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Intraocular Carbonic Anhydrase Inhibitor

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1. Intraocular Carbonic Anhydrase Inhibitor

Intraocular Carbonic Anhydrase Inhibitor Intraocular Carbonic Anhydrase Inhibitor Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Intraocular Carbonic Anhydrase Inhibitor Intraocular Carbonic Anhydrase Inhibitor Aka: Intraocular Carbonic Anhydrase Inhibitor , Dorzolamide , Trusopt , Brinzolamide , Azopt II. Indication Patients unable to tolerate or as adjunct III. Mechanism Inhibits bicarbonate formation in the ciliary body Results in decreased aqueous production IV. Preparations Topical Dorzolamide (Trusopt) 2%, 1 drop three times daily Brinzolamide (Azopt) 1%, 1 drop three times daily Available as combination with (Simbrinza

2018 FP Notebook

2. Efficacy of additional topical betamethasone in persistent cystoid macular oedema after carbonic anhydrase inhibitor treatments in retinitis pigmentosa (Full text)

Efficacy of additional topical betamethasone in persistent cystoid macular oedema after carbonic anhydrase inhibitor treatments in retinitis pigmentosa We investigated the efficacy of additional topical betamethasone in persistent cystoid macular oedema (CMO) after carbonic anhydrase inhibitors (CAIs) therapy.This retrospective cohort study included 16 eyes of 10 patients with retinitis pigmentosa (RP). All patients were previously administered CAI for at least 3 months to treat CMO secondary (...) to RP and lacking an effective reduction (≥11%) of central foveal thickness (CFT). We administered topical 0.1% betamethasone daily in each affected eye following a preceding course of the CAI medication as a first treatment. CMO was diagnosed using spectral-domain optical coherence tomography. CFT was regarded as the average of vertical and horizontal foveal thickness. Best-corrected visual acuity (BCVA) and intraocular pressure (IOP) were obtained from patient medical records. We compared the CFT

2018 BMJ Open Ophthalmology PubMed

3. Intraocular Carbonic Anhydrase Inhibitor

Intraocular Carbonic Anhydrase Inhibitor Intraocular Carbonic Anhydrase Inhibitor Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Intraocular Carbonic Anhydrase Inhibitor Intraocular Carbonic Anhydrase Inhibitor Aka: Intraocular Carbonic Anhydrase Inhibitor , Dorzolamide , Trusopt , Brinzolamide , Azopt II. Indication Patients unable to tolerate or as adjunct III. Mechanism Inhibits bicarbonate formation in the ciliary body Results in decreased aqueous production IV. Preparations Topical Dorzolamide (Trusopt) 2%, 1 drop three times daily Brinzolamide (Azopt) 1%, 1 drop three times daily Available as combination with (Simbrinza

2015 FP Notebook

4. Meta-analysis of α2-adrenergic agonists versus carbonic anhydrase inhibitors as adjunctive therapy.

Meta-analysis of α2-adrenergic agonists versus carbonic anhydrase inhibitors as adjunctive therapy. To evaluate the efficacy of α2-adrenergic agonist (AA) brimonidine and topical carbonic anhydrase inhibitors (CAIs) dorzolamide and brinzolamide in reducing intraocular pressure (IOP) when used as adjunctive therapy to β-blockers (BBs) or prostaglandin analogs (PGAs).Pertinent publications were identified through systematic searches of PubMed, EMBASE, and the Cochrane Controlled Trials Register (...) : 1.04 mmHg [0.08 to 2.00]).Brimonidine provides greater IOP-lowering efficacy than topical carbonic anhydrase inhibitors as adjunctive therapy to BBs or PGAs.

2014 Current medical research and opinion

5. Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors. (Full text)

Acetazolamide therapeutic use Carbonic Anhydrase Inhibitors adverse effects pharmacology therapeutic use Dichlorphenamide therapeutic use Glaucoma drug therapy Humans Intraocular Pressure drug effects Methazolamide therapeutic use 1968 8 1 1968 8 1 0 1 1968 8 1 0 0 ppublish 5724852 PMC506660 (...) Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors. 5724852 1969 01 31 2013 11 21 0007-1161 52 8 1968 Aug The British journal of ophthalmology Br J Ophthalmol Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors. 642-3 Kanski J J JJ eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 Carbonic Anhydrase Inhibitors O3FX965V0I Acetazolamide VVJ6673MHY Dichlorphenamide W733B0S9SD Methazolamide IM

