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Intramuscular Injection

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1. Wilms tumour antigen 1 Immunity via DNA fusion gene vaccination in haematological malignancies by intramuscular injection followed by intramuscular electroporation: a Phase II non-randomised clinical trial (WIN)

Wilms tumour antigen 1 Immunity via DNA fusion gene vaccination in haematological malignancies by intramuscular injection followed by intramuscular electroporation: a Phase II non-randomised clinical trial (WIN) Wilms' tumour antigen 1 Immunity via DNA fusion gene vaccination in haematological malignancies by intramuscular injection followed by intramuscular electroporation: a Phase II non-randomised clinical trial (WIN) Journals Library An error occurred retrieving content to display, please

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2016 NIHR HTA programme

2. Unfiltered Needles for Withdrawing Medication from Glass Ampoules for Intramuscular Injections: Safety and Guidelines

Unfiltered Needles for Withdrawing Medication from Glass Ampoules for Intramuscular Injections: Safety and Guidelines Unfiltered Needles for Withdrawing Medication from Glass Ampoules for Intramuscular Injections: Safety and Guidelines | CADTH.ca Find the information you need Unfiltered Needles for Withdrawing Medication from Glass Ampoules for Intramuscular Injections: Safety and Guidelines Unfiltered Needles for Withdrawing Medication from Glass Ampoules for Intramuscular Injections: Safety (...) and Guidelines Last updated: May 23, 2019 Project Number: RA1033-000 Product Line: Research Type: Drug Report Type: Reference List Result type: Report Question What is the safety/harm of using non-filtered needles when withdrawing medication from glass ampules versus vials for intramuscular injections? What are the guidelines regarding the use of unfiltered needles intended for intramuscular administration? Key Message No relevant literature was identified regarding the safety of using unfiltered needles

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

4. Is there a place in therapy for Kenalog (triamcinolone acetonide) intramuscular injection for seasonal allergic rhinitis (hay fever)?

Is there a place in therapy for Kenalog (triamcinolone acetonide) intramuscular injection for seasonal allergic rhinitis (hay fever)? Is there a place in therapy for Kenalog® (triamcinolone acetonide) intramuscular injection for seasonal allergic rhinitis (hay fever)? – SPS - Specialist Pharmacy Service – The first stop for professional medicines advice Menu · · 9th July 2019 · London and South east Regional Medicines Information Kenalog® (triamcinolone acetomide) intramuscular injection used (...) treatments, including oral prednisolone, use of depot injections of triamcinolone is no longer acceptable. Due to continued interest by patients in using this treatment, a review was conducted to identify new evidence since the publication of the DTB, to determine if its conclusions remain unchanged. Attachments · Word · 64 KB Medicines Information Pharmacist, London and South East Regional Medicines Information · · Copyright © 2019 SPS - Specialist Pharmacy Service. All Rights Reserved.

2019 Specialist Pharmacy Services

5. Are side effects reduced if practice nurses administer the intramuscular (IM) contraceptive injection via the ventrogluteal site compared to the dorsogluteal site?

Are side effects reduced if practice nurses administer the intramuscular (IM) contraceptive injection via the ventrogluteal site compared to the dorsogluteal site? Getting Evidence in Clinical Practice: General Practice Nurse Evidence Based Practice (CAT group) Date: May 2017 CAT Lead: Gwenllian Wynne-Jones and Katherine Gatensbury Date CAT completed: May 2017 Email: g.wynne-jones@keele.ac.uk Date CAT to be reviewed: May 2018 Clinical bottom line There is no evidence regarding side effects (...) of intramuscular injection site for the administration of the contraceptive injection. There is some weak evidence that the ventrogluteal site is preferable for intramuscular injections, where the drug manufactures state that this is an option in their guidance, and where practitioners take into account the health status and preferences of the patient. There is also evidence that training is required to ensure that practitioners are able to use the ventrogluteal method appropriately. Why is this important

2017 Home Modification Information Clearinghouse

6. Intramuscular glucocorticoid injection versus placebo injection in hip osteoarthritis: a 12-week blinded randomised controlled trial

