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21. Hillary Clinton is “medically unfit to serve” as President and Donald Trump has narcissistic personality disorder: Stop this uninformed medical speculation about the candidates!

as a cerebral venous thrombosis. She was treated with anticoagulation and recovered. Neurosurgeons interviewed for the story agreed that this sort of clot was uncommon after a concussion with no associated skull fracture and was a potentially life-threatening condition for which treatment was indicated. Clinton was treated, and, by all accounts, made a complete recovery. At this point it’s not inappropriate to note that Dr. Orient’s organization, the AAPS, is a an embarrassingly quacky physician (...) Times published an article by Benedict Carey entitled The story starts noting an incident from history: In the midst of a deeply divisive presidential campaign, more than 1,000 psychiatrists declared the Republican candidate unfit for the office, citing severe personality defects, including paranoia, a grandiose manner and a Godlike self-image. One doctor called him “a dangerous lunatic.” The year was 1964, and after losing in a landslide, the candidate, Senator Barry Goldwater of Arizona, sued

2016 Respectful Insolence

22. A Survey of Academic Emergency Medicine Department Chairs on Hiring New Attending Physicians. (Abstract)

residency programs in March of 2011. The questions assessed the desirability of different candidate attributes and the difficulty in recruiting EM-trained physicians. Respondents were also asked to give the current number of available job openings.Fifty-five percent of eligible department chairs responded. On a 5-point scale, the most important parts of a candidate's application were the interview (4.8 ± 0.4), another employee's recommendation (4.7 ± 0.5), and the program director's recommendation (4.5 (...) ± 0.7). The single most important attribute possessed by a candidate was identified as "Ability to work in a team," with 58% of respondents listing it as their top choice. Advanced training in ultrasound was listed as the most sought-after fellowship by 55% of the chairs. Overall, department chairs did not have a difficult time in recruiting EM-trained physicians, with 56% of respondents stating that they had no current job openings.How a physician relates to others was consistently rated

2013 Journal of Emergency Medicine

23. Cancer quackery, Republican presidential candidates, and political influence

Cancer quackery, Republican presidential candidates, and political influence Cancer quackery, Republican presidential candidates, and political influence | ScienceBlogs Advertisment Search Search Toggle navigation Main navigation Cancer quackery, Republican presidential candidates, and political influence By on September 25, 2015. Yesterday, I wrote about how pediatric neurosurgeon turned presidential candidate Ben Carson is demonstrating how the vast majority of physicians and surgeons, even (...) to the antivaccine crowd during last week's Republican debate. At the time I speculated that a combination of his religion plus a trait all too common in physicians and surgeons, namely not knowing one's own limitations with respect to science, contributed greatly to Carson's having so thoroughly embarrassed himself with respect to science. Unfortunately, in today's world, the science didn't matter much, if at all, as Dr. Carson is doing much better in the polls. Even though he's never run anything larger than

2015 Respectful Insolence

24. Study in Leucocytes From Patients With Type 1 and Type 2 Diabetes Genetic Markers of Inflammation and Oxidative Stress (TÉLOMÈRES/ CANDIDATE GENES) According to the Type A or Type B Behavior Profile

: Baselines ] Scores on psychiatric/psychological scales [ Time Frame: Baselines ] Analysis of the specific psychological interview EMIC [ Time Frame: Baselines ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided (...) Study in Leucocytes From Patients With Type 1 and Type 2 Diabetes Genetic Markers of Inflammation and Oxidative Stress (TÉLOMÈRES/ CANDIDATE GENES) According to the Type A or Type B Behavior Profile Study in Leucocytes From Patients With Type 1 and Type 2 Diabetes Genetic Markers of Inflammation and Oxidative Stress (TÉLOMÈRES/ CANDIDATE GENES) According to the Type A or Type B Behavior Profile - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer

