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Instilling Eye Drops

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141. Clinical evaluation of an oil-based lubricant eyedrop in dry eye patients with lipid deficiency. (PubMed)

Clinical evaluation of an oil-based lubricant eyedrop in dry eye patients with lipid deficiency. To evaluate and compare the efficacy of a lipid-based lubricant eyedrop formulation (hydroxypropyl guar/propylene glycol/phospholipid [HPG/PG/PL]) with preservative-free saline for the treatment of dry eye.This was a prospective, multicenter, randomized, single-masked, parallel-group phase 4 clinical study. Patients ≥18 years diagnosed with dry eye received 1 drop of saline 4 times daily (QID (...) ) for 15 days during a run-in phase, followed by randomization. Patients then instilled HPG/PG/PL or saline QID through day 35 and as needed through day 90. Change in tear film break-up time (TFBUT), change in total ocular surface staining (TOSS) score, and Impact of Dry Eye on Everyday Life (IDEEL) were evaluated on day 35.Increase in TFBUT from baseline to day 35 was assessed during the interim and final analyses. Mean ± SE difference between the HPG/PG/PL (n = 110) and saline groups (n = 100

2017 European journal of ophthalmology

142. Cross-linked Hyaluronic Acid and Coenzyme Q10 in the Treatment of Dry Eye

" Information provided by (Responsible Party): Pasquale Aragona, Azienda Ospedaliera Universitaria Policlinico "G. Martino" Study Details Study Description Go to Brief Summary: Background: Dry eye disease (DED) is a common condition causing burden on visual function and reducing quality of life. Corticosteroids and/or cyclosporine eye drops are able to improve DED symptoms, however, side effects of immune suppression and cost lead patients often to suspend treatment. Consequently, is important to identify (...) therapies alleviating DED symptoms. A randomized, controlled, single masked study, was performed in 40 patients affected by mild to moderate DED, to evaluate efficacy and safety of a collyrium based on cross-linked hyaluronic acid (XLHA) added with Coenzyme Q10 (CoQ10) in comparison to an eye drop considered a gold standard for tear substitutes, based on hyaluronic acid (HA) 0.15%. Methods: eye drops were administered four times a day for 90 days to enrolled subjects divided in two groups: group

2017 Clinical Trials

143. Safety and Efficacy of TOP1630 for Dry Eye Syndrome

will be measured using the EDTRS chart to assess changes from baseline Slit-lamp Biomicroscopy [ Time Frame: Part 1: 12 days time frame; Part 2: 35 days time frame ] Slit lamp biomicroscopy exams will be performed to assess any changes from baseline Vital Signs [ Time Frame: Part 1: 12 days time frame; Part 2: 35 days time frame ] Blood Pressure, Pulse and SPo2 will be performed to assess changes from baseline Drop Comfort Assessment [ Time Frame: Part 1: 12 days time frame ] The comfort of the eye drop (...) : Be at least 18 years of age; Provide written informed consent; Have a reported history of dry eye; Have a history of use of eye drops for dry eye symptoms; Additionally for Part 2 Symptoms of dry eye syndrome including: Ocular discomfort Conjunctival redness Tear film break up time Schirmer test score Signs of dry eye syndrome including: Conjunctival staining score Exclusion Criteria: Have any clinically significant slit lamp findings at entry visit ; Be diagnosed with an ongoing ocular infection; Have

2017 Clinical Trials

144. Dry Eye Disease Study With Brimonidine

days or systemic corticosteroids/immunosuppressives within the past 3 months Received cyclosporine ophthalmic emulsion 0.05% (Restasis®) or lifitegrast ophthalmic solution 5% (Xiidra™) within 30 days prior to Screening visit In the opinion of Investigator or Study Coordinator, be unwilling or unable to comply with study protocol or unable to successfully instill eye drops Disease, condition, or disorder that in the judgement of Investigator could confound study assessments or limit compliance (...) eye drops (with and without corticosteroid eye drops) for the treatment of Dry Eye Disease (DED). Condition or disease Intervention/treatment Phase Dry Eye Drug: Brimonidine Drug: Brimonidine Mono Therapy Drug: sodium carboxymethylcellulose Drug: Corticosteroid Eye Drop Phase 2 Detailed Description: Subjects will assess their tolerance to the administration of the study drug, utilizing a Visual Analog Scale (VAS). The VAS is a 100-mm horizontal line with verbal descriptors at either end. The VAS