Intramuscular glucocorticoid injection versus placebo injection in hip osteoarthritis: a 12-week blinded randomised controlled trial Guidelines recommend intra-articular glucocorticoid injection in patients with painful hip osteoarthritis. However, intra-articular hip injection is an invasive procedure. The efficacy of systemic glucocorticoid treatment for pain reduction in hip osteoarthritis is unknown. This randomised, double-blind, trial assessed effectiveness in hip pain reduction (...) of an intramuscular glucocorticoid injection compared with a placebo injection in patients with hip osteoarthritis.Patients with painful hip osteoarthritis were randomised to either 40 mg triamcinolone acetate or placebo with an intramuscular injection into the gluteus muscle. The primary outcomes were severity of hip pain at rest, during walking (0-10) and WOMAC pain at 2-week postinjection. We used linear mixed models for repeated measurements at 2, 4, 6 and 12 weeks for the intention-to-treat data analysis.Of

2018 EvidenceUpdates

7. Can small volume intramuscular injections be given to patients taking oral anticoagulants?

Can small volume intramuscular injections be given to patients taking oral anticoagulants? Can small volume intramuscular injections be given to patients taking oral anticoagulants? – SPS - Specialist Pharmacy Service – The first stop for professional medicines advice Menu · · 17th September 2018 This Medicines Q&A discusses the potential risks associated with the administration of small volume IM injections to patients taking oral anticoagulants. It has been partially updated (Sept 2018

2018 Specialist Pharmacy Services

8. Can small volume intramuscular injections be given to patients taking oral anticoagulants?

Can small volume intramuscular injections be given to patients taking oral anticoagulants? Can small volume intramuscular injections be given to patients taking oral anticoagulants? – SPS - Specialist Pharmacy Service – The first stop for professional medicines advice Menu · · 17th September 2018 This Medicines Q&A discusses the potential risks associated with the administration of small volume IM injections to patients taking oral anticoagulants. It has been partially updated (Sept 2018

2018 Specialist Pharmacy Services

9. Effect of the Buzzy Application on Pain and Injection Satisfaction in Adult Patients Receiving Intramuscular Injections. (PubMed)

Effect of the Buzzy Application on Pain and Injection Satisfaction in Adult Patients Receiving Intramuscular Injections. The aim of this study was to investigate the effect of the Buzzy application on pain and satisfaction during injections.Intramuscular injections usually cause some degree of pain at the injection site. Patients are often afraid of receiving injections because they perceive that it will be painful.The study was a single-blind, randomized controlled trial.Patients (n = 65) who (...) receive diclofenac sodium intramuscularly at a state hospital in a city in the western region of Turkey were included in the study. The study data were collected by The Patient Information Form and Visual Analog Scale (VAS). Pain intensity and injection satisfaction scores were evaluated using the VAS.According to the findings of this research, the post-injection pain intensity and injection satisfaction scores of patients in the application group were found to be higher than in the control group.In

2019 Pain management nursing : official journal of the American Society of Pain Management Nurses Controlled trial quality: uncertain

10. WHO guideline on the use of safety-engineered syringes for intramuscular, intradermal and subcutaneous injections in health care settings

WHO guideline on the use of safety-engineered syringes for intramuscular, intradermal and subcutaneous injections in health care settings WHO guideline on the use of safety-engineered syringes for intramuscular, intradermal and subcutaneous injections in health care settings JavaScript is disabled for your browser. Some features of this site may not work without it. Toggle navigation Toggle navigation Search Browse Statistics Related Links WHO guideline on the use of safety-engineered syringes (...) for intramuscular, intradermal and subcutaneous injections in health care settings View/ Open View Statistics Altmetrics Share Citation World Health Organization . (‎2016)‎. WHO guideline on the use of safety-engineered syringes for intramuscular, intradermal and subcutaneous injections in health care settings. World Health Organization. Description 49 p. ISBN 9789241549820 Other Language Versions Collections Language English Metadata Related items Showing items related by title and MeSH subject.  World Health

2016 WHO

11. Muscle loss following a single high-dose intramuscular injection of corticosteroids to treat disease flare in patients with rheumatoid arthritis (PubMed)

Muscle loss following a single high-dose intramuscular injection of corticosteroids to treat disease flare in patients with rheumatoid arthritis Adverse changes in body composition, specifically decreased muscle mass (MM) and increased fat mass, characterize rheumatoid arthritis (RA). These changes, termed rheumatoid cachexia (RC), are important contributors to the disability and elevated co-morbidity risk of RA. Recently, we observed substantial muscle loss (~2 kg) in a patient with RA (...) following a single intramuscular (IM) corticosteroid (CS) injection to treat a disease flare. The aim of the current study is to determine whether this apparent iatrogenic effect of IM CS is typical, i.e., does this routine, recommended treatment contribute to RC?Body composition was assessed by dual-energy X-ray absorptiometry (DXA) in eight patients with established RA who received a 120 mg IM methylprednisolone injection to treat a disease flare. DXA scans estimated appendicular lean mass (ALM

