How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,317 results for

Instilling Eye Drops

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1241. Epiphora (Watering Eyes)

with facial palsy and arise as a result of neurogenic reflex watering (thought of food, eating or chewing). Investigation Investigations may include: Fluorescein disappearance test: a tiny drop of fluorescein 2% is instilled at the start of history. After about five minutes, a judgement is made about tear film height and dilution of the fluorescein. If the tear film is high and the fluorescein diluted, there is overproduction. If it remains undiluted, there is impaired drainage. Syringing: saline (...) is irrigated through the canaliculi via the puncti after instilling a drop of local anaesthetic. Reflux through the upper canaliculus suggests obstruction at the common canaliculus. If the patient feels it trickling at the back of the throat, there is some degree of patency at least. Dacryocystogram (DCG): radioactive isotope is injected into the nasolacrimal duct and its passage is recorded with a series of sequential pictures. This can be a useful investigation both to assess whether there is patency

2008 Mentor

1242. Eye Trauma

). Specific information on poisons is available from the National Poisons Information Service. How to irrigate following chemical eye injury A number of saline bags, a giving set and towels are needed. Sit the patient by a sink. Instil anaesthetic drops and gently tilt the patient's head back so that they are holding it over the rim of the sink, explaining what you are going to do (this is easy to forget in the rush - irrigation can be unpleasant in the first few moments, until a steady stream is achieved (...) wound of the eyeball (wound occurs at the impact site by an outside-in mechanism). Contusion : no full-thickness wound; injury is due to direct energy delivery by the object (eg, choroidal rupture) or to changes in the shape of the globe. Lamellar laceration : partial-thickness wound of the eye wall caused by a sharp object. Rupture : full-thickness wound of the eye wall caused by a blunt object: since the eye is filled with incompressible liquid; the impact causes momentary increase in intraocular

2008 Mentor

1243. Topically applied pilocarpine. Human pupillary response as a function of drop size. (Abstract)

Topically applied pilocarpine. Human pupillary response as a function of drop size. Previous studies with use of animal models have shown that, for topically applied ophthalmic drugs, the fraction of dose absorbed into the eye is increased as the volume in which the drug is instilled is decreased. Such findings have not previously been confirmed in humans. In the present study, the miotic response to instilled doses of 20 and 50 microL of 0.5% pilocarpine hydrochloride was compared in ten adult (...) human volunteers. Although the 20-microL drop represents a substantial dosage reduction, the miotic response was essentially equivalent to that obtained with the 50-microL drop. These findings imply that, due to the large drainage loss of topically applied ophthalmic drugs, volumes delivered by commerical ophthalmic droppers may in some cases be larger than required to achieve the desired response.

1980 Archives of ophthalmology Controlled trial quality: uncertain

1244. The effect of timolol drops on respiratory function. Full Text available with Trip Pro

ocular hypertensive patients with intraocular pressures over 21 mmHg, normal optic discs and full visual fields by Humphrey perimetry. Subjects received single-dose units of timolol maleate 0.5% drops or normal saline drops. Both were instilled in one eye or systemically (sublingually). The peak expiratory flow rate (PFR), forced expiratory volume (FEV), vital capacity (VC) and FEV/VC (%) ratio were all measured both before and after each type of drop and route of administration.Two hours after (...) The effect of timolol drops on respiratory function. Recently, attention has been focused on the adverse drug reactions of topical timolol, especially with regard to respiratory function in the elderly. This study was designed to assess whether timolol causes an alteration in lung function in patients without pre-existing respiratory disease and who have not suffered the impact of long-term beta 2 blockade.A placebo-controlled randomised, double-masked, cross-over study was carried out on 20

