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41. Treatment of patients with non-severe and severe coronavirus disease 2019: an evidence-based guideline

, Luis Enrique Colunga-Lozano MD MSc, Li Jiang MD, Younsuck Koh MD, Dong Liu PhD, Fang Liu MSc, Jason Phua MRCP, Aizong Shen MSc, Tianyi Huo BSc, Bin Du MD, Suodi Zhai BSc, Gordon H. Guyatt MD MSc n Cite as: CMAJ 2020. doi: 10.1503/cmaj.200648; early-released April 29, 2020 CMAJ Podcasts: author interview at https://soundcloud.com/cmajpodcasts/200648-guide This guideline will be updated at https://app.magicapp.org/app#/guideline/EK6W0n as new evidence becomes available. KEY POINTS • The available (...) as potential treatments for COVID-19. • Rigorous randomized trials are urgently needed to establish the benefits and risk of candidate interventions. Early release, published at www.cmaj.ca on April 29, 2020. Subject to revision.2 CMAJ GUIDELINE Scope Health care providers represent the target audience of this guide- line. The guideline includes 3 categories of interventions: cortico- steroids, convalescent plasma therapy and antiviral drugs. We address the use of these interventions for COVID-19

2020 Covid-19 Ad hoc guidelines

42. Deceased organ and tissue donation after medical assistance in dying and other conscious and competent donors: guidance for policy

the options, ask questions and plan accordingly. Patients and their families should be provided with standardized information resources, such as online material or pamphlets, to help guide responses to donation inquiries. The decision to proceed with MAiD or WLSM must precede discussions about donation. Consent The patient must have the ability to provide first-person consent to MAiD or WLSM as well as to organ and tissue donation. Physicians, MAiD assessors, and WLSM or MAiD providers should be cognizant (...) article at www.cmaj.ca/lookup/doi/10.1503/cmaj.190352 CMAJ Podcasts: author interview at https://soundcloud.com/cmajpodcasts/181648-guide KEY POINTS • First-person consent for organ donation after medical assistance in dying (MAiD) or withdrawal of life-sustaining measures (WLSM) should be an option in jurisdictions that allow MAiD or WLSM and donation after circulatory determination of death. • The most important ethical concern — that the decision for MAiD or WLSM is being driven by a desire

2019 CPG Infobase

43. Children and young people exposed prenatally to alcohol

at risk of FASD, including child development specialists, clinical and educational psychologists, clinical geneticists, general practitioners (GPs) and members of the primary care team, health visitors, members of the judicial system, midwives, neonatologists, nurses (eg school, learning disability and others), obstetricians, occupational therapists, paediatricians, physicians, physiotherapists, psychiatrists, social workers and speech and language therapists. It will also be of interest to people (...) sources, including clinical interview, questionnaire, file review and direct clinical observation during neurodevelopmental testing. Executive function, including impulse control and hyperactivity Executive function refers to a set of higher-level skills involved in organising and controlling one’s own thoughts and behaviours in order to meet long-term goals. Although there is some overlap between attention and executive function in many conceptualisations, it is here defined as impairments in working

2019 SIGN

44. Optimisation of RIZIV – INAMI lump sums for incontinence

: To the physicians who participated to the interviews; Gilles Capaert (Service Public Francophone Bruxellois), Kristien Houben (VAPH), Lara Classen (Dienststelle für Selbstbestimmtes Leben der Deutschsprachigen Gemeinschaft Belgiens), Nicolas Fairon (KCE), Mattias Neyt (KCE), Johan Van der Heyden (Sciensano) Reported interests: ‘All experts and stakeholders consulted within this report were selected because of their involvement in the topic. Therefore, by definition, each of them might have a certain degree (...) prevalence is seen in nursing homes; with 70% of the population suffering from urinary or faecal incontinence or both. Of note, the spectrum severity of incontinence complaints of patients seen in hospital settings do not necessarily reflect the disease spectrum in the community. The Belgian Health Interview Survey data from 2013 showed that for women aged 18 to 64, 5.4% had problems with UI and also had consulted their doctor, while for the above 65 year old women this increased to 15.7% [4

