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Instilling Eye Drops

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1261. A Single Dose Comfort Comparison of Travatan Z in One Eye Versus Xalatan in the Opposite Eye in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension

, and the order in which the first test medicine was instilled (either travoprost or latanoprost), was randomly assigned. Drug: Travoprost ophthalmic solution 0.004% with SofZia® preservative system (TRAVATAN Z®) Ophthalmic solution for the treatment of open-angle glaucoma or ocular hypertension, one drop, single dose. Referred to as travoprost. Other Name: TRAVATAN Z® Active Comparator: Latanoprost Latanoprost assigned to one eye, with travoprost assigned to the fellow eye for intra-individual control. One (...) drop, single dose. The eye, and the order in which the first test medicine was instilled (either travoprost or latanoprost), was randomly assigned. Drug: Latanoprost ophthalmic solution 0.005% (XALATAN®) Ophthalmic solution for the treatment of open-angle glaucoma or ocular hypertension, one drop, single dose. Referred to as latanoprost. Other Name: XALATAN® Outcome Measures Go to Primary Outcome Measures : Comfort Immediately After Dosing [ Time Frame: 5 seconds ] Comfort was assessed

2007 Clinical Trials

1262. Postoperative instillation of 0.04% mitomycin C in the treatment of primary pterygium in Zaire. (Abstract)

Postoperative instillation of 0.04% mitomycin C in the treatment of primary pterygium in Zaire. to investigate, in the first report in Central Africa, the influence of tropical Mitomycin C on the recurrence rate and on the complications after surgical treatment for primary pterygium.Sixty-six patients with primary pterygia underwent excision of the lesion, leaving the sclera bare. Patients were randomized in two groups: in one group (36 eyes in 33 patients) 0.04% mitomycin C eye drops were used (...) ) and transient ocular hypertension. In group 2, complications were noted in four eyes (9.8%) and included conjunctival granulomas (three eyes) and symblepharon (one eye). Ocular hypertension could be due to instillation of mitomycin C. No group had significantly more complications.primary excision of pterygium with postoperative instillation of 0.04% mitomycin C had a higher rate of occurrence in this study than previously reported in Japan, in the USA and Europe.

1996 Bulletin de la Société belge d'ophtalmologie Controlled trial quality: uncertain

1263. Randomised prospective masked study comparing patient comfort following the instillation of topical proxymetacaine and amethocaine. Full Text available with Trip Pro

Randomised prospective masked study comparing patient comfort following the instillation of topical proxymetacaine and amethocaine. To evaluate the claim that topical proxymetacaine produces little or no discomfort on instillation by comparing it against topical amethocaine.This randomised, masked, double blind, prospective study involved 53 consecutive patients. Each patient received one drop of amethocaine 0.5% in one eye and one drop of proxymetacaine 0.5% in the other. The duration (...) a successful tonometry rate of 93% and amethocaine 98%.This clinical study confirms that proxymetacaine is more comfortable on instillation than amethocaine. Minimising unnecessary patient discomfort is not only ideal, but encourages cooperation in apprehensive patients especially in children.

1998 British Journal of Ophthalmology Controlled trial quality: uncertain

1264. Effect of betaxolol on the retinal circulation in eyes with ocular hypertension: a pilot study. Full Text available with Trip Pro

Effect of betaxolol on the retinal circulation in eyes with ocular hypertension: a pilot study. This study investigated the effect of betaxolol, a beta 1 selective blocker, on the retinal circulation in 10 patients with ocular hypertension. In a masked randomised fashion, one eye of each subject received betaxolol and the fellow eye received placebo (hypromellose). Retinal blood flow (RBF) was determined in a major temporal vein of each eye just prior to instillation of drops and 2 h later (...) , using laser Doppler velocimetry and monochromatic fundus photography. There was an increase of 15.0% in RBF (p = 0.03) in the betaxolol-treated eyes. No significant change was observed in the placebo-treated eyes. Intraocular pressure was reduced by 27.7% in the treated eyes, resulting in an increase of 16.9% in perfusion pressure (p = 0.02) compared with an 8.4% increase in placebo-treated eyes (p = 0.15). This study demonstrated that betaxolol increases RBF in eyes with ocular hypertension

1994 Eye (London, England) Controlled trial quality: uncertain

1265. Latanoprost and physostigmine have mostly additive ocular hypotensive effects in human eyes. (Abstract)

volunteers (median age, 25 years; age range, 17-30 years).Between 7 AM and 7 PM, 1 drop of physostigmine salicylate (8 mg/mL) was instilled in 1 eye every other hour. At 8 AM, 1 drop of either latanoprost (50 mg/L) or placebo was instilled in both eyes. This protocol was repeated a second time with latanoprost administered to previously placebo-treated eyes and vice versa.Intraocular pressure differences were measured with Goldmann applanation tonometry hourly for 13 hours.Latanoprost reduced (...) Latanoprost and physostigmine have mostly additive ocular hypotensive effects in human eyes. To investigate if a pronounced ciliary muscle contraction, induced by physostigmine salicylate, can abolish the ocular hypotensive effect of latanoprost, a prostaglandin analogue, via inhibition of the uveoscleral outflow.A randomized, crossover study that was double-masked for latanoprost. Physostigmine was the second factor in a 2(2) factorial experiment.A total of 20 male and female healthy