1998 Eye (London, England) Controlled trial quality: uncertain

1245. Comparison of single-drop mitomycin C regime with other mitomycin C regimes in pterygium surgery. (Abstract)

Comparison of single-drop mitomycin C regime with other mitomycin C regimes in pterygium surgery. To evaluate the safety and efficacy of single-drop instillation of mitomycin C (MMC) in pterygium surgery and to compare the results with both postoperative and intraoperative application of MMC.Eighty eyes of 72 patients with pterygium were randomised into 4 equal groups: group 1--control--bare scleral excision (BSE); group 2--BSE with single-drop instillation of mitomycin C (MMC) 0.02% at the end (...) %) and 16 (80%) eyes of group 2, 3, and 4 respectively. The incidence of scleral defects was significantly lower in group 2 compared to group 3 (P=0.0001) and group 4 (P=0.0001). Compared to group 1 and 2, a significant delay in wound epithelialisation occurred in group 3 (P=0.003) and 4 (P=0.004). An ischaemic area in the bare sclera developed in 8 (40%) and 6 (30%) eyes of group 3 and 4 respectively, while ischaemic area did not develop in group 1 and 2.Single-drop instillation of 0.02% mitomycin C

2003 Indian journal of ophthalmology Controlled trial quality: uncertain

1246. Comparison of the effectiveness of 4 anti-inflammatory drops in relieving photophobia after pupil dilation. (Abstract)

Comparison of the effectiveness of 4 anti-inflammatory drops in relieving photophobia after pupil dilation. To compare the relative effectiveness of diclofenac, flurbiprofen, ketorolac, and prednisolone acetate in relieving photophobia after pupil dilation for fundus examination.Eye, Ear, Nose, and Throat Hospital, New Orleans, Louisiana, USA.This prospective, blind, placebo-controlled study comprised 105 patients randomly assigned to 1 of 10 treatment groups. Five minutes after instillation (...) of dilating drops, each patient received drops of different test medications in the right and left eyes. Light sensitivity and pupil measurement tests were performed over 2 hours after the pharmacological mydriasis. After photostimulation, patients were asked to rate their photosensitivity on numerical and analog scales and to indicate a filter value required to alleviate right-induced discomfort. Test results were analyzed to detect differences among the pain levels associated with each treatment.There

1999 Journal of cataract and refractive surgery Controlled trial quality: uncertain

1247. Measuring drug-induced eye irritation: a simple new clinical assay. (Abstract)

Measuring drug-induced eye irritation: a simple new clinical assay. Thirty-six normal subjects received a drop in either eye of two of four ophthalmic solutions, balanced saline (S), carteolol, 1% (C1), carteolol, 2% (C2), or timolol, 0.5% (T), in a double-blind, randomized trial in a balanced incomplete block design. Subjects reported immediately, at three, and again at ten minutes after administration whether one eye felt more irritated and marked an analog scale of irritation. An observer (...) also made ratings at three minutes based on responses to stereotyped questions. Significant differences in irritation between timolol and each of the other drugs and placebo were shown by analog scale scores immediately after instillation of the solutions. Maximum likelihood estimates were calculated based on statements of subject preference, and a significant preference was demonstrated. Observer ratings also demonstrated a treatment effect. This simple clinical assay system provides a new, valid

1985 Journal of clinical pharmacology Controlled trial quality: uncertain

1248. Decreased intraocular pressure in the hypertensive human eye with betaxolol, a beta 1-adrenergic antagonist. (Abstract)

Decreased intraocular pressure in the hypertensive human eye with betaxolol, a beta 1-adrenergic antagonist. In a double-masked randomized prospective study, 19 adult white subjects with primary open-angle glaucoma or ocular hypertension were treated twice daily with drops of 0.25% betaxolol (a relatively selective beta 1-adenoceptor antagonist) or placebo for six weeks. The nine betaxolol-treated subjects demonstrated a statistically significant average decrease in intraocular pressure of 3.8 (...) +/- 5 mm Hg, evident after one week and persisting throughout the entire six-week treatment period. The ten placebo-treated subjects exhibited a statistically nonsignificant increase in intraocular pressure of 0.4 +/- 2.4 mm Hg. Mean systemic arterial blood pressure, pulse rate, corneal sensitivity, pupil diameter, and basal tear secretion remained unchanged in both groups. Transient stinging upon instillation of the eyedrops was the only side effect in the betaxolol-treated subjects but in no case

1985 American journal of ophthalmology Controlled trial quality: uncertain

1249. [Treatment of dry eye syndrome with lacrimal gel: a randomized multicenter study]. (Abstract)