2014 Clinical Trials

25. 7 things doctors should consider before signing for a new job

7 things doctors should consider before signing for a new job 7 things doctors should consider before signing for a new job 7 things doctors should consider before signing for a new job | | December 16, 2015 215 Shares So, you’ve finished all your job interviews and think you’ve found a perfect fit. Graduating from residency is exciting, but did you get any training on what it all means to sign on the dotted line? Below is a quick and dirty run-down of the contracting process from an industry (...) happen is that you get shot down, but asking about it should not scare your future employer away. 3. Are the non-compete clauses enforceable? Yes and no. The greater question is whether the health care entity will spend the time and energy to enforce it. I’ve also been acquainted with several providers that have successfully lawyered up and removed themselves from the non-compete upon departure from the health care entity. I’ve also known a physician to be successfully sued for violating the terms

2015 KevinMD blog

26. A Pilot Study to Determine the Relative Bioavailability of Mosapride 5mg From Two Candidate Formulations of GR107719B Relative to One 5mg Tablet of Reference Mosapride Citrate (GASMOTINâ„¢) in Healthy Adult Human Subjects Under Fasting Conditions

medical history for study eligibility, as obtained via a verbal interview with the subject or from the subject's medical records; or postmenopausal defined as 12 months of spontaneous amenorrhea [in questionable cases a blood sample with simultaneous follicle stimulating hormone (FSH) > 40 milli-international units per milliliter (MlU/mL) and estradiol < 40 picograms per mililiter (pg/mL) [<147 picomole per liter] is confirmatory]. Females on hormone replacement therapy (HRT) and whose menopausal (...) A Pilot Study to Determine the Relative Bioavailability of Mosapride 5mg From Two Candidate Formulations of GR107719B Relative to One 5mg Tablet of Reference Mosapride Citrate (GASMOTINâ„¢) in Healthy Adult Human Subjects Under Fasting Conditions A Pilot Study to Determine the Relative Bioavailability of Mosapride 5mg From Two Candidate Formulations of GR107719B Relative to One 5mg Tablet of Reference Mosapride Citrate (GASMOTIN™) in Healthy Adult Human Subjects Under Fasting Conditions - Full

2013 Clinical Trials

27. The lost art of asking questions

is it, then, that in health care, so little value is placed on when and how you ask sensitive or important questions? In health care, we are constantly told that we must ask the most personal and intrusive questions of anyone who walks through our doors before we even ask what brings them to the doctor in the first place. And, unlike other interviewers, we must use “standardized” and “validated” questionnaires, because our work isn’t like other forms of fact or truth finding; our purpose is to collect data and to apply (...) in that. So, let’s imagine that our mandates applied in other areas of life: What if criminal investigations were conducted by administration of nationally established “criminology assessment protocols”? What if lawyers could only use validated questionnaires and weren’t allowed to cross-examine witnesses? What if all celebrity interviewers could only ask the same set of questions? What if the presidential election was determined by having our citizens vote for candidates based on their answers

2016 KevinMD blog

28. Clinical guideline for homeless and vulnerably housed people, and people with lived homelessness experience

, Stephen Hwang MD, Vicky Stergiopoulos MD, Peter Tugwell MD n Cite as: CMAJ 2020 March 9;192:E240-54. doi: 10.1503/cmaj.190777 CMAJ Podcasts: author interview at https://soundcloud.com/cmajpodcasts/190777-guide See related article at www.cmaj.ca/lookup/doi/10.1503/cmaj.200199 KEY POINTS • Clinical assessment and care of homeless and vulnerably housed populations should include tailoring approaches to a person’s gender, age, Indigenous heritage, ethnicity and history of trauma; and advocacy (...) facilities, managed alcohol programs) via appropriate local resources such as public health or community health centre or local community services centre. Clinical considerations: In case of active opioid use disorder, facilitate patient access to OAT . Patients should be made aware of supervised consumption facility locations (Appendix 1, available at www.cmaj.ca/lookup/suppl/ doi:10.1503/cmaj.190777/-/DC1). Conditional recommendation Note: LGBTQ2+ = lesbian, gay, bisexual, transgender, questioning