1997 Archives of ophthalmology Controlled trial quality: uncertain

1266. Effect of timolol maleate on the retinal circulation of human eyes with ocular hypertension. (Abstract)

subject received timolol maleate 0.5% and the fellow eye received placebo. Vessel diameter, maximum velocity of red blood cells, and volumetric blood flow rate were determined in a major retinal vein of each eye just prior to the instillation of drops, and then 2 hr later. In comparison to the baseline value, there was an increase of 12.0% in average red blood cell velocity (P less than 0.005, statistically significant) and of 8.4% in volumetric blood flow rate in the timolol-treated eyes (P less than (...) Effect of timolol maleate on the retinal circulation of human eyes with ocular hypertension. We studied the effect of topical timolol maleate 0.5% on the retinal circulation of eyes with ocular hypertension using laser Doppler velocimetry and monochromatic fundus photography. Patients with ocular hypertension had normal eye examinations and had documented elevated intraocular pressures of 23 mmHg or higher on two or more separate occasions. In a double-masked randomized design, one eye of each

1990 Investigative ophthalmology & visual science Controlled trial quality: uncertain

1267. In a patient with rosacea and dry eyes is there a specific therapy which is of greater benefit than simple lubricant drops (eg viscotears)?

. benzalkonium hexachloride) can irritate the eye. Control symptoms and limit damage with artificial tears (drops). Initially use artificial tears at up to 30-minute intervals if symptoms are severe. Decrease the frequency as symptoms improve. Use preservative-free preparations if more than 6 applications per day are necessary: the more frequently drops containing benzalkonium chloride are used, the greater the risk of ocular irritation.” PRODIGY also advocates the following additional therapies: “ Consider (...) . Contact lenses may be replaced in the morning. Note: contact lenses are best avoided where eye ointments are administered in the daytime. Other ocular lubricants have been shown to be effective and some have been reported as having an increased contact time with the eye. However, there is no good evidence of clinical advantage of any product over hypromellose. For people with viscous, stringy, mucous tears acetylcysteine eye drops are effective; however, they sting.” [1] The American Academy

2006 TRIP Answers

1268. A prospective randomized double masked controlled clinical trial to determine the efficacy of multiple drop centbucridine as an ocular surface anaesthetic. (Abstract)

A prospective randomized double masked controlled clinical trial to determine the efficacy of multiple drop centbucridine as an ocular surface anaesthetic. In this study, the ocular surface anaesthetic and analgesic efficacies of 0.5% and 1% centbucridine both in saline were compared with 4% lignocaine drops in distilled water in normal healthy volunteers divided into three equal groups. In 99 healthy eyes, keeping one eye as an unanaesthetized control, one drop of any of the above three coded (...) drugs was instilled in the contralateral eye, followed by one more drop of the same drug in the same eye after 3 minutes. The oneset of anaesthesia, achievement and duration of peak activity, total duration of action, the depth of analgesia, and period of burning sensation were all noted in this double-masked randomized controlled trial with the various drug solutions. Total peak duration of anaesthetic as well as analgesic effects in the 99 healthy normal eyes were found to be the highest

2004 Indian journal of physiology and pharmacology Controlled trial quality: uncertain

1269. A 12-Month Study to Evaluate the Efficacy and Safety of Once-Daily Instillation of Combination Glaucoma Therapy in Patients With Open-Angle Glaucoma or Ocular Hypertension

Experimental: Travoprost/Timolol 1 drop in the affected eye(s) once daily in the morning for 12 months Drug: Travoprost 0.004%/Timolol maleate 0.5% ophthalmic solution Investigational ophthalmic solution intended for the treatment of open-angle glaucoma or ocular hypertension Active Comparator: Latanoprost/Timolol 1 drop in the affected eye(s) once daily in the morning for 12 months Drug: Latanoprost 0.005%/Timolol 0.005% ophthalmic solution Commercially marketed ophthalmic solution intended (...) A 12-Month Study to Evaluate the Efficacy and Safety of Once-Daily Instillation of Combination Glaucoma Therapy in Patients With Open-Angle Glaucoma or Ocular Hypertension A 12-Month Study to Evaluate the Efficacy and Safety of Once-Daily Instillation of Combination Glaucoma Therapy in Patients With Open-Angle Glaucoma or Ocular Hypertension - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search