[Treatment of dry eye syndrome with lacrimal gel: a randomized multicenter study]. The appearance on the French market of a carbomer tear substitute, Gel-Larmes, an original galenic form, constitutes a real therapeutic progress in the treatment of dry eye syndrome. An open randomized multicentric trial was conducted comparing the tolerance and efficacy of Gel-Larmes with those of eye drops containing chondroitin sulphate. The statistical analysis evidences an inferior average number of daily (...) instillations for Gel-Larmes, its better efficacy on the symptoms as well as on the objective criteria: biomicroscopic examination, break-up time, rose Bengal test. The tolerance of the product is excellent and 81% of the patients express their wish to pursue Gel-Larmes versus 54% for the reference product.

1991 Journal français d'ophtalmologie Controlled trial quality: uncertain

1250. A comparison of proparacaine and tetracaine eye anesthetics. (Abstract)

A comparison of proparacaine and tetracaine eye anesthetics. To compare two topical eye anesthetics, proparacaine and tetracaine, for pain of instillation and duration of activity.Volunteers received both anesthetics in a prospective, randomized, double-masked protocol. The subjects were given one drop of a study solution in the lower lid fornix of the left eye. Immediately after receiving the medication, they rated the pain of instillation on a previously validated visual-analog pain scale (...) available for analysis. Twenty subjects reported proparacaine hurt less than tetracaine, two felt the pain was the same for the two agents, and only one reported that proparacaine was more painful. The mean pain score for tetracaine was 24 mm (100 mm maximum) higher than that for proparacaine (p < 0.0002). Proparacaine lasted 1.3 minutes longer than tetracaine, 10.7 minutes versus 9.4 minutes (p = 0.0001).Proparacaine eye drops cause less pain than tetracaine eye drops upon instillation. Anesthesia from

1995 Academic Emergency Medicine Controlled trial quality: uncertain

1251. Effects on intraocular pressure and aqueous flow of various dose regimens of latanoprost in human eyes. (Abstract)

Effects on intraocular pressure and aqueous flow of various dose regimens of latanoprost in human eyes. To examine if different dose regimens of latanoprost cause a difference in daytime intraocular pressure (IOP) in normal eyes and if such changes could be attributed to an increase in aqueous flow.In a randomised, open, cross-over study latanoprost 50 microg/ml was instilled in one eye of 18 volunteers. Three dose regimens (one/three drops once daily or one drop twice daily) were evaluated (...) . IOP was measured at the end of each 14-day treatment period. Aqueous flow and endothelial permeability were assessed by fluorophotometry.All dose regimens reduced IOP significantly (p < 0.001). Once daily applications reduced IOP more than twice daily (p < 0.01). No statistically significant difference in aqueous flow was detected between different treatments. One drop daily increased aqueous flow compared with control eyes (p < 0.05). A similar, but not statistically significant tendency

1997 Acta ophthalmologica Scandinavica Controlled trial quality: uncertain

1252. Physostigmine increases aqueous humor production in human eyes. (Abstract)

Physostigmine increases aqueous humor production in human eyes. To investigate if part of the progressive reduction of intraocular pressure (IOP), seen when physostigmine is applied on alternate hours, is due to a reduced aqueous flow.In a randomized, open study, one drop of physostigmine salicylate, 8 mg/ml, was instilled at 7 AM in one randomly assigned eye in each of twenty healthy volunteers. Instillations were repeated on alternate hours throughout the day. Each subject's untreated eye (...) served as control. Fluorophotometry of the anterior segment was performed hourly between 7 Am and 8 PM and aqueous flow was calculated. Subsequently, the subjects underwent tomography and tonometry. The change in anterior chamber depth and volume induced by physostigmine was assessed separately.The mean aqueous flow during the day was 25-28% higher in the physostigmine-treated eye than in the control eye. The difference was statistically significant from 9 AM (p < 0.05-p < 0.001). Each dose caused