2020 Belgian Health Care Knowledge Centre

45. Health literacy: what lessons can be learned from the experiences of other countries?

Questions related to health literacy in the Health Survey 2018 26 LIST OF TABLES Table 1 – Scope of the studied HL action plans 33 Table 2 – Overview of the HL levels of the studied countries 34 Table 3 – Initiative of the studied HL action plans 37 6 Health literacy KCE Report 322 LIST OF ABBREVIATIONS ABBREVIATION DEFINITION ABS Australian Bureau of Statistics ACSQHC Australian Commission on Safety and Quality in Health Care ALLS Adult Literacy and Lifeskills Survey ASBL Association Sans But Lucratif (...) Federal Public Service FWB Fédération Wallonie-Bruxelles GP General Practitioner HiAP Health in All Policies approach HIS Health Interview Survey HL Health literacy HLS-EU The European Health Literacy Survey HSE Health Service Executive (Ireland) IALS International Adult Literacy Surveys IE Ireland KCE Report 322 Health literacy 7 IROHLA Intervention Research On Health Literacy of the Ageing population in Europe IUHPE International Union for Health Promotion and Education KAGB Koninklijke Academie

2020 Belgian Health Care Knowledge Centre

46. Preparing Emerging Leaders for Alternative Futures in Health Systems Across Canada

. Merit review The evidence brief was reviewed by a small number of policymakers, stakeholders and researchers in order to ensure its scientific rigour and system relevance. Acknowledgments We are grateful to the 26 key informants who were interviewed to help with the iterative development of the list of expected futures (which later came to be called ‘alternative futures’), and to the 19 key informants who were interviewed to provide feedback on the terms of reference for this evidence brief. We wish (...) implementation considerations. Whenever possible, the evidence brief summarizes research evidence drawn from systematic reviews of the research literature and occasionally from single research studies. A systematic review is a summary of studies addressing a clearly formulated question that uses systematic and explicit methods to identify, select and appraise research studies and to synthesize data from the included studies. The evidence brief does not contain recommendations, which would have required

2019 McMaster Health Forum

48. Learning from the Experience of Accountable Care Organizations in the U.S.

of a question from a policymaker or stakeholder (in this case, the Government of Ontario); 2) identifying, selecting, appraising and synthesizing relevant research evidence about the question; 3) conducting key informant interviews 4) drafting the rapid synthesis in such a way as to present concisely and in accessible language the research evidence; and 5) finalizing the rapid synthesis based on the input of at least two merit reviewers. McMaster Health Forum 5 Evidence >> Insight >> Action Based (...) the experiences of accountable care organizations in the U.S. Hamilton: McMaster Health Forum, 18 July 2019. Product registration numbers ISSN 2292-7999 (online)McMaster Health Forum 3 Evidence >> Insight >> Action KEY MESSAGES Questions • What are accountable care organizations (ACOs) and how have they evolved in the U.S.? • How do general features of public ACOs differ from the proposed design for Ontario Health Teams? • What effects have been achieved through ACOs and what can we learn from

2019 McMaster Health Forum

49. Diagnosis and Treatment of Low Back Pain

results. The ultimate judgment regarding any specific procedure or treatment is to be made by the physician and patient in light of all circumstances presented by the patient and the needs and resources particular to the locality or institution. Objective The objective of the North American Spine Society (NASS) Clinical Guideline for the Diagnosis and Treat- ment of Low Back Pain is to provide evidence-based recommendations to address key clinical questions surrounding the diagnosis and treatment (...) acceptable methods of care reasonably directed to obtaining the same results. The ultimate judgment regarding any specific procedure or treatment is to be made by the physician and patient in light of all circumstances presented by the patient and the needs and resources particular to the locality or institution. 2 Authors & Contributors Evidence-Based Guideline Development Committee Co-Chairs D. Scott Kreiner, MD Paul Matz, MD Diagnosis Section Section Chair: Daniel K. Resnick, MD, MS Authors: Norman B

2020 North American Spine Society

50. 2020-2023 Value Assessment Framework

associated with any intervention. This commitment extends not only from using available published sources, but includes the possibility of working with life science companies, patient groups, or data aggregator companies to develop and analyze new sources of real-world evidence in a way that will meet the evidentiary standards relevant to the questions being addressed. ©Institute for Clinical and Economic Review, 2020 Page 6 2020-2023 Value Assessment Framework Return to Table of Contents In short, ICER (...) for potential budget impact that should trigger additional policy maker consideration of short-term affordability. Delivery System Innovations There are also many distinctive challenges to evaluating the evidence on the effectiveness and value of delivery system interventions. Chief among these is that in most cases a delivery system intervention will be highly variable in its implemented form across different settings, raising great questions about the generalizability of results from studies of one