2006 Clinical Trials

1270. The Importance of Eyelid Closure and Nasolacrimal Occlusion Following the Ocular Instillation of Topical Glaucoma Medications, and the Need for the Universal Inclusion of One of these Techniques in All Patient Treatments and Clinical Studies Full Text available with Trip Pro

The Importance of Eyelid Closure and Nasolacrimal Occlusion Following the Ocular Instillation of Topical Glaucoma Medications, and the Need for the Universal Inclusion of One of these Techniques in All Patient Treatments and Clinical Studies To review the effects of nasolacrimal occlusion (NLO) and eyelid closure (ELC) on the ocular and systemic absorption of topically applied glaucoma medications and emphasize the need for the universal application of these techniques during patient treatment (...) affects the therapeutic index of glaucoma medications in unpredictable and undesirable ways. The undesirable influence on the therapeutic index of each drug influences the safety and efficacy and has implications for the cost of medical treatments, the reproducibility of clinical study results, and dosing regimens, including those of combination therapy, as reflected in the peer-reviewed literature.Patients should use NLO or ELC for 5 minutes following eye drop treatment with topically applied

2008 Transactions of the American Ophthalmological Society

1271. Determinants of eye drop size. (Abstract)

Determinants of eye drop size. Ophthalmic solutions are available for multidose or single-dose administration in a wide variety of glass and plastic dropper bottles which deliver drops with a volume between 25 and 70 microl. From a biopharmaceutical and economic point of view, however, smaller volumes of 5 to 15 microl should be instilled. In this review, the technical, pharmaceutical, and therapeutic aspects of eye drop formation and delivery are presented. The different types of containers (...) are described and the determinants of eye drop size are discussed, such as the design and physical characteristics of the dropper tip and bottle, the physico-chemical properties of the solution, and the manner in which the patient dispenses the drops. Preferred and alternative instillation techniques and aids to facilitate the administration of eye drops by elderly patients are described.

2004 Survey of Ophthalmology

1272. Acute Comfort and Blurring Profile Evaluation of Marketed Lubricant Eye Drops

Lubricant Eye Drops GenTeal Moderate Lubricant Eye Drops 1 drop each eye one time Other: GenTeal Moderate Lubricant Eye Drops GenTeal Moderate Lubricant Eye Drops one drop each eye one time Outcome Measures Go to Primary Outcome Measures : Drop Comfort [ Time Frame: once upon instillation ] Drop comfort grading scale is a 0 to 9 scale, with 0 meaning most comfortable and 9 meaning most uncomfortable. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate (...) Acute Comfort and Blurring Profile Evaluation of Marketed Lubricant Eye Drops Acute Comfort and Blurring Profile Evaluation of Marketed Lubricant Eye Drops - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2008 Clinical Trials

1273. Acute Comfort of Lubricant Eye Drop FID 111421

Drop Optive Lubricant Eye Drop 1 drop each eye one time Outcome Measures Go to Primary Outcome Measures : Drop Comfort Upon Instillation [ Time Frame: upon instillation ] Drop comfort grading scale is a scale from 0 to 9, with 0 meaning most comfortable and 9 meaning most uncomfortable. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding (...) Acute Comfort of Lubricant Eye Drop FID 111421 Acute Comfort of Lubricant Eye Drop FID 111421 - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Acute Comfort of Lubricant Eye Drop FID 111421 The safety

2008 Clinical Trials

1274. Acute Comfort of Lubricant Eye Drops FID 112903

time Other: Optive Lubricant Eye Drops Optive Lubricant Eye Drops Outcome Measures Go to Primary Outcome Measures : Drop Comfort Upon Instillation [ Time Frame: Three minutes ] Drop comfort grading scale is a scale from 0 to 9, with 0 meaning most comfortable and 9 meaning most uncomfortable. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about (...) Acute Comfort of Lubricant Eye Drops FID 112903 Acute Comfort of Lubricant Eye Drops FID 112903 - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Acute Comfort of Lubricant Eye Drops FID 112903 The safety

2008 Clinical Trials

1275. Ocular Tolerance, Safety and Ocular Pharmacokinetics After 1 Drop of T1225 0.5, 1.0, 1.5% in 48 Healthy Volunteers

, 2006 Last Update Posted : July 27, 2006 Sponsor: Laboratoires Thea Information provided by: Laboratoires Thea Study Details Study Description Go to Brief Summary: To compare the ocular tolerance, the safety and the ocular pharmacokinetics of 3 concentrations (0.5% - 1.0% - 1.5%) and the vehicle of T1225 after one drop instillation Condition or disease Intervention/treatment Phase Eye Infections, Bacterial Drug: Azithromycin (T1225) Phase 1 Detailed Description: The aim of the present study (...) was to compare the ocular tolerance, safety and the ocular pharmacokinetics after a single administration of T1225 eye drops (0.5%, 1.0%, or 1.5%) in healthy volunteers. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double Primary Purpose: Treatment Official Title: Comparison of the Ocular Tolerance, the Safety and the Ocular Pharmacokinetics After One Drop of Three Different