1997 Current eye research Controlled trial quality: uncertain

1253. The effect of scleral search coil lens wear on the eye Full Text available with Trip Pro

on visual function.Six volunteer subjects were selected to undergo coil wear and baseline measurements were taken of logMAR visual acuity, non-contact tonometry, keratometry, and slit lamp examination. Four drops of 0.4% benoxinate hydrochloride were instilled before insertion of the lens by an experienced clinician. The lens then remained on the eye for 30 minutes. Measurements of the four ocular health parameters were repeated after 15 and 30 minutes of lens wear. The lens was then removed (...) The effect of scleral search coil lens wear on the eye Scleral search coils are used to measure eye movements. A recent abstract suggests that the coil can affect the eye by decreasing visual acuity, increasing intraocular pressure, and damaging the corneal and conjunctival surface. Such findings, if repeated in all subjects, would cast doubt on the credibility of the search coil as a reliable investigative technique. The aim of this study was to reassess the effect of the scleral search coil

2001 The British journal of ophthalmology

1254. The effect of dapiprazole on accommodative amplitude in eyes dilated with 0.5 percent tropicamide. (Abstract)

in pupil size.In the present single masked study, the accommodative amplitudes of forty-eight age-matched subjects previously dilated with 0.5% tropicamide were measured through a 3 millimeter artificial pupil following random instillation of dapiprazole in one eye and a placebo drop in the other eye.Area under the curve analysis determined that the magnitude of accommodative response to dapiprazole was significant at p < 0.001 (paired t-test). The McNemar test also showed that the accommodative (...) amplitude was greater in eyes treated with dapiprazole at all observation points (p < 0.005), beginning at 15 mins after the instillation of the test drug.The results demonstrate that dapiprazole accelerates the return of accommodation independent of pupil size.

1993 Journal of the American Optometric Association Controlled trial quality: uncertain

1255. Effects of dopamine antagonists in human eye accommodation. (Abstract)

Effects of dopamine antagonists in human eye accommodation. The purpose of this study was to evaluate the effects of dopamine antagonists in accommodation of the human eye. The dopamine antagonist drugs used in this experiment include 0.5% metoclopramide and 0.25% droperidol. Eighteen healthy subjects were enrolled; they were randomly assigned, in double-masked fashion, to receive topical administration of a single drop of either 0.5% metoclopramide or 0.25% droperidol in one eye (...) , with the fellow eye receiving isotonic saline as control. The accommodative abilities of both eyes were measured before instillation, and also at 3 and 6 hr after instillation of drugs, respectively. We studied the latency of reaction, the rate of accommodation, the average accommodative power, the rate of recovering and the total recovering time as the five parameters for evaluating the accommodative ability of each eye. The results showed that there were significant changes in two parameters: the rate

2001 Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Controlled trial quality: uncertain

1256. The acute effect of pilocarpine on pulsatile ocular blood flow in ocular hypertension. Full Text available with Trip Pro

The acute effect of pilocarpine on pulsatile ocular blood flow in ocular hypertension. To determine the acute effects of application of 2% pilocarpine on pulsatile ocular blood flow.In a randomised prospective controlled study of an exploratory nature, 18 subjects with ocular hypertension had pilocarpine 2% eye drops instilled into a randomly chosen eye three times at 10 min intervals. Physiological saline was instilled into the contralateral control eye. Intraocular pressure (IOP (...) with the contralateral control eye (p = 0.001; median difference -4.25 mmHg; 95% confidence interval, -5.85 to -2.40). There was a significant increase in POBF at 90 min in the treated eye in comparison with the contralateral control eye (p < 0.001; median difference 4.60 microl/s; 95% confidence interval, 2.35 to 6.75).Acute application of pilocarpine 2% drops increased POBF to a significant extent in untreated ocular hypertension.