2017 Clinical Trials

145. Fingerprick Autologous Blood (FAB) in Severe Dry Eye Disease (DED)

) with the lower lid pulled down slightly by the patient. The blood will be applied 4 times a day. A fresh finger should be used for each eye. FAB should be applied at least 15 minutes after any artificial tears and no other drops applied for at least half an hour afterwards Other: Fingerprick autologuos blood (FAB) Intervention involves the instillation of whole blood obtained from the prick of a clean finger 4 times a day. Other Name: FAB No Intervention: Control group Arm B - Conventional treatment only (...) " containing the substances of tears. Blood, and several blood derived products, including autologous serum, have been studied as tear substitute candidates. This study proposes to test the use of finger prick autologous blood (FAB) technique in which whole blood is applied to the eye from a cleaned finger. Condition or disease Intervention/treatment Phase Dry Eye Syndromes Other: Fingerprick autologuos blood (FAB) Not Applicable Detailed Description: Autologous serum (AS) eye drops have been found

2017 Clinical Trials

146. A standardized extract of Rhynchosia volubilis Lour. exerts a protective effect on benzalkonium chloride-induced mouse dry eye model. (PubMed)

ethanol extract of R. volubilis (EERV) can protect the cornea in a benzalkonium chloride (BAC)-induced mouse dry eye model.Experimental dry eye was induced by the instillation of 0.2% BAC on mouse cornea. A standardized ethanol extract of R. volubilis (EERV) was orally administered following BAC treatment. The positive control group was treated with commercial eye drops. Fluorescein staining, tear break-up time (BUT), and hematoxylin and eosin staining were evaluated on the ocular surface. Squamous (...) A standardized extract of Rhynchosia volubilis Lour. exerts a protective effect on benzalkonium chloride-induced mouse dry eye model. In contrast to other leguminous plants generally used as food, Rhynchosia volubilis Loureiro, a small soybean with a black seed coat, has been used as a traditional oriental remedy for various human diseases in Eastern Asia. In this study, we demonstrated the protective effect of R. volubilis against dry eye disease.We aimed to investigate whether a standardized

2017 Journal of Ethnopharmacology

147. Optive Brand For Day And Night Dry Eye Management

of Optive eyedrops and gel combination for day and night dry eye management Condition or disease Intervention/treatment Phase Dry Eye Device: Optive® Fusion + Optive® Gel Drop Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 35 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Optive Brand For Day And Night Dry Eye Management Actual Study Start (...) Date : July 3, 2017 Actual Primary Completion Date : September 6, 2017 Actual Study Completion Date : September 6, 2017 Arms and Interventions Go to Arm Intervention/treatment Experimental: Optive® Fusion + Optive® Gel Drop Optive® Fusion eyedrop will be used as needed up to four times a day but at least twice a day. The eyedrop will be used once in the evening; the gel drop being instilled any time during the last hour prior to sleep. The treatment regimen will be used for one month. Device

2017 Clinical Trials

148. Assessing Safety and Efficacy of DE-089 Ophthalmic Solution in Patients With Dry Eye Disease

provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: 3% DE-089 ophthalmic solution Drug: Placebo ophthalmic solution and 3% DE-089 ophthalmic solution Placebo ophthalmic solution; 1 drop, 6 times daily (every 2-3 hours) instilled into both eyes for 2-week run-in period 3% DE-089 ophthalmic solution; ; 1 drop, 6 times daily (every 2-3 hours) instilled into both eyes for 4-week treatment period Outcome Measures Go to Primary (...) Assessing Safety and Efficacy of DE-089 Ophthalmic Solution in Patients With Dry Eye Disease Assessing Safety and Efficacy of DE-089 Ophthalmic Solution in Patients With Dry Eye Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2017 Clinical Trials

149. Intense Pulsed Light Study for Dry Eye Disease

medications which makes light therapy contraindicated (the use of doxycycline is allowed); Tattoos in the treatment area; Patients who have had intense pulsed light therapy, Lipiflow or Meibothermoflo within the past six months; Contact lens wear more than one time/week or history of refractive surgery; Glaucoma drop use Ophthalmic steroid use within the past 30 days; Punctal plugs if instilled within 30 days of the start of the study; Obvious asymmetry between the two eyes deemed significant (...) Intense Pulsed Light Study for Dry Eye Disease Intense Pulsed Light Study for Dry Eye Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Intense Pulsed Light Study for Dry Eye Disease The safety

2017 Clinical Trials

150. Comparative Study of Rohto Dry-Aid® and Systane® Ultra in Patients With Dry Eye

] Tear Film Break Up Time after instillation of fluorescein dye Visual Function Assessment [ Time Frame: 28 days ] Reading Test Secondary Outcome Measures : Drop Comfort Assessment [ Time Frame: Day 1 ] The comfort of the eye drop will be performed to assess changes from baseline Visual Acuity [ Time Frame: 28 Days ] Visual Acuity will be measured using the EDTRS chart to assess changes from baseline Slit-Lamp Biomicroscopy [ Time Frame: 28 Days ] Slit lamp biomicroscopy exams will be performed (...) information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Be at least 18 years of age Provide written informed consent Have a reported history of dry eye Have a history of use of eye drops for dry eye symptoms Ocular discomfort Conjunctival redness Tear film break up time Corneal and Conjunctival Staining Exclusion Criteria: Have any clinically significant slit lamp findings at entry visit