2006 Clinical Trials

1276. Efficacy and Safety of 2 Dosing Regimens of T1225 Eye Drops 1.5% Versus Oral Azithromycin in Treatment of Trachoma

. The study was to be performed in approximately 600 children (aged 1 to 10 years) from Guinea Conakry and Pakistan. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double Primary Purpose: Treatment Official Title: Clinical Efficacy and Safety of 2 Dosing Regimens of T1225 Eye Drops 1.5% (Instilled Twice Daily for 2 or 3 Days) Versus Oral Azithromycin in Treatment of Trachoma Study (...) Efficacy and Safety of 2 Dosing Regimens of T1225 Eye Drops 1.5% Versus Oral Azithromycin in Treatment of Trachoma Efficacy and Safety of 2 Dosing Regimens of T1225 Eye Drops 1.5% Versus Oral Azithromycin in Treatment of Trachoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2006 Clinical Trials

1277. Local Tolerability and Safety of Povidone K25 Eye Drops (Artificial Tears Containing Povidone) Versus Placebo in Healthy Volunteers

Recruitment Status : Completed First Posted : August 26, 2005 Last Update Posted : November 17, 2011 Sponsor: Novartis Information provided by (Responsible Party): Novartis Study Details Study Description Go to Brief Summary: Instillation of artificial tears is standard treatment in dry eye syndrome and in patients experiencing dry eye symptoms when wearing contact lenses. Povidone K25 eye drops (povidone) is an isotonic solution containing povidone to simulate normal tears viscosity. Safety and local (...) Local Tolerability and Safety of Povidone K25 Eye Drops (Artificial Tears Containing Povidone) Versus Placebo in Healthy Volunteers Local Tolerability and Safety of Povidone K25 Eye Drops (Artificial Tears Containing Povidone) Versus Placebo in Healthy Volunteers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have

2005 Clinical Trials

1278. Eye Drop Use in Glaucoma Patients Through Patient Surveys and Video Observations

Syndrome Conjunctivitis Detailed Description: Approximately 100 patients will take part in a one time procedure and survey as part of this project. After appropriate consent patients are asked to complete a short 2 page survey about themselves and their eye drops. Then a video recording will be made of the patient instilling eye drops in their habitual manner. The eye drops used will be sterile saline placed in either Travatan-like or Systane bottles to simulate the corresponding prescribed medication (...) . The videos will be graded for instillation technique and combined with scoring of survey answers. Patients will be asked to instill the drops to their left eye with their dominant hand as we expect this to be most difficult. Patients with severe (>20/200) vision loss will instill drops into their better seeing eye. Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 200 participants Time Perspective: Prospective Official Title: Evaluation of Eye Drop

2007 Clinical Trials

1279. Observational Study of How Patients Take Eye Drops

Information provided by: Robin, Alan L., M.D. Study Details Study Description Go to Brief Summary: This study is interested in monitoring how patients take eye drops, both through video-recordings and adherence monitoring, as well as their perceptions about their eye medications; including the dosing schedules, instillation techniques and effect on their disease. Condition or disease Intervention/treatment Glaucoma Device: MEMS cap Study Design Go to Layout table for study information Study Type (...) expect to continue drop use for the next 3 months subjects instill their own eye drops subject is able to take HVF tests subject will expect to complete the 3 months enrollment period Exclusion Criteria: unable/unwilling to instill own medications eye drops are discontinued unable to take HVF test unable to complete follow-up investigators discontinue subject for safety reasons not using drops in left eye Contacts and Locations Go to Information from the National Library of Medicine To learn more

2008 Clinical Trials

1280. Randomised double masked trial comparing the efficacy and tolerance of 0.05% mequitazine eye drops versus 0.05% levocabastine and placebo in allergic conjunctivitis induced by a conjunctival provocation test with Dermatophagoides pteronyssinus. Full Text available with Trip Pro

superiority of topical antihistamines with placebo, when a single dose of treatment was instilled following CPT. However mequitazine 0.05% eye drops were superior to placebo in preventing a reaction to CPT, after 2 weeks of treatment. (...) Randomised double masked trial comparing the efficacy and tolerance of 0.05% mequitazine eye drops versus 0.05% levocabastine and placebo in allergic conjunctivitis induced by a conjunctival provocation test with Dermatophagoides pteronyssinus. A double masked randomised trial comparing 0.05% mequitazine eye drops with 0.05% levocabastine and placebo was carried out in otherwise healthy volunteers allergic to house dust mites (Dermatophagoides pteronyssinus).Double masked, randomised, single

2004 British Journal of Ophthalmology Controlled trial quality: uncertain

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