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121. Primary Prevention of Cervical Cancer Resource-Stratified Guideline

of failures within different health care systems at levels of prevention (eg, vaccination and screening) and disease treatment and management, there are large regional and global disparities in cervical cancer incidence and mortality. THE BOTTOM LINE Primary Prevention of Cervical Cancer: American Society of Clinical Oncology Resource-Stratified Guideline Guideline Question What is the optimal method for the primary prevention of cervical cancer? Target Population General population Target Audience Public (...) -stratified guidelines, ASCO has adopted its framework from the four-tier resource setting approach (basic, limited, enhanced, maximal; ) developed by the Breast Health Global Initiative and modifications to that framework based on the Disease Control Priorities 3. , ASCO uses an evidence-based approach to inform guideline recommendations. Table 1 Framework of Resource Stratification: Primary Prevention Table 1Framework of Resource Stratification: Primary Prevention GUIDELINE QUESTION Section

2017 American Society of Clinical Oncology Guidelines

122. Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children

and pediatric patients with CDI was convened to develop these practice guidelines. A systematic evidence-based approach was adopted for the guideline questions and population, intervention, comparator, outcome (PICO) formulations, the selection of patient-important outcomes, as well as the literature searches and screening of the uncovered citations and articles. The rating of the quality of evidence and strength of recommendation was supported by a Grading of Recommendations Assessment, Development (...) in the category of good practice statements that should not be graded, we followed published principles by the GRADE working group on how to identify such recommendations and use appropriate wording choices [13]. Accordingly, a formal GRADE rating was not pursued for those statements as these statements would make it clear that they would do greater good than harm or greater harm than good, and thus a study would not be warranted to address such a question. Discrepancies were discussed and resolved, and all

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2017 Infectious Diseases Society of America

123. Repetitive transcranial magnetic stimulation for treatment-resistant major depression

AND EVIDENCE INCLUDED 18 2.1 ASSESSMENT TEAM 18 2.2 SOURCE OF ASSESSMENT ELEMENTS 18 2.3 SEARCH 18 2.4 STUDY SELECTION 20 2.5 QUALITY RATING OF STUDIES 22 2.6 STATISTICAL-ANALYSIS 22 2.7 DESCRIPTION OF THE EVIDENCE 24 2.8 DEVIATIONS FROM PROJECT PLAN 25 3 DESCRIPTION AND TECHNICAL CHARACTERISTICS OF TECHNOLOGY (TEC) 26 3.1 RESEARCH QUESTIONS 26 3.2 RESULTS 26 3.3 DISCUSSION 33 4 HEALTH PROBLEM AND CURRENT USE OF THE TECHNOLOGY (CUR) 35 4.1 RESEARCH QUESTIONS 35 4.2 RESULTS 35 4.3 DISCUSSION 41 5 CLINICAL (...) EFFECTIVENESS (EFF) 42 5.1 RESEARCH QUESTIONS 42 5.2 RESULTS 42 5.3 DISCUSSION 50 6 SAFETY (SAF) 52 6.1 RESEARCH QUESTIONS 52 6.2 RESULTS 52 6.3 DISCUSSION 55 7 REFERENCES 56 APPENDIX 1: METHODS AND DESCRIPTION OF THE EVIDENCE USED 65 DOCUMENTATION OF THE SEARCH STRATEGIES 65 DESCRIPTION OF THE EVIDENCE USED 71 APPENDIX 2: REGULATORY AND REIMBURSEMENT STATUS 115 APPENDIX 3: CHECKLIST FOR POTENTIAL ETHICAL, ORGANISATIONAL, PATIENT AND SOCIAL AND LEGAL ASPECTS 120 APPENDIX 4: DIAGNOSTIC CRITERIA ACCORDING