1968 The British journal of ophthalmology PubMed

6. Costs and persistence of carbonic anhydrase inhibitor versus alpha-2 agonists, associated with beta-blockers, in glaucoma and ocular hypertension: an analysis of the UK-GPRD database

MeSH Adrenergic alpha-Agonists /administration & Adrenergic beta-Antagonists /administration & Aged; Carbonic Anhydrase Inhibitors /administration & Cohort Studies; Confidence Intervals; Cost of Illness; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Glaucoma /diagnosis /drug therapy; Great Britain; Humans; Intraocular Pressure /drug effects; Male; Middle Aged; Ocular Hypertension /diagnosis /drug therapy; Probability (...) Costs and persistence of carbonic anhydrase inhibitor versus alpha-2 agonists, associated with beta-blockers, in glaucoma and ocular hypertension: an analysis of the UK-GPRD database Costs and persistence of carbonic anhydrase inhibitor versus alpha-2 agonists, associated with beta-blockers, in glaucoma and ocular hypertension: an analysis of the UK-GPRD database Costs and persistence of carbonic anhydrase inhibitor versus alpha-2 agonists, associated with beta-blockers, in glaucoma and ocular

2008 NHS Economic Evaluation Database.

7. Meta-analysis of α2-adrenergic agonists versus carbonic anhydrase inhibitors as adjunctive therapy.

Meta-analysis of α2-adrenergic agonists versus carbonic anhydrase inhibitors as adjunctive therapy. To evaluate the efficacy of α2-adrenergic agonist (AA) brimonidine and topical carbonic anhydrase inhibitors (CAIs) dorzolamide and brinzolamide in reducing intraocular pressure (IOP) when used as adjunctive therapy to β-blockers (BBs) or prostaglandin analogs (PGAs).Pertinent publications were identified through systematic searches of PubMed, EMBASE, and the Cochrane Controlled Trials Register (...) : 1.04 mmHg [0.08 to 2.00]).Brimonidine provides greater IOP-lowering efficacy than topical carbonic anhydrase inhibitors as adjunctive therapy to BBs or PGAs.

2012 Current medical research and opinion

8. Oral versus topical carbonic anhydrase inhibitors in ocular hypertension after scleral tunnel cataract surgery. (PubMed)

Oral versus topical carbonic anhydrase inhibitors in ocular hypertension after scleral tunnel cataract surgery. To compare the effect of oral acetazolamide and topical 2% dorzolamide in prevention of ocular hypertension after scleral tunnel cataract surgery.Ophthalmic department, Sana'a University, Yemen Sana'a from March 2007 to October 2007.This prospective double-blind, randomized study included 150 eyes undergoing scleral tunnel cataract surgery with hard posterior chamber intraocular (...) , for three days postoperatively. Intraocular pressures (IOP) were measured by Goldman applanation tonometry one hour preoperatively and 16, 24, and 48 hours postoperatively.At 16 hours, IOP between the three groups increased significantly with a statistically significant p-value of 0.008, but the mean IOP of acetazolamide patients was less than other groups. IOP nearly returned to the normal level 24 and 48 hours postoperatively, but this was not statistically significant (p = 0.452 and 0.138

2011 Clinical ophthalmology (Auckland, N.Z.)

9. Can Acetazolamide be used to reduce the intraocular pressure rise from Laparoscopic Colorectal Surgery?

prostatectomy. Anesthesia and analgesia, 2009 2. Grosso, A., et al., Intraocular pressure variation during colorectal laparoscopic surgery: standard pneumoperitoneum leads to reversible elevation in intraocular pressure. Surg Endosc, 2013 3. Chauhan, B.C., et al., Effect of intraocular pressure on optic disc topography, electroretinography, and axonal loss in a chronic pressure-induced rat model of optic nerve damage. Invest Ophthalmol Vis Sci, 2002. Acetazolamide • Carbonic anhydrase inhibitor • Reduces (...) aqueous humor production • Limited effect if IOP low/normal • Routinely used to treat glaucoma • Plasma Half life 4 hours – 30 tablets cost £16.99 Centofanti, M., et al., Comparative effects on intraocular pressure between systemic and topical carbonic anhydrase inhibitors: a clinical masked, cross-over study. Pharmacological research, 1997. TaPPs Study Aim: •Investigate if acetazolamide reduces the IOP rise that occurs whilst in the Trendelenburg (TB) position. Methods: •Randomised cross-over blinded

