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Instilling Eye Drops

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141. Epigallocatechin Gallate-Loaded Gelatin-g-Poly(N-Isopropylacrylamide) as a New Ophthalmic Pharmaceutical Formulation for Topical Use in the Treatment of Dry Eye Syndrome Full Text available with Trip Pro

time point within 3 days of release. In a rabbit dry eye model, corneal epithelial defects was ameliorated by treatment with single-dose administration of EGCG-containing GN. Furthermore, drug molecules released from carrier materials could prevent further tear evaporation and loss of mucin-secreting goblet cells in diseased animals. Our findings suggest that GN carrier is responsible for enhanced pharmacological efficacy of topically instilled EGCG, thereby demonstrating the benefits of using (...) biodegradable in situ gelling delivery system to overcome the drawbacks of limited dry eye relief associated with eye drop dosage form.

2017 Scientific reports

142. Clinical evaluation of an oil-based lubricant eyedrop in dry eye patients with lipid deficiency. (Abstract)

Clinical evaluation of an oil-based lubricant eyedrop in dry eye patients with lipid deficiency. To evaluate and compare the efficacy of a lipid-based lubricant eyedrop formulation (hydroxypropyl guar/propylene glycol/phospholipid [HPG/PG/PL]) with preservative-free saline for the treatment of dry eye.This was a prospective, multicenter, randomized, single-masked, parallel-group phase 4 clinical study. Patients ≥18 years diagnosed with dry eye received 1 drop of saline 4 times daily (QID (...) ) for 15 days during a run-in phase, followed by randomization. Patients then instilled HPG/PG/PL or saline QID through day 35 and as needed through day 90. Change in tear film break-up time (TFBUT), change in total ocular surface staining (TOSS) score, and Impact of Dry Eye on Everyday Life (IDEEL) were evaluated on day 35.Increase in TFBUT from baseline to day 35 was assessed during the interim and final analyses. Mean ± SE difference between the HPG/PG/PL (n = 110) and saline groups (n = 100

2017 European journal of ophthalmology Controlled trial quality: uncertain

143. A standardized extract of Rhynchosia volubilis Lour. exerts a protective effect on benzalkonium chloride-induced mouse dry eye model. Full Text available with Trip Pro

ethanol extract of R. volubilis (EERV) can protect the cornea in a benzalkonium chloride (BAC)-induced mouse dry eye model.Experimental dry eye was induced by the instillation of 0.2% BAC on mouse cornea. A standardized ethanol extract of R. volubilis (EERV) was orally administered following BAC treatment. The positive control group was treated with commercial eye drops. Fluorescein staining, tear break-up time (BUT), and hematoxylin and eosin staining were evaluated on the ocular surface. Squamous (...) A standardized extract of Rhynchosia volubilis Lour. exerts a protective effect on benzalkonium chloride-induced mouse dry eye model. In contrast to other leguminous plants generally used as food, Rhynchosia volubilis Loureiro, a small soybean with a black seed coat, has been used as a traditional oriental remedy for various human diseases in Eastern Asia. In this study, we demonstrated the protective effect of R. volubilis against dry eye disease.We aimed to investigate whether a standardized

2017 Journal of Ethnopharmacology

144. Cross-linked Hyaluronic Acid and Coenzyme Q10 in the Treatment of Dry Eye

" Information provided by (Responsible Party): Pasquale Aragona, Azienda Ospedaliera Universitaria Policlinico "G. Martino" Study Details Study Description Go to Brief Summary: Background: Dry eye disease (DED) is a common condition causing burden on visual function and reducing quality of life. Corticosteroids and/or cyclosporine eye drops are able to improve DED symptoms, however, side effects of immune suppression and cost lead patients often to suspend treatment. Consequently, is important to identify (...) therapies alleviating DED symptoms. A randomized, controlled, single masked study, was performed in 40 patients affected by mild to moderate DED, to evaluate efficacy and safety of a collyrium based on cross-linked hyaluronic acid (XLHA) added with Coenzyme Q10 (CoQ10) in comparison to an eye drop considered a gold standard for tear substitutes, based on hyaluronic acid (HA) 0.15%. Methods: eye drops were administered four times a day for 90 days to enrolled subjects divided in two groups: group