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2018 European journal of rheumatology

12. A systematic review of intramuscular injection technique and the effect on pain

A systematic review of intramuscular injection technique and the effect on pain Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO

13. Intramuscular glucocorticoid injection versus placebo injection in hip osteoarthritis: a 12-week blinded randomised controlled trial. (PubMed)

Intramuscular glucocorticoid injection versus placebo injection in hip osteoarthritis: a 12-week blinded randomised controlled trial. Guidelines recommend intra-articular glucocorticoid injection in patients with painful hip osteoarthritis. However, intra-articular hip injection is an invasive procedure. The efficacy of systemic glucocorticoid treatment for pain reduction in hip osteoarthritis is unknown. This randomised, double-blind, trial assessed effectiveness in hip pain reduction (...) of an intramuscular glucocorticoid injection compared with a placebo injection in patients with hip osteoarthritis.Patients with painful hip osteoarthritis were randomised to either 40 mg triamcinolone acetate or placebo with an intramuscular injection into the gluteus muscle. The primary outcomes were severity of hip pain at rest, during walking (0-10) and WOMAC pain at 2-week postinjection. We used linear mixed models for repeated measurements at 2, 4, 6 and 12 weeks for the intention-to-treat data analysis.Of

2018 Annals of the Rheumatic Diseases Controlled trial quality: predicted high

14. Evaluation of Vaccines Injection Order on Pain Score of Intramuscular Injection of Diphtheria, Whole Cell Pertussis and Tetanus Vaccine. (PubMed)

Evaluation of Vaccines Injection Order on Pain Score of Intramuscular Injection of Diphtheria, Whole Cell Pertussis and Tetanus Vaccine. To determine, whether or not intramuscular injection of diphtheria, pertussis and tetanus (DwPT) vaccine should be given first and subcutaneous injection of measles, mumps and rubella (MMR) thereafter or vice versa and can this cause less pain of DwPT vaccine injection.In a randomized parallel group clinical trial, seventy 18-mo-old healthy children who were (...) was crying duration during DwPT injection.Thirty seven girls and 33 boys were evaluated in two groups. Pain scores of DwPT and MMR injections, the frequency of pain score obtained to be less than three during DwPT injection and the crying duration were not different in both groups. But, overall pain score of vaccination was lower when subcutaneous injection of MMR vaccine was given before intramuscular injection of DwPT vaccine. (14.23 ± 1.35 vs. 15.61 ± 2.65; P = 0.04).Overall pain score of vaccination

2018 Indian journal of pediatrics Controlled trial quality: uncertain

15. Intramuscular glucocorticoid injection versus placebo injection in hip osteoarthritis: a 12-week blinded randomised controlled trial. (PubMed)

Intramuscular glucocorticoid injection versus placebo injection in hip osteoarthritis: a 12-week blinded randomised controlled trial. Guidelines recommend intra-articular glucocorticoid injection in patients with painful hip osteoarthritis. However, intra-articular hip injection is an invasive procedure. The efficacy of systemic glucocorticoid treatment for pain reduction in hip osteoarthritis is unknown. This randomised, double-blind, trial assessed effectiveness in hip pain reduction (...) of an intramuscular glucocorticoid injection compared with a placebo injection in patients with hip osteoarthritis.Patients with painful hip osteoarthritis were randomised to either 40 mg triamcinolone acetate or placebo with an intramuscular injection into the gluteus muscle. The primary outcomes were severity of hip pain at rest, during walking (0-10) and WOMAC pain at 2-week postinjection. We used linear mixed models for repeated measurements at 2, 4, 6 and 12 weeks for the intention-to-treat data analysis.Of

2018 Annals of the Rheumatic Diseases Controlled trial quality: predicted high

16. Treatment of acquired Brown syndrome in a child with a single intramuscular systemic depot steroid injection. (PubMed)

Treatment of acquired Brown syndrome in a child with a single intramuscular systemic depot steroid injection. A 10-year-old girl presented with a complaint of diplopia and mild superomedial orbital pain in the left eye of 2 weeks' duration. She had limited elevation of the left eye, especially in adduction, moderate limitation of elevation in the primary position, mild limitation of elevation in abduction, downshoot in adduction, mild hypotropia in the primary position, and normal abduction (...) . There was mild swelling and tenderness in the superomedial aspect of her left orbit. Fundus examination revealed intorsion of the left fundus on upgaze. She was diagnosed with acquired Brown syndrome, due presumably to a local inflammatory cause, and treated with a single intramuscular depot injection of betamethasone in her deltoid muscle. One week later, her symptoms were resolving, and there was marked improvement of elevation of the left eye in adduction, with near normal elevation in the primary