2017 Clinical Trials

151. Epigallocatechin Gallate-Loaded Gelatin-g-Poly(N-Isopropylacrylamide) as a New Ophthalmic Pharmaceutical Formulation for Topical Use in the Treatment of Dry Eye Syndrome (PubMed)

time point within 3 days of release. In a rabbit dry eye model, corneal epithelial defects was ameliorated by treatment with single-dose administration of EGCG-containing GN. Furthermore, drug molecules released from carrier materials could prevent further tear evaporation and loss of mucin-secreting goblet cells in diseased animals. Our findings suggest that GN carrier is responsible for enhanced pharmacological efficacy of topically instilled EGCG, thereby demonstrating the benefits of using (...) biodegradable in situ gelling delivery system to overcome the drawbacks of limited dry eye relief associated with eye drop dosage form.

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2017 Scientific reports

152. Changes in Tear Volume after 3% Diquafosol Treatment in Patients with Dry Eye Syndrome: An Anterior Segment Spectral-domain Optical Coherence Tomography Study (PubMed)

images acquired by anterior segment spectral-domain optical coherence tomography were analyzed using National Institutes of Health's image-analysis software (ImageJ 1.44p). Tear meniscus area and tear meniscus height were measured at baseline, 5 minutes, 10 minutes, and 30 minutes after instillation of a drop of diquafosol in one eye and normal saline in the other eye. Changes in ocular surface disease index score, tear film break-up time, corneal staining score by Oxford schema, and meibomian (...) Changes in Tear Volume after 3% Diquafosol Treatment in Patients with Dry Eye Syndrome: An Anterior Segment Spectral-domain Optical Coherence Tomography Study To evaluate changes in the tear meniscus area and tear meniscus height over time in patients with dry eye syndrome, using anterior segment spectral-domain optical coherence tomography after the instillation of 3% diquafosol ophthalmic solution.Sixty eyes from 30 patients with mild to moderate dry eye syndrome were included. Tear meniscus

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2017 Korean journal of ophthalmology : KJO

153. Local anaesthetic eye drops for prevention of pain in preterm infants undergoing screening for retinopathy of prematurity. (PubMed)

Local anaesthetic eye drops for prevention of pain in preterm infants undergoing screening for retinopathy of prematurity. Screening examinations for retinopathy of prematurity (ROP) are performed routinely in the neonatal intensive care unit and are a recognised cause of pain in the newborn.To determine the effect of instillation of topical anaesthetic eye drops compared with placebo or no treatment on pain in infants undergoing ROP screening.We used the standard search strategy

2011 Cochrane database of systematic reviews (Online)

154. Effectiveness of polyethylene covers versus carbomer drops (Viscotears) to prevent dry eye syndrome in the critically ill. (PubMed)

covered with a polyethylene cover every 12 hours, and carbomer drops were instilled on the other eye every six hours. All eyes were checked for an ocular surface abnormality by the same ophthalmologist everyday. The study interventions were continued until a defect was detected or for five days. Patients with a defect detected completed the study and were recorded as positive for the primary endpoint. Results.  Carbomer drop was effective in prophylaxis of dry eye syndrome in only three of 18 patients (...) Effectiveness of polyethylene covers versus carbomer drops (Viscotears) to prevent dry eye syndrome in the critically ill. The purpose of this study was to compare the effectiveness of the polyethylene covers versus carbomer eye drops to prevent dry eye syndrome in intensive care unit patients.Concerns about eye care for critically ill patients remain an issue. Few studies have focused on the effect of polyethylene covers and eye drops. In addition, there are no studies comparing polyethylene

2011 Journal of clinical nursing

155. The Effect of Mydriatic Eye Drops on Cerebral and Mesenteric Oxygenation in Preterm Infants

the investigators investigated the effect of mydriatic eye drops on cerebral and mesenteric oxygenation in preterm infants Condition or disease Intervention/treatment Phase Prematurity of Fetus Device: near infrared spectroscopy: invos 5100 Phase 4 Detailed Description: The cerebral and mesenteric oxygenation will be measured by NIRS before, during and after the mydriatic eye drops are instilled. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated (...) cerebral and mesenteric oxygenation will be measured before, during and after mydriatic eye drops are instilled. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table

2011 Clinical Trials

156. Safety Evaluation of a New Preservative in a Lubricating Eye Drop

Intervention/treatment Experimental: Healthy Subjects Healthy Subjects instill 1-2 drops of the experimental eye drops into each eye four times per day for two weeks. Other: Eye Drops with Experimental Preservative Glycerin, Hypromellose, Polyethylene glycol 400 with experimental preservative PQ-42 Other Name: PF-006676 Experimental: Dry-Eye Subjects Dry-Eye Subjects instill 1-2 drops of the experimental eye drops into each eye four times per day for two weeks. Other: Eye Drops with Experimental (...) Safety Evaluation of a New Preservative in a Lubricating Eye Drop Safety Evaluation of a New Preservative in a Lubricating Eye Drop - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety Evaluation of a New