2017 EUnetHTA

124. CVD Prevention in Clinical Practice

these into national or regionalprevention frameworks and to translate these in locally delivered healthcareservices, in line with the recommendations of the World Health Organization(WHO) global status report on non-communicable diseases 2010. As in the present guidelines, the model presented in the previous document fromthe Fifth European Joint Task Force has been structured around four core questions: (i)What is CVD prevention? (ii) Who will benefit from prevention? (iii) How tointervene? (iv) Where

2016 European Society of Cardiology

125. Crisis Intervention for Adults Using a Trauma-Informed Approach: Initial Four Weeks of Management Third Edition

developed, evidence-based documents that include recommendations on specific clinical and healthy work environment topics for nurses, members of the interprofessional team G , educators, leaders and policy-makers, and persons and their families. Members of the interprofessional team caring for persons experiencing crisis include nurses and other health-care providers (e.g., physicians, social workers, and counselors), first responders (e.g., police officers, paramedics, and firefighters), and peer (...) of what is known about the role of nurses and the interprofessional team in crisis management and intervention. ? It conducted 15 key informant interviews with experts in the field, including those who actively implement the 2002 and 2006 guidelines. The results of the analysis demonstrated that an expanded scope is required. As such, this Guideline provides evidence-based best practice recommendations G on effective crisis intervention using trauma-informed approaches for adults (18 years and older

2017 Registered Nurses' Association of Ontario

126. The Diagnosis and Acute Management of Childhood Stroke, Clinical Guideline

11.1 Recognition of intracranial pressure 36 11.2 Decompressive craniectomy 37 12 STROKE AND CONGENITAL HEART DISEASE 40 13 PATIENT AND FAMILY CONSIDERATIONS 42 14 RESEARCH RECOMMENDATIONS 43 15 APPENDICES 44 15.1 Appendix 1 – Case series of children receiving neuro-interventions for stroke 44 15.2 Appendix 2 – PICO questions 49 16 REFERENCES 50Australian Childhood Stroke Advisory Committee ii Figure 1. Quick Reference guide to the diagnosis and acute management of childhood stroke 1 Figure 2

2017 Stroke Foundation - Australia

127. Model for the organization and reimbursement of psychological and orthopedagogical care in Belgium

ORTHOPEDAGOGISTS AND PSYCHOTHERAPISTS IN THE BELGIAN MENTAL HEALTH CARE SYSTEM 21 ‘Centra voor geestelijke gezondheid’ (CGG) – ‘Services de santé mentale’ (SSM) 21 Various new initiatives 23 The 6 th State Reform 26 4.3 MENTAL HEALTHCARE PRACTITIONERS: REGULATION, EDUCATION AND WORK SETTING . 26 Physicians 26 Clinical psychologists 27 Psychotherapists 28 Clinical orthopedagogists 29 4.4 CURRENT FINANCING OF AMBULATORY PSYCHOLOGICAL AND PSYCHOTHERAPY INTERVENTIONS 30 Financing of psychological (...) and psychotherapeutic interventions delivered by physicians in ambulatory setting 30 2 Model for the organization and reimbursement of psychological and orthopedagogical care in Belgium KCE Report 265 Financing for psychological and psychotherapeutic interventions delivered by psychologists or psychotherapists in ambulatory settings 31 Financing for psychological and psychotherapeutic interventions delivered in centres for mental health care (CGG – SSM) 32 4.5 COST OF PSYCHOLOGISTS AND PSYCHOTHERAPISTS IN BELGIUM

2016 Belgian Health Care Knowledge Centre

128. Gene expression profiling of breast cancer

is that, on the basis of these test results, women may be denied treatment that may, in fact, be of benefit to them. It is also of concern that only a small subset of women would be good candidates for gene expression profiling testing, however, consumer demand for these tests is likely to increase. HealthPACT does not support public investment in this technology in clinical practice at this time and not until after consideration of published results of studies demonstrating clinical utility. Therefore, HealthPACT (...) from an Oncotype DX assay, which involved microdissection and RNA extraction, for testing with Prosigna. As a result, the integrity of the samples has been questioned. 35 A retrospective comparison (level III-2) 22 of PAM50 ROR and Oncotype DX RS was performed on 1,017 FFPE samples from the ATAC trial (post-menopausal hormone receptor +ve primary breast cancer patients from the tamoxifen or anastrozole-only arms). A trial- f The Austrian breast and Colorectal Cancer Study Group-8 (ABCSG-8) trial