2019 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

17. Using Buzzy, Shotblocker, and Bubble Blowing in a Pediatric Emergency Department to Reduce the Pain and Fear Caused by Intramuscular Injection: A Randomized Controlled Trial. (PubMed)

Using Buzzy, Shotblocker, and Bubble Blowing in a Pediatric Emergency Department to Reduce the Pain and Fear Caused by Intramuscular Injection: A Randomized Controlled Trial. Procedural pain in general, and intramuscular (IM) injection pain in particular, is one of the most distressing and painful health care experiences for children. Pharmacologic and nonpharmacologic methods are used as forms of pain control for children undergoing acute painful interventions in emergency departments.This (...) study was a prospective, randomized controlled trial. The sample consisted of children aged 5 to 10 years old who required IM injections. Children were placed in 4 subgroups through randomization, using a computer program: the Buzzy (MMJ Labs. Atlanta, GA) group (n = 40), the ShotBlocker (Bionix Development Corporation, Toledo, OH) group (n = 40), the bubble-blowing group (n = 40), and the control group (n = 40). Immediately before and after the injection, the children, their parents

2019 Journal of Emergency Nursing Controlled trial quality: uncertain

18. Intramuscular injection, intravenous infusion, and intravenous bolus of oxytocin in the third stage of labor for prevention of postpartum hemorrhage: a three-arm randomized control trial. (PubMed)

Intramuscular injection, intravenous infusion, and intravenous bolus of oxytocin in the third stage of labor for prevention of postpartum hemorrhage: a three-arm randomized control trial. Oxytocin for postpartum hemorrhage (PPH) prophylaxis is commonly administered by either intramuscular (IM) injection or intravenous (IV) infusion with both routes recommended equally and little discussion of potential differences between the two. This trial assesses the effectiveness and safety of 10 IU (...) effects were reported in any arm.Intravenous oxytocin is more effective than intramuscular injection for the prevention of PPH in the third stage of labor. Oxytocin delivered by IV bolus presents no safety concerns after vaginal delivery and should be considered a safe option for PPH prophylaxis.clinicaltrials.gov # NCT01914419 , posted August 2, 2013.

2019 BMC Pregnancy and Childbirth Controlled trial quality: predicted high

19. Effectiveness and safety of early intramuscular botulinum toxin injections to prevent shoulder deformity in babies with brachial plexus birth injury (POPB-TOX), a randomised controlled trial: study protocol. (PubMed)

Effectiveness and safety of early intramuscular botulinum toxin injections to prevent shoulder deformity in babies with brachial plexus birth injury (POPB-TOX), a randomised controlled trial: study protocol. In children with brachial plexus birth injury (BPBI), denervation of the shoulder muscles leads to bony deformity in the first months of life, reducing active and passive range of motion (ROM) and causing activity limitation. The aim of this multicentre randomised controlled trial (...) is to evaluate the effectiveness of botulinum toxin injections (BTI) in the shoulder internal rotator muscles of 12-month-old babies in limiting the progression of posterior subluxation of the glenohumeral joint, compared with a sham procedure mimicking BTI. The secondary aims are to evaluate the effectiveness of BTI in (1) limiting the progression of glenoid retroversion and three-dimensional (3D) deformity and (2) improving shoulder ROM and upper limb function, as well as to confirm the tolerance

2019 BMJ open

20. Ropivacaine Intramuscular Paracervical Injections for Pediatric Headache: A Randomized Placebo-Controlled Trial

Ropivacaine Intramuscular Paracervical Injections for Pediatric Headache: A Randomized Placebo-Controlled Trial We seek to determine whether ropivacaine cervical paraspinal injections compared with normal saline solution injections provide headache relief to pediatric patients that is sufficient for emergency department (ED) discharge.We enrolled children aged 7 to 17 years in a double-blinded, randomized, controlled trial of patients presenting to a pediatric ED with headache. Subjects were (...) randomized into 1 of 3 groups: bilateral cervical paraspinal injections of either (1) 0.5% ropivacaine or (2) normal saline solution, or (3) a natural history group (not blinded) receiving no headache therapy for the first 30 minutes. Pain scores were assessed at enrollment and at 10-, 20-, and 30-minute intervals after the administration of the injections. After the intervention period of 30 minutes, additional therapy was provided as needed. Primary outcome was the proportion of children discharged

2017 EvidenceUpdates

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