2020 California Technology Assessment Forum

51. Osseointegrated Prosthetic Implants for People With Lower-Limb Amputation

osseointegrated prosthetic implants in Ontario over the next 5 years, for a small population of eligible candidates, would range from $1.5 million in year 1 to $0.6 million in year 5, for a 5-year total of $5.3 million. We interviewed 13 people with a lower-limb amputation; nine had experience with both a conventional socket prosthesis and an osseointegrated prosthetic implant, three had experience with a conventional socket prosthesis only, and one had only recently undergone amputation and had not yet (...) case of the primary economic evaluation represented a conservative estimate of cost-effectiveness and found osseointegration may be cost-effective, but there is a large degree of uncertainty given parameter uncertainty and the need to use proxy costs. Scenario analyses explored potential variations in approaches to modelling and parameter selection. Qualitative interviews with people with a lower-limb amputation and caregivers underscored the challenges of conventional socket prostheses, but cost

2019 Health Quality Ontario

52. Staff and associate specialist (SAS) grade handbook

. It is also supported by the SAS section of the Association of Anaesthetists website www.anaesthetists.org. I hope that you will find it a helpful reference to support you in your career and professional life, and to answer some of the commonly occurring questions and queries. SAS doctors make up over 20% of the anaesthetic workforce, and have been described as the hidden heroes of the NHS. They are a diverse group, often working in isolation or frequent out of hours work, and in the past have sometimes (...) posts in the NHS. The support includes mentoring schemes, induction programmes and web forums. Useful websites • British Association of Physicians of Indian Origin • British International Doctors’ Association • Medical Association of Nigerians Across Great Britain • Association of Pakistani Physicians & Surgeons of the UK • Egyptian Medical Society • Sri Lankan Medical and Dental Association in the UK Dr Achuthan Sajayan Consultant Anaesthetist, University Hospital, Birmingham Former SAS Committee

2020 Association of Anaesthetists of GB and Ireland

53. Exploring Models for Health Workforce Planning

of policy reforms, new models of care, changes in labour markets). • This rapid synthesis examines the health workforce planning models in place across select Canadian provinces and comparator jurisdictions to determine what models, processes and characteristics are important to establishing successful predictive models. What we found • We identified three systematic reviews and nine primary studies that related to the questions and complemented these findings with insights from interviews with 11 key (...) a 30- business-day timeframe and involved five steps: 1) submission of a question from a policymaker or stakeholder (in this case, the Ministry of Health in British Columbia); 2) identifying, selecting, appraising and synthesizing relevant research evidence about the question; 3) conducting key informant interviews; 4) drafting the rapid synthesis in such a way as to present concisely and in accessible language the research evidence; and 5) finalizing the rapid synthesis based on the input

2019 McMaster Health Forum

54. Palliative Care for Adults

Documents 11 Definitions 11 Annotations 12–45 Quality Improvement Support 46–56 Aims and Measures 47–48 Implementation Recommendations 49 Implementation Tools and Resources 50 Implementation Tools and Resources Tables 51–56 Assessment Tools 51 Physician Education Resources (Fast Facts) 51–52 General Tools and Resources 52–56 Supporting Evidence 57–76 References 58–63 Appendices 64–76 Appendix A: Literature Search Terms 64–65 Appendix B: How to Discuss Serious Illness 66–68 Appendix C: Signs and Symptoms (...) Improvement 5 Palliative Care for Adults Sixth Edition /January 2020 Topic Quality of Evidence Recommendation(s) Strength of Recommendation Annotation Number Relevant Resources Interdisciplinary Care Team Low The interdisciplinary care team (IDT) of health care providers should ideally include at a minimum physicians, advance practice providers, nurses, social workers, spiritual counselors, and bereavement staff. Other clinicians may also participate on the IDT. Strong 2 Bakitas, 2009 (Randomized Control