2017 Clinical Trials

145. Intense Pulsed Light Study for Dry Eye Disease

medications which makes light therapy contraindicated (the use of doxycycline is allowed); Tattoos in the treatment area; Patients who have had intense pulsed light therapy, Lipiflow or Meibothermoflo within the past six months; Contact lens wear more than one time/week or history of refractive surgery; Glaucoma drop use Ophthalmic steroid use within the past 30 days; Punctal plugs if instilled within 30 days of the start of the study; Obvious asymmetry between the two eyes deemed significant (...) Intense Pulsed Light Study for Dry Eye Disease Intense Pulsed Light Study for Dry Eye Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Intense Pulsed Light Study for Dry Eye Disease The safety

2017 Clinical Trials

146. Safety and Efficacy of TOP1630 for Dry Eye Syndrome

will be measured using the EDTRS chart to assess changes from baseline Slit-lamp Biomicroscopy [ Time Frame: Part 1: 12 days time frame; Part 2: 35 days time frame ] Slit lamp biomicroscopy exams will be performed to assess any changes from baseline Vital Signs [ Time Frame: Part 1: 12 days time frame; Part 2: 35 days time frame ] Blood Pressure, Pulse and SPo2 will be performed to assess changes from baseline Drop Comfort Assessment [ Time Frame: Part 1: 12 days time frame ] The comfort of the eye drop (...) : Be at least 18 years of age; Provide written informed consent; Have a reported history of dry eye; Have a history of use of eye drops for dry eye symptoms; Additionally for Part 2 Symptoms of dry eye syndrome including: Ocular discomfort Conjunctival redness Tear film break up time Schirmer test score Signs of dry eye syndrome including: Conjunctival staining score Exclusion Criteria: Have any clinically significant slit lamp findings at entry visit ; Be diagnosed with an ongoing ocular infection; Have

2017 Clinical Trials

147. Evaluation of Tear Osmolarity Over Time With Sustained Use of Thera Tears Lubricating Drops

Osmolarity Over Time With Sustained Use of Thera Tears Lubricating Study Start Date : October 2015 Actual Primary Completion Date : March 2016 Actual Study Completion Date : March 2016 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: TheraTears Lubrication Drop TheraTears Lubricating Eye Drops to be instilled 1 drop in both eyes 4 times per day over a period of 8 weeks. Drug: TheraTears (...) Group Collaborator: Akorn, Inc. Information provided by (Responsible Party): Koffler Vision Group Study Details Study Description Go to Brief Summary: The objective of the study is to demonstrate a change in osmolarity over time when moderate to severe dry eye subjects are treated with TheraTears lubricating drops. Condition or disease Intervention/treatment Phase Dry Eye Syndrome Drug: TheraTears Lubricating Eye Drops Phase 4 Detailed Description: Symptomatic dry eye subjects exhibited

2016 Clinical Trials

148. An upright eyedrop bottle: accuracy, usage of excess drops, and contamination compared to a conventional bottle Full Text available with Trip Pro

usage, participants were observed instilling eyedrops. Participants were instructed to instill a single eyedrop in each eye with both a standard bottle and the UEB. They repeated this process three times. With each trial, the amount of time taken to instill drops was recorded, as well as whether a drop landed in the eye (accuracy), if excess drops were used, and if the bottle tip was contaminated.Forty participants were enrolled, with an average age of 72.4±8.9 years; the majority were females (24 (...) females). Thirty-four participants had been using eyedrops for at least 1 year. The time required to instill eyedrops was significantly less with the UEB in the second and third trials. There was no difference in accuracy between the conventional bottle and the UEB in the left or right eye in any trials. Significantly more participants used excess number of drops while using the conventional bottle in both the left and right eyes in all three trials. The bottle tip was never contaminated with the UEB

