konsensus Vægtestimat på -15 til -22 % ved UL Begreber: Definitionen af begreberne IUGR (Intrauterine Growth Restriction) FGR (Fetal Growth Restriction) samt SGA (Small for Gestational Age

2017 Nordic Federation of Societies of Obstetrics and Gynecology

192. Clinical Practice Guideline for the Care of Women with Decreased Fetal Movements

) Also known as ‘intrauterine growth restriction’ (IUGR). This term is often used interchangeably with the term ‘small for gestational age’ (SGA). SGA is defined as a baby with an antenatal ultrasound biometry assessment less than the 10 th percentile for gestational age. FGR refers to babies that have failed to reach their growth potential during pregnancy, which can be assessed by serial ultrasound scans. They are frequently but not always SGA. Page 2 Flow cytometry A test used to detect FMH (...) and disturbed neurodevelopment 47, 48 , intrauterine infections 49 , low Apgar scores and acidaemia 37, 39 , hypoglycaemia 36 , umbilical cord complications and placental insufficiency 8, 16, 42 , emergency delivery, induction of labour and Caesarean section, stillbirths and neonatal deaths 50-54 . Fetal growth restriction appears to be a major factor contributing to the increased risk of adverse outcomes in these pregnancies 16, 51, 55-59 . A case-control study from the UK reported that FGR was present

2017 Clinical Practice Guidelines Portal

194. CRACKCast E130 – Viruses

, and headache. Secondary infections (once you have it, you have it for LIFE!) Rarely, immunocompetent patients will develop CMV colitis or CMV myelitis/encephalitis/meningitis Congenital CMV infection causes a number of delayed illnesses: premature birth, intrauterine growth retardation, microcephaly, seizures, thrombocytopenia, hepatosplenomegaly, or pneumonitis. Sequelae of congenital CMV infection can present up to 2 years after birth. Frequent complications that occur are hearing loss, neurologic (...) , intrauterine fetal death, miscarriage Brachial plexus neuropathy Hemophagocytic syndrome Serositis of any organ Less severe complications: Rash = slapped cheek – associated with Parvovirus B19 – erythema infectiosum/fifth disease Reticulated blanching erythematous rash in children Gloves and socks syndrome: Papular-purpuric rash in hands and feet Arthropathy/arthritis Treatment: Prevention! Hand washing! Treat severe anemia with blood + IVIG Parainfluenza (4 types), Adenoviruses, rhinoviruses, influenza

2017 CandiEM

196. Management of Pregnancy in Patients With Complex Congenital Heart Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association Full Text available with Trip Pro

. Although listed as a category C agent, spironolactone is not recommended for use during pregnancy or lactation because of the reported antiandrogenic effects and feminization of male fetuses. Amiodarone has been associated with a 9% incidence of fetal hypothyroidism and a 21% incidence of intrauterine growth retardation and should be reserved for cases of refractory ventricular arrhythmias. Drugs listed as category X include the following: Anticoagulants. Vitamin K antagonists cross the placenta (...) the Marfan, Holt-Oram, Noonan, Alagille, CHARGE (coloboma, heart defect, atresia choanae, retarded growth and development, genital abnormality, and ear abnormality), 22q11.2 microdeletion, and Williams syndromes. For CHD that arises de novo, the risk of CHD recurrence in offspring is between 3% and 5%. The risk of recurrence is higher with heterotaxy, atrioventricular septal defect, and obstructive lesions of the left ventricular outflow tract. Besides genetic factors, it is important to assess

2017 American Heart Association

197. Multiple Gestations

develop in later gestation in 3% to 10%, either before or after laser coagulation therapy of TTTS [32]. Recent data suggest that the right ventricular outflow obstruction may also develop in the donor twin and in monochorionic twins affected by selective intrauterine growth retardation. Selective IUGR or twin discordance complicates approximately 10% of all monochorionic twin pregnancies. These potentially high-risk groups may require surgery or catheter intervention in the newborn period. Discussion (...) , regardless of chorionicity, closer surveillance may be warranted. Selective intrauterine growth restriction (sIUGR), or selective fetal growth restriction, does not have a consistent definition amongst clinicians. A commonly used definition would be a condition in which one fetus has an estimated fetal weight (EFW) below the 10th percentile and the intertwin EFW discordance is >25%. Some consider that a discordance of 20% is acceptable to triage the pregnancies at increased risk of adverse outcome

2017 American College of Radiology

198. Diagnosis and management of Silver-Russell syndrome: 1st international consensus statement Full Text available with Trip Pro

Endocrinology and the Molecular Diagnosis Laboratory concerning growth disorders, and an INSERM research team leader. She is a research pioneer in Silver–Russell syndrome (SRS) with 60 PubMed publications, and her current research interests include the role of the insulin-like growth factor (IGF) system in intrauterine growth retardation and imprinting anomalies leading to fetal growth disorders. She is an instigator of the French multidisciplinary clinical services for SRS and Beckwith–Wiedemann syndrome (...) -recognized, condition associated with prenatal and postnatal growth retardation. The syndrome was first described by Silver et al . and Russell , who independently described a subset of children with low birth weight, postnatal short stature, characteristic facial features and body asymmetry. Almost all patients with SRS are born small for gestational age (SGA; ). The aetiology of intrauterine growth retardation and SGA is extremely heterogeneous. Children with SRS can be distinguished from those

2017 Pediatric Endocrine Society

199. Neofordex - dexamethasone. To treat adults with multiple myeloma

and retardation of growth, respectively, were observed. By 21 days post dose, body weight gains ranged from 11 to 104 g. At autopsy, multiple small abscesses in the lungs, kidneys, and/or liver were observed in randomly selected animals (Tonelli, 1966). Repeat dose toxicity A tabulated summary of the major findings observed after repeated administrations of dexamethasone in rats and dogs is presented in Table 6. Table 6. Main Findings in Rats and Dogs after Repeated Administration of Dexamethasone ALAT (...) . Interleukin-6 (IL-6; a growth factor for multiple myeloma) blocked dexamethasone-induced apoptosis in the cultured MM.1S cells and prevented the mitochondrial release of Smac. Thalidomide, its IMiDs pomalidomide and lenalidomide and dexamethasone induced cell death in MM.1S cells (Hideshima et al., 2000; Hideshima at al., 2001). These IMiDs act directly by inducing apoptosis or G1 growth arrest in myeloma cell lines and in patient multiple myeloma cells that are resistant to dexamethasone, melphalan

2016 European Medicines Agency - EPARs

200. British Association for Psychopharmacology consensus guidance on the use of psychotropic medication preconception, in pregnancy and postpartum

of amphetamines, cocaine and stimulant-type novel psychoactive substances (NPS) is a public health problem presenting with medical, psychiatric, legal and socio-economic consequences. Cocaine and other stim- ulant use during pregnancy has been associated with preterm labour, congenital anomalies, intrauterine growth retardation (IUGR), placental abruption, low-birthweight infants, neonatal death and SIDS (Debooy et al., 1993; Fox, 1994; Ryan et al., 1987). Maternal complications include a pre-eclampsia-like (...) ). Cannabis use often occurs with other drugs such as tobacco and alcohol which also have an independent effect on fetal outcomes (e.g. Kuhn et al., 2000). Opioid misuse/dependence. Opioid dependence is associated with increased maternal and neonatal complications. Untreated opioid dependence is associated with increased risk of fetal growth retardation, placental abruption, fetal death and preterm delivery (Center for Substance Abuse Treatment, 2008). Stimulant misuse/dependence. The misuse

2017 British Association for Psychopharmacology

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