2016 Association of Coloproctology of Great Britain and Ireland

10. Effect of a Carbonic Anhydrase Inhibitor (Diamox) on Intra-Ocular Pressure of Rabbits and Cats (Full text)

Acetazolamide Animals Carbonic Anhydrase Inhibitors Cats Diuretics Eye drug effects Hydro-Lyases Intraocular Pressure Rabbits Tonometry, Ocular 5629:21706 DIURETICS/effects EYE/effect of drugs on HYDRASES 1955 11 1 1955 11 1 0 1 1955 11 1 0 0 ppublish 13269690 PMC1324752 Klin Monbl Augenheilkd Augenarztl Fortbild. 1954;125(3):271-9 13222765 Br J Ophthalmol. 1950 Jun;34(6):351-4 15420370 AMA Arch Ophthalmol. 1954 Sep;52(3):333-48 13188476 AMA Arch Ophthalmol. 1954 Apr;53(4):463-7 14360875 AMA Arch Ophthalmol (...) Effect of a Carbonic Anhydrase Inhibitor (Diamox) on Intra-Ocular Pressure of Rabbits and Cats 13269690 2003 05 01 2018 12 01 0007-1161 39 11 1955 Nov The British journal of ophthalmology Br J Ophthalmol Effect of a carbonic anhydrase inhibitor (diamox) on intra-ocular pressure of rabbits and cats. 647-58 GLOSTER J J PERKINS E S ES eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 Carbonic Anhydrase Inhibitors 0 Diuretics EC 4.2.1.- Hydro-Lyases O3FX965V0I Acetazolamide OM

1955 The British journal of ophthalmology PubMed

11. SPECIFICITY AND COMPARATIVE ACTIVITY OF THE CARBONIC ANHYDRASE INHIBITORS NEPTAZANE AND DIAMOX ON ANIMAL AND HUMAN EYES (Full text)

Acetazolamide analogs & derivatives Animals Carbonic Anhydrase Inhibitors Eye Humans Intraocular Pressure drug effects Tonometry, Ocular 5935:14105:5:305 ACETAZOLAMIDE/related compounds INTRAOCULAR PRESSURE/effect of drugs on 1958 10 1 1958 10 1 0 1 1958 10 1 0 0 ppublish 13584707 PMC509710 J Pharmacol Exp Ther. 1956 Aug;117(4):385-401 13358050 Br J Ophthalmol. 1957 Dec;41(12):746-58 13489160 Biochem J. 1948;43(4):525-8 16748445 AMA Arch Ophthalmol. 1954 Jun;51(6):735-9 13157706 Physiol Rev. 1958 Apr;38(2 (...) SPECIFICITY AND COMPARATIVE ACTIVITY OF THE CARBONIC ANHYDRASE INHIBITORS NEPTAZANE AND DIAMOX ON ANIMAL AND HUMAN EYES 13584707 2000 07 01 2018 12 01 0007-1161 42 10 1958 Oct The British journal of ophthalmology Br J Ophthalmol Specificity and comparative activity of the carbonic anhydrase inhibitors neptazane and diamox on animal and human eyes. 577-88 LANGHAM M E ME eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 Carbonic Anhydrase Inhibitors O3FX965V0I Acetazolamide OM

1958 The British journal of ophthalmology PubMed

12. AVOIDANCE OF SIDE-REACTIONS AND LOSS OF DRUG EFFICACY DURING LONG-TERM ADMINISTRATION OF CARBONIC ANHYDRASE INHIBITORS BY CONCOMITANT SUPPLEMENTAL ELECTROLYTE ADMINISTRATION (Full text)

W eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 Carbonic Anhydrase Inhibitors 0 Electrolytes O3FX965V0I Acetazolamide RWP5GA015D Potassium OM Acetazolamide Carbonic Anhydrase Inhibitors Drug Therapy Electrolytes Eye Diseases Geriatrics Glaucoma Humans Intraocular Pressure Manometry Potassium Tonometry, Ocular Toxicology Water-Electrolyte Balance ACETAZOLAMIDE CARBONIC ANHYDRASE INHIBITORS DRUG THERAPY GERIATRICS GLAUCOMA INTRAOCULAR PRESSURE POTASSIUM TONOMETRY TOXICOLOGIC (...) AVOIDANCE OF SIDE-REACTIONS AND LOSS OF DRUG EFFICACY DURING LONG-TERM ADMINISTRATION OF CARBONIC ANHYDRASE INHIBITORS BY CONCOMITANT SUPPLEMENTAL ELECTROLYTE ADMINISTRATION 14196143 1996 12 01 2018 12 01 0007-1161 47 1963 Aug The British journal of ophthalmology Br J Ophthalmol AVOIDANCE OF SIDE-REACTIONS AND LOSS OF DRUG EFFICACY DURING LONG-TERM ADMINISTRATION OF CARBONIC ANHYDRASE INHIBITORS BY CONCOMITANT SUPPLEMENTAL ELECTROLYTE ADMINISTRATION. 457-68 DRAEGER J J GRUETTNER R R THEILMANN W

1963 The British journal of ophthalmology PubMed

13. Effect of Topical Hypotensive Medications for Preventing Intraocular Pressure Increase after Cataract Surgery in Eyes with Glaucoma. (Full text)

groups to receive each medication immediately postoperatively: 1) prostaglandin F2α analogue (travoprost), 2) β-blocker (timolol maleate), or 3) carbonic anhydrase inhibitor (brinzolamide). IOP was measured using a rebound tonometer at 1 h preoperatively; at the end of surgery; and at 2, 4, 6, 8, and 24 h postoperatively. The incidence of eyes exhibiting a marked IOP increase to greater than 25 mmHg was compared between goups.At 1 h preoperatively and at the end of surgery, mean IOP did not differ (...) Effect of Topical Hypotensive Medications for Preventing Intraocular Pressure Increase after Cataract Surgery in Eyes with Glaucoma. To compare the effects of a topical intraocular pressure (IOP)-lowering medication for preventing an IOP increase after cataract surgery in eyes with glaucoma.Randomized clinical study.One hundred sixty-five eyes of 165 patients with primary open-angle glaucoma or pseudoexfoliation glaucoma scheduled for phacoemulsification were randomly assigned to one of three

2019 American Journal of Ophthalmology PubMed

14. EFFECT OF INTRAOCULAR PRESSURE-LOWERING MEDICATIONS ON NEOVASCULAR AGE-RELATED MACULAR DEGENERATION TREATMENT OUTCOMES IN THE COMPARISON OF AGE-RELATED MACULAR DEGENERATION TREATMENT TRIALS. (PubMed)

A: topical prostaglandins) or suppressed aqueous production (Group B: topical beta blockers and carbonic anhydrase inhibitors). Eyes were excluded if mixed-mechanism intraocular pressure-lowering agents or medications from more than one group were taken. Anatomical and vision responses to treatment at years 1, 2, and over the entire 2-year period in each group were compared with controls (no intraocular pressure-lowering medications).Inclusion criteria were met by 28 Group A patients, 19 Group B patients (...) EFFECT OF INTRAOCULAR PRESSURE-LOWERING MEDICATIONS ON NEOVASCULAR AGE-RELATED MACULAR DEGENERATION TREATMENT OUTCOMES IN THE COMPARISON OF AGE-RELATED MACULAR DEGENERATION TREATMENT TRIALS. To evaluate the effect of intraocular pressure-lowering medications on treatment outcomes in the Comparison of AMD Treatments Trials.Secondary analysis of Comparison of AMD Treatments Trials data. Medication logs were reviewed for continuous 2-year use of agents that increased aqueous outflow (Group

2018 Retina

15. Effect of Fixed Brinzolamide-brimonidine Combination on Intraocular Pressure After Phacoemulsification

that consists of Viscoat (chondroitin sulfate 4.0%-sodium hyaluronate 3.0%) in combination with Provisc (sodium hyaluronate 1.0%) is the most frequently used OVD during cataract surgery. To prevent IOP spikes postoperatively, various antiglaucoma agents have been used. Brinzolamide is a carbonic anhydrase inhibitor that acts upon the ciliary processes and reduces aqueous humor secretion.Brimonidine is a highly selective a2-adrenergic agonist that increases uveoscleral outflow and reduces aqueous humor (...) Carbonic Anhydrase Inhibitors Enzyme Inhibitors