2020 CPG Infobase

29. Scientific elaboration of concepts for the generation of data related to clinical practice and their evaluation for the purpose of benefit assessments of drugs §35a Social Code Book V - Rapid report

literature search for scientific questions arising as part of the conceptual work (e.g. on the informative value of studies without randomization, depending on existing data constellations). ? Interviews with registry experts on criteria for the quality and methodological requirements of the data collected within the framework of the respective generation of data. Extract of rapid report A19-43 Version 1.0 Routine practice data for the benefit assessment of drugs 10 January 2020 Institute for Quality (...) assessment of drugs cannot be answered in a generalized manner, but depends on the specific research question. However, from a technical and organisational point of view, the registries are usually prepared to implement any necessary extensions of the data set. It was also possible to deduce various factors from the interviews that are beneficial or obstructive to the operation of the registry. From this and generally from the results of the interviews, recommendations for action can be derived

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

30. Prostate cancer screening with the PSA test

PSA screening 24 April 2020 Institute for Quality and Efficiency in Health Care (IQWiG) - 18 - Physicians (DEGAM) includes the term “unbiased” [2] 3 . Hence, it is questionable how often men receive an unbiased consultation on the topic of prostate cancer screening with the PSA test as a basis for making a well-informed decision in favour or against it. In addition, men for whom no evidence is available from randomized studies on the screening chain, e.g. men over 75 years of age, are often (...) , Germany IQWiG thanks the external experts for their collaboration in the project. IQWiG employees ? Ulrike Paschen ? Moritz Felsch ? Daniel Fleer ? Ulrike Lampert ? Sibylle Sturtz Keywords: Mass Screening, Prostatic Neoplasms, Benefit Assessment, Systematic Review Extract of final report S19-01 Version 1.0 PSA screening 24 April 2020 Institute for Quality and Efficiency in Health Care (IQWiG) - iii - Key statement Research question The objective of this investigation is to assess the benefit

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

31. Genome-Wide Sequencing for Unexplained Developmental Disabilities or Multiple Congenital Anomalies

Question 2 162 Appendix 10: Letter of Information 164 Appendix 11: Interview Guide 165 REFERENCES 166 March 2020 Ontario Health Technology Assessment Series; Vol. 20: No. 11, pp. 1–178, March 2020 8 LIST OF TABLES Table 1: Characteristics of Included Systematic Reviews 21 Table 2: Diagnostic Yield from Subset of Comparative Effectiveness Studies 24 Table 3: Diagnostic Yield of Genome-Wide Sequencing by Use of Trio Testing 25 Table 4: Diagnostic Yield of Genome-Wide Sequencing Comparing Trio Testing (...) sequencing for diagnostic purposes. We conducted a quantitative evaluation on preferences in literature, engaged directly with family members of people with these conditions through interviews, and used reviews by the Canadian Agency for Drugs and Technologies in Health (CADTH) of published qualitative literature and ethical considerations. What Did This Health Technology Assessment Find? Compared with standard genetic testing (chromosomal microarray and targeted single-gene tests or gene panels), genome

2020 Health Quality Ontario

32. Auditory Brainstem Implantation for Adults With Neurofibromatosis 2 or Severe Inner Ear Abnormalities

Technology Assessment Series; Vol. 20: No. 4, pp. 1–85, March 2020 13 CLINICAL EVIDENCE Research Questions • What are the clinical effectiveness and safety of auditory brainstem implantation for adults with neurofibromatosis 2 (NF2) who are not candidates for cochlear implantation? • What are the clinical effectiveness and safety of auditory brainstem implantation for adults with severe inner ear abnormalities who are not candidates for cochlear implantation? Methods We developed the research questions (...) for adults with NF2 or severe inner ear abnormalities would lead to a small budget increase in Ontario, about $130,000 to $260,000 per year, because only a few people each year would be candidates for this surgery. Hearing loss from NF2 and inner ear abnormalities can have a large negative impact on the people affected, causing emotional distress and challenges in activities of daily living. We spoke with six people, including two who had received an auditory brainstem implant. They said it restored some