2016 COAG Health Council - Horizon Scanning Technology Briefs

129. Palliative Care

. Key Informant Interviews 128 A10. Policy Roundtable Participants 129 ©Institute for Clinical and Economic Review, 2016 Page v List of Abbreviations Used in this Report ABMS American Board of Medical Specialties ACA Affordable Care Act ACGME Accreditation Council for Graduate Medical Education ACHPN Advanced Certified Hospice and Palliative Nurse ACHP-SW The Advanced Certified Hospice and Palliative Social Worker AIM Advance Illness Management APN Advanced Practice Nurse ATT Average Treatment (...) Palliative Care Leadership Center PC Palliative care PCP Primary Care Physician PHQ-9 Patient Health Questionnaire POM Profile of Mood States PPCHETA Palliative Care and Hospice Education and Training Act PPS Palliative Performance Scale PROMIS Patient Reported Outcomes Measurement Information System PRISMA Preferred Reporting Items for Systematic Reviews QoL Quality of Life QUAL-E Quality of Life at the End of Life RCT Randomized Control Trial TOI The Trial Outcome Index USPSTF U.S. Preventive Services

2016 California Technology Assessment Forum

130. Multiple Myeloma: Evidence Report

changing the price of PAN alone. Potential Budgetary Impact Model: Results We used available prevalence data to estimate the number of individuals with MM in the U.S. (approximately 92,000). 44 Data from a claims-based analysis suggested proportions of patients receiving second- and third-line therapy (approximately 37% and 13% respectively). This resulted in candidate population sizes of 33,941 and 11,930 patients. Based on several criteria, we estimated that the theoretical “unmanaged” uptake (...) of these newest regimens would be very high, with 75% of candidate patients receiving at least one of the regimens of interest by year five following their introduction. Uptake was assumed to be very high because of the gains in progression-free survival that have been demonstrated in available clinical trials as well as acceptable levels of toxicity in most circumstances. Uptake was apportioned equally to the three second-line regimens of interest (i.e., 25% each by year 5) and the four third-line regimens

2016 California Technology Assessment Forum

131. ERBP Guideline on Management of Older Patients with Chronic Kidney Disease

and Information Network RR Relative Risk RRT Renal replacement therapy SGA Subjective global assessment 95% CI 95% Confidence Interval 2. FOREWORD The mean age of the general population is increasing, resulting in a higher prevalence of older patients. The health management of this specific subpopulation poses serious questions, which are not limited to clinical issues, but also involve ethical and social issues. Despite the growing number of frail and older patients with eGFR <45 mL/min/1.73 m 2 , most (...) , a working group convened in May 2013 and decided on the composition of the guideline development group, taking into account the clinical and research expertise of each proposed candidate. It was decided that, next to the actual members of the guideline development group, additional external experts would be approached for their expertise in specific areas. Next to setting up a guideline development group, it was decided to perform a formal scoping procedure [ ] to define the topics of interest

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2016 European Renal Best Practice

132. Evidence-Based Policy Making: Assessment of the American Heart Association?s Strategic Policy Portfolio

base; and for impact assessment of all policies, to monitor determinants of population CVH and outcomes through significantly enhanced surveillance at the national, state, and local levels. This need is discussed at 2 levels: (1) the overarching questions of implementation science, cost-effectiveness research, and impact evaluation and (2) specific questions relevant to each metric and indicator to be monitored under the 2020 goals. Aligning the AHA’s Policy Agenda With the 2020 Strategic Impact (...) , risks, and impact on other policy priorities within the AHA agenda are also considered. This report focuses on the 2 foremost considerations: alignment of a candidate policy with the overall AHA strategic priorities and the strength of the scientific evidence to support a particular policy. (The other considerations will be described in detail in a future publication.) Increasingly, the AHA is assessing the cost-effectiveness of interventions and incorporating economic analyses into its work