2016 Clinical ophthalmology (Auckland, N.Z.)

149. Post-operative ocular inflammation: A single sub-conjunctival injection of XG-102 compared to dexamethasone drops in a randomized trial. Full Text available with Trip Pro

surgery were eligible to participate. Patients were administered a single subconjunctival injection of 250 μL XG-102 90 μg (n = 47) or 900 μg (n = 48) or placebo (n = 50) at the end of ocular surgery. Subconjunctival injection for each group (XG-102 90 μg, XG-102 900 μg, or placebo) was followed by eye drops instilled 4 times per day for 21 days with placebo, placebo, or dexamethasone solution, respectively. The primary outcome measure was anterior chamber cell grades at day 28 comparing XG-102 900 μg (...) Post-operative ocular inflammation: A single sub-conjunctival injection of XG-102 compared to dexamethasone drops in a randomized trial. To evaluate the efficacy and safety of XG-102 (brimapitide) compared to dexamethasone eye drops in the treatment of postoperative ocular inflammation.Multicenter, randomized, parallel group, double-masked, noninferiority clinical trial.Patients who underwent anterior and posterior segments combined surgery or glaucoma surgery or complex posterior segment

2016 American Journal of Ophthalmology Controlled trial quality: predicted high

150. Evaluation of the Effectiveness of ST266 Ophthalmic Drops Compared to Placebo to Treat Allergic Conjunctivitis

Conjunctival Allergen Challenge Model Actual Study Start Date : December 2016 Actual Primary Completion Date : February 2017 Actual Study Completion Date : November 2017 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Group 1 1X ST266 dosed 4 times a day for 8 days Biological: ST266 One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days. Placebo Comparator (...) : Group 2 Placebo dosed 4 times a day for 8 days Drug: Saline (0.9% NaCl) One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days. Outcome Measures Go to Primary Outcome Measures : Ocular itching [ Time Frame: Day 8 ] Ocular itching evaluated by the subject. Conjunctival redness [ Time Frame: Day 8 ] Conjunctival redness evaluated by the investigator. Secondary Outcome Measures : Ocular itching [ Time Frame: Day 7 ] Ocular itching evaluated by the subject

2016 Clinical Trials

151. A Clinical Randomized Trial Comparing the Cycloplegic Effect of Cyclopentolate Drops Applied to Closed Eyelids Versus Open Eyelids. (Abstract)

for annual refraction were enrolled. Three were excluded as they did not finish the testing. One drop of Alcaine® and one drop of cyclopentolate HCL 1% were used in each eye. Cyclopentolate drops were placed on the inner canthus near the lid margin on the closed eye and directly onto the conjunctiva of the fellow eye.Overall, 145/174 eyes (83%) were fully cyclopleged with one drop. The methods of instillation were equally successful (seventy-two indirect vs. seventy-three direct). Age, eye color (...) A Clinical Randomized Trial Comparing the Cycloplegic Effect of Cyclopentolate Drops Applied to Closed Eyelids Versus Open Eyelids. Adequate cycloplegia and dilation are required for refraction and fundus exam in children. Standard practice is to instill cycloplegic drops in the inferior cul-de-sac, and this is often traumatic for children. Our study assesses the use of cyclopentolate on closed lids as a method of instillation for ensuring complete cycloplegia.Ninety children presenting

2016 The American orthoptic journal Controlled trial quality: uncertain

152. Glaucoma Eye Drop Instillation: Impact of Education

Glaucoma Eye Drop Instillation: Impact of Education Glaucoma Eye Drop Instillation: Impact of Education - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Glaucoma Eye Drop Instillation: Impact of Education (...) on proper eye drop instillation technique Other: Placebo video education on healthy eating tips Not Applicable Detailed Description: Glaucoma is a leading cause of irreversible vision loss worldwide, and as such has a large public health impact. The only treatment proven to slow or arrest the progression of the disease process is intraocular pressure (IOP) reduction, which relies heavily on patient cooperation. Previously, nonadherence to glaucoma medications has ranged from 24% to 59%. Barriers