2001 Eye (London, England) Controlled trial quality: uncertain

1257. [Clinical evaluation of the ocular safety of Amukine 0.06% solution for local application versus povidone iodine (Bétadine) 5% solution for ocular irrigation) in preoperative antisepsis]. (Abstract)

patients, aged between 49 and 90 years, were included and split, after randomization, into two groups: one testing Amukine 0.06%, the other testing a 5% povidone iodine solution. For each group, after local anesthesia, the antiseptic procedure consisted of an antisepsis of periocular teguments followed by an eye antisepsis through the instillation of two drops of the tested product in the conjunctival fornices. The safety evaluation was performed by grading superficial punctate keratitis 24 hours after (...) [Clinical evaluation of the ocular safety of Amukine 0.06% solution for local application versus povidone iodine (Bétadine) 5% solution for ocular irrigation) in preoperative antisepsis]. The aim of this monocentric, randomized, comparative, open study was to evaluate the safety of Amukine 0.06% solution (an isotonic hypochloride sodium solution) versus a 5% povidone iodine solution (Bétadine 5% solution for ocular irrigation) in antisepsis before cataract surgery.One hundred and thirteen

2002 Journal français d'ophtalmologie Controlled trial quality: uncertain

1258. Protective effect of D-beta-hydroxybutyrate on corneal epithelia in dry eye conditions through suppression of apoptosis. (Abstract)

evaporation. During desiccation, one eye of each rat was treated with HBA (20, 40, or 80 mM) or rat serum (5%, 20%, or 100%), and in the other eye a drop of phosphate-buffered saline (PBS) was instilled as the control. Histopathologic examination and quantification of the epithelial defect area were performed. The apoptosis in the epithelia was determined by chromatin condensation using the Hoechst 33342 fluorescein probe.In PBS-treated eyes, thinning in the cell layer was seen on the periphery (...) Protective effect of D-beta-hydroxybutyrate on corneal epithelia in dry eye conditions through suppression of apoptosis. To investigate the effect of D-beta-hydroxybutyrate (HBA) on ocular surface epithelial disorders induced by tear fluid deficiency, the potency of HBA and serum, the efficacy of which has been well documented in clinical application, were compared.Rat corneal epithelial erosion was induced by exposure of rat eyes to continuous low-humidity airflow, which accelerated the tear

2003 Investigative Ophthalmology & Visual Science

1259. A Single Dose Comfort Comparison of Travatan Z in One Eye Versus Xalatan in the Opposite Eye in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension

, and the order in which the first test medicine was instilled (either travoprost or latanoprost), was randomly assigned. Drug: Travoprost ophthalmic solution 0.004% with SofZia® preservative system (TRAVATAN Z®) Ophthalmic solution for the treatment of open-angle glaucoma or ocular hypertension, one drop, single dose. Referred to as travoprost. Other Name: TRAVATAN Z® Active Comparator: Latanoprost Latanoprost assigned to one eye, with travoprost assigned to the fellow eye for intra-individual control. One (...) drop, single dose. The eye, and the order in which the first test medicine was instilled (either travoprost or latanoprost), was randomly assigned. Drug: Latanoprost ophthalmic solution 0.005% (XALATAN®) Ophthalmic solution for the treatment of open-angle glaucoma or ocular hypertension, one drop, single dose. Referred to as latanoprost. Other Name: XALATAN® Outcome Measures Go to Primary Outcome Measures : Comfort Immediately After Dosing [ Time Frame: 5 seconds ] Comfort was assessed

2007 Clinical Trials

1260. Postoperative instillation of 0.04% mitomycin C in the treatment of primary pterygium in Zaire. (Abstract)

Postoperative instillation of 0.04% mitomycin C in the treatment of primary pterygium in Zaire. to investigate, in the first report in Central Africa, the influence of tropical Mitomycin C on the recurrence rate and on the complications after surgical treatment for primary pterygium.Sixty-six patients with primary pterygia underwent excision of the lesion, leaving the sclera bare. Patients were randomized in two groups: in one group (36 eyes in 33 patients) 0.04% mitomycin C eye drops were used (...) ) and transient ocular hypertension. In group 2, complications were noted in four eyes (9.8%) and included conjunctival granulomas (three eyes) and symblepharon (one eye). Ocular hypertension could be due to instillation of mitomycin C. No group had significantly more complications.primary excision of pterygium with postoperative instillation of 0.04% mitomycin C had a higher rate of occurrence in this study than previously reported in Japan, in the USA and Europe.

1996 Bulletin de la Société belge d'ophtalmologie Controlled trial quality: uncertain

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>