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2016 American Heart Association

133. ICU Admission, Discharge, and Triage Guidelines

of the literature, discussion, and consensus, recommendations were written. Conclusion: Although these are administrative guidelines, the subjects addressed encompass complex ethical and medico-legal aspects of patient care that affect daily clinical practice. A limited amount of high-quality evidence made it difficult to answer all the questions asked related to ICU admission , discharge , and triage . Despite these limitations, the members of the Task Force believe that these recommendations provide (...) 1) to update the SCCM Guidelines for ICU ADT and 2) to provide a framework for the development of institutional policies, further research, and discussion for future refinement of these recommendations. | Topic Refinement The population considered for these guidelines consisted of adult critically ill patients who are candidates for critical care services or admission to the ICU. Adults are considered to be persons 18 years old and older. Critical care and critical illness are defined

2016 Society of Critical Care Medicine

134. Diagnosis of Right Lower Quadrant Pain and Suspected Acute Appendicitis

. Transparency and stakeholder input are essential to the Effective Health Care Program. Please visit the Web site (www.effectivehealthcare.ahrq.gov) to see draft research questions and reports or to join an email list to learn about new program products and opportunities for input. If you have comments on this systematic review, they may be sent by mail to the Task Order Officer named below at: Agency for Healthcare Research and Quality, 5600 Fishers Lane, Rockville, MD 20857, or by email to epc (...) and Quality iv Key Informants In designing the study questions, the EPC consulted several Key Informants who represent the end-users of research. The EPC sought the Key Informant input on the priority areas for research and synthesis. Key Informants are not involved in the analysis of the evidence or the writing of the report. Therefore, in the end, study questions, design, methodological approaches, and/or conclusions do not necessarily represent the views of individual Key Informants. Key Informants

2016 Effective Health Care Program (AHRQ)

135. Gynecologic Care for Women and Adolescents With Human Immunodeficiency Virus

Women with Biopsy-Confirmed Cervical Intraepithelial Neoplasia—Grade 2,3 (CIN 2,3) in Special Circumstances” (21) should be considered for HIV-infected adolescents and women younger than 25 years, as well as those women who, after counseling by their clinicians, consider risk to future pregnancies from treating cervical abnormalities to outweigh risk of cancer during observation of those abnormalities; although if adherence is questionable, treatment may be preferable. Human papillomavirus (...) with HIV status. Women with HIV should receive the same treatment for bacterial vaginosis as women without HIV infection (24). Vulvovaginal Candidiasis Vulvovaginal candidiasis is diagnosed in the same way in women with HIV as in women without HIV infection (11). Uncomplicated vulvovaginal candidiasis in women with HIV should be treated with topical antifungals or oral fluconazole as in women without HIV. Women with HIV who have severe or recurrent vulvovaginal candidal infection should be treated

2016 American College of Obstetricians and Gynecologists

136. Immersion in Water During Labor and Delivery

associated with this choice. If the physician believes, based on evidence, that second-stage immersion and giving birth while submerged would be detrimental to the overall health and welfare of the woman or the fetus, he or she should not perform such a delivery ( ). Although it has not been the focus of specific trials, facilities that plan to offer immersion during labor and delivery need to establish rigorous protocols for candidate selection; maintenance and cleaning of tubs and pools; infection (...) of Obstetricians and Gynecologists that birth occur on land, not in water. A woman who requests to give birth while submerged in water should be informed that the maternal and perinatal benefits and risks of this choice have not been studied sufficiently to either support or discourage her request. Facilities that plan to offer immersion during labor and delivery need to establish rigorous protocols for candidate selection; maintenance and cleaning of tubs and pools; infection control procedures, including