2020 Institute for Clinical Systems Improvement

55. KDOQI Clinical Practice Guidelines for Nutrition in CKD

References…………………………………………………………………………………………………. 206 Guideline on Nutrition in CKD Page 4 TABLES Table 1. Key Questions for Evidence Review …………………………………………………. 16 Table 2. Evidence Review Inclusion and Exclusion Criteria …………………………………... 18 Table 3. Quality of Evidence Grades …………………………………………………………… 24 Table 4. Implications of strong and weak recommendations for different users of guidelines …. 25 FIGURES Figure 1. Flow diagram of identified studies for Assessment questions ………………..……….. 21 Figure 2 (...) . Flow diagram of identified studies for Intervention questions ……………….…..…… 22Guideline on Nutrition in CKD Page 5 ABBREVIATIONS AND ACRONYMS ACE Angiotensin converting enzyme inhibitors APD Animal-based Protein Diet AND Academy of Nutrition and Dietetics ARB Angiotensin II receptor blocker BF Body fat BIA Bio-electrical impedance analysis BMI Body mass index BP Blood pressure BPI Body protein index CAPD Continuous ambulatory peritoneal dialysis CIMT Constraint induced movement therapy CK Creatinine

2020 National Kidney Foundation

56. Public health guidance on prevention and control of blood-borne viruses in prison settings

was designed to answer the following questions: ? Which prevention, care and treatment interventions for BBVs are effective in prison settings? ? Which service models for prevention, care and/or treatment of BBVs are effective in prison settings? ? Which prevention, care and/or treatment interventions aimed at control of HIV are cost-effective in prison settings? ? Which service models for prevention, care and/or treatment of BBVs are cost-effective in prison settings? ? What is the acceptance/uptake

2019 European Centre for Disease Prevention and Control - Public Health Guidance

57. Public health guidance on screening and vaccination for infectious diseases in newly arrived migrants within the EU/EEA

and strongyloidiasis. Charles Hui and Jessica Dunn led the systematic review and provided an initial draft of the chapter on vaccine-preventable diseases. Eric N. Agbata is a doctoral candidate for PhD in Methodology of Biomedical Research and Public Health (Department of Paediatrics, Obstetrics, Gynaecology and Preventive Medicine), Universidad Autònoma de Barcelona, Barcelona, Spain. His contributions to the section on schistosomiasis and strongyloidiasis guidance will form part of his thesis. ECDC would (...) (International Organisation for Migration), Denis Onyango (Africa Advocacy Foundation), Kathy Attawell and Andreas Sandgren (independent consultants), Alexandra Ortega (International Panel Physicians Association), and Joao Pires and Santino Severoni (World Health Organization, Regional Office for Europe). ECDC would also like to acknowledge the Cochrane and Campbell Equity Methods Group and the following researchers for supporting the systematic evidence reviews, GRADE evidence profiles and GRADE evidence

2019 European Centre for Disease Prevention and Control - Public Health Guidance

59. Programmatic management of latent tuberculosis infection in the European Union

areas in relation to programmatic management of LTBI: target risk groups; diagnosis; treatment and programmatic issues of LTBI management. Evidence-based public health guidance A comprehensive assessment of the public health options for implementing programmatic management of LTBI was conducted. The key topic areas and corresponding research questions were identified through consultation with experts. Scientific evidence was collected using systematic literature reviews, mathematical modelling (...) in the European Union 5 3.2 Evidence collection, appraisal and synthesis 3.2.1 Assessment of scientific evidence A detailed description of the methods for identification, collection and appraisal of scientific evidence, and the corresponding results are provided in a separate report [5]. The following sections briefly summarise the methodology applied. Questions addressed in the guidance The contributions from the inventory of expert opinions were regrouped into four key areas and corresponding main research

2019 European Centre for Disease Prevention and Control - Public Health Guidance

60. Istradefylline (Nourianz) - Parkinson's disease

worsening effect on these important efficacy endpoints. These effects were most clearly observed in patients outside of Japan. A weight effect was not clearly observed in the Japanese trials but most of the patients in these trials were in the 2 lowest weight categories. These results raise the question whether patients outside of Japan experience decreasing istradefylline efficacy as weight increases and that some “heavier” patients might not experience any efficacy from istradefylline. The explanation

2019 FDA - Drug Approval Package

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