2011 Clinical Trials

153. Pupil dilation using drops vs gel: a comparative study Full Text available with Trip Pro

Pupil dilation using drops vs gel: a comparative study To compare the efficacy in pupil dilation and degree of discomfort between topical instillation of mydriatic drops and gel.The study included 60 patients with no previous ocular history of trauma and surgery. One eye was dilated with two drops (tropicamide 0.5% and phenylephrine 10%), and the other with one drop of gel (tropicamide 0.5%+phenylephrine 5%). Pupil size was measured by a Colvard pupillometer at baseline and 5, 15, 30, and 45 (...)  min following instillation. Pain upon instillation was measured by visual analog scale (VAS).There was no difference in pupil size at baseline. Use of the gel achieved greater mydriasis than drops (P=0.01), and was also associated with lower pain scores (P=0.003). In diabetic patients, pupil size was smaller at baseline and following instillation of drops and gel. Use of the gel achieved an even greater degree of pupil dilation in this subset of patients than drops (P=0.019).Gel formulation

2015 Eye

154. Dry Eye

Contacts) Consider eye lubricants (e.g. lacrilube) for moderate symptoms (esp. at night), but may blur vision Avoid agents with (e.g. Visine original) Consider s and other agents in refractory to other measures (Restasis) ( ) ( ) Other options in refractory cases Lifitegrast (Xiidra) function-associated antigen-1 (LFA-1) antagonist ophthalmic solution One drop instilled every 12 hours Expensive (>$400/month), with risk of eye irritation, altered es must be out of eye for installation for at least 15 (...) . Epidemiology As many as 30% of over age 50 years old complain of dry, irritated eyes III. Causes Decreased blinking with prolonged reading or driving Chronic exposure to dry, dusty conditions See (e.g. s, s, ) IV. Management ral measures Room humidifiers Take computer breaks Protect eyes from fan Avoid drying, s ( s, s, s) Artificial tears or ointments Preservative-free solutions are preferred (e.g. Refresh Plus), esp. if used more than 4x/day users may try rewetting drops (e.g. Renu rewetting, Blink

2018 FP Notebook

155. Cyclosporine - Moderate to moderately severe dry eye disease

Canada-approved dose is one drop instilled twice a day in each eye, approximately 12 hours apart. Summary of CEDAC Considerations: The Committee considered the following information prepared by the Common Drug Review (CDR): a systematic review of RCTs of cyclosporine ophthalmic emulsion, a critique of the manufacturer’s pharmacoeconomic evaluation, and patient group-submitted information about outcomes and issues important to patients. Common Drug Review CEDAC Meeting – June 15, 2011 Notice of CEDAC (...) , painful, and sun- and wind-sensitive. • Patients provided examples of how their quality of life was affected by their reduced ability to read, watch television, drive, and participate in outside activities because of their dry eye disease. • Patients considered twice-daily application of cyclosporine ophthalmic suspension to be more convenient than artificial tears, which are commonly instilled many times per day. They mentioned adverse consequences of ophthalmic corticosteroids as a concern. Other

2011 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

156. Time course of changes in tear meniscus radius and blink rate after instillation of artificial tears. Full Text available with Trip Pro

-guar and glycol (SYS) or saline (SAL). A dose of 35 μL was applied in one eye in a randomized order with a washout period between each drop.For SAL, compared to baseline TMR (0.33 ± 0.08 mm), TMR significantly increased with drop instillation (1.55 ± 0.69 mm) and at 1 minute (0.66 ± 0.36 mm; P < 0.05), but returned to baseline after 5 minutes. For SYS, TMR (0.32 ± 0.07 mm) remained significantly increased after application (1.62 ± 0.81 mm), and at 1 minute (0.81 ± 0.43 mm) and 5 minutes (0.39 (...) ± 0.08 mm; P < 0.05). Compared to baseline BR with SAL (14.8 ± 7.7) and SYS (14.9 ± 9.4), values were significantly increased upon drop instillation (22.5 ± 11.8; 21.3 ± 11.8; P < 0.05), but returned to baseline after 1 minute. Dry eye symptoms were correlated with baseline BR (r = 0.550, P = 0.008).Results indicate that PDM can detect changes in TMR following instillation of artificial tears. Difference in residence time reflects the different viscosity of each drop. An overload with a large drop