2020 Health Quality Ontario

33. Cell-Free Circulating Tumour DNA Blood Testing to Detect EGFR T790M Mutation in People With Advanced Non–Small Cell Lung Cancer

liquid biopsy) can determine if a person with advanced non–small cell lung cancer (NSCLC) whose disease is progressing has developed the epidermal growth factor receptor (EGFR) T790M resistance mutation. Identifying this resistance mutation can help physicians choose appropriate treatment (i.e., osimertinib if positive and chemotherapy if negative). Tissue biopsy is typically used to look for the resistance mutation, but this is an invasive test that might not be feasible if the patient is too ill (...) 15 PROSPERO Registration 15 CLINICAL EVIDENCE 16 Research Questions 16 Methods 16 Clinical Literature Search 16 Eligibility Criteria 16 Literature Screening 17 Data Extraction 18 Statistical Analysis 18 Critical Appraisal of Evidence 20 Results 20 Clinical Literature Search 20 Diagnostic Accuracy 21 Concordance Rate 24 Clinical Utility 27 Time to Test Result 27 Progression-Free Survival 28 Overall Survival 31 Response Rate 32 Tissue Biopsies Avoided and Adverse Events 34 Ongoing Studies 34

2020 Health Quality Ontario

34. Gene Expression Profiling Tests for Early-Stage Invasive Breast Cancer

. One challenge is whether to recommend chemotherapy for breast cancer recurrence. While chemotherapy helps prevent cancer recurrence, it can cause negative side effects. Gene expression profiling (GEP) tests analyze a sample of the breast cancer tissue to identify the presence or absence of certain genes in the cancer cell. This information may help physicians determine the likelihood that the cancer will return after surgery and can help guide decision-making about whether the patient may benefit (...) other than the breast and patient survival. Some tests may also predict chemotherapy benefit. They also lead to changes in chemotherapy treatment decisions and generally increase physician confidence in treatment recommendations. Compared with the current model of funding GEP tests through the out-of-country program, publicly funding GEP tests to be conducted in Ontario would cost an additional $1 million to $2 million annually, depending on how many additional people choose to receive the test

2020 Health Quality Ontario

35. Transcatheter Aortic Valve Implantation in Patients With Severe, Symptomatic Aortic Valve Stenosis at Intermediate Surgical Risk

versus SAVR in patients with severe, symptomatic aortic valve stenosis at intermediate surgical risk, which included an evaluation of effectiveness, safety, cost-effectiveness, budget impact, and patient preferences and values. We performed a literature search to retrieve systematic reviews and selected one that was relevant to our research question. We complemented the systematic review with a literature search to identify randomized controlled trials published after the review. Applicable (...) receiving TAVI have a shorter hospital stay (= 3 days). We interviewed 13 people who had lived experience with aortic valve stenosis. People who had undergone TAVI reported reduced physical and psychological effects and a shorter recovery time. Patients and caregivers living in remote or northern regions reported lower out-of-pocket costs with TAVI because the length of hospital stay was reduced. People said that TAVI increased their quality of life in the short-term immediately after the procedure

2020 Health Quality Ontario

36. Extracorporeal Membrane Oxygenation for Cardiac Indications in Adults

. In the decision to receive the procedure, participants generally relied on the expertise and judgment of physicians. Conclusions For adults treated for refractory cardiac arrest, ECPR may improve survival and likely improves long-term neurological outcomes compared with conventional cardiopulmonary resuscitation. For patients treated for cardiogenic shock, ECMO may improve 30-day survival compared with intra-aortic balloon pump, but there is considerable uncertainty. For adults with refractory cardiac arrest (...) . 1–121, March 2020 5 TABLE OF CONTENTS LIST OF TABLES 8 LIST OF FIGURES 10 OBJECTIVE 11 BACKGROUND 11 Health Conditions 11 Clinical Need and Target Population 11 Current Treatment Options 12 Health Technology Under Review 12 Regulatory Information 13 Ontario, Canadian, and International Context 14 Expert Consultation 15 PROSPERO Registration 15 CLINICAL EVIDENCE 16 Research Questions 16 Methods 16 Clinical Literature Search 16 Eligibility Criteria 16 Literature Screening 17 Data Extraction 18