2011 Clinical Trials

157. Atenolol versus adrenaline eye drops and an evaluation of these two combined. (PubMed)

Atenolol versus adrenaline eye drops and an evaluation of these two combined. In a 1-day, 1-dose, double-masked, randomised trial, with each of 12 patients acting as his/her own control, atenolol drops 4% (a selective beta1-adrenergic blocker) produced a significantly greater fall in ocular tension measured by applanation than did adrenaline drops 1% (P is less than 0.01 Wilcoxon matched pairs signed ranks test). The mean differences, which favoured atenolol, between the falls in pressure (...) produced by these 2 drugs at 1.5 hours, 3.5 hours, 5.5 hours, and 7 hours after instillation of the drops was 2.1, 4.6, 4.0, and 3.6 mmHg, respectively. Long-term studies would be required before any conclusion was justified about the relative merits of these 2 drugs in the treatment of glaucoma. There was no significant difference between the ocular hypotensive effects of atenolol-then-adrenaline and adrenaline-then-atenolol. It was disappointing that the expected adjuvant effect of atenolol's

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1978 British Journal of Ophthalmology

158. Piloplex, a new long-acting pilocarpine polymer salt. B: Comparative study of the visual effects of pilocarpine and Piloplex eye drops. (PubMed)

Piloplex, a new long-acting pilocarpine polymer salt. B: Comparative study of the visual effects of pilocarpine and Piloplex eye drops. Induced accommodation and changes in vision (distance and near) were measured monocularly and binocularly in 9 young healthy volunteers in a double blind study after administering to them pilocarpine hydrochloride 4%, Piloplex 3.4, and saline eye drop instillations. Piloplex 3.4, a new long-acting pilocarpine polymer salt, and pilocarpine hydrochloride 4% (both (...) contain equal amounts of pilocarpine-3.4%) induced changes in vision and accommodation. These changes were greater with pilocarpine hydrochloride than with Piloplex. The maximum changes occurred half an hour after instillation and the effect vanished after an additional period up to 3 hours. The changes were greater when measured monocularly than binocularly. Piloplex initiates a prolonged hypotensive effect which lasts for 12 hours. Patients with glaucoma are thus able to use Piloplex on a twice

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1979 British Journal of Ophthalmology

159. Time course of changes in tear meniscus radius and blink rate after instillation of artificial tears. (PubMed)

-guar and glycol (SYS) or saline (SAL). A dose of 35 μL was applied in one eye in a randomized order with a washout period between each drop.For SAL, compared to baseline TMR (0.33 ± 0.08 mm), TMR significantly increased with drop instillation (1.55 ± 0.69 mm) and at 1 minute (0.66 ± 0.36 mm; P < 0.05), but returned to baseline after 5 minutes. For SYS, TMR (0.32 ± 0.07 mm) remained significantly increased after application (1.62 ± 0.81 mm), and at 1 minute (0.81 ± 0.43 mm) and 5 minutes (0.39 (...) ± 0.08 mm; P < 0.05). Compared to baseline BR with SAL (14.8 ± 7.7) and SYS (14.9 ± 9.4), values were significantly increased upon drop instillation (22.5 ± 11.8; 21.3 ± 11.8; P < 0.05), but returned to baseline after 1 minute. Dry eye symptoms were correlated with baseline BR (r = 0.550, P = 0.008).Results indicate that PDM can detect changes in TMR following instillation of artificial tears. Difference in residence time reflects the different viscosity of each drop. An overload with a large drop

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2014 Investigative Ophthalmology & Visual Science

160. Topical Ophthalmic AGN-195263 for the Treatment of Evaporative Dry Eye

Intervention/treatment Experimental: AGN-195263 Drug: AGN-195263 1 drop of AGN-195263 will be instilled in each eye twice daily. Placebo Comparator: Vehicle Drug: Vehicle 1 drop of AGN-195263 vehicle (placebo) will be instilled in each eye twice daily. Outcome Measures Go to Primary Outcome Measures : Overall Ocular Discomfort Score (0 to 4 Scale; 0=None, 4=Very Severe) [ Time Frame: 6 month visit ] The overall ocular discomfort will be assessed on a questionnaire using a 0 to 4 scale on which 0=none, 1 (...) Topical Ophthalmic AGN-195263 for the Treatment of Evaporative Dry Eye Topical Ophthalmic AGN-195263 for the Treatment of Evaporative Dry Eye - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical

2016 Clinical Trials

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