2018 Clinical Trials

16. Managing normal tension glaucoma by lowering the intraocular pressure. (PubMed)

address: daniellee@willseye.org. eng Journal Article Review 2018 10 06 United States Surv Ophthalmol 0404551 0039-6257 0 Antihypertensive Agents IM Antihypertensive Agents therapeutic use Disease Management Filtering Surgery methods Humans Intraocular Pressure physiology Low Tension Glaucoma physiopathology therapy Prostaglandin analogs alpha 2-agonists beta-blockers carbonic anhydrase inhibitors glaucoma progression intraocular pressure laser trabeculoplasty normal tension glaucoma trabeculectomy (...) Managing normal tension glaucoma by lowering the intraocular pressure. 30300624 2019 01 17 2019 01 17 1879-3304 64 1 2019 Jan - Feb Survey of ophthalmology Surv Ophthalmol Managing normal tension glaucoma by lowering the intraocular pressure. 111-116 S0039-6257(18)30138-3 10.1016/j.survophthal.2018.07.003 Razeghinejad M Reza MR Wills Eye Hospital, Glaucoma Service, Philadelphia, Pennsylvania, USA. Lee Daniel D Wills Eye Hospital, Glaucoma Service, Philadelphia, Pennsylvania, USA. Electronic

2018 Survey of Ophthalmology

17. BREMEN Eye Drops Versus Combigan and Azopt for Open-angle Glaucoma or Intraocular Hypertension

of Pharmacological Action Physiological Effects of Drugs Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists Adrenergic Agonists Carbonic Anhydrase Inhibitors Enzyme Inhibitors (...) BREMEN Eye Drops Versus Combigan and Azopt for Open-angle Glaucoma or Intraocular Hypertension BREMEN Eye Drops Versus Combigan and Azopt for Open-angle Glaucoma or Intraocular Hypertension - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2017 Clinical Trials

18. Effect of Acetazolamide on Intraocular Pressure After Being in the Trendelenburg Position.

Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by University of Nottingham: Trendelenburg Laparoscopic colorectal surgery POVL Additional relevant MeSH terms: Layout table for MeSH terms Acetazolamide Anticonvulsants Carbonic Anhydrase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Diuretics Natriuretic Agents Physiological Effects of Drugs (...) Effect of Acetazolamide on Intraocular Pressure After Being in the Trendelenburg Position. Effect of Acetazolamide on Intraocular Pressure After Being in the Trendelenburg Position. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2017 Clinical Trials

19. Twenty-Four-Hour Variation of Intraocular Pressure in Primary Open-Angle Glaucoma Treated with Triple Eye Drops (Full text)

Twenty-Four-Hour Variation of Intraocular Pressure in Primary Open-Angle Glaucoma Treated with Triple Eye Drops Objectives. To evaluate 24-hour intraocular pressure (IOP) variation in patients with primary open-angle glaucoma (POAG) treated with triple eye drops. Subjects and Methods. The IOP was measured in 74 eyes in 74 POAG patients (seated) on triple therapy (PG analogue, β-blocker, carbonic anhydrase inhibitor) at about every 3 hours. Results. The peak IOP was 13.5 ± 3.1 at 1:00

2017 Journal of ophthalmology PubMed

20. Different Glaucoma Treatments Effect on Intraocular Pressure Fluctuation With Postural Change in Eyes With Open-angle Glaucoma

in decreasing the chance for irreversible optic nerve damage. Several studies of Liu JH(9-11) have investigated the effect of hypotensive drops on nocturnal IOP. While prostaglandin analogues (PGA) and carbonic anhydrase inhibitors (CAI) seemed to have a significant nocturnal IOP lowering effect, the effect seen with beta blockers and alpha agonists was minimal. Mansouri et al.(12) recently showed that PGA seem to flatten the IOP-related increase when moving from the sitting to the supine position (...) Different Glaucoma Treatments Effect on Intraocular Pressure Fluctuation With Postural Change in Eyes With Open-angle Glaucoma Different Glaucoma Treatments Effect on Intraocular Pressure Fluctuation With Postural Change in Eyes With Open-angle Glaucoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2016 Clinical Trials

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