2020 Health Quality Ontario

37. Portable Normothermic Cardiac Perfusion System in Donation After Cardiocirculatory Death

CLINICAL EVIDENCE 14 Research Question 14 Methods 14 Clinical Literature Search 14 Inclusion Criteria 14 Exclusion Criteria 14 Outcomes of Interest 15 Literature Screening 15 Data Extraction 15 Statistical Analysis 16 Critical Appraisal of Evidence 16 Results 16 Literature Search 16 Characteristics of Included Studies 17 Heart Transplant Outcomes With Hearts Donated After Cardiocirculatory Death Using a Portable Normothermic Cardiac Perfusion System Versus Hearts Donated After Neurological (...) Determination of Death 19 Case Reports and Case Series 24 Discussion 27 Ongoing Studies 28 Conclusions 29 ECONOMIC EVIDENCE 30 Research Question 30 Methods 30 Economic Literature Search 30 Inclusion Criteria 30 Exclusion Criteria 30 March 2020 Ontario Health Technology Assessment Series; Vol. 20: No. 3, pp. 1–90, March 2020 6 Outcomes of Interest 30 Literature Screening 30 Data Extraction 31 Study Applicability and Limitations 31 Results 32 Literature Search 32 Overview of Included Economic Study 33

2020 Health Quality Ontario

38. 10-kHz High-Frequency Spinal Cord Stimulation for Adults With Chronic Noncancer Pain

Ontario Context 11 Expert Consultation 12 PROSPERO Registration 12 CLINICAL EVIDENCE 13 Research Question 13 Methods 13 Clinical Literature Search 13 Eligibility Criteria 13 Literature Screening 14 Data Extraction 14 Statistical Analysis 15 Critical Appraisal of Evidence 15 Results 16 Clinical Literature Search 16 Characteristics of Included Studies 17 Risk of Bias in the Included Studies 18 Pain Intensity 19 Functional Disability 22 Opioid Use 23 Patient Satisfaction 23 Global Impression of Change 24 (...) Sleep Quality 26 Health-Related Quality of Life 27 Safety 28 Discussion 29 Limitations 31 Conclusions 31 ECONOMIC EVIDENCE 32 Research Question 32 Methods 32 Economic Literature Search 32 Eligibility Criteria 32 Literature Screening 33 March 2020 Ontario Health Technology Assessment Series; Vol. 20: No. 6, pp. 1–109, March 2020 5 Data Extraction 33 Study Applicability and Limitations 33 Results 34 Economic Literature Search 34 Overview of Included Economic Studies 35 Applicability and Limitations

2020 Health Quality Ontario

39. Implantable Devices for Single-Sided Deafness and Conductive or Mixed Hearing Loss

candidates for standard hearing aids and do not meet the current indication (i.e., bilateral deafness) for publicly funded cochlear implants in Canada. Methods We conducted a health technology assessment, which included an evaluation of clinical benefits and harms, cost-effectiveness, budget impact, and patient preferences and values related to implantable devices for single-sided deafness and conductive or mixed hearing loss. We performed a systematic literature search for systematic reviews and cost (...) -effectiveness studies of cochlear implants and bone-conduction implants, compared to no interventions, for these conditions in adults and children. We conducted cost–utility analyses and budget impact analyses from the perspective of the Ontario Ministry of Health to examine the impact of publicly funding both types of hearing implants for the defined populations. We also interviewed 22 patients and parents of children about their experience with hearing loss and hearing implants. Results We included 20

2020 Health Quality Ontario

40. Examining the Effects of Prenatal Education

health-system issues of our time, based on the best available research evidence and systematically elicited citizen values and stakeholder insights. We aim to strengthen health systems – locally, nationally, and internationally – and get the right programs, services and drugs to the people who need them. Authors Kerry Waddell, M.Sc., Lead Evidence Synthesis, McMaster Health Forum, McMaster University Ahmad Belal, PhD Candidate, McMaster University Saif Alam, Research Assistant, McMaster Health Forum (...) A, Alam S, Wilson MG. Rapid synthesis: Examining the effects of prenatal education. Hamilton, Canada: McMaster Health Forum, 27 September 2019. Product registration numbers ISSN 2292-7999 (online)McMaster Health Forum 3 Evidence >> Insight >> Action KEY MESSAGES Questions • For which populations is prenatal education most effective for improving maternal, infant and dyad (e.g., mother and child) outcomes? • What delivery methods are most acceptable and effective? • What are optimal ways to provide

2020 McMaster Health Forum

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