2016 American College of Obstetricians and Gynecologists

137. Management of Concussion-mild Traumatic Brain Injury (mTBI)

and Assessment 43 B. Treatment 43 C. Care Delivery 43 Appendix A: Guideline Development Methodology 44 A. Developing the Scope and Key Questions 44 B. Conducting the Systematic Review 45 C. Convening the Face-to-face Meeting 72 D. Grading Recommendations 72 VA/DoD Clinical Practice Guideline for the Management of Concussion-mild Traumatic Brain Injury February 2016 Page 4 of 133 E. Recommendation Categorization 75 F. Drafting and Submitting the Final CPG 77 Appendix B: Clinical Symptom Management 79 (...) implementation and to evaluate the effect of guideline adherence on clinical outcomes. This guideline is intended for VA and DoD healthcare providers including physicians, nurse practitioners, physician assistants, psychologists, social workers, nurses, speech-language pathologists, occupational therapists, physical therapists, and others involved in the primary care of Service Members or Veterans who have a history of suspected or diagnosed mTBI. This CPG is not intended to serve as a standard of care

2016 VA/DoD Clinical Practice Guidelines

138. Guidelines for adult stroke rehabilitation and recovery

review therapy, motivational interviewing, nursing support programs, and physical exercise. Rehabilitation, Exercise, and Recovery A study with 49 depressed patients (24 treated for depres- sion and 25 not treated as determined by physician prefer- ence) was conducted to evaluate the effects of poststroke depression and antidepressant therapy on the improvement of motor scores and disability. 229 Poststroke depression was found to have negative effects on functional recovery, and the pharmacological (...) Committee review before consideration and approval by the AHA Science Advisory and Coordinating Committee. Results—Stroke rehabilitation requires a sustained and coordinated effort from a large team, including the patient and his or her goals, family and friends, other caregivers (eg, personal care attendants), physicians, nurses, physical and occupational therapists, speech-language pathologists, recreation therapists, psychologists, nutritionists, social workers, and others. Communication

2016 American Academy of Neurology

139. Palliative Care and Cardiovascular Disease and Stroke: A Policy Statement From the American Heart Association/American Stroke Association

) declined from 15.8 deaths per 100 wait-list years in 2002 to 12.4 in 2012. Although the decrease in HT candidate mortality is no doubt due to the use of VADs as a bridge to transplantation, mortality is still high. HT is associated with 1-year survival of 85% to 90% and relief from most, if not all, HF symptoms. Median posttransplantation survival is 11.6 to 12.7 years if the recipient survives the first year. Median survival for infants after heart transplantation is 20 years but is closer to 12 years (...) for adolescents. Increasingly, these children are considered for second or third transplantations, with worse outcomes each time. Although pretransplantation mortality has declined over the past several years, it is highest for HT candidates <1 year of age, at 53 deaths per 100 wait-list years in 2010 to 2012. Adverse Events Long-term complications of HT are common. Patients are at particular risk for cellular rejection, especially during the first year after transplantation, although rates of rejection

2016 American Heart Association

140. AHA/ASA Guidelines for Adult Stroke Rehabilitation and Recovery

, and Scientific Statements Oversight Committee review before consideration and approval by the AHA Science Advisory and Coordinating Committee. Results— Stroke rehabilitation requires a sustained and coordinated effort from a large team, including the patient and his or her goals, family and friends, other caregivers (eg, personal care attendants), physicians, nurses, physical and occupational therapists, speech-language pathologists, recreation therapists, psychologists, nutritionists, social workers (...) are directed under the leadership of physicians trained in physical medicine and rehabilitation (physiatrist) or by neurologists who have specialized training or board certification in rehabilitation medicine. Other health professionals who play an essential role in the process include social workers, psychologists, psychiatrists, and counselors. Health care provided during the acute hospital stay is focused primarily on the acute stabilization of the patient, the delivery of acute stroke treatments

2016 American Heart Association

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