2014 Investigative Ophthalmology & Visual Science

157. Dry Eye

Contacts) Consider eye lubricants (e.g. lacrilube) for moderate symptoms (esp. at night), but may blur vision Avoid agents with (e.g. Visine original) Consider s and other agents in refractory to other measures (Restasis) ( ) ( ) Other options in refractory cases Lifitegrast (Xiidra) function-associated antigen-1 (LFA-1) antagonist ophthalmic solution One drop instilled every 12 hours Expensive (>$400/month), with risk of eye irritation, altered es must be out of eye for installation for at least 15 (...) . Epidemiology As many as 30% of over age 50 years old complain of dry, irritated eyes III. Causes Decreased blinking with prolonged reading or driving Chronic exposure to dry, dusty conditions See (e.g. s, s, ) IV. Management ral measures Room humidifiers Take computer breaks Protect eyes from fan Avoid drying, s ( s, s, s) Artificial tears or ointments Preservative-free solutions are preferred (e.g. Refresh Plus), esp. if used more than 4x/day users may try rewetting drops (e.g. Renu rewetting, Blink

2017 FP Notebook

158. Effect of antibiotic drops on adverse events during extended lens wear. Full Text available with Trip Pro

events (CIEs) and on the ocular microbiota and lens contamination.This is a prospective, open-label, controlled, parallel-group, 1-month clinical study in which 241 subjects were dispensed with lotrafilcon A silicone hydrogel lenses for 30 days of continuous wear. Subjects were randomized into either test (moxifloxacin 0.5%) or control (rewetting solution) group. One drop was instilled into each eye on waking and before sleeping, while lenses were on-eye. Follow-ups were conducted after one night (...) Effect of antibiotic drops on adverse events during extended lens wear. Overnight lens wear is associated with increased lens contamination and risk of developing a corneal infiltrate or infectious event. Antibacterial lenses have been proposed as a potential strategy for reducing lens contamination. A proof-of-principle study was conducted to investigate what effect control of potential pathogens, through the use of antibiotic eye drops, would have on the incidence of corneal infiltrative

2014 Optometry and vision science : official publication of the American Academy of Optometry Controlled trial quality: uncertain

159. Effect of Lifitegrast on Dry Eye Disease Signs and Symptoms

Study Details Study Description Go to Brief Summary: To determine whether a fall in tear osmolarity precedes improvement in symptoms and signs of dry eye in dry eye patients treated topically with 5% lifitegrast drops for 3 months. Condition or disease Intervention/treatment Phase Dry Eye Drug: Lifitegrast Phase 4 Detailed Description: A longitudinal, single-arm, prospective study will recruit up to 30 subjects with moderate to severe dry eye disease. Subjects will be >18 years of age, diagnosed (...) with moderate to severe dry eye (tear osmolarity > 320 mOsm/L and Visual Analog Scale (VAS) score > 40), willing to adhere to twice daily dosing (BID) and follow up visit schedule, have no history of ocular pathology / degeneration / allergy, not on any T-cell modulatory therapy, not have instilled any artificial tears within 2 hours of study visit, and not participating in any concurrent clinical trials. All subjects will complete an informed consent form indicating their voluntary participation

2016 Clinical Trials

160. The leaves of Diospyros kaki exert beneficial effects on a benzalkonium chloride–induced murine dry eye model Full Text available with Trip Pro

treatment. Preservative-free eye drops were instilled in the positive-control group. The tear secretion volume (Schirmer's test), tear break-up time (BUT), and fluorescein score were measured on the ocular surface. BAC-induced corneal damage was tested with hematoxylin-eosin staining. Moreover, apoptotic cell death in the corneal epithelial layer was investigated with terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining. The protein expression level of interleukin (...) The leaves of Diospyros kaki exert beneficial effects on a benzalkonium chloride–induced murine dry eye model In this study, the beneficial effects of the oral administration of ethanol extract of Diospyros kaki (EEDK) were tested on a mouse dry eye model induced by benzalkonium chloride (BAC).A solution of 0.2% BAC was administered topically to mouse eyes for 14 days, twice daily, to induce dry eye. Various concentrations of EEDK were administrated daily by oral gavage for 14 days after BAC

2016 